{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:06:27Z","timestamp":1791043587692,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.bcp.2004.03.030","type":"journal-article","created":{"date-parts":[[2004,5,30]],"date-time":"2004-05-30T20:55:21Z","timestamp":1085950521000},"page":"351-360","source":"Crossref","is-referenced-by-count":32,"title":["Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP"],"prefix":"10.1016","volume":"68","author":[{"given":"Hong Wa","family":"Yung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wyttenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva M.","family":"Tolkovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2004.03.030_BIB1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2004.03.030_BIB2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj20021535","article-title":"The specificities of protein kinase inhibitors: an update","volume":"371","author":"Bain","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2004.03.030_BIB3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.3291115","article-title":"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains","volume":"241","author":"Hanks","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bcp.2004.03.030_BIB4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/bss0660181","article-title":"The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury","volume":"66","author":"Halestrap","year":"1999","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.bcp.2004.03.030_BIB5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0006-2952(02)01181-4","article-title":"Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues","volume":"64","author":"Xue","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2004.03.030_BIB6","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1182\/blood.V96.10.3537","article-title":"Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria","volume":"96","author":"Genini","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2004.03.030_BIB7","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1021\/jm020427b","article-title":"Kinase inhibitors: not just for kinases anymore","volume":"46","author":"McGovern","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB8","doi-asserted-by":"crossref","first-page":"18623","DOI":"10.1074\/jbc.273.29.18623","article-title":"Identification of a novel inhibitor of mitogen-activated protein kinase kinase","volume":"273","author":"Favata","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB9","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","article-title":"A synthetic inhibitor of the mitogen-activated protein kinase cascade","volume":"92","author":"Dudley","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2004.03.030_BIB10","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","article-title":"PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo","volume":"270","author":"Alessi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0028-3908(01)00162-9","article-title":"Non-specific effects of the MEK inhibitors PD098,059 and U0126 on glutamate release from hippocampal synaptosomes","volume":"42","author":"Pereira","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2004.03.030_BIB12","doi-asserted-by":"crossref","first-page":"28766","DOI":"10.1074\/jbc.273.44.28766","article-title":"Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase","volume":"273","author":"Borsch-Haubold","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB13","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/10533","article-title":"Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo","volume":"5","author":"Sebolt-Leopold","year":"1999","journal-title":"Nat. Med. (N.Y.)"},{"key":"10.1016\/j.bcp.2004.03.030_BIB14","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1046\/j.1471-4159.2003.01946.x","article-title":"Erasure of kinase phosphorylation in astrocytes during oxygen-glucose deprivation is controlled by ATP levels and activation of phosphatases","volume":"86","author":"Yung","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB15","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.89.10.4221","article-title":"MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts","volume":"89","author":"Chomyn","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2004.03.030_BIB16","doi-asserted-by":"crossref","first-page":"22983","DOI":"10.1074\/jbc.273.36.22983","article-title":"Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells","volume":"273","author":"Buchet","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1046\/j.1432-1327.1999.00350.x","article-title":"Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA","volume":"262","author":"Appleby","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/glia.1077","article-title":"Ischemia-induced apoptosis in primary cultures of astrocytes","volume":"35","author":"Yu","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.bcp.2004.03.030_BIB19","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1523\/JNEUROSCI.19-02-00664.1999","article-title":"A role for MAPK\/ERK in sympathetic neuron survival, protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside","volume":"19","author":"Anderson","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2004.03.030_BIB20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0006-8993(91)91538-C","article-title":"Characterization of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in primary cultures of mouse cerebral cortical astrocytes","volume":"563","author":"Sorg","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2004.03.030_BIB21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/bj3180401","article-title":"Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations","volume":"318","author":"James","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2004.03.030_BIB22","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1073\/pnas.261560998","article-title":"Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection","volume":"98","author":"Almeida","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2004.03.030_BIB23","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1523\/JNEUROSCI.21-17-06608.2001","article-title":"The mitochondrial permeability transition pore and nitric oxide synthase mediate early mitochondrial depolarization in astrocytes during oxygen-glucose deprivation","volume":"21","author":"Reichert","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2004.03.030_BIB24","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1111\/j.1460-9568.1995.tb00637.x","article-title":"Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons","volume":"7","author":"Virdee","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bcp.2004.03.030_BIB25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/jnci\/91.2.163","article-title":"In vivo eradication of human BCR\/ABL-positive leukemia cells with an ABL kinase inhibitor","volume":"91","author":"le Coutre","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bcp.2004.03.030_BIB26","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/jm010533y","article-title":"A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening","volume":"45","author":"McGovern","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-8993(96)01293-0","article-title":"Vulnerability to glucose deprivation injury correlates with glutathione levels in astrocytes","volume":"748","author":"Papadopoulos","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2004.03.030_BIB28","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/(SICI)1097-4547(19981215)54:6<870::AID-JNR15>3.0.CO;2-3","article-title":"Potentiated glucose deprivation-induced death of astrocytes after induction of iNOS","volume":"54","author":"Choi","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bcp.2004.03.030_BIB29","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.cdd.4401079","article-title":"Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation","volume":"9","author":"Gonin-Giraud","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2004.03.030_BIB30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.onc.1205068","article-title":"Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway","volume":"21","author":"Nam","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2004.03.030_BIB31","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1046\/j.1471-4159.1995.65062812.x","article-title":"Phosphorylation of F1F0 ATPase delta-subunit is regulated by platelet-derived growth factor in mouse cortical neurons in vitro","volume":"65","author":"Zhang","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2004.03.030_BIB32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1023\/A:1020204518513","article-title":"Phosphorylation of a peptide related to subunit c of the F0F1-ATPase\/ATP synthase and relationship to permeability transition pore opening in mitochondria","volume":"34","author":"Azarashvili","year":"2002","journal-title":"J. Bioenerg. Biomembr."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295204002102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295204002102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T09:16:46Z","timestamp":1585819006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295204002102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0006295204002102"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2004.03.030","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}