{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:36:44Z","timestamp":1777063004052,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Medical University of \u0141\u00f3d\u017a","award":["503\/01-093-01\/503-01"],"award-info":[{"award-number":["503\/01-093-01\/503-01"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.bcmd.2014.11.022","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T15:04:09Z","timestamp":1416927849000},"page":"139-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical relevance of vascular endothelial growth factor type A (VEGFA) and VEGF receptor type 2 (VEGFR2) gene polymorphism in chronic lymphocytic leukemia"],"prefix":"10.1016","volume":"54","author":[{"given":"Joanna","family":"G\u00f3ra-Tybor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Szemraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Robak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Jamroziak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2014.11.022_bb0005","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.semcancer.2010.09.003","article-title":"Molecular basis of CLL","volume":"20","author":"Pekarsky","year":"2010","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.beha.2010.01.007","article-title":"Signalling to drug resistance in CLL","volume":"23","author":"Hertlein","year":"2010","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0015","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/sj.leu.2401825","article-title":"Increased bone marrow angiogenesis in B-cell chronic lymphocytic leukemia","volume":"14","author":"Kini","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0145-2126(01)00002-9","article-title":"Angiogenesis in B-chronic lymphocytic leukemia","volume":"25","author":"Kay","year":"2001","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/0962935031000134888","article-title":"Circulating proangiogenic cytokines and angiogenesis inhibitor endostatin in untreated patients with chronic lymphocytic leukemia","volume":"12","author":"G\u00f3ra-Tybor","year":"2003","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0030","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1053\/j.seminoncol.2006.01.008","article-title":"The clinical and biologic importance of neovascularization and angiogenic signaling pathways in chronic lymphocytic leukemia","volume":"33","author":"Shanafelt","year":"2006","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0035","first-page":"203","article-title":"Regulation of angiogenesis via vascular endothelial growth factor receptors","volume":"60","author":"Veikkola","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0040","first-page":"41","article-title":"Circulating vascular endothelial growth factor (VEGF) and its soluble receptors in patients with chronic lymphocytic leukemia","volume":"16","author":"Gora-Tybor","year":"2005","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0045","first-page":"795","article-title":"High levels of vascular endothelial growth factor receptor-2 correlate with shortened survival in chronic lymphocytic leukemia","volume":"7","author":"Ferrajoli","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0050","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1161\/01.CIR.93.8.1493","article-title":"Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3","volume":"93","author":"Vincenti","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0055","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00432-009-0714-1","article-title":"The importance of \u2212460 C\/T and +405 G\/C single nucleotide polymorphisms to the function of vascular endothelial growth factor A in colorectal cancer","volume":"136","author":"Hansen","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0060","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000054076","article-title":"A common 936 C\/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels","volume":"37","author":"Renner","year":"2000","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0065","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2407-9-144","article-title":"The \u2212271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer","volume":"9","author":"An","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0070","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jacc.2007.04.074","article-title":"Polymorphisms of KDR gene are associated with coronary heart disease","volume":"50","author":"Wang","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0075","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1080\/10428190410001710812","article-title":"Routine analysis of IgVH mutational status in CLL patients using BIOMED-2 standardized primers and protocols","volume":"45","author":"Matthews","year":"2004","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cyto.b.20132","article-title":"Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: a multicentric international harmonization process","volume":"70","author":"Letestu","year":"2006","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0085","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0090","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/bioinformatics\/btg276","article-title":"LDA\u2014a Java-based linkage disequilibrium analyzer","volume":"19","author":"Ding","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0095","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1158\/1535-7163.MCT-09-0302","article-title":"The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors","volume":"8","author":"Jain","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0100","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1017\/thg.2012.34","article-title":"Current evidence on VEGF+405G\/C polymorphism and malignancy susceptibility: a meta-analysis involving 30 studies","volume":"15","author":"Hu","year":"2012","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0105","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2141.2007.06856.x","article-title":"Chronic lymphocytic leukemia and small lymphocytic lymphoma: overview of the descriptive epidemiology","volume":"139","author":"Linet","year":"2007","journal-title":"Br. J. Hematol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0110","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1182\/blood-2010-07-294975","article-title":"Inherited genetic susceptibility to monoclonal B-cell lymphocytosis","volume":"116","author":"Crowther-Swanepoel","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ng.510","article-title":"Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk","volume":"42","author":"Crowther-Swanepoel","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0120","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2141.2010.08270.x","article-title":"Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk","volume":"150","author":"Crowther-Swanepoel","year":"2010","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2141.2011.08706.x","article-title":"Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk","volume":"154","author":"Crowther-Swanepoel","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0130","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3324\/haematol.2011.043471","article-title":"Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial","volume":"96","author":"Wade","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2014.11.022_bb0135","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1349-7006.2011.02168.x","article-title":"VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma","volume":"103","author":"Kim","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcmd.2014.11.022_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2141.2007.06887.x","article-title":"Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients","volume":"140","author":"Kim","year":"2008","journal-title":"Br. J. Haematol."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979614001557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979614001557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:29:53Z","timestamp":1761049793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979614001557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1079979614001557"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2014.11.022","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical relevance of vascular endothelial growth factor type A (VEGFA) and VEGF receptor type 2 (VEGFR2) gene polymorphism in chronic lymphocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2014.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}