{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:17:34Z","timestamp":1791670654941,"version":"4.3.4"},"reference-count":91,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.bcp.2005.12.003","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T14:00:46Z","timestamp":1137679246000},"page":"1085-1095","source":"Crossref","is-referenced-by-count":84,"title":["Redefining penems"],"prefix":"10.1016","volume":"71","author":[{"given":"Axel","family":"Dalhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa","family":"Janjic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Echols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2005.12.003_bib1","first-page":"226","article-title":"On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae","volume":"10","author":"Fleming","year":"1929","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.bcp.2005.12.003_bib2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(01)08728-1","article-title":"Penicillin as a chemotherapeutic agent","volume":"236","author":"Chain","year":"1940","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2005.12.003_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/183257b0","article-title":"Synthesis of penicillin, 6-amino-penicillanic acid in penicillin fermentations","volume":"183","author":"Batchelor","year":"1959","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2005.12.003_bib4","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1021\/ja00876a034","article-title":"Chemistry of cephalosporin antibiotics I. 7-Aminocephalosporanic acid from cephalosporin C","volume":"84","author":"Morin","year":"1962","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bcp.2005.12.003_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/22.1.5","article-title":"The Garrod lecture. The influence of 6-aminopenicillanic acid on antibiotic development","volume":"22","author":"Rolinson","year":"1988","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000220491","article-title":"Chemical manipulations of the penicillin nucleus: a review","volume":"12","author":"Hamilton-Miller","year":"1967","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bcp.2005.12.003_bib7","doi-asserted-by":"crossref","first-page":"668","DOI":"10.7164\/antibiotics.29.668","article-title":"Naturally occurring \u03b2-lactamase inhibitors with antibacterial activity","volume":"29","author":"Brown","year":"1976","journal-title":"J Antibiot"},{"key":"10.1016\/j.bcp.2005.12.003_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1039\/C39770000523","article-title":"Structures of olivine acid derivatives MM4550 and MM13902; two new, fused \u03b2-lactam isolated from Streptomyces olivaceus","author":"Brown","year":"1977","journal-title":"J Chem Soc Chem Commun"},{"key":"10.1016\/j.bcp.2005.12.003_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.7164\/antibiotics.29.492","article-title":"a new monocyclic \u03b2-lactam antibiotic. I. Discovery, isolation and characterisation","volume":"29","author":"Aoki","year":"1976","journal-title":"J Antibiot"},{"key":"10.1016\/j.bcp.2005.12.003_bib10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.7164\/antibiotics.34.621","article-title":"Sulfazecin, a novel \u03b2-lactam antibiotic of bacterial origin. Isolation and chemical characterisation","volume":"34","author":"Asai","year":"1981","journal-title":"J Antibiot"},{"key":"10.1016\/j.bcp.2005.12.003_bib11","series-title":"Recent advances in the chemistry of beta-lactams","first-page":"167","author":"Woodward","year":"1977"},{"key":"10.1016\/j.bcp.2005.12.003_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7164\/antibiotics.32.1","article-title":"Thienamycin, a new beta-lactam antibiotic I: Discovery, taxonomy, isolation and physical properties","volume":"32","author":"Kahan","year":"1979","journal-title":"J Antibiot"},{"issue":"Suppl. 6A","key":"10.1016\/j.bcp.2005.12.003_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0002-9343(85)90097-X","article-title":"Carbapenems, a new class of beta-lactam antibiotics","volume":"78","author":"Birnbaum","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.bcp.2005.12.003_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000070616","article-title":"The art of fusion: from penams and cephems to penems","volume":"49","author":"Dalhoff","year":"2003","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bcp.2005.12.003_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/jac\/44.6.729","article-title":"Beta-lactams: variations on a chemical theme, with some surprising biological results","volume":"44","author":"Hamilton-Miller","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543784.4.8.705","article-title":"Penems: new oral beta-lactam drugs","volume":"4","author":"Bryskier","year":"1995","journal-title":"Exp Opin Investig Drugs"},{"key":"10.1016\/j.bcp.2005.12.003_bib17","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/AAC.46.8.2327-2332.2002","article-title":"Comparative stability studies of antipseudomonal \u03b2-lactams for potential administration through portable electrometric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units)","volume":"46","author":"Viaene","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib18","series-title":"The chemistry of beta-lactams","first-page":"79","article-title":"Structure\u2013activity