{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:54:19Z","timestamp":1789973659150,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.bcp.2005.04.015","type":"journal-article","created":{"date-parts":[[2005,5,15]],"date-time":"2005-05-15T11:13:40Z","timestamp":1116155620000},"page":"90-101","source":"Crossref","is-referenced-by-count":29,"title":["Site specific alterations of adipose tissue mitochondria in 3\u2032-azido-3\u2032-deoxythymidine (AZT)-treated rats: An early stage in lipodystrophy?"],"prefix":"10.1016","volume":"70","author":[{"given":"Catherine","family":"Deveaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Beauvoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Hagry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Galinier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Carri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Salin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Caspar-Bauguil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Gordien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Breilh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Penicaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Casteilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Rigoulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2005.04.015_bib1","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.bcp.2005.04.015_bib2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)77775-8","article-title":"Abnormal fat distribution and use of protease inhibitors","volume":"351","author":"Carr","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2005.04.015_bib3","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1258\/0956462981921189","article-title":"Disorders of fat distribution in HIV infection","volume":"9","author":"Shaw","year":"1998","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.bcp.2005.04.015_bib4","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1097\/00002030-199911120-00019","article-title":"Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy","volume":"13","author":"Kakuda","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.bcp.2005.04.015_bib5","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S0140-6736(99)06102-4","article-title":"Mitochondrial toxicity induced by nucleoside analogue reverse transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral therapy related lipodystrophy","volume":"354","author":"Brinkman","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2005.04.015_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0306-3623(98)00041-X","article-title":"Mitochondria as cell targets of AZT (zidovudine)","volume":"31","author":"Barile","year":"1998","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.bcp.2005.04.015_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1172\/JCI1418","article-title":"AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins","volume":"102","author":"De la Asuncion","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2005.04.015_bib8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/hep.510290353","article-title":"Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver","volume":"29","author":"De la Asuncion","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.bcp.2005.04.015_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0891-5849(98)00199-3","article-title":"Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat","volume":"314","author":"Szabados","year":"1999","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.bcp.2005.04.015_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/15216540152845957","article-title":"The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology","volume":"52","author":"Lenaz","year":"2001","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bcp.2005.04.015_bib11","first-page":"R1460","article-title":"Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum","volume":"274","author":"Digirolamo","year":"1998","journal-title":"Am J. Physiol."},{"key":"10.1016\/j.bcp.2005.04.015_bib12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.5414\/CPP38532","article-title":"Similarity in the linear and non-linear oral absorption of drugs between human and rat","volume":"38","author":"Chiou","year":"2000","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.bcp.2005.04.015_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1139\/y98-151","article-title":"Zidovudine (AZT) induced alterations in mitochondrial biogenesis in rat striated muscles","volume":"77","author":"Freyssenet","year":"1999","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.bcp.2005.04.015_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0344-0338(96)80218-4","article-title":"Hepatic morphological alterations induced by zidovudine (ZDV) in an experimental model","volume":"192","author":"Corcuera","year":"1996","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.bcp.2005.04.015_bib15","unstructured":"Bergenmeyer HU. Methods in enzymatic analysis, vol. VI and VIII, 3rd ed. Verlag Chemie Weinhein, New York, San Francisco, London: Academic Press; 1986."},{"key":"10.1016\/j.bcp.2005.04.015_bib16","first-page":"486","article-title":"Pyridine nucleotide in liver mitochondria. An analysis of their redox relationships","volume":"331","author":"Klingenberg","year":"1959","journal-title":"Biochem Z"},{"key":"10.1016\/j.bcp.2005.04.015_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(69)13005-0","article-title":"Citrate synthase","volume":"13","author":"Srere","year":"1969","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.bcp.2005.04.015_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0009-8981(94)90055-8","article-title":"Biochemical and molecular investigations in respiratory chain deficiencies","volume":"228","author":"Rustin","year":"1994","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.bcp.2005.04.015_bib19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/clinchem\/47.2.256","article-title":"HPLC analysis of reduced and oxidized coenzyme Q10 in human