{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:29Z","timestamp":1786985069420,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.bcmd.2013.11.003","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T09:35:41Z","timestamp":1385976941000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease"],"prefix":"10.1016","volume":"52","author":[{"given":"Marion E.","family":"Reid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Halter","family":"Hipsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Hue-Roye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Hoppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1537-2995.2002.00007.x","article-title":"Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions","volume":"42","author":"Aygun","year":"2002","journal-title":"Transfusion (Paris)"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0010","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1537-2995.1997.37497265334.x","article-title":"Severe reactions associated with transfusion of patients with sickle cell disease","volume":"37","author":"Garratty","year":"1997","journal-title":"Transfusion (Paris)"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1537-2995.1977.17477216857.x","article-title":"Blood group alloantibodies: an assessment of some laboratory practices","volume":"17","author":"Giblett","year":"1977","journal-title":"Transfusion (Paris)"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0020","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1365-2141.1995.tb05425.x","article-title":"A prospective study to determine the frequency and clinical significance of alloimmunization post-transfusion","volume":"91","author":"Heddle","year":"1995","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0025","first-page":"42","article-title":"Multiple red cell transfusions and alloimmunization. Experience with 6996 antibodies detected in a total of 159,262 patients from 1985 to 1993","volume":"119","author":"Hoeltge","year":"1995","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0030","first-page":"216","article-title":"A prospective study of the incidence of red cell allo-immunisation following transfusion","volume":"71","author":"Redman","year":"1996","journal-title":"Vox Sang."},{"issue":"7","key":"10.1016\/j.bcmd.2013.11.003_bb0035","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1182\/blood.V76.7.1431.1431","article-title":"Transfusion and alloimmunization in sickle cell disease. The cooperative study of sickle cell disease","volume":"76","author":"Rosse","year":"1990","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM199807023390102","article-title":"Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography","volume":"339","author":"Adams","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.bcmd.2013.11.003_bb0045","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1067\/mpd.2001.119593","article-title":"Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia","volume":"139","author":"Miller","year":"2001","journal-title":"J. Pediatr."},{"issue":"26","key":"10.1016\/j.bcmd.2013.11.003_bb0050","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1056\/NEJMoa050460","article-title":"Optimizing primary stroke prevention in sickle cell anemia trial I. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease","volume":"353","author":"Adams","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.bcmd.2013.11.003_bb0055","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1182\/blood-2003-08-2733","article-title":"Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study","volume":"103","author":"Adams","year":"2004","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0060","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood-2010-12-326298","article-title":"Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II","volume":"118","author":"Abboud","year":"2011","journal-title":"Blood"},{"issue":"18","key":"10.1016\/j.bcmd.2013.11.003_bb0065","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1001\/jama.2010.562","article-title":"Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia","volume":"303","author":"Vichinsky","year":"2010","journal-title":"JAMA"},{"issue":"9870","key":"10.1016\/j.bcmd.2013.11.003_bb0070","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0140-6736(12)61726-7","article-title":"The Transfusion Alternatives Preoperatively in sickle cell disease (TAPS) study: a randomised, controlled, multicentre clinical trial","volume":"381","author":"Howard","year":"2013","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bcmd.2013.11.003_bb0075","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tmrv.2006.11.003","article-title":"Transfusion in the patient with sickle cell disease: a critical review of the literature and transfusion guidelines","volume":"21","author":"Josephson","year":"2007","journal-title":"Transfus. Med. Rev."},{"issue":"Suppl. 3","key":"10.1016\/j.bcmd.2013.11.003_bb0080","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1016\/j.revmed.2009.07.001","article-title":"Guidelines for management of adult sickle cell disease","volume":"30","author":"Lionnet","year":"2009","journal-title":"Rev. Med. Interne"},{"issue":"5","key":"10.1016\/j.bcmd.2013.11.003_bb0280","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.hoc.2005.07.002","article-title":"Transfusion management in sickle cell disease","volume":"19","author":"Wanko","year":"2005","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"6","key":"10.1016\/j.bcmd.2013.11.003_bb0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1365-2141.2010.08451.x","article-title":"Blood transfusion usage among adults with sickle cell disease \u2014 a single institution experience over ten years","volume":"152","author":"Drasar","year":"2011","journal-title":"Br. J. Haematol."