{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:47:13Z","timestamp":1783100833081,"version":"3.54.6"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"am","delay-in-days":292,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL158159"],"award-info":[{"award-number":["R01HL158159"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bcmd.2025.102955","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:58:35Z","timestamp":1755241115000},"page":"102955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A case series of cerebrovascular abnormalities in Townes sickle cell mice visualized with magnetic resonance imaging and angiography"],"prefix":"10.1016","volume":"115","author":[{"given":"Liana","family":"Hatoum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Song","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Oshinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Botchwey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu O.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2025.102955_bb0005","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1016\/S2352-3026(23)00118-7","article-title":"Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000\u20132021: a systematic analysis from the Global Burden of Disease Study 2021","volume":"10","author":"Thomson","year":"2023","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.bcmd.2025.102955_bb0010","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene-Frempong","year":"1998","journal-title":"Blood, the Journal of the American Society of Hematology"},{"key":"10.1016\/j.bcmd.2025.102955_bb0015","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1182\/blood-2011-02-272682","article-title":"Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104864","article-title":"The role of MRA in pediatric sickle cell disease with normal transcranial Doppler imaging velocities","volume":"29","author":"Alshehri","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.bcmd.2025.102955_bb0025","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1182\/blood-2003-06-1972","article-title":"Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study","volume":"103","author":"Abboud","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0030","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1182\/blood-2006-02-004812","article-title":"Correction of sickle cell disease by homologous recombination in embryonic stem cells","volume":"108","author":"Wu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0035","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.278.5339.876","article-title":"Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease","volume":"278","author":"Paszty","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2025.102955_bb0040","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.120.314045","article-title":"Sickle cell anemia mediates carotid artery expansive remodeling that can be prevented by inhibition of JNK (c-Jun N-terminal kinase)","volume":"40","author":"Song","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcmd.2025.102955_bb0045","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nbd.2015.10.004","article-title":"Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum","volume":"85","author":"Wang","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bcmd.2025.102955_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2020.102493","article-title":"Sickle cell disease mice have cerebral oxidative stress and vascular and white matter abnormalities","volume":"86","author":"Khaibullina","year":"2021","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2025.102955_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146968","article-title":"Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum","volume":"1746","author":"Almeida","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.bcmd.2025.102955_bb0060","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/0271678X17732275","article-title":"Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease","volume":"39","author":"Hyacinth","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bcmd.2025.102955_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.976063","article-title":"Adhesion molecules and cerebral microvascular hemodynamic abnormalities in sickle cell disease","volume":"13","author":"Abi Rached","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bcmd.2025.102955_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adp7690","article-title":"Bone marrow transplant protects mice from sickle cell\u2013mediated large artery remodeling","volume":"17","author":"Hatoum","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bcmd.2025.102955_bb0075","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1182\/blood-2010-08-301366","article-title":"Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S","volume":"117","author":"Gavins","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0080","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1182\/blood-2014-01-549717","article-title":"Increased stroke size following MCA occlusion in a mouse model of sickle cell disease","volume":"123","author":"Luo","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0085","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1161\/STROKEAHA.117.018334","article-title":"Sickle mice are sensitive to hypoxia\/ischemia-induced stroke but respond to tissue-type plasminogen activator treatment","volume":"48","author":"Sun","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.bcmd.2025.102955_bb0090","series-title":"Allen Mouse Brain Atlas","author":"A.I.f.B. Science","year":"2011"},{"key":"10.1016\/j.bcmd.2025.102955_bb0095","doi-asserted-by":"crossref","first-page":"102486","DOI":"10.1016\/j.bcmd.2020.102486","article-title":"Age-dependent characterization of carotid and cerebral artery geometries in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography","volume":"85","author":"Rivera","year":"2020","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2025.102955_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1474-4422(06)70469-0","article-title":"Pathophysiology and treatment of stroke in sickle-cell disease: present and future","volume":"5","author":"Switzer","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bcmd.2025.102955_bb0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/10739680490278600","article-title":"Pathophysiology of stroke in sickle cell disease","volume":"11","author":"Hillery","year":"2004","journal-title":"Microcirculation"},{"key":"10.1016\/j.bcmd.2025.102955_bb0110","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1212\/WNL.38.7.1012","article-title":"Cerebral infarction in sickle cell anemia: mechanism based on CT and MRI","volume":"38","author":"Adams","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.bcmd.2025.102955_bb0115","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.121.037980","article-title":"Evolution of extracranial internal carotid artery disease in children with sickle cell anemia","author":"Verlhac","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.bcmd.2025.102955_bb0120","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1182\/blood-2011-03-337915","article-title":"Cervical carotid artery disease in sickle cell anemia: clinical and radiological features","volume":"118","author":"Telfer","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1182\/blood-2013-12-545186","article-title":"Magnetic resonance imaging\/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial","volume":"124","author":"Helton","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2025.102955_bb0130","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209247","article-title":"Distribution of silent cerebral infarcts in adults with sickle cell disease","volume":"102","author":"Jones","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.bcmd.2025.102955_bb0135","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1177\/0271678X16649194","article-title":"Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice","volume":"37","author":"Cahill","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bcmd.2025.102955_bb0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/jon.12418","article-title":"Quantitative analysis of extracranial arterial tortuosity in patients with sickle cell disease","volume":"27","author":"Buch","year":"2017","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.bcmd.2025.102955_bb0145","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.81090","article-title":"Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice","volume":"1","author":"Ghosh","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.bcmd.2025.102955_bb0150","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1161\/STROKEAHA.118.018920","article-title":"Transcranial Doppler and magnetic resonance in Tanzanian children with sickle cell disease","volume":"50","author":"Kija","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.bcmd.2025.102955_bb0155","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1161\/01.STR.0000206440.48756.f7","article-title":"Carotid artery diameter in men and women and the relation to body and neck size","volume":"37","author":"Krejza","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.bcmd.2025.102955_bb0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00247-003-1109-0","article-title":"Radiological approach to disorders of arterial brain vessels associated with childhood arterial stroke\u2014a comparison between MRA and contrast angiography","volume":"34","author":"Husson","year":"2004","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.bcmd.2025.102955_bb0165","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1212\/WNL.51.3_Suppl_3.S47","article-title":"Diffusion-weighted MRI for evaluation of acute stroke","volume":"51","author":"Albers","year":"1998","journal-title":"Neurology"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979625000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979625000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T23:41:27Z","timestamp":1757115687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979625000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":33,"alternative-id":["S1079979625000476"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2025.102955","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case series of cerebrovascular abnormalities in Townes sickle cell mice visualized with magnetic resonance imaging and angiography","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2025.102955","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102955"}}