{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:24:21Z","timestamp":1783826661900,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bcmd.2020.102462","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T02:08:47Z","timestamp":1593050927000},"page":"102462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis"],"prefix":"10.1016","volume":"85","author":[{"given":"Timothy M.","family":"Bahr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michell","family":"Lozano-Chinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana M.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Meznarich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Gerday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Smoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2020.102462_bb0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41372-019-0566-8","article-title":"Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015","volume":"40","author":"Donneborg","year":"2020","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","article-title":"Neonatal hyperbilirubinaemia: a global perspective","volume":"2","author":"Olusanya","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.bcmd.2020.102462_bb0015","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000495518","article-title":"The neonatal acute bilirubin encephalopathy registry (NABER): background, aims, and protocol","volume":"115","author":"Bahr","year":"2019","journal-title":"Neonatology"},{"key":"10.1016\/j.bcmd.2020.102462_bb0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcmd.2018.05.002","article-title":"Acute neonatal bilirubin encephalopathy in the State of Utah 2009-2018","volume":"72","author":"Christensen","year":"2018","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2020.102462_bb0025","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/jp.2008.211","article-title":"Clinical report from the pilot USA Kernicterus Registry (1992 to 2004)","volume":"29","author":"Johnson","year":"2009","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bcmd.2012.10.004","article-title":"Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system","volume":"50","author":"Christensen","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2020.102462_bb0035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1573396313666170123151408","article-title":"Update on predicting severe hyperbilirubinemia and bilirubin neurotoxicity risks in neonates","volume":"13","author":"Chang","year":"2017","journal-title":"Curr. Pediatr. Rev."},{"key":"10.1016\/j.bcmd.2020.102462_bb0040","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/bjh.14131","article-title":"Clinical utility of next-generation sequencing in the diagnosis of hereditary haemolytic anaemias","volume":"174","author":"Agarwal","year":"2016","journal-title":"Br. J. Haematol."},{"issue":"Suppl. 1","key":"10.1016\/j.bcmd.2020.102462_bb0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/ijlh.13014","article-title":"Molecular diagnostic update in hereditary hemolytic anemia and neonatal hyperbilirubinemia","volume":"41","author":"Rets","year":"2019","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0050","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/jp.2014.68","article-title":"Causes of hemolysis in neonates with extreme hyperbilirubinemia","volume":"34","author":"Christensen","year":"2014","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0055","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1542\/peds.2008-2654","article-title":"Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system","volume":"123","author":"Jopling","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.bcmd.2020.102462_bb0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/sj.jp.7211852","article-title":"The erythrocyte indices of neonates, defined using data from over 12,000 patients in a multihospital health care system","volume":"28","author":"Christensen","year":"2008","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0065","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1053\/j.seminhematol.2004.01.003","article-title":"Hereditary elliptocytosis: spectrin and protein 4.1R","volume":"41","author":"Gallagher","year":"2004","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bcmd.2016.07.003","article-title":"Genotype-phenotype correlations in hereditary elliptocytosis and hereditary pyropoikilocytosis","volume":"61","author":"Niss","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2020.102462_bb0075","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1203\/00006450-198206000-00017","article-title":"Hereditary pyropoikilocytosis and elliptocytosis: clinical, laboratory, and ultrastructural features in infants and children","volume":"16","author":"Prchal","year":"1982","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bcmd.2020.102462_bb0080","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1515\/cclm-2016-0041","article-title":"Evaluation of the hypochromic erythrocyte and reticulocyte hemoglobin content provided by the Sysmex XE-5000 analyzer in diagnosis of iron deficiency erythropoiesis","volume":"54","author":"Buttarello","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bcmd.2020.102462_bb0085","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000491626","article-title":"Automated quantification of fragmented red blood cells: neonatal reference intervals and clinical