{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:25:08Z","timestamp":1772810708677,"version":"3.50.1"},"reference-count":101,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bcmd.2013.08.002","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T15:46:07Z","timestamp":1379087167000},"page":"12-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["DNA damage response, redox status and hematopoiesis"],"prefix":"10.1016","volume":"52","author":[{"given":"Cary N.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2013.08.002_bb0005","series-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0010","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/sj.leu.2403515","article-title":"Regulation of hematopoietic stem cell growth","volume":"18","author":"Attar","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0015","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0092-8674(86)90566-0","article-title":"Developmental potential and dynamic behavior of hematopoietic stem cells","volume":"45","author":"Lemischka","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.273.5272.242","article-title":"Long-term lymphohematopoietic reconstitution by a single CD34-low\/negative hematopoietic stem cell","volume":"273","author":"Osawa","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0025","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1182\/blood-2005-05-2140","article-title":"SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity","volume":"107","author":"Yilmaz","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0030","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0035","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0040","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s12185-011-0793-z","article-title":"Maintenance of genomic integrity in hematopoietic stem cells","volume":"93","author":"Naka","year":"2011","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0045","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1073\/pnas.96.6.3120","article-title":"In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells","volume":"96","author":"Cheshier","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature06115","article-title":"Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU","volume":"449","author":"Kiel","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0055","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0060","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrg2269","article-title":"Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation","volume":"9","author":"Orford","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0070","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2005.01.028","article-title":"DNA repair, genome stability, and aging","volume":"120","author":"Lombard","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0075","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/j.seminhematol.2006.04.005","article-title":"Fanconi anemia","volume":"43","author":"Bagby","year":"2006","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0080","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMra0804615","article-title":"DNA damage, aging, and cancer","volume":"361","author":"Hoeijmakers","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0085","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm2351","article-title":"Regulation of DNA repair throughout the cell cycle","volume":"9","author":"Branzei","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0090","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0095","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nrm3060","article-title":"DNA damage response in adult stem cells: pathways and consequences","volume":"12","author":"Mandal","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0105","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0110","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cell.2008.01.036","article-title":"Stems cells and the pathways to aging and cancer","volume":"132","author":"Rossi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0115","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/stem.437","article-title":"Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1","volume":"28","author":"Parmar","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0120","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1182\/blood-2010-04-278226","article-title":"Fancd2\u2212\/\u2212 mice have hematopoietic defects that can be partially corrected by resveratrol","volume":"116","author":"Zhang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0125","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2006.03.011","article-title":"Stem cells and cancer: two faces of eve","volume":"124","author":"Clarke","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0130","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0140","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature05862","article-title":"Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age","volume":"447","author":"Rossi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0145","doi-asserted-by":"crossref","first-page":"e17487","DOI":"10.1371\/journal.pone.0017487","article-title":"Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging","volume":"6","author":"Rube","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0150","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2012.01.040","article-title":"A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0160","first-page":"5991","article-title":"Ataxia-telangiectasia and cellular responses to DNA damage","volume":"55","author":"Meyn","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0170","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0175","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.stem.2011.09.010","article-title":"Metabolic regulation of hematopoietic stem cells in the hypoxic niche","volume":"9","author":"Suda","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0180","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis","volume":"297","author":"Bjelakovic","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0185","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1182\/blood.V82.7.2031.2031","article-title":"The role of hypoxia in the maintenance of hematopoietic stem cells","volume":"82","author":"Cipolleschi","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0190","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.stem.2010.07.007","article-title":"Oxygen in stem cell biology: a critical component of the stem cell niche","volume":"7","author":"Mohyeldin","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0195","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1182\/blood-2007-05-087759","article-title":"A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche","volume":"110","author":"Jang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0200","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1038\/sj.onc.1203172","article-title":"Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation","volume":"18","author":"Takao","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0205","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.1365-2249.2000.01098.x","article-title":"Spontaneous and oxidative stress-induced programmed cell death in lymphocytes from patients with ataxia telangiectasia (AT)","volume":"119","author":"Schubert","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0210","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(00)01422-8","article-title":"Protective roles for ATM in cellular response to oxidative stress","volume":"472","author":"Takao","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0215","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0220","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.4161\/cc.9.24.14323","article-title":"ATM activation in the presence of oxidative stress","volume":"9","author":"Guo","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0225","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0230","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature02989","article-title":"Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells","volume":"431","author":"Ito","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0235","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1084\/jem.20052477","article-title":"Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice","volume":"203","author":"Oguro","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0240","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1126\/science.287.5459.1804","article-title":"Hematopoietic stem cell quiescence maintained by p21cip1\/waf1","volume":"287","author":"Cheng","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0245","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1101\/gad.869001","article-title":"Ataxia telangiectasia mutated is essential during adult neurogenesis","volume":"15","author":"Allen","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0250","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/jcp.22561","article-title":"The p53 tumor suppressor protein regulates hematopoietic stem cell fate","volume":"226","author":"Asai","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0255","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1182\/blood-2012-05-356014","article-title":"The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans","volume":"120","author":"Pant","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0260","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1182\/blood-2011-11-393983","article-title":"Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem\/progenitor cells","volume":"120","author":"Asai","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0265","doi-asserted-by":"crossref","first-page":"5774","DOI":"10.1038\/sj.onc.1206677","article-title":"P53 and radiation responses","volume":"22","author":"Fei","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0270","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0275","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrm2147","article-title":"p53 in health and disease","volume":"8","author":"Vousden","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0280","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Haupt","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0285","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/cdd.2010.35","article-title":"p53-family proteins and their regulators: hubs and spokes in tumor suppression","volume":"17","author":"Collavin","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0290","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1371\/journal.pgen.0010028","article-title":"Differential expression of novel potential regulators in hematopoietic stem