{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:30Z","timestamp":1786985070108,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bcmd.2024.102908","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T12:08:27Z","timestamp":1734437307000},"page":"102908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Short- and long-term alterations of hematopoietic cell lineages in rats with congenital iron deficiency"],"prefix":"10.1016","volume":"111","author":[{"given":"Anthony","family":"Babu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narmin","family":"Mukhtarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashajyothi M.","family":"Siddappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Kling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2024.102908_bb0005","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/ajcn\/77.4.924","article-title":"Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy","volume":"77","author":"O\u2019Brien","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bcmd.2024.102908_bb0010","first-page":"R405","article-title":"Tissue iron status following fetal erythropoietin stimulation","author":"Georgieff","year":"1992","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bcmd.2024.102908_bb0015","first-page":"99","article-title":"The relationship between fetal arterial oxygen saturation and heart and skeletal muscle myoglobin concentrations in the ovine fetus","volume":"19","author":"Guiang","year":"1993","journal-title":"J. Dev. Physiol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0020","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/pr.2016.20","article-title":"Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs","volume":"79","author":"Zamora","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bcmd.2024.102908_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1017\/S0029665113003637","article-title":"Iron deficiency during pregnancy: the consequences for placental function and fetal outcome","volume":"73","author":"McArdle","year":"2014","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.bcmd.2024.102908_bb0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MPH.0b013e3182707f2e","article-title":"Impact of multiple prenatal risk factors on newborn iron status at delivery","volume":"35","author":"McLimore","year":"2013","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0035","doi-asserted-by":"crossref","first-page":"G470","DOI":"10.1152\/ajpgi.00463.2010","article-title":"Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats","volume":"300","author":"Hegde","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0040","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/00043426-200206000-00011","article-title":"Thrombocytopenia in children with severe iron deficiency","volume":"24","author":"Perlman","year":"2002","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0045","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/ajh.26189","article-title":"Iron and platelets: a subtle, under-recognized relationship","volume":"96","author":"Brissot","year":"2021","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0050","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1038\/leu.2008.64","article-title":"Transformation of severe congenital neutropenia to early acute lymphoblastic leukemia in a patient with HAX1 mutation and without G-CSF administration or receptor mutation","volume":"22","author":"Yetgin","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2024.102908_bb0055","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ajh.23682","article-title":"Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin","volume":"89","author":"Evstatiev","year":"2014","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0060","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3109\/09537104.2014.931570","article-title":"Alterations of platelet functions in children and adolescents with iron-deficiency anemia and response to therapy","volume":"26","author":"Mokhtar","year":"2015","journal-title":"Platelets"},{"key":"10.1016\/j.bcmd.2024.102908_bb0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.pedneo.2014.02.002","article-title":"Mean platelet volume and ischemia modified albumin levels in cord blood of infants of diabetic mothers","volume":"55","author":"Topaloglu","year":"2014","journal-title":"Pediatr. Neonatol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0070","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.placenta.2011.11.017","article-title":"Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome","volume":"33","author":"Toblli","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.bcmd.2024.102908_bb0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1753-4887.1997.tb06462.x","article-title":"Iron, anemia, and infection","volume":"55","author":"Walter","year":"1997","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bcmd.2024.102908_bb0080","first-page":"793","article-title":"Iron deficiency anemia-induced lymphocytopenia in a young female, case rep","volume":"13","author":"Abdelmahmuod","year":"2020","journal-title":"Oncol"},{"key":"10.1016\/j.bcmd.2024.102908_bb0085","series-title":"Iron Regulatory Proteins Appear to Be Critical for Neutrophil Development","author":"Dembeck","year":"2020"},{"key":"10.1016\/j.bcmd.2024.102908_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259681","article-title":"Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome","volume":"16","author":"Dowsett","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bcmd.2024.102908_bb0095","first-page":"251","article-title":"Neutrophil hypersegmentation and thrombocytosis in children with iron deficiency anemia","volume":"47","author":"Duzgun","year":"2005","journal-title":"Turk. J. Pediatr."