{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:40:47Z","timestamp":1761093647732,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bcmd.2017.09.001","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T03:01:35Z","timestamp":1504494095000},"page":"53-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association of silent infarcts in sickle cell anemia with decreased annexin A5 resistance"],"prefix":"10.1016","volume":"69","author":[{"given":"Kerry A.","family":"Morrone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia H.","family":"Pecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-6820","authenticated-orcid":false,"given":"Jacob","family":"Rand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-1952","authenticated-orcid":false,"given":"Jennifer","family":"Davila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzette","family":"Oyeku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A.","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Xiaonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Manwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcmd.2017.09.001_bb0005","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-2143(99)90149-X","article-title":"Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease","volume":"134","author":"Westerman","year":"1999","journal-title":"J. Lab. Clin. Med."},{"issue":"1","key":"10.1016\/j.bcmd.2017.09.001_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029786","article-title":"Association of coagulation activation with clinical complications in sickle cell disease","volume":"7","author":"Ataga","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.bcmd.2017.09.001_bb0015","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00277-011-1184-5","article-title":"Anti-annexin V IgG and IgM antibodies in sickle cell disease patients with vaso-occlusive crisis","volume":"90","author":"Sater","year":"2011","journal-title":"Ann. Hematol."},{"issue":"3","key":"10.1016\/j.bcmd.2017.09.001_bb0020","first-page":"107","article-title":"Antiphospholipid antibodies: lupus anticoagulants, anticardiolipin and antiphospholipid isotypes in patients with sickle cell disease","volume":"40","author":"Nsiri","year":"1998","journal-title":"Hematol. Cell Ther."},{"issue":"5","key":"10.1016\/j.bcmd.2017.09.001_bb0025","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/ard.51.5.671","article-title":"Antiphospholipid antibodies in homozygous sickle cell disease","volume":"51","author":"De Ceulaer","year":"1992","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.bcmd.2017.09.001_bb0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ajh.2830420409","article-title":"Antiphospholipid antibodies in sickle cell disease","volume":"42","author":"Kucuk","year":"1993","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.bcmd.2017.09.001_bb0035","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/acr.22066","article-title":"Estimated frequency of antiphospholipid antibodies in patients with pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature","volume":"65","author":"Andreoli","year":"2013","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.bcmd.2017.09.001_bb0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1182\/asheducation-2007.1.136","author":"Rand","year":"2007","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"issue":"7","key":"10.1016\/j.bcmd.2017.09.001_bb0045","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1538-7836.2011.04327.x","article-title":"\u03b22-Glycoprotein I: evolution, structure and function","volume":"9","author":"de Groot","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bcmd.2017.09.001_bb0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1182\/asheducation-2015.1.53","article-title":"The antiphospholipid syndrome: still an enigma","volume":"2015","author":"Chaturvedi","year":"2015","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"issue":"5","key":"10.1016\/j.bcmd.2017.09.001_bb0055","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1182\/blood.V88.5.1873.1873","article-title":"Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometric measurement and clinical associations","volume":"88","author":"Wood","year":"1996","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bcmd.2017.09.001_bb0060","first-page":"291","article-title":"Prevalence of antiphospholipid antibodies in patients with sickle cell disease","volume":"62","author":"Diatta","year":"2004","journal-title":"Ann. Biol. Clin."},{"issue":"9","key":"10.1016\/j.bcmd.2017.09.001_bb0065","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1182\/blood-2004-01-0203","article-title":"Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome","volume":"104","author":"Rand","year":"2004","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.bcmd.2017.09.001_bb0070","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1182\/blood-2009-04-213520","article-title":"Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug","volume":"115","author":"Rand","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2017.09.001_bb0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ebiom.2016.06.024","article-title":"Precision medicine in assisted conception: a multicenter observational treatment cohort study of the annexin A5 M2 haplotype as a biomarker for antithrombotic treatment to improve pregnancy outcome","volume":"10","author":"Fishel","year":"2016","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.bcmd.2017.09.001_bb0080","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/0961203313490241","article-title":"Annexin A5 anticoagulant activity in children with systemic lupus erythematosus and the association with antibodies to domain I of beta2-glycoprotein I","volume":"22","author":"Wahezi","year":"2013","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.bcmd.2017.09.001_bb0085","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4103\/0019-5154.55635","article-title":"Lupus anticoagulant and leg ulcers in sickle cell anemia","volume":"54","author":"Olayemi","year":"2009","journal-title":"Indian J. Dermatol."