{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:57:21Z","timestamp":1776502641659,"version":"3.51.2"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005386","name":"Israeli Centers for Research Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.bcp.2004.05.027","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T10:23:46Z","timestamp":1092479026000},"page":"989-996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis"],"prefix":"10.1016","volume":"68","author":[{"given":"S","family":"Freimann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Ben-Ami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Hirsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Amsterdam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2004.05.027_BIB1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1210\/edrv-8-3-309","article-title":"Structure-function relationships during granulosa cell differentiation","volume":"8","author":"Amsterdam","year":"1987","journal-title":"Endocrinol. Rev."},{"key":"10.1016\/j.bcp.2004.05.027_BIB2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0968-0004(89)90012-1","article-title":"Coordinated regulation of morphological and biochemical differentiation in a steroidogenic cell","volume":"14","author":"Amsterdam","year":"1989","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bcp.2004.05.027_BIB3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1083\/jcb.67.3.894","article-title":"Distribution of binding sites for human chorionic gonadotropin in the preovulatory follicle of the rat","volume":"67","author":"Amsterdam","year":"1975","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.bcp.2004.05.027_BIB4","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1210\/endo-129-6-3200","article-title":"Localization of luteinizing hormone receptor messenger ribonucleic acid expression in ovarian cell types during follicle development and ovulation","volume":"129","author":"Peng","year":"1991","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bcp.2004.05.027_BIB5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1242\/jcs.21.1.93","article-title":"Organization of intramembrane particles in freeze-cleaved gap junctions of rat graafian rollicles: optical-diffraction analysis","volume":"21","author":"Amsterdam","year":"1976","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bcp.2004.05.027_BIB6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/bjc.1986.55","article-title":"An immunohistochemical study of the incidence and significance of human gonadotrophin and prolactin binding sites in normal and neoplastic human ovarian tissue","volume":"53","author":"Al-Timimi","year":"1986","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bcp.2004.05.027_BIB7","unstructured":"Amsterdam A, Rotmensch S, Ben-Ze\u2019ev A. Structure-function relationships in the differentiating granulosa cell. In: Motta PM, editor. Progress in chemical and biological research, vol. 296. Developments in ultrastructure of reproduction. New York: Alan Liss; 1989. p. 121\u201330."},{"key":"10.1016\/j.bcp.2004.05.027_BIB8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1095\/biolreprod46.4.513","article-title":"Structure-function relationships during differentiation of normal and oncogene transformed granulosa cells","volume":"46","author":"Amsterdam","year":"1992","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bcp.2004.05.027_BIB9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0015-0282(01)02863-1","article-title":"Multiple novel roles of luteinizing hormone","volume":"76","author":"Rao","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bcp.2004.05.027_BIB10","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0959-8049(97)00166-4","article-title":"Messenger ribonucleic acid expression of LH\/hCG receptor gene in human ovarian carcinomas","volume":"33","author":"Mandai","year":"1997","journal-title":"Eur J. Cancer"},{"key":"10.1016\/j.bcp.2004.05.027_BIB11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0002-9378(89)90749-7","article-title":"Localization of gonadotropin binding sites in human ovarian neoplasms","volume":"161","author":"Nakano","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0090-8258(90)90178-N","article-title":"Human chorionic gonadotropin, follicle-stimulating hormone, and luteinizing hormone in patients with epithelial ovarian carcinoma","volume":"36","author":"Mahlck","year":"1990","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/172460089801300308","article-title":"Gonadotropin levels in ovarian cyst fluids: a predictor of malignancy?","volume":"13","author":"Kramer","year":"1998","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.bcp.2004.05.027_BIB14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1046\/j.1525-1438.1999.99075.x","article-title":"Peritoneal fluid gonadotropins and ovarian hormones in patients with ovarian cancer","volume":"9","author":"Halperin","year":"1999","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.bcp.2004.05.027_BIB15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0301-2115(03)00122-2","article-title":"Luteinizing hormone in peritoneal and ovarian cyst fluids: a predictor of ovarian carcinoma","volume":"110","author":"Halperin","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB16","doi-asserted-by":"crossref","unstructured":"Park JY, Su YQ, Ariga M, Law E, Jin SL, Conti M. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 2004;303(5658):682\u20134.","DOI":"10.1126\/science.1092463"},{"key":"10.1016\/j.bcp.2004.05.027_BIB17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF01555453","article-title":"Ovarian carcinoma in a patient hyperstimulated by gonadotropin therapy for in vitro fertilization: a case report","volume":"4","author":"Carter","year":"1987","journal-title":"J. In Vitro Fertil. Embryo Transfer"},{"key":"10.1016\/j.bcp.2004.05.027_BIB18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0090-8258(91)90255-4","article-title":"Human epithelial ovarian cancer cell steroid secretion and its control by gonadotropins","volume":"41","author":"Wimalasena","year":"1991","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB19","first-page":"1520","article-title":"Immunoreactive human chorionic gonadotropin and its free beta subunit in serum and ascites of patients with malignant tumors","volume":"52","author":"Hoermann","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2004.05.027_BIB20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1056\/NEJM199409223311204","article-title":"Ovarian tumors in a cohort of infertile women","volume":"331","author":"Rossing","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2004.05.027_BIB21","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1001\/jama.1995.03530240036037","article-title":"Serum