plasma","volume":"47","author":"Tang","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.bcp.2005.04.015_bib20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxyde anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.bcp.2005.04.015_bib21","series-title":"Catalase activity in handbook of methods for oxygen radical research","first-page":"283","author":"Clairborne","year":"1985"},{"key":"10.1016\/j.bcp.2005.04.015_bib22","first-page":"444","article-title":"An improved coupled test procedure for glutathione peroxidase (EC 1-11-1-9-) in blood","volume":"12","author":"G\u00fcnzler","year":"1974","journal-title":"Z klin Chem Klin Biochem"},{"key":"10.1016\/j.bcp.2005.04.015_bib23","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0955-2863(99)00033-9","article-title":"A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection","volume":"10","author":"Melnyk","year":"1999","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.bcp.2005.04.015_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-4347(00)83313-7","article-title":"Fluorimetric determination of total Vitamin C in whole blood by high-performance liquid chromatography with pre-column derivatization","volume":"305","author":"Speek","year":"1984","journal-title":"J Chromatogr"},{"key":"10.1016\/j.bcp.2005.04.015_bib25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0076-6879(84)05042-4","article-title":"Lipid peroxydation. Assay for blood plasma or serum","volume":"105","author":"Yagi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.bcp.2005.04.015_bib26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","article-title":"A simple, rapid, and sensitive DNA assay procedure","volume":"102","author":"Labarca","year":"1980","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bcp.2005.04.015_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1248\/bpb.19.599","article-title":"Intestinal absorption and first-pass elimination of 2\u2032,3\u2032-dideoxynucleosides following oral adminstration in rats","volume":"19","author":"Hasegawa","year":"1996","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bcp.2005.04.015_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1042\/bj1030514","article-title":"The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver","volume":"103","author":"Williamson","year":"1967","journal-title":"Biochem J"},{"key":"10.1016\/j.bcp.2005.04.015_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1023\/B:MCBI.0000049374.52989.9b","article-title":"Regional differences in oxidative capacity of rat white adipose tissue are linked to the mitochondrial content of mature adipocytes","volume":"267","author":"Deveaud","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.bcp.2005.04.015_bib30","first-page":"516","article-title":"Effect of stavudine on mitochondrial genome and fatty acid oxidation in lean and obese mice","volume":"297","author":"Gaou","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2005.04.015_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0925-4439(92)90014-E","article-title":"Linear correlation between acetoacetate\/beta-hydroxybutyrate in arterial blood and oxidized flavoprotein\/reduced pyridine nucleotide in freeze-trapped human liver tissue","volume":"1138","author":"Ozawa","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2005.04.015_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0003-9861(79)90289-3","article-title":"Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds","volume":"196","author":"Hassan","year":"1979","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bcp.2005.04.015_bib33","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/S0140-6736(03)14858-1","article-title":"HIV-associated adipose redistribution syndrome as a selective autonomic neuropathy","volume":"362","author":"Fliers","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2005.04.015_bib34","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1210\/jc.2003-031507","article-title":"Molecular determinants of human adipose tissue: differences between visceral and subcutaneous compartments in obese women","volume":"89","author":"Giusti","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2005.04.015_bib35","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1097\/00002030-200109280-00009","article-title":"Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy","volume":"15","author":"Shikuma","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.bcp.2005.04.015_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00042560-200202010-00002","article-title":"Evidence of nucleoside analogue reverse transcriptase inhibitor-associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients","volume":"29","author":"Walker","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.bcp.2005.04.015_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00126334-200207010-00002","article-title":"Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat","volume":"30","author":"Cherry","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.bcp.2005.04.015_bib38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/135965350300800614","article-title":"Contribution of nucleoside-analogue reverse transcriptase inhibitor therapy to lipoatrophy from the population to the cellular level","volume":"8","author":"Nolan","year":"2003","journal-title":"Antivir Ther"},{"key":"10.1016\/j.bcp.2005.04.015_bib39","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1128\/AAC.47.11.3384-3392.2003","article-title":"Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single-and three dual-NRTI treatments","volume":"47","author":"Note","year":"2003","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295205002467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295205002467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T07:02:33Z","timestamp":1683097353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295205002467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0006295205002467"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2005.04.015","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}