{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:41:20Z","timestamp":1761093680633,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bcmd.2022.102700","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T21:27:33Z","timestamp":1661635653000},"page":"102700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Immunological profile in a pediatric population of patients with spherocytosis. A single-center experience"],"prefix":"10.1016","volume":"98","author":[{"given":"Silvio","family":"Marchesani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Bertaina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Marini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Ambrosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Di Mauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Cossutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Schettini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariachiara","family":"Lodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino Andrea","family":"Rotulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Palma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Ceglie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2022.102700_bb0005","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.pcl.2013.09.001","article-title":"Abnormalities of the erythrocyte membrane","volume":"60","author":"Gallagher","year":"2013","journal-title":"Pediatr. Clin. N. Am."},{"issue":"Suppl 1","key":"10.1016\/j.bcmd.2022.102700_bb0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/ijlh.12657","article-title":"Red cell membrane disorders","volume":"39","author":"Narla","year":"2017","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1046\/j.1365-2141.2001.02501.x","article-title":"Clinical and molecular evaluation of non-dominant hereditary spherocytosis","volume":"112","author":"Miraglia del Giudice","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1365-2141.1998.00688.x","article-title":"Frequent de novo monoallelic expression of beta-spectrin gene (SPTB) in children with hereditary spherocytosis and isolated spectrin deficiency","volume":"101","author":"Miraglia del Giudice","year":"1998","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0022-3476(98)70495-0","article-title":"High frequency of de novo mutations in ankyrin gene (ANK1) in children with hereditary spherocytosis","volume":"132","author":"Miraglia del Giudice","year":"1998","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bcmd.2022.102700_bb0030","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.blre.2013.04.003","article-title":"Hereditary spherocytosis, elliptocytosis, and other red cell membrane disorders","volume":"27","author":"Da Costa","year":"2013","journal-title":"Blood Rev."},{"key":"10.1016\/j.bcmd.2022.102700_bb0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0609.1981.tb00448.x","article-title":"High prevalence of increased osmotic fragility of red blood cells among norwegian blood donors","volume":"27","author":"Godal","year":"1981","journal-title":"Scand. J. Haematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0040","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/blood-2012-01-404103","article-title":"Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen","volume":"120","author":"Safeukui","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2022.102700_bb0045","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2012-05-425991","article-title":"What does the spleen see?","volume":"120","author":"Schrier","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2022.102700_bb0050","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2141.2011.08921.x","article-title":"General haematology task force of the british Committee for Standards in haematology, guidelines for the diagnosis and management of hereditary spherocytosis\u20132011 update","volume":"156","author":"Bolton-Maggs","year":"2012","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0055","first-page":"168","article-title":"Hereditary spherocytosis. Review. Part II. Symptomatology, outcome, complications, and treatment","volume":"113","author":"Nacional","year":"2015","journal-title":"Arch. Argent. Pediatr."},{"key":"10.1016\/j.bcmd.2022.102700_bb0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0929-693X(03)00043-5","article-title":"Recombinant human erythropoietin (r-HuEPO) therapy in a newborn with hereditary spherocytosis","volume":"10","author":"Schiff","year":"2003","journal-title":"Arch. Pediatr."},{"key":"10.1016\/j.bcmd.2022.102700_bb0065","doi-asserted-by":"crossref","first-page":"6228965","DOI":"10.1155\/2022\/6228965","article-title":"Study on management of blood transfusion therapy in patients with hereditary spherocytosis","volume":"2022","author":"Ma","year":"2022","journal-title":"Appl. Bionics Biomech."},{"key":"10.1016\/j.bcmd.2022.102700_bb0070","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3324\/haematol.2016.161166","article-title":"Working study group on red cells and iron of the EHA, recommendations regarding splenectomy in hereditary hemolytic anemias","volume":"102","author":"Iolascon","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2022.102700_bb0075","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1365-2141.2009.07694.x","article-title":"Risks and benefits of splenectomy versus no splenectomy for hereditary spherocytosis\u2013a personal view","volume":"145","author":"Schilling","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0080","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1538-7836.2008.03024.x","article-title":"Delayed adverse vascular events after splenectomy in hereditary spherocytosis","volume":"6","author":"Schilling","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bcmd.2022.102700_bb0085","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3324\/haematol.2013.092460","article-title":"Long-term risks after splenectomy among 8,149 cancer-free american veterans: a cohort study with up to 27 years follow-up","volume":"99","author":"Kristinsson","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2022.102700_bb0090","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/pbc.21954","article-title":"Splenectomy in hereditary spherocytosis: review of 1,657 patients and application of the pediatric quality indicators","volume":"52","author":"Abdullah","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bcmd.2022.102700_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26592","article-title":"A long-term follow-up study of subtotal splenectomy in children with hereditary spherocytosis","volume":"64","author":"Rosman","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bcmd.2022.102700_bb0100","doi-asserted-by":"crossref","first-page":"eaau6085","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0105","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0110","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/imj.13348","article-title":"Spleen Australia guidelines for the prevention of sepsis in patients with asplenia and hyposplenism in Australia and New Zealand","volume":"47","author":"Kanhutu","year":"2017","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.bcmd.2022.102700_bb0115","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.thj.6200328","article-title":"Overwhelming postsplenectomy infection: is quality of patient knowledge enough for prevention?","volume":"5","author":"El-Alfy","year":"2004","journal-title":"Hematol. J."