},{"issue":"3","key":"10.1016\/j.bcmd.2017.09.001_bb0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ppul.20996","article-title":"Tricuspid regurgitant jet velocity elevation and its relationship to lung function in pediatric sickle cell disease","volume":"44","author":"Liem","year":"2009","journal-title":"Pediatr. Pulmonol."},{"issue":"6","key":"10.1016\/j.bcmd.2017.09.001_bb0095","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/SMJ.0b013e318256b55b","article-title":"Misclassification of pulmonary hypertension in adults with sickle hemoglobinopathies using Doppler echocardiography","volume":"105","author":"Fitzgerald","year":"2012","journal-title":"South. Med. J."},{"issue":"4","key":"10.1016\/j.bcmd.2017.09.001_bb0100","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2141.2009.07779.x","article-title":"Doppler-defined pulmonary hypertension and the risk of death in children with sickle cell disease followed for a mean of three years","volume":"146","author":"Lee","year":"2009","journal-title":"Br. J. Haematol."},{"issue":"7","key":"10.1016\/j.bcmd.2017.09.001_bb0105","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/jth.13699","article-title":"Reduction of annexin A5 anticoagulant ratio identifies antiphospholipid antibody-positive patients with adverse clinical outcomes","volume":"15","author":"Wolgast","year":"2017","journal-title":"J. Thromb. Haemost."},{"issue":"16","key":"10.1016\/j.bcmd.2017.09.001_bb0110","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1182\/blood-2011-05-349621","article-title":"Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.bcmd.2017.09.001_bb0115","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJMc1411133","article-title":"Transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"DeBaun","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bcmd.2017.09.001_bb0120","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1182\/blood-2010-06-293514","article-title":"Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort","volume":"117","author":"Bernaudin","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcmd.2017.09.001_bb0125","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/bjh.13179","article-title":"Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease","volume":"168","author":"van der Land","year":"2015","journal-title":"Br. J. Haematol."},{"issue":"8","key":"10.1016\/j.bcmd.2017.09.001_bb0130","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1401731","article-title":"Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"DeBaun","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.bcmd.2017.09.001_bb0135","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1182\/blood-2014-09-599852","article-title":"Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia","volume":"125","author":"Bernaudin","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2017.09.001_bb0140","doi-asserted-by":"crossref","DOI":"10.2119\/molmed.2016.00026","article-title":"Annexin A5 increases survival in murine sepsis model by inhibiting HMGB1-mediated pro-inflammation and coagulation","volume":"22","author":"Park","year":"2016","journal-title":"Mol. Med."},{"key":"10.1016\/j.bcmd.2017.09.001_bb0145","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ijcard.2016.08.244","article-title":"Concomitant measurements of serum annexin A5 levels and hematological indices as markers in recent and old myocardial infarction with low ejection fraction: a preliminary study","volume":"223","author":"Alhusseiny","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"10","key":"10.1016\/j.bcmd.2017.09.001_bb0150","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1177\/0961203308095029","article-title":"Resistance to annexin A5 anticoagulant activity: a thrombogenic mechanism for the antiphospholipid syndrome","volume":"17","author":"Rand","year":"2008","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.bcmd.2017.09.001_bb0155","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/1756-185X.12044","article-title":"Role of anti-annexin A5 in pathogenesis of hypercoagulable state in patients with antiphospholipid syndrome","volume":"16","author":"Singh","year":"2013","journal-title":"Int. J. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.bcmd.2017.09.001_bb0160","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbrc.2009.09.102","article-title":"Plasma annexin A5 and microparticle phosphatidylserine levels are elevated in sickle cell disease and increase further during painful crisis","volume":"390","author":"van Tits","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bcmd.2017.09.001_bb0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3324\/haematol.11763","article-title":"Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension","volume":"93","author":"Ataga","year":"2008","journal-title":"Haematologica"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979617301675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979617301675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:33:48Z","timestamp":1761050028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979617301675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":33,"alternative-id":["S1079979617301675"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2017.09.001","relation":{},"ISSN":["1079-9796"],"issn-type":[{"type":"print","value":"1079-9796"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of silent infarcts in sickle cell anemia with decreased annexin A5 resistance","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2017.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}