disorders of neonatal intensive care unit patients with high values","volume":"115","author":"Judkins","year":"2019","journal-title":"Neonatology"},{"key":"10.1016\/j.bcmd.2020.102462_bb0090","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bcmd.2014.11.018","article-title":"End-tidal carbon monoxide as an indicator of the hemolytic rate","volume":"54","author":"Christensen","year":"2015","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2020.102462_bb0095","doi-asserted-by":"crossref","first-page":"G156","DOI":"10.1152\/ajpgi.2000.278.1.G156","article-title":"A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane","volume":"278","author":"K\u00f6nig","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0100","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1515\/cclm-2015-0649","article-title":"HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [HBA2:c.3G>T], HB Gran V\u00eda [HBA2:c.98T>G], HB Macarena [HBA2:c.358C>T] and HB El Retiro [HBA2:c.364_366dupGTG]: description of five new hemoglobinopathies","volume":"54","author":"de la Fuente-Gonzalo","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bcmd.2020.102462_bb0105","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000365586","article-title":"Novel \u03b1-spectrin mutation in trans with \u03b1-spectrinLEPRA causing severe neonatal jaundice from hereditary spherocytosis","volume":"106","author":"Nussenzveig","year":"2014","journal-title":"Neonatology"},{"key":"10.1016\/j.bcmd.2020.102462_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000354884","article-title":"Variations in both \u03b1-spectrin (SPTA1) and \u03b2-spectrin (SPTB) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis","volume":"105","author":"Christensen","year":"2014","journal-title":"Neonatology"},{"key":"10.1016\/j.bcmd.2020.102462_bb0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cca.2018.10.020","article-title":"Whole-exome sequencing for the genetic diagnosis of congenital red blood cell membrane disorders in Taiwan","volume":"487","author":"Lin","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bcmd.2020.102462_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/bjh.16126","article-title":"Advances in understanding the pathogenesis of red cell membrane disorders","volume":"187","author":"Iolascon","year":"2019","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0125","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1172\/JCI115669","volume":"89","author":"Gallagher","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcmd.2020.102462_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2141.1996.d01-1869.x","article-title":"Epidemiological studies of spectrin mutations related to hereditary elliptocytosis and spectrin polymorphisms in Benin","volume":"95","author":"Glele-Kakai","year":"1996","journal-title":"Br. J. Haematol."},{"issue":"753","key":"10.1016\/j.bcmd.2020.102462_bb0135","first-page":"83","article-title":"Malaria and hereditary elliptocytosis","volume":"83","author":"Boctor","year":"2008","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcmd.2020.102462_bb0140","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1182\/blood.V73.8.2196.2196","article-title":"Molecular basis of Sp alpha I\/65 hereditary elliptocytosis in North Africa: insertion of a TTG triplet between codons 147 and 149 in the alpha-spectrin gene from five unrelated families","volume":"173","author":"Roux","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2020.102462_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27531","article-title":"Hereditary elliptocytosis-associated alpha-spectrin mutation p.L155dup as a modifier of sickle cell disease severity","volume":"66","author":"Risinger","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bcmd.2020.102462_bb0150","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bcmd.2017.09.004","article-title":"Molecular basis of \u03b1-thalassemia","volume":"70","author":"Cornelis","year":"2018","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2020.102462_bb0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/03630260500454550","article-title":"Hb Bart's in cord blood: an accurate indicator of alpha-thalassemia","volume":"30","author":"Rugless","year":"2006","journal-title":"Hemoglobin"},{"key":"10.1016\/j.bcmd.2020.102462_bb0160","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1172\/JCI112905","article-title":"Modulation of erythrocyte membrane mechanical stability by 2,3-diphosphoglycerate in the neonatal poikilocytosis\/elliptocytosis syndrome","volume":"79","author":"Mentzer","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcmd.2020.102462_bb0165","article-title":"Coinheritance of beta-thalassemia minor and hereditary pyropoikilocytosis: case report","volume":"19","author":"Naoum","year":"2019","journal-title":"Hematol Transfus Cell Ther"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997962030214X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997962030214X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:35:10Z","timestamp":1761050110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107997962030214X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":33,"alternative-id":["S107997962030214X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2020.102462","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2020.102462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102462"}}