},{"key":"10.1016\/j.bcmd.2022.102700_bb0120","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF01696210","article-title":"Alterations of humoral and cellular immunity after splenectomy (author\u2019s transl)","volume":"59","author":"Winkelmeyer","year":"1981","journal-title":"Klin. Wochenschr."},{"key":"10.1016\/j.bcmd.2022.102700_bb0125","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/jcp.32.10.1045","article-title":"Changes in T and B blood lymphocytes after splenectomy","volume":"32","author":"Millard","year":"1979","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0130","first-page":"235","article-title":"Cellular immunity in splenectomized patients","volume":"1","author":"Balsalobre","year":"1991","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0135","first-page":"158","article-title":"Peripheral blood leucocyte subpopulations in patients splenectomized for trauma","volume":"70","author":"Ferrante","year":"1987","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4049\/immunohorizons.1900089","article-title":"High-dimensional analysis of postsplenectomy peripheral immune cell changes","volume":"4","author":"Borgers","year":"2020","journal-title":"Immunohorizons."},{"key":"10.1016\/j.bcmd.2022.102700_bb0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/cei.12387","article-title":"Rapid reconstitution of functionally active 6-sulfoLacNAc(+) dendritic cells (slanDCs) of donor origin following allogeneic haematopoietic stem cell transplant","volume":"178","author":"Mimiola","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0150","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/jcp.54.3.214","article-title":"Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed","volume":"54","author":"Waghorn","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s100240010145","article-title":"Asplenic-hyposplenic overwhelming sepsis: postsplenectomy sepsis revisited","volume":"4","author":"Hansen","year":"2001","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0160","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00068-016-0679-0","article-title":"Temporal changes in hematologic markers after splenectomy, splenic embolization, and observation for trauma","volume":"43","author":"Wernick","year":"2017","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"10.1016\/j.bcmd.2022.102700_bb0165","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12185-017-2335-9","article-title":"Persistent changes in circulating white blood cell populations after splenectomy","volume":"107","author":"Rab","year":"2018","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0170","first-page":"343","article-title":"Natural killer cells","volume":"22","author":"Kay","year":"1986","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.bcmd.2022.102700_bb0175","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0180","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2249.2007.03517.x","article-title":"Effect of non-operative management (NOM) of splenic rupture versus splenectomy on the distribution of peripheral blood lymphocyte populations and cytokine production by T cells","volume":"150","author":"Theodorou","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0185","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1182\/blood.V96.3.1180","article-title":"Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool","volume":"96","author":"Seabrook","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2022.102700_bb0190","first-page":"120","article-title":"Peripheral blood lymphocyte subpopulations after splenectomy for trauma","volume":"66","author":"Chelazzi","year":"1987","journal-title":"Boll. Ist. Sieroter. Milan."},{"key":"10.1016\/j.bcmd.2022.102700_bb0195","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.4049\/jimmunol.181.5.3684","article-title":"Memory B cells and pneumococcal antibody after splenectomy","volume":"181","author":"Wasserstrom","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0200","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ajh.2830280406","article-title":"Lymphocyte and complement abnormalities in splenectomized patients with hematologic disorders","volume":"28","author":"Wang","year":"1988","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0205","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0171-2985(85)80038-3","article-title":"Abnormalities of B-cell activation and immunoregulation in splenectomized patients","volume":"169","author":"Sieber","year":"1985","journal-title":"Immunobiology"},{"key":"10.1016\/j.bcmd.2022.102700_bb0210","first-page":"432","article-title":"Evaluation of the immune system following splenectomy in childhood: preliminary study","volume":"15","author":"Peregud-Pogorzelski","year":"2003","journal-title":"Pol. Merkur. Lekarski"},{"key":"10.1016\/j.bcmd.2022.102700_bb0215","first-page":"185","article-title":"T lymphocyte subsets, natural killer cell cytotoxicity and autologous mixed lymphocyte response in children after splenectomy because of hereditary spherocytosis","volume":"6","author":"Tch\u00f3rzewski","year":"1989","journal-title":"Exp. Clin. Immunogenet."},{"key":"10.1016\/j.bcmd.2022.102700_bb0220","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2141.1999.01686.x","article-title":"Long-term decrease of CD4+CD45RA+ T cells and impaired primary immune response after post-traumatic splenectomy","volume":"107","author":"Wolf","year":"1999","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0225","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.4049\/jimmunol.155.6.2866","article-title":"T cell precursors in the spleen give rise to complex T cell repertoires in the thymus and the intestine","volume":"155","author":"Hamad","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2022.102700_bb0230","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0167-5699(97)01211-5","article-title":"CD4+ T-cell memory, CD45R subsets and the persistence of antigen\u2013a unifying concept","volume":"19","author":"Bell","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/j.bcmd.2022.102700_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V27.1.1.1","article-title":"The splenic platelet pool","volume":"27","author":"Penny","year":"1966","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2022.102700_bb0240","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12979-016-0079-7","article-title":"Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines\/cytokine receptors","volume":"13","author":"Lin","year":"2016","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.bcmd.2022.102700_bb0245","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4049\/immunohorizons.1900089","article-title":"High-dimensional analysis of postsplenectomy peripheral immune cell changes","volume":"18","author":"Borgers","year":"2020","journal-title":"Immunohorizons"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979622000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979622000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:36:17Z","timestamp":1761050177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979622000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":49,"alternative-id":["S1079979622000572"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2022.102700","relation":{},"ISSN":["1079-9796"],"issn-type":[{"type":"print","value":"1079-9796"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological profile in a pediatric population of patients with spherocytosis. A single-center experience","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2022.102700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102700"}}