{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:03:13Z","timestamp":1791590593725,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHR 327\/5-2"],"award-info":[{"award-number":["SCHR 327\/5-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.bcp.2004.11.017","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T08:49:19Z","timestamp":1105606159000},"page":"657-667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes"],"prefix":"10.1016","volume":"69","author":[{"given":"Annette","family":"Baumgart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Schrenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2004.11.017_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0273-2300(91)90029-U","article-title":"Dietary exposure to furocoumarins","volume":"14","author":"Wagstaff","year":"1991","journal-title":"Reg Toxicol Pharmacol"},{"key":"10.1016\/j.bcp.2004.11.017_bib2","first-page":"129","article-title":"Inhibition of cytochrome P450 by furancoumarins in grapefruit juice and herbal medicines","volume":"25","author":"Guo","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.bcp.2004.11.017_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/285407a0","article-title":"5-Methoxypsoralen, an ingredient in several suntan preparations, has lethal, mutagenic and clastogenic properties","volume":"285","author":"Ashwood-Smith","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2004.11.017_bib4","unstructured":"IARC. Some naturally occurring and synthetic food components, furocoumarins and ultraviolet radiation. IARC Working Group. Lyon, 15\u201322 October 1985. IARC Monogr Eval Carcinog Risk Chem Hum 1986;40:1\u2013415."},{"key":"10.1016\/j.bcp.2004.11.017_bib5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/1011-1344(94)07101-S","article-title":"Psoralen-protein photochemistry \u2013 a forgotten field","volume":"B27","author":"Schmitt","year":"1995","journal-title":"J Photochem Photobiol"},{"key":"10.1016\/j.bcp.2004.11.017_bib6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1006\/abbi.2000.1835","article-title":"Inhibition selectivity of grapefruit juice components on human cytochromes P450","volume":"378","author":"Tassaneeyakul","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bcp.2004.11.017_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00007691-200002000-00028","article-title":"Influence of dietary components on the gastrointestinal metabolism and transport of drugs","volume":"22","author":"Evans","year":"2000","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.bcp.2004.11.017_bib8","first-page":"216","article-title":"Grapefruit juice\u2013drug interactions","volume":"52","author":"Bailey","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.bcp.2004.11.017_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF03190450","article-title":"The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism","volume":"27","author":"Jakovljevic","year":"2002","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.bcp.2004.11.017_bib10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3109\/00498259109044396","article-title":"Inhibition and induction of drug metabolism by psoralens: alterations in duration of sleep induced by hexobarbital and in clearance of caffeine and hexobarbital in mice","volume":"21","author":"Apseloff","year":"1991","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bcp.2004.11.017_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0090-9556(25)06703-0","article-title":"Disposition of 8-methoxypsoralen in the rat. Induction of metabolism in vivo and in vitro and identification of urinary metabolites by thermospray mass spectrometry","volume":"15","author":"Mays","year":"1987","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bcp.2004.11.017_bib12","first-page":"179","article-title":"Dietary psoralens induce hepatotoxicity in C57 mice","volume":"9","author":"Diawara","year":"2000","journal-title":"J Nat Toxins"},{"key":"10.1016\/j.bcp.2004.11.017_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3835(97)82727-9","article-title":"Induction of rat hepatic cytochrome P4501A and P4502B by the methoxsalen","volume":"109","author":"Jeong","year":"1996","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2004.11.017_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0009-2797(02)00070-4","article-title":"Aryl hydrocarbon receptors: diversity and evolution","volume":"141","author":"Hahn","year":"2002","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bcp.2004.11.017_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0300-483X(94)02994-6","article-title":"Potency of mixtures of polychlorinated biphenyls as inducers of dioxin receptor-regulated CYP1A activity in rat hepatocytes and H4IIE cells","volume":"99","author":"Schmitz","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2004.11.017_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/1056-8719(96)00071-8","article-title":"A rapid beta-NADH-linked fluoresence assay for lactate dehydrogenase in cellular death","volume":"36","author":"Moran","year":"1996","journal-title":"Pharmacol Toxciol Meth"},{"key":"10.1016\/j.bcp.2004.11.017_bib17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0003-2697(80)90505-9","article-title":"A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions","volume":"107","author":"Pohl","year":"1980","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bcp.2004.11.017_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/abio.1994.1476","article-title":"Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader","volume":"222","author":"Kennedy","year":"1994","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bcp.2004.11.017_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0009-2797(98)00105-7","article-title":"Potency of various polycyclic aromatic hydrocarbons as inducers of CYP1A1 in rat hepatocyte cultures","volume":"117","author":"Till","year":"1999","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bcp.2004.11.017_bib20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/bbrc.1998.8340","article-title":"Sequence analysis and functional characterization of the 5\u2032-flanking region of the rat