},{"issue":"6 Pt 1","key":"10.1016\/j.bcmd.2013.11.003_bb0095","doi-asserted-by":"crossref","first-page":"e661","DOI":"10.1542\/peds.111.6.e661","article-title":"Delayed hemolytic transfusion reaction\/hyperhemolysis syndrome in children with sickle cell disease","volume":"111","author":"Talano","year":"2003","journal-title":"Pediatrics"},{"issue":"23","key":"10.1016\/j.bcmd.2013.11.003_bb0100","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1056\/NEJM199006073222301","article-title":"Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood [see comments]","volume":"322","author":"Vichinsky","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1537-2995.2009.02527.x","article-title":"Transfusion management of patients with sickle cell disease: the continuing dilemma","volume":"50","author":"King","year":"2010","journal-title":"Transfusion (Paris)"},{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1537-2995.2009.02435.x","article-title":"Red blood cell alloimmunization in sickle cell disease patients in Uganda","volume":"50","author":"Natukunda","year":"2010","journal-title":"Transfusion (Paris)"},{"issue":"3","key":"10.1016\/j.bcmd.2013.11.003_bb0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1365-2141.2001.02819.x","article-title":"Red cell antibodies in patients with homozygous sickle cell disease: a comparison of patients in Jamaica and the United Kingdom","volume":"113","author":"Olujohungbe","year":"2001","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.bcmd.2013.11.003_bb0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ajh.2830430206","article-title":"A simple, practical model for reducing alloimmunization in patients with sickle cell disease","volume":"43","author":"Sosler","year":"1993","journal-title":"Am. J. Hematol."},{"issue":"7","key":"10.1016\/j.bcmd.2013.11.003_bb0125","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1046\/j.1537-2995.1994.34794330008.x","article-title":"Antigen-matched donor blood in the transfusion management of patients with sickle cell disease","volume":"34","author":"Tahhan","year":"1994","journal-title":"Transfusion (Paris)"},{"issue":"9","key":"10.1016\/j.bcmd.2013.11.003_bb0130","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1046\/j.1537-2995.2001.41091086.x","article-title":"Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial","volume":"41","author":"Vichinsky","year":"2001","journal-title":"Transfusion (Paris)"},{"issue":"6","key":"10.1016\/j.bcmd.2013.11.003_bb0135","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1182\/blood-2013-03-490623","article-title":"High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors","volume":"122","author":"Chou","year":"2013","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0140","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1537-2995.2012.03796.x","article-title":"Red blood cell alloimmunization in sickle cell disease: prevalence in 2010","volume":"53","author":"Miller","year":"2013","journal-title":"Transfusion (Paris)"},{"issue":"9","key":"10.1016\/j.bcmd.2013.11.003_bb0145","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/pbc.24530","article-title":"Alloimmunization in sickle cell anemia in the era of extended red cell typing","volume":"60","author":"O'Suoji","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0285","series-title":"The Blood Group Antigen FactsBook","author":"Reid","year":"2012"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0290","series-title":"AABB Technical Manual","year":"2008"},{"issue":"Database issue","key":"10.1016\/j.bcmd.2013.11.003_bb0295","doi-asserted-by":"crossref","first-page":"D1023","DOI":"10.1093\/nar\/gkr958","article-title":"BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems","volume":"40","author":"Patnaik","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.bcmd.2013.11.003_bb0165","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1182\/blood.V95.12.3662.012k12_3662_3668","article-title":"RHD gene deletion occurred in the Rhesus box","volume":"95","author":"Wagner","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1182\/blood.V95.1.12","article-title":"The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in Africans with the Rh D-negative blood group phenotype","volume":"95","author":"Singleton","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0175","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/clinchem\/47.4.667","article-title":"Determination of RhD zygosity: comparison of a double amplification refractory mutation system approach and a multiplex real-time quantitative PCR approach","volume":"47","author":"Chiu","year":"2001","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bcmd.2013.11.003_bb0300","series-title":"BeadChip Molecular Immunohematology: Toward Routine Donor and Patient Antigen Profiling by DNA Analysis","first-page":"122","article-title":"Identification of altered RHD and RHCE alleles: a comparison of manual and automated molecular methods","author":"Vege","year":"2011"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0305","series-title":"BeadChip Molecular Immunohematology: Toward Routine Donor and Patient Antigen Profiling by DNA Analysis","first-page":"101","article-title":"Matching SCD patients for RH variants","author":"Reid","year":"2011"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0310","series-title":"BeadChip Molecular Immunohematology: Toward Routine Donor and Patient Antigen Profiling by DNA Analysis","first-page":"17","article-title":"The BeadChip system: a flexible array format for complex nucleic acid and protein analysis","author":"Hashmi","year":"2011"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0315","series-title":"BeadChip Molecular Immunohematology: Toward Routine Donor and Patient Antigen