gonadotropins and steroid hormones and the development of ovarian cancer","volume":"274","author":"Helzlsouer","year":"1995","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bcp.2004.05.027_BIB22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000217944","article-title":"Induction of ovarian tumors by endogenous gonadotropins in rats bearing intrasplenic ovarian grafts","volume":"16","author":"Jager","year":"1995","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0015-0282(16)58020-0","article-title":"Human menopausal gonadotropin and the risk of epithelial ovarian cancer","volume":"65","author":"Shushan","year":"1996","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bcp.2004.05.027_BIB24","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1210\/jcem.87.7.8676","article-title":"Stimulation of apoptosis in human granulosa cells from in vitro fertilization patients and its prevention by dexamethasone: involvement of cell contact and bcl-2 expression","volume":"87","author":"Sasson","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2004.05.027_BIB25","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1096\/fj.02-0740com","article-title":"Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action","volume":"17","author":"Sasson","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2004.05.027_BIB26","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.bbrc.2003.10.097","article-title":"Activation of multiple signal transduction pathways by glucocorticoids: protection of ovarian follicular cells against apoptosis","volume":"311","author":"Sasson","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2004.05.027_BIB27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/molehr\/2.6.391","article-title":"Expression of Ad4-BP\/cytochrome P450 side chain cleavage enzyme and induction of cell death in long-term cultures of human granulosa cells","volume":"2","author":"Breckwoldt","year":"1996","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bcp.2004.05.027_BIB28","doi-asserted-by":"crossref","unstructured":"Amsterdam A, Sasson R. Generation and application of ovarian steroidogenic cell lines. In: Leung PCK, Adashi EY, editors. The ovary. Elsevier Academic Press; 2004. p. 353\u2013402.","DOI":"10.1016\/B978-012444562-8\/50023-9"},{"issue":"3","key":"10.1016\/j.bcp.2004.05.027_BIB29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2165\/00003495-200464030-00005","article-title":"Contemporary pharmacological manipulation in assisted reproduction","volume":"64","author":"Huirne","year":"2004","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.bcp.2004.05.027_BIB30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1043-2760(03)00075-4","article-title":"Reproductive biology and IVF: ovarian stimulation and luteal phase consequences","volume":"14","author":"Fauser","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.bcp.2004.05.027_BIB31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/molehr\/gah041","article-title":"Gonadotropins induced gene regulation in human granulosa cells obtained from IVF patients. Modulation of steroidogenic cytoskeletal and genes coding for apoptotic signaling and kinases","volume":"10","author":"Sasson","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bcp.2004.05.027_BIB32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0303-7207(03)00074-1","article-title":"Novel genes regulated by gonadotropins in granulosa cells: new perspectives on their physiological functions","volume":"202","author":"Amsterdam","year":"2003","journal-title":"Mol. Cell Endocrinol."},{"issue":"10","key":"10.1016\/j.bcp.2004.05.027_BIB33","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1210\/jc.2003-030704","article-title":"Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells","volume":"88","author":"Liu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.bcp.2004.05.027_BIB34","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1210\/jc.2002-021325","article-title":"Differential expression, regulation, and induction of Smads, transforming growth factor-beta signal transduction pathway in leiomyoma, and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog","volume":"88","author":"Xu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2004.05.027_BIB35","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/sj.onc.1201458","article-title":"Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4","volume":"15","author":"Komurasaki","year":"1997","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.bcp.2004.05.027_BIB36","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/molehr\/gag082","article-title":"Clinical implications of coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine leiomyoma","volume":"9","author":"Sun","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bcp.2004.05.027_BIB37","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1210\/en.2002-220440","article-title":"Transcriptional regulation of the epiregulin gene in the rat ovary","volume":"143","author":"Sekiguchi","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2004.05.027_BIB38","first-page":"7495","article-title":"A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes","volume":"270","author":"Toyoda","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.05.027_BIB39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bj3260069","article-title":"Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family","volume":"326","author":"Toyoda","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2004.05.027_BIB40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0014-2999(97)81928-0","article-title":"Epiregulin stimulates proliferation of rabbit gastric cells in primary culture through autophosphorylation of the epidermal growth factor receptor","volume":"338","author":"Sasaki","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB41","first-page":"6886","article-title":"Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells","volume":"60","author":"Baba","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2004.05.027_BIB42","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1006\/bbrc.2000.3033","article-title":"Epiregulin is up-regulated in pancreatic cancer and stimulates pancreatic cancer cell growth","volume":"273","author":"Zhu","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2004.05.027_BIB43","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1038\/sj.onc.1201458","article-title":"Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4","volume":"15","author":"Komurasaki","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2004.05.027_BIB44","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/path.902","article-title":"Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions","volume":"194","author":"Ma","year":"2001","journal-title":"J. Pathol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB45","first-page":"941","article-title":"Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas","volume":"21","author":"D\u2019Antonio","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1101\/gad.1039703","article-title":"The