relationships: chemical (Chapter 2)","author":"Page","year":"1992"},{"key":"10.1016\/j.bcp.2005.12.003_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/AAC.22.1.62","article-title":"Metabolism of thienamycin and related carbapenems antibiotics by the renal dipeptidase, dehydropeptidase-I","volume":"22","author":"Kropp","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl. D","key":"10.1016\/j.bcp.2005.12.003_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/12.suppl_D.1","article-title":"Thienamycin: development of imipenem\/cilastatin","volume":"12","author":"Kahan","year":"1983","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/AAC.33.2.215","article-title":"In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase 1","volume":"33","author":"Edwards","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib22","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1128\/AAC.29.5.936","article-title":"Degradation kinetics of imipenem in normal saline and in human serum","volume":"29","author":"Swanson","year":"1986","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib23","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/jps.2600790816","article-title":"Stability and kinetics of degradation of imipenem in aqueous solution","volume":"79","author":"Smith","year":"1990","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.bcp.2005.12.003_bib24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1248\/cpb.43.689","article-title":"Stability of a 1-\u03b2-methylcarbapenem antibiotic, meropenem (SM-7338) in aqueous solution","volume":"43","author":"Takuguchi","year":"1995","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bcp.2005.12.003_bib25","series-title":"Infectious diseases","first-page":"197","article-title":"Other beta-lactam antibiotics","author":"Sanders","year":"1998"},{"key":"10.1016\/j.bcp.2005.12.003_bib26","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0968-0896(97)00073-4","article-title":"Structure\u2013activity relationships of penem antibiotics: crystallographic structures and implications for their antimicrobial activities","volume":"5","author":"Tanaka","year":"1997","journal-title":"Bioorg Med Chem"},{"issue":"S-1","key":"10.1016\/j.bcp.2005.12.003_bib27","first-page":"13","article-title":"SY5555, its in vitro antibacterial activity, affinity to penicillin binding proteins, inactivation of beta-lactamases, synergy with serum complement or cultured macrophages in bactericidal effect and stability against DHP-1","volume":"42","author":"Yokota","year":"1994","journal-title":"Chemotherapy (Tokyo)"},{"key":"10.1016\/j.bcp.2005.12.003_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/jac\/dkh298","article-title":"Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluation","volume":"54","author":"Jones","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib29","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1128\/AAC.48.8.3136-3140.2004","article-title":"Activities of doripenem (S-4661) against drug-resistant clinical pathogens","volume":"48","author":"Jones","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1517\/13543784.10.6.1157","article-title":"Ertapenem: a new carbapenem","volume":"10","author":"Odenholt","year":"2001","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.bcp.2005.12.003_bib31","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1128\/AAC.46.11.3669-3675.2002","article-title":"In vitro activities of faropenem against 579 strains of anaerobic bacteria","volume":"46","author":"Wexler","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/jac\/49.1.220","article-title":"In vitro activity of faropenem and 20 other compounds against \u03b2-lactamase-positive and -negative Moraxella catarrhalis and Haemophilus isolates and the effect of serum on faropenem MICs","volume":"49","author":"Schmitz","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/jac\/48.1.148","article-title":"In vitro activity of faropenem and 21 other compounds against 385 different genetically characterized isolates of antibiotic-resistant Streptococcus pneumoniae","volume":"48","author":"Schmitz","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/AAC.46.2.550-555.2002","article-title":"Activities of faropenem, an oral \u03b2-lactam, against recent U.S. isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis","volume":"46","author":"Critchley","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib35","series-title":"Proceedings of the 41st ICAAC, Abstract no. 791","article-title":"Faropenem: activity against ESBL, AmpC and other \u03b2-lactamase producing Enterobacteriaceae","author":"Black","year":"2001"},{"key":"10.1016\/j.bcp.2005.12.003_bib36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/jac\/dki166","article-title":"Emergence of Enterobacteriacea producing extended-spectrum \u03b2-lactamase (ESBLs) in the community","volume":"56","author":"Pitout","year":"2005","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl E","key":"10.1016\/j.bcp.2005.12.003_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/18.Supplement_E.9","article-title":"Mechanism by which imipenem may overcome resistance in Gram-negative bacilli","volume":"18","author":"Williams","year":"1986","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl E","key":"10.1016\/j.bcp.2005.12.003_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/jac\/18.Supplement_E.15","article-title":"The effects on \u03b2-lactams susceptibility of phenotypic induction and genotypic derepression of \u03b2-lactamase synthesis","volume":"18","author":"Shannon","year":"1986","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl A","key":"10.1016\/j.bcp.2005.12.003_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/jac\/24.suppl_A.149","article-title":"Comparative activity of meropenem against Pseudomonas aeruginosa strains with well-characterized resistance mechanisms","volume":"24","author":"Livermore","year":"1989","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib40","series-title":"Proceedings of the 45th ICAAC, Abstract no. C1-78","article-title":"High stability to beta-lactamase and low propensity for beta-lactamase induction by faropenem","author":"Dalhoff","year":"2005"},{"key":"10.1016\/j.bcp.2005.12.003_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000071141","article-title":"Target affinities of faropenem and its impact on the morphology of Gram-positive and Gram-negative bacteria","volume":"49","author":"Dalhoff","year":"2003","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bcp.2005.12.003_bib42","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1128\/AAC.43.2.424","article-title":"Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems","volume":"43","author":"K\u00f6hler","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib43","series-title":"Proceedings of the 41st ICAAC, Abstract no. 1519","article-title":"Interaction of faropenem with OprD porin and active efflux in P. aeruginosa","author":"K\u00f6hler","year":"2001"},{"key":"10.1016\/j.bcp.2005.12.003_bib44","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1128\/AAC.45.7.1964-1971.2001","article-title":"Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay","volume":"45","author":"Okamoto","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib45","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1128\/AAC.44.12.3322-3327.2000","article-title":"Substrate specificities of MexAB-OprM, MexCD-OprJ and MexXY-OprM efflux pumps in Pseudomonas aeruginosa","volume":"44","author":"Masuda","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib46","series-title":"Proceedings of the 41st ICAAC, Abstract no. 1518","article-title":"Ertapenem resistance selection in Pseudomonas aeruginosa","author":"Kohler","year":"2001"},{"key":"10.1016\/j.bcp.2005.12.003_bib47","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1128\/AAC.43.6.1379","article-title":"Emergence of antibiotic resistant Pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents","volume":"43","author":"Carmeli","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl","key":"10.1016\/j.bcp.2005.12.003_bib48","first-page":"63","article-title":"Killing and regrowth of bacteria in vitro: a review","volume":"74","author":"Craig","year":"1991","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.bcp.2005.12.003_bib49","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1128\/AAC.48.8.3086-3092.2004","article-title":"Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants and transconjugants and resistance selection potential","volume":"48","author":"Mushtaq","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib50","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1128\/AAC.43.2.424","article-title":"Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems","volume":"43","author":"K\u00f6hler","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/jac\/47.3.247","article-title":"Of Pseudomonas, porins, pumps, and carbapenems","volume":"47","author":"Livermore","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib52","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/jac\/dki009","article-title":"Selectivity of ertapenem for Pseudomonas aeruginosa mutants cross-resistant to other carbapenems","volume":"55","author":"Livermore","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib53","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF01964287","article-title":"Correlation between pharmacokinetics, pharmacodynamics and efficacy of antibacterial agents in animal models","volume":"9","author":"Dalhoff","year":"1990","journal-title":"Eur J Clin Micro Infect Dis"},{"key":"10.1016\/j.bcp.2005.12.003_bib54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0924-8579(02)00022-5","article-title":"Animal model pharmacokinetics and pharmacodynamics: a critical review","volume":"19","author":"Andes","year":"2002","journal-title":"Int J Antimicrob Agents"},{"issue":"Suppl A","key":"10.1016\/j.bcp.2005.12.003_bib55","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/jac\/24.suppl_A.239","article-title":"Bactericidal activity of meropenem and interaction with other antibiotics","volume":"24","author":"Ferrara","year":"1989","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl A","key":"10.1016\/j.bcp.2005.12.003_bib56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/jac\/24.suppl_A.225","article-title":"The postantibiotic effect of meropenem and imipenem on selected bacteria","volume":"24","author":"Nadler","year":"1989","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 6a","key":"10.1016\/j.bcp.2005.12.003_bib57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0002-9343(85)90099-3","article-title":"Carbapenems: special properties contributing to their activity","volume":"78","author":"Neu","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.bcp.2005.12.003_bib58","doi-asserted-by":"crossref","unstructured":"Schaper K, Schubert S, Dalhoff A. Kinetics and quantification of antibacterial effects of beta-lactams, macrolide and fluoroquinolones against Gram-positive and Gram-negative pathogens. Infection 2006;33(Suppl2), in press.","DOI":"10.1007\/s15010-005-8202-2"},{"key":"10.1016\/j.bcp.2005.12.003_bib59","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/jac\/39.3.415","article-title":"Pharmacodynamic properties of faropenem demonstrated by studies of time-kill kinetics and postantibiotic effect","volume":"39","author":"Boswell","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib60","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1469-0691.1999.tb00142.x","article-title":"Antimicrobial activity of faropenem, a new oral penem, against lower respiratory tract pathogens","volume":"5","author":"Marchese","year":"1999","journal-title":"Clin Micro Infect"},{"key":"10.1016\/j.bcp.2005.12.003_bib61","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/AAC.29.5.797","article-title":"Evaluation of the bactericidal activity of beta-lactam antibiotics on slowly growing bacteria cultured in the chemostat","volume":"29","author":"Cozens","year":"1986","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib62","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1128\/AAC.49.3.889-894.2005","article-title":"In vitro activity of tebipenem, a new oral carbapenems antibiotic, against penicillin-susceptible Streptococcus pneumoniae","volume":"49","author":"Kobayashi","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib63","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1128\/AAC.33.10.1819","article-title":"Role of autolysins in the activities of imipenem and CGP31608, a novel penem, against slowly growing bacteria","volume":"33","author":"Cozens","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 3","key":"10.1016\/j.bcp.2005.12.003_bib64","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/clinids\/8.Supplement_3.S279","article-title":"Phenotypic tolerance: the search for beta-lactam antibiotics that kill non-growing bacteria","author":"Tuomanen","year":"1986","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.bcp.2005.12.003_bib65","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1128\/AAC.43.8.2010","article-title":"In vitro antibacterial activity of LJC 11,036, an active metabolite of L-084, a new oral carbapenem antibiotic with potent antipneumococcal activity","volume":"43","author":"Hikida","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib66","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1128\/AAC.35.9.1824","article-title":"Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria","volume":"35","author":"Eng","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib67","first-page":"1297","article-title":"The rate of killing Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth","volume":"132","author":"Tuomanen","year":"1986","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.bcp.2005.12.003_bib68","series-title":"Proceedings of the 41st ICAAC, Abstract no. 2094","article-title":"In vivo pharmacodynamics activity of faropenem against Streptococcus pneumoniae","author":"Craig","year":"2001"},{"key":"10.1016\/j.bcp.2005.12.003_bib69","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jac\/dkg042","article-title":"Antimicrobial-induced release of endotoxin from Pseudomonas aeruginosa: comparison of in vitro and animals models","volume":"51","author":"Tsuji","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0732-8893(95)00053-D","article-title":"Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins","volume":"22","author":"Craig","year":"1995","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.bcp.2005.12.003_bib71","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/AAC.42.9.2375","article-title":"In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations","volume":"42","author":"Andes","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib72","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10156-003-0292-0","article-title":"Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis","volume":"10","author":"Takata","year":"2004","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib73","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/14756369209040743","article-title":"Beta-lactams: a new class of conformationally rigid inhibitors of \u03b3-aminobutyric acid aminotransferase","volume":"6","author":"Hopkins","year":"1992","journal-title":"J Enzym Inhib"},{"key":"10.1016\/j.bcp.2005.12.003_bib74","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.7164\/antibiotics.46.1145","article-title":"Effect of cephalosporins on \u03b3-aminobutyric acid receptor binding with or without non-steroidal anti-inflammatory drugs","volume":"46","author":"Hori","year":"1993","journal-title":"J Antibiot"},{"key":"10.1016\/j.bcp.2005.12.003_bib75","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/AAC.37.2.199","article-title":"Low neurotoxicity of LJC 10,627, a novel 1-beta-methyl carbapenem antibiotic: inhibition of gamma-aminobutyric acid A, benzodiazepine, and glycine receptor binding in relation to lack of central nervous system toxicity in rats","volume":"37","author":"Hikida","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib76","doi-asserted-by":"crossref","first-page":"408","DOI":"10.7164\/antibiotics.48.408","article-title":"Structural features resulting in convulsive activity of carbapenem compounds: effect of C-2 side chain","volume":"48","author":"Sunagawa","year":"1995","journal-title":"J Antibiot"},{"key":"10.1016\/j.bcp.2005.12.003_bib77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/45.1.5","article-title":"Neurotoxicity of carbapenem antibiotics: consequences for their use in bacterial meningitis","volume":"45","author":"Norrby","year":"2000","journal-title":"Antimicrob Chemother"},{"issue":"Suppl A","key":"10.1016\/j.bcp.2005.12.003_bib78","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jac\/24.suppl_A.307","article-title":"Meropenem: evidence of lack of proconvulsive tendency in mice","volume":"24","author":"Patel","year":"1989","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib79","series-title":"Proceedings of the 32nd ICAAC, Abstract no. 301","article-title":"Epileptogenic activity of meropenem. A new carbapenem. A comparative study on epileptogenic activity of carbapenems and beta-lactams","author":"Hori","year":"1992"},{"key":"10.1016\/j.bcp.2005.12.003_bib80","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.7164\/antibiotics.45.1983","article-title":"Structure\u2013activity relationships of carbapenems and penem compounds for the convulsive property","volume":"45","author":"Sunagawa","year":"1992","journal-title":"J Antibiot"},{"key":"10.1016\/j.bcp.2005.12.003_bib81","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/AAC.42.1.94","article-title":"In vitro and in vivo antibacterial activities of S-4661, a new carbapenem","volume":"42","author":"Tsuji","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"issue":"S1","key":"10.1016\/j.bcp.2005.12.003_bib82","first-page":"201","article-title":"A neurochemical study on convulsant activity of SY5555, a new penem antibiotic","volume":"42","author":"Hori","year":"1994","journal-title":"Chemotherapy (Tokyo)"},{"issue":"S1","key":"10.1016\/j.bcp.2005.12.003_bib83","first-page":"205","article-title":"General pharmacological studies on SY5555; effects on central nervous system","volume":"42","author":"Hirotsu","year":"1994","journal-title":"Chemotherapy (Tokyo)"},{"key":"10.1016\/j.bcp.2005.12.003_bib84","series-title":"Proceedings of the 41st ICAAC, Abstract no. 2196","article-title":"Determination of the excitatory potency of faropenem in the central nervous system by an in vitro model","author":"Schmuck","year":"2001"},{"key":"10.1016\/j.bcp.2005.12.003_bib85","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/AAC.37.2.199","article-title":"Low neurotoxicity of LJC 10,627, a novel 1-\u03b2-methyl carbapenem antibiotic: inhibition of gamma-amino butyric acid A, benzodiazepine, and glycine receptor binding in relation to lack of central nervous system toxicity in rats","volume":"37","author":"Hikida","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bcp.2005.12.003_bib86","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0300-483X(99)00078-5","article-title":"Low convulsive activity of a new carbapenem antibiotic, DK-35C, as compared with existing congeners","volume":"138","author":"Jin","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2005.12.003_bib87","series-title":"Proceedings of the 37th ICAAC, Abstract no. F220","article-title":"S-4661, a new carbapenems, has weak convulsant activity. A comparative study on convulsant activity of carbapenem and cephalosporins","author":"Hori","year":"1997"},{"key":"10.1016\/j.bcp.2005.12.003_bib88","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.8.4.557","article-title":"\u03b2-Lactamases in laboratory and clinical resistance","volume":"8","author":"Livermore DM","year":"1995","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bcp.2005.12.003_bib89","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/CMR.18.2.306-325.2005","article-title":"Metallo \u03b2-lactamases: the quiet before the storm?","volume":"18","author":"Walsh","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bcp.2005.12.003_bib90","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJMra041359","article-title":"The new \u03b2-lactamases","volume":"352","author":"Jacoby","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bcp.2005.12.003_bib91","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/jac\/dkg224","article-title":"Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy","volume":"51","author":"vanBambeke","year":"2003","journal-title":"J Antmicrob Chemother"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295205008105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295205008105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T01:31:57Z","timestamp":1586655117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295205008105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":91,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0006295205008105"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2005.12.003","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}