{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:26:12Z","timestamp":1783149972862,"version":"3.54.6"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016642","name":"Japan Chemical Industry Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment, Government of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001863","name":"New Energy and Industrial Technology Development Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.bcp.2006.01.014","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T07:24:24Z","timestamp":1141370664000},"page":"1349-1357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Organotin compounds enhance 17\u03b2-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: Potential promotion of 17\u03b2-estradiol biosynthesis in human placenta"],"prefix":"10.1016","volume":"71","author":[{"given":"Tsuyoshi","family":"Nakanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhei","family":"Hiromori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihoko","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ichi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2006.01.014_bib1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1210\/edrv-11-1-124","article-title":"Placental steroid hormone biosynthesis in primate pregnancy","volume":"11","author":"Albrecht","year":"1990","journal-title":"Endocr Rev"},{"key":"10.1016\/j.bcp.2006.01.014_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0303-7207(00)00425-1","article-title":"Type 5 17\u03b2-hydroxysteroid dehydrogenase: its role in the formation of androgens in women","volume":"171","author":"Luu-The","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1677\/joe.0.1650217","article-title":"Localization of type 1 17\u03b2-hydroxysteroid dehydrogenase mRNA and protein in syncytiotrophoblasts and invasive cytotrophoblasts in the human term villi","volume":"165","author":"Bonenfant","year":"2000","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1677\/joe.0.1400409","article-title":"Expression of 17\u03b2-hydroxysteroid dehydrogenase in the rat ovary during follicular development and luteinization induced with pregnant mare serum gonadotrophin and human chorionic gonadotrophin","volume":"140","author":"Ghersevich","year":"1994","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0303-7207(94)90004-3","article-title":"Compartmentalization of type I 17\u03b2-hydroxysteroid oxidoreductase in the human ovary","volume":"99","author":"Sawetawan","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib6","first-page":"290","article-title":"17\u03b2-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin","volume":"52","author":"Poutanen","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2006.01.014_bib7","first-page":"582","article-title":"Immunohistochemical localization of 17\u03b2-hydroxysteroid dehydrogenase in the human endometrium during the menstrual cycle","volume":"65","author":"Maentausta","year":"1991","journal-title":"Lab Invest"},{"key":"10.1016\/j.bcp.2006.01.014_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0300-