multidrug resistance protein 2 (mrp2) gene","volume":"245","author":"Kauffmann","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2004.11.017_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.abb.2003.10.005","article-title":"Single nucleotide polymorphism analysis and functional characterization of the human Ah receptor (AhR) gene promotor","volume":"421","author":"Racky","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bcp.2004.11.017_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0167-4889(82)90030-1","article-title":"Penetration and localization of furocoumarins in single living cells studied by microspectroflurometry","volume":"721","author":"Moreno","year":"1982","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.bcp.2004.11.017_bib23","first-page":"155","article-title":"Photo-C4-cyclo-addition reactions to the nucleic acids","volume":"3","author":"Musajo","year":"1972","journal-title":"Res Prog Org Biol Med Chem"},{"key":"10.1016\/j.bcp.2004.11.017_bib24","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/0006-2952(88)90449-2","article-title":"Dark and photochemical interactions between monofunctional furocoumarins and DNA","volume":"37","author":"Dall\u2019Acqua","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2004.11.017_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/1011-1344(89)80086-7","article-title":"Method for the determination of the in vivo irreversible binding of 8-methoxypsoralen (8-MOP) to epidermal lipids, proteins, and DNA\/RNA of rats after PUVA treatment","volume":"3","author":"Beijersbergen von Henegouwen","year":"1989","journal-title":"J Photochem Photobiol B"},{"key":"10.1016\/j.bcp.2004.11.017_bib26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1751-1097.1983.tb03384.x","article-title":"Photoaddition of 8-methoxypsoralen to E. coli DNA polymerase. 1. Role of psoralen photoadducts in the photosensitized alterations of pol 1 enzymatic activities","volume":"38","author":"Granger","year":"1983","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.bcp.2004.11.017_bib27","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/bms.1200071123","article-title":"The use of stable isotopes to prove the saturable first-pass effect of methoxsalen","volume":"7","author":"Schmid","year":"1980","journal-title":"Biomed Mass Spectromet"},{"key":"10.1016\/j.bcp.2004.11.017_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0022-5347(24)06136-6","article-title":"The metabolism of 14C-methoxsalen by the dog","volume":"7","author":"Kolis","year":"1979","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bcp.2004.11.017_bib29","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1126\/science.6719117","article-title":"Reactive metabolites from bioactivation of toxic methylfurans","volume":"224","author":"Ravindranath","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.bcp.2004.11.017_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-3565(25)38813-0","article-title":"Inactivation of cytochrome P450 by the drug methoxsalen","volume":"236","author":"Fouin-Fortunet","year":"1986","journal-title":"J Pharrmacol Exp Ther"},{"key":"10.1016\/j.bcp.2004.11.017_bib31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-3565(25)25042-X","article-title":"Inactivation and induction of cytochrome P450 by various psoralen derivatives in rats","volume":"238","author":"Letteron","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2004.11.017_bib32","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0022-3565(25)22744-6","article-title":"Suicide inactivation of cytochrome P-450 by methoxsalen. Evidence for the covalent binding of a reactive intermediate to the protein moiety","volume":"250","author":"Labbe","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2004.11.017_bib33","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/tx950208b","article-title":"Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins","volume":"9","author":"Cai","year":"1996","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.bcp.2004.11.017_bib34","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0090-9556(25)08464-8","article-title":"Identification of 6\u2032,7\u2032-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice","volume":"24","author":"Edwards","year":"1996","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bcp.2004.11.017_bib35","first-page":"1228","article-title":"Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins","volume":"25","author":"Schmiedlin-Ren","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bcp.2004.11.017_bib36","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/tx00036a018","article-title":"Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins","volume":"6","author":"Cai","year":"1993","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.bcp.2004.11.017_bib37","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1124\/dmd.30.9.977","article-title":"Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes","volume":"30","author":"Wen","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bcp.2004.11.017_bib38","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2004.11.017_bib39","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/carcin\/18.8.1521","article-title":"Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice","volume":"18","author":"Cai","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2004.11.017_bib40","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1006\/bbrc.1995.1450","article-title":"Suppression of cytochrome P450 (CYP1A-1) induction in mouse hepatoma Hepa-1C1C7 cells by methoxsalen","volume":"208","author":"Jeong","year":"1995","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295204007853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295204007853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:58:57Z","timestamp":1762095537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295204007853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0006295204007853"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2004.11.017","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2004.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}