Profiling by DNA Analysis","first-page":"133","article-title":"Bayesian classification algorithms for automated allele assignment","author":"Podual","year":"2011"},{"issue":"6","key":"10.1016\/j.bcmd.2013.11.003_bb0200","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/j.1537-2995.2009.02573.x","article-title":"DIIIa and DIII Type 5 are encoded by the same allele and are associated with altered RHCE*ce alleles: clinical implications","volume":"50","author":"Westhoff","year":"2010","journal-title":"Transfusion (Paris)"},{"issue":"1 Suppl.","key":"10.1016\/j.bcmd.2013.11.003_bb0205","first-page":"40S","article-title":"The BloodGen project: toward mass-scale comprehensive genotyping of blood donors in the European Union and beyond","volume":"47","author":"Avent","year":"2007","journal-title":"Transfusion (Paris)"},{"issue":"5","key":"10.1016\/j.bcmd.2013.11.003_bb0210","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1537-2995.2005.04319.x","article-title":"Rapid genotyping of blood group antigens by multiplex polymerase chain reaction and DNA microarray hybridization","volume":"45","author":"Beiboer","year":"2005","journal-title":"Transfusion (Paris)"},{"issue":"5","key":"10.1016\/j.bcmd.2013.11.003_bb0215","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1537-2995.2005.04318.x","article-title":"Microarray-based genotyping for blood groups: comparison of gene array and 5\u2032-nuclease assay techniques with human platelet antigen as a model","volume":"45","author":"Bugert","year":"2005","journal-title":"Transfusion (Paris)"},{"issue":"5","key":"10.1016\/j.bcmd.2013.11.003_bb0220","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1537-2995.2005.04365.x","article-title":"High-throughput multiplex single-nucleotide polymorphism analysis for red cell and platelet antigen genotypes","volume":"45","author":"Denomme","year":"2005","journal-title":"Transfusion (Paris)"},{"issue":"5","key":"10.1016\/j.bcmd.2013.11.003_bb0225","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1537-2995.2005.04362.x","article-title":"A flexible array format for large-scale, rapid blood group DNA typing","volume":"45","author":"Hashmi","year":"2005","journal-title":"Transfusion (Paris)"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0230","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1537-2995.2007.01178.x","article-title":"Determination of 24 minor red blood cell antigens for more than 2000 blood donors by high-throughput DNA analysis","volume":"47","author":"Hashmi","year":"2007","journal-title":"Transfusion (Paris)"},{"issue":"6","key":"10.1016\/j.bcmd.2013.11.003_bb0235","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/01.moh.0000245695.77758.3d","article-title":"Molecular testing for transfusion medicine","volume":"13","author":"Westhoff","year":"2006","journal-title":"Curr. Opin. Hematol."},{"issue":"1","key":"10.1016\/j.bcmd.2013.11.003_bb0240","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.transci.2010.12.012","article-title":"Mass-scale red cell genotyping of blood donors","volume":"44","author":"Denomme","year":"2011","journal-title":"Transfus. Apher. Sci."},{"issue":"12","key":"10.1016\/j.bcmd.2013.11.003_bb0245","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1182\/blood-2002-01-0229","article-title":"Rare RHCE phenotypes in black individuals of Afro\u2013Caribbean origin: identification and transfusion safety","volume":"100","author":"Noizat-Pirenne","year":"2002","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0250","doi-asserted-by":"crossref","first-page":"158","DOI":"10.21307\/immunohematology-2019-334","article-title":"A confusion in antibody identification: anti-D production after anti-hrB","volume":"23","author":"Lomas-Francis","year":"2007","journal-title":"Immunohematology"},{"issue":"4","key":"10.1016\/j.bcmd.2013.11.003_bb0255","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1537-2995.2012.03800.x","article-title":"RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa","volume":"53","author":"Westhoff","year":"2013","journal-title":"Transfusion (Paris)"},{"issue":"12","key":"10.1016\/j.bcmd.2013.11.003_bb0260","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1182\/blood.V94.12.4337","article-title":"DAR, a new RhD variant involving exons 4, 5, and 7, often in linkage with ceAR, a new Rhce variant frequently found in African blacks","volume":"94","author":"Hemker","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1471-2164-14-221","article-title":"Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics","volume":"14","author":"Danzer","year":"2013","journal-title":"BMC Genomics"},{"issue":"11","key":"10.1016\/j.bcmd.2013.11.003_bb0270","doi-asserted-by":"crossref","first-page":"e47768","DOI":"10.1371\/journal.pone.0047768","article-title":"Mind the gap: upgrading genomes with Pacific Biosciences RS long-read sequencing technology","volume":"7","author":"English","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcmd.2013.11.003_bb0275","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/2153-3539.103013","article-title":"Next generation sequencing in clinical medicine: challenges and lessons for pathology and biomedical informatics","volume":"3","author":"Gullapalli","year":"2012","journal-title":"J. Pathol. Inform."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979613002404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979613002404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:29:44Z","timestamp":1761049784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979613002404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1079979613002404"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2013.11.003","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2013.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}