{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:35:42Z","timestamp":1784082942975,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.bcmd.2012.05.007","type":"journal-article","created":{"date-parts":[[2012,6,10]],"date-time":"2012-06-10T07:56:45Z","timestamp":1339315005000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comprehensive profile of cytogenetics in 2308 Chinese children and adults with de novo acute myeloid leukemia"],"prefix":"10.1016","volume":"49","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lannan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2012.05.007_bb0005","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1056\/NEJM199909303411407","article-title":"Acute myeloid leukemia","volume":"341","author":"Lowenberg","year":"1999","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0010","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2009-07-235358","article-title":"Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet","volume":"115","author":"D\u00f6hner","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0015","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1200\/JCO.2010.30.1820","article-title":"Therapeutic advances in acute myeloid leukemia","volume":"29","author":"Burnett","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0020","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"109","article-title":"Acute myeloid leukaemia and related precursor neoplasms","author":"Arber","year":"2008"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0025","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V92.7.2322","article-title":"The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties","volume":"92","author":"Grimwade","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0030","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1182\/blood.V96.13.4075","article-title":"Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group\/Eastern Cooperative Oncology Group Study","volume":"96","author":"Slovak","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0035","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1182\/blood.V98.5.1312","article-title":"The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial","volume":"98","author":"Grimwade","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0040","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1182\/blood-2002-03-0772","article-title":"Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)","volume":"100","author":"Byrd","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0045","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0268-960X(03)00040-7","article-title":"Cytogenetics in acute leukemia","volume":"18","author":"Mr\u00f3zek","year":"2004","journal-title":"Blood Rev."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1182\/asheducation-2006.1.169","article-title":"Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia","author":"Mr\u00f3zek","year":"2006","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0055","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1600-0609.2009.01308.x","article-title":"Cytogenetics of pediatric acute myeloid leukemia","volume":"83","author":"Manola","year":"2009","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3324\/haematol.2010.029660","article-title":"Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia","volume":"96","author":"Balgobind","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0065","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1200\/JCO.2009.24.8997","article-title":"Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12","volume":"28","author":"Harrison","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0070","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1200\/JCO.2009.25.6321","article-title":"Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98","volume":"28","author":"von Neuhoff","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0075","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1182\/blood-2009-11-254441","article-title":"Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials","volume":"116","author":"Grimwade","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0080","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/leu.2009.107","article-title":"Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China","volume":"23","author":"Cheng","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0085","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cancergen.2011.06.003","article-title":"A single-center cytogenetic study of 629 Chinese patients with de novo acute myeloid leukemia\u2014evidence of major ethnic differences and a high prevalence of acute promyelocytic leukemia in Chinese patients","volume":"204","author":"So","year":"2011","journal-title":"Cancer Genet."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0090","doi-asserted-by":"crossref","first-page":"620","DOI":"10.7326\/0003-4819-103-4-620","article-title":"Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group","volume":"103","author":"Bennett","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2141.1991.tb04444.x","article-title":"Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-M0)","volume":"78","author":"Bennett","year":"1991","journal-title":"Br. J. Haematol."},{"issue":"Suppl. 2","key":"10.1016\/j.bcmd.2012.05.007_bb0100","first-page":"1","article-title":"The classification of acute leukaemia","volume":"6","author":"Catovsky","year":"1992","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0105","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias, European Group for the Immunological Characterization of Leukemias","volume":"9","author":"Bene","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0463.2010.02694.x","article-title":"Relevance of immunophenotypes to prognostic subgroups of age, WBC, platelet count, and cytogenetics in de novo acute myeloid leukemia","volume":"119","author":"Li","year":"2011","journal-title":"APMIS"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0115","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.leukres.2011.12.016","article-title":"A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia","volume":"36","author":"Li","year":"2012","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0120","series-title":"An International System for Human Cytogenetic Nomenclature","year":"2009"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0125","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cancergencyto.2007.04.013","article-title":"A report of early cytogenetic response to imatinib in two patients with chronic myeloid leukemia at accelerated phase and carrying the e19a2 BCR-ABL transcript","volume":"176","author":"Li","year":"2007","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0130","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/sj.leu.2401592","article-title":"Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia","volume":"13","author":"van Dongen","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0135","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","article-title":"Standardization and quality control studies of \u2018real-time\u2019 quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia\u2014a Europe Against Cancer program","volume":"17","author":"Gabert","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0140","first-page":"12","article-title":"Incidence survey of leukemia in China","volume":"14","author":"Chinese Epidemiologic Study Group of Leukemia and Aplastic Anemia","year":"1992","journal-title":"Acta Acad. Med. Sin."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-8722-3-21","article-title":"An epidemiological investigation of leukemia incidence between 2003 and 2007 in Nanjing, China","volume":"3","author":"Chen","year":"2010","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0155","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1471-2407-9-252","article-title":"The incidence of and mortality from leukaemias in the UK: a general population-based study","volume":"9","author":"Bhayat","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0165-4608(95)00084-4","article-title":"Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan","volume":"84","author":"Tien","year":"1995","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0160","first-page":"1082","article-title":"The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenetic subgroups","volume":"89","author":"Schoch","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0165","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1200\/JCO.2007.15.4245","article-title":"Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group","volume":"27","author":"B\u00fcchner","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0170","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1182\/blood-2008-07-172007","article-title":"Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry","volume":"113","author":"Juliusson","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.leu.2401638","article-title":"Geographic heterogeneity of cellular characteristics of acute myeloid leukemia: a comparative study of Australian and Japanese adult cases","volume":"14","author":"Nakase","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0185","series-title":"Hematology: Basic Principles and Practice","first-page":"933","article-title":"Clinical manifestations of acute myeloid leukemia","author":"Miller","year":"2009"},{"key":"10.1016\/j.bcmd.2012.05.007_bb0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-0-387-69259-3_3","article-title":"Chromosomal translocations in AML: detection and prognostic significance","volume":"145","author":"Palanisamy","year":"2010","journal-title":"Cancer Treat. Res."},{"key":"10.1016\/j.bcmd.2012.05.007_bb0195","first-page":"1297","article-title":"Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party","volume":"96","author":"Grimwade","year":"2000","journal-title":"Blood"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979612000964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979612000964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:28:29Z","timestamp":1761049709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979612000964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1079979612000964"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2012.05.007","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive profile of cytogenetics in 2308 Chinese children and adults with de novo acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2012.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}