ADAMs family of metalloproteases: multidomain proteins with multiple functions","volume":"17","author":"Seals","year":"2003","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bcp.2004.05.027_BIB47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1091\/mbc.e03-06-0427","article-title":"The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras\/Rac pathway","volume":"15","author":"Offenhauser","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"11","key":"10.1016\/j.bcp.2004.05.027_BIB48","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1074\/jbc.M309884200","article-title":"Participation of p97Eps8 in Src-mediated transformation","volume":"279","author":"Leu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.05.027_BIB49","first-page":"255","article-title":"Ovarian surface epithelium: biology, endocrinology, and pathology","volume":"22","author":"Auersperg","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bcp.2004.05.027_BIB50","doi-asserted-by":"crossref","unstructured":"Ausberg N, Woo MMM. Development and differenciation of ovarian surface epithelium:cause for the basis of its malignant potential. In: Leung PCK, Adashi EY, editors. The ovary. Elsevier Academic Press; 2004. p. 579\u201386.","DOI":"10.1016\/B978-012444562-8\/50036-7"},{"key":"10.1016\/j.bcp.2004.05.027_BIB51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-2001-13907","article-title":"Nongonadal LH\/hCG receptors in pig: functional importance and parallels to human","volume":"19","author":"Ziecik","year":"2001","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.bcp.2004.05.027_BIB52","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1210\/en.2002-220490","article-title":"Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin","volume":"143","author":"Rulli","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2004.05.027_BIB53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0028-2243(93)90236-6","article-title":"The post-operative gonadotropin level in post-menopausal women with epithelial ovarian cancer","volume":"52","author":"Blaakaer","year":"1993","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB54","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0028-2243(89)90195-0","article-title":"Some observations on the effect of a GnRH analog in ovarian cancer","volume":"32","author":"Jager","year":"1989","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB55","doi-asserted-by":"crossref","unstructured":"Vanderhyden BC, Shaw TJ, Carson K, Tonary AM. Ovarian carcinogenesis. In: Leung PCK, Adashi EY, editors. The ovary. Elsevier Academic Press; 2004. p. 591\u2013602.","DOI":"10.1016\/B978-012444562-8\/50037-9"},{"issue":"42","key":"10.1016\/j.bcp.2004.05.027_BIB56","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1038\/sj.onc.1206772","article-title":"Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor","volume":"22","author":"Surmacz","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2004.05.027_BIB57","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1095\/biolreprod.102.005173","article-title":"Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat","volume":"6","author":"Espey","year":"2002","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.bcp.2004.05.027_BIB58","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1046\/j.0007-1323.2001.02022.x","article-title":"Anti-human epidermal growth factor receptor 2 monoclonal antibody therapy for breast cancer","volume":"89","author":"Leonard","year":"2002","journal-title":"Br. J. Surg."},{"issue":"20","key":"10.1016\/j.bcp.2004.05.027_BIB59","doi-asserted-by":"crossref","first-page":"12747","DOI":"10.1073\/pnas.202162199","article-title":"External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator","volume":"99","author":"Asada","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.bcp.2004.05.027_BIB60","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ijc.2910620603","article-title":"Epidermal growth factor expression in human colon and colon carcinomas: anti-sense epidermal growth factor receptor RNA down-regulates the proliferation of human colon cancer cells","volume":"62","author":"Rajagopal","year":"1995","journal-title":"Int. J. Cancer"},{"issue":"10","key":"10.1016\/j.bcp.2004.05.027_BIB61","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1093\/emboj\/cdg231","article-title":"TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells","volume":"22","author":"Gschwind","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2004.05.027_BIB62","doi-asserted-by":"crossref","unstructured":"Sales KJ, Maudsley S, Jabbour HN. Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes VEGF expression via cAMP-mediated transactivation of the EGF receptor and ERK1\/2 signaling pathways. Mol Endocrinol 2004;18:1533\u201345.","DOI":"10.1210\/me.2004-0022"},{"key":"10.1016\/j.bcp.2004.05.027_BIB63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0303-7207(01)00701-8","article-title":"Mechanisms of gonadotropin desensitization","volume":"187","author":"Amsterdam","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bcp.2004.05.027_BIB64","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1210\/jc.2002-020913","article-title":"Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1","volume":"88","author":"Tajima","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2004.05.027_BIB65","doi-asserted-by":"crossref","first-page":"13957","DOI":"10.1074\/jbc.M006852200","article-title":"The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis","volume":"276","author":"Seger","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2004.05.027_BIB66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0303-7207(01)00701-8","article-title":"Mechanisms of gonadotropin desensitization","volume":"187","author":"Amsterdam","year":"2001","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295204003521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295204003521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:00:41Z","timestamp":1762095641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295204003521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0006295204003521"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2004.05.027","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2004.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}