},{"key":"10.1016\/j.bcmd.2024.102908_bb0100","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1203\/pdr.0b013e318045be53","article-title":"Maternal stress during pregnancy predisposes for iron deficiency in infant monkeys impacting innate immunity","volume":"61","author":"Coe","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bcmd.2024.102908_bb0105","first-page":"329","article-title":"Hematological and serum biochemical changes with age in term fetuses, offspring and dams in normal Sprague-Dawley rats","volume":"41","author":"Katoh","year":"1992","journal-title":"Jikken Dobutsu"},{"key":"10.1016\/j.bcmd.2024.102908_bb0110","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000041038","article-title":"Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis","volume":"103","author":"Akan","year":"2000","journal-title":"Acta Haematol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1568-9972(02)00143-X","article-title":"The role of iron in T cell development and autoimmunity","volume":"2","author":"Bowlus","year":"2003","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bcmd.2024.102908_bb0120","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.thj.6200574","article-title":"The effect of iron deficiency anemia on the function of the immune system","volume":"5","author":"Ekiz","year":"2005","journal-title":"Hematol. J."},{"key":"10.1016\/j.bcmd.2024.102908_bb0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/JBM.S342321","article-title":"Effects of iron deficiency and its indicators on lymphocyte subsets: a study at king Fahd Hospital of the University","volume":"13","author":"AlRajeh","year":"2022","journal-title":"Saudi Arabia, J Blood Med"},{"key":"10.1016\/j.bcmd.2024.102908_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000047184","article-title":"Iron deficient erythropoiesis in neonatal rats","volume":"81","author":"Dubuque","year":"2002","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.bcmd.2024.102908_bb0135","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1203\/01.PDR.0000058922.67035.D5","article-title":"Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain","volume":"53","author":"Siddappa","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bcmd.2024.102908_bb0140","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/sj.jcbfm.9600376","article-title":"Perinatal iron deficiency predisposes the developing rat hippocampus to greater injury from mild to moderate hypoxia-ischemia","volume":"27","author":"Rao","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bcmd.2024.102908_bb0145","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1071\/RD15358","article-title":"Dietary-induced gestational iron deficiency inhibits postnatal tissue iron delivery and postpones the cessation of active nephrogenesis in rats","volume":"29","author":"Sun","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.bcmd.2024.102908_bb0150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1203\/PDR.0b013e31817328e5","article-title":"Reticulocyte enrichment of zinc protoporphyrin\/heme discriminates impaired iron supply during early development","volume":"64","author":"Blohowiak","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bcmd.2024.102908_bb0155","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1007\/s12035-022-02798-3","article-title":"Gestational and lactational iron deficiency anemia impairs myelination and the neurovascular unit in infant rats","volume":"59","author":"Isasi","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0160","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/jp.2015.21","article-title":"Maternal pregnancy weight gain and cord blood iron status are associated with eosinophilia in infancy","volume":"35","author":"Weigert","year":"2015","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpeds.2016.02.023","article-title":"Maternal obesity affects inflammatory and iron indices in umbilical cord blood","volume":"172","author":"Dosch","year":"2016","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bcmd.2024.102908_bb0170","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1017\/S0007114514003122","article-title":"An exploratory study of the associations between maternal iron status in pregnancy and childhood wheeze and atopy","volume":"112","author":"Nwaru","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bcmd.2024.102908_bb0175","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1183\/09031936.04.00117803","article-title":"Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema","volume":"24","author":"Shaheen","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bcmd.2024.102908_bb0180","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/cea.13034","article-title":"Haemoglobin concentrations in pregnancy and respiratory and allergic outcomes in childhood: birth cohort study","volume":"47","author":"Shaheen","year":"2017","journal-title":"Clin. Exp. Allergy"},{"issue":"2","key":"10.1016\/j.bcmd.2024.102908_bb0185","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1113\/jphysiol.2003.051383","article-title":"Iron deficiency during pregnancy affects postnatal blood pressure in the rat","volume":"552","author":"Gambling","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0190","first-page":"213","article-title":"The effects of folate and iron deficiency followed by supplementation on blood morphology and inflammation