cells","volume":"1","author":"Forsberg","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0295","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.stem.2008.11.006","article-title":"p53 regulates hematopoietic stem cell quiescence","volume":"4","author":"Liu","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0300","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature06869","article-title":"Long-term haematopoietic reconstitution by Trp53\u2212\/\u2212p16Ink4a\u2212\/\u2212p19Arf\u2212\/\u2212 multipotent progenitors","volume":"453","author":"Akala","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0305","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0301-472X(03)00072-9","article-title":"Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice","volume":"31","author":"TeKippe","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0310","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2006.02.017","article-title":"The transcription factor MEF\/ELF4 regulates the quiescence of primitive hematopoietic cells","volume":"9","author":"Lacorazza","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0315","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm1320","article-title":"The antioxidant function of the p53 tumor suppressor","volume":"11","author":"Sablina","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0320","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stem.2010.09.013","article-title":"Mdm2 is required for survival of hematopoietic stem cells\/progenitors via dampening of ROS-induced p53 activity","volume":"7","author":"Abbas","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0325","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.stem.2010.05.016","article-title":"A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal","volume":"7","author":"Milyavsky","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0330","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nature02060","article-title":"Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation","volume":"425","author":"Molofsky","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0335","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","article-title":"Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells","volume":"423","author":"Park","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0340","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature08040","article-title":"Bmi1 regulates mitochondrial function and the DNA damage response pathway","volume":"459","author":"Liu","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0345","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/B978-0-12-380888-2.00003-0","article-title":"The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer","volume":"108","author":"Smith","year":"2010","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0350","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nm1388","article-title":"Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells","volume":"12","author":"Ito","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0355","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.4049\/jimmunol.168.12.5984","article-title":"Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia","volume":"168","author":"Verma","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0360","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0365","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cell.2005.06.014","article-title":"Proapoptotic BID is an ATM effector in the DNA-damage response","volume":"122","author":"Kamer","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0370","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cell.2005.06.022","article-title":"A role for proapoptotic BID in the DNA-damage response","volume":"122","author":"Zinkel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0375","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/sj.cdd.4402181","article-title":"Nucleocytoplasmic shuttling of BID is involved in regulating its activities in the DNA-damage response","volume":"14","author":"Oberkovitz","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0380","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ncb2468","article-title":"The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells","volume":"14","author":"Maryanovich","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0385","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1182\/blood-2011-01-330050","article-title":"Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells","volume":"118","author":"Yahata","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0390","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2007.02.001","article-title":"Foxo3a is essential for maintenance of the hematopoietic stem cell pool","volume":"1","author":"Miyamoto","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0395","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cell.2007.01.003","article-title":"FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress","volume":"128","author":"Tothova","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0400","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2006.12.029","article-title":"FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis","volume":"128","author":"Paik","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0405","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0410","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0960-9822(00)00728-4","article-title":"Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1","volume":"10","author":"Dijkers","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0415","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1038\/sj.emboj.7601236","article-title":"Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells","volume":"25","author":"Yamazaki","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0420","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","article-title":"Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress","volume":"419","author":"Kops","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0425","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature04703","article-title":"Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells","volume":"441","author":"Yilmaz","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0430","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature04747","article-title":"PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention","volume":"441","author":"Zhang","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0435","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.273.22.13375","article-title":"The tumor suppressor, PTEN\/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate","volume":"273","author":"Maehama","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0440","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/hmg\/8.2.185","article-title":"PTEN is inversely correlated with the cell survival factor Akt\/PKB and is inactivated via multiple mechanisms in haematological malignancies","volume":"8","author":"Dahia","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0445","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1182\/blood-2009-06-229443","article-title":"Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice","volume":"115","author":"Kharas","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0450","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1182\/blood-2009-09-241000","article-title":"AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species","volume":"115","author":"Juntilla","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0455","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature11895","article-title":"FOXO3A directs a protective autophagy program in haematopoietic stem cells","volume":"494","author":"Warr","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0460","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1038\/sj.onc.1203283","article-title":"DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis","volume":"18","author":"Dasika","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0465","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0470","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.dnarep.2008.06.018","article-title":"Comparison of nonhomologous end joining and homologous recombination in human cells","volume":"7","author":"Mao","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0475","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00018-002-8429-3","article-title":"Double-strand breaks and translocations in cancer","volume":"59","author":"Elliott","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0480","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1182\/blood-2005-06-2437","article-title":"A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair","volume":"107","author":"Weinstock","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0485","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.dnarep.2006.05.028","article-title":"Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells","volume":"5","author":"Weinstock","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0490","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2010.06.014","article-title":"Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis","volume":"7","author":"Mohrin","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0495","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1182\/blood.V86.1.122.bloodjournal861122","article-title":"Variations in radiation sensitivity and repair among different hematopoietic stem cell subsets following fractionated irradiation","volume":"86","author":"Down","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.08.002_bb0500","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1084\/jem.20050967","article-title":"Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates","volume":"202","author":"Passegue","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcmd.2013.08.002_bb0505","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.stem.2010.07.006","article-title":"Differential DNA damage response in stem and progenitor cells","volume":"7","author":"Seita","year":"2010","journal-title":"Cell Stem Cell"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997961300199X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997961300199X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:29:30Z","timestamp":1761049770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107997961300199X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S107997961300199X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2013.08.002","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA damage response, redox status and hematopoiesis","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2013.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}