biomarkers in rats","volume":"20","author":"Radziejewska","year":"2021","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"10.1016\/j.bcmd.2024.102908_bb0195","doi-asserted-by":"crossref","first-page":"F46","DOI":"10.1136\/fn.85.1.F46","article-title":"Cord blood transferrin receptors to assess fetal iron status","volume":"85","author":"Sweet","year":"2001","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.bcmd.2024.102908_bb0200","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0022-3476(87)80088-4","article-title":"Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia","volume":"111","author":"Chockalingam","year":"1987","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bcmd.2024.102908_bb0205","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/jp.2014.42","article-title":"Neonatal iron status is impaired by maternal obesity and excessive weight gain during pregnancy","volume":"34","author":"Phillips","year":"2014","journal-title":"J. Perinatol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0210","first-page":"234","article-title":"Neonatal thrombocytopenia in the hypertensive disorders of pregnancy","volume":"76","author":"Burrows","year":"1990","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0215","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-2003-37948","article-title":"Risk factors for neonatal thrombocytopenia in preterm infants","volume":"20","author":"Beiner","year":"2003","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0220","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1440-1754.1996.tb01537.x","article-title":"Neonatal neutropenia and thrombocytopenia following maternal hypertension","volume":"32","author":"Fraser","year":"1996","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.bcmd.2024.102908_bb0225","first-page":"1212","article-title":"Association between thrombocytosis and iron deficiency anemia in inflammatory bowel disease","volume":"25","author":"Voudoukis","year":"2013","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/nu15224790","article-title":"Relationship between Iron deficiency and thyroid function: a systematic review and Meta-analysis","volume":"15","author":"Garofalo","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bcmd.2024.102908_bb0235","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2016-000049","article-title":"Pre-eclampsia and the risk of retinopathy of prematurity in preterm infants with birth weight <1500 g and\/or <31 weeks' gestation","volume":"1","author":"Alshaikh","year":"2017","journal-title":"BMJ Open Ophthalmol"},{"key":"10.1016\/j.bcmd.2024.102908_bb0240","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.earlhumdev.2004.10.013","article-title":"Neonatal thrombocytopenia","volume":"81","author":"Chakravorty","year":"2005","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.bcmd.2024.102908_bb0245","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/14767050903184173","article-title":"Neonatal outcomes of premature infants born to preeclamptic mothers","volume":"23","author":"Cetinkaya","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.bcmd.2024.102908_bb0250","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJM198908313210901","article-title":"Incidence, neutrophil kinetics, and natural history of neonatal neutropenia associated with maternal hypertension","volume":"321","author":"Koenig","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcmd.2024.102908_bb0255","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/eji.201141523","article-title":"The influence of mTOR on T helper cell differentiation and dendritic cell function","volume":"41","author":"Salmond","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bcmd.2024.102908_bb0260","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-2141.1996.d01-1919.x","article-title":"Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy","volume":"95","author":"Kling","year":"1996","journal-title":"Brit J Haematol"},{"key":"10.1016\/j.bcmd.2024.102908_bb0265","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0022-3476(96)70331-1","article-title":"Serum erythropoietin levels during infancy: associations with erythropoiesis","volume":"128","author":"Kling","year":"1996","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bcmd.2024.102908_bb0270","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1447-0756.2011.01740.x","article-title":"Effects of preeclampsia on the yield of hematopoietic stem cells obtained from umbilical cord blood at delivery","volume":"38","author":"Wahid","year":"2012","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.bcmd.2024.102908_bb0275","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1067\/mob.2001.117343","article-title":"Effect of preeclampsia on umbilical cord blood hematopoietic progenitor-stem cells","volume":"185","author":"Surbek","year":"2001","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997962400086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997962400086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T14:51:04Z","timestamp":1741013464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107997962400086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":55,"alternative-id":["S107997962400086X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2024.102908","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short- and long-term alterations of hematopoietic cell lineages in rats with congenital iron deficiency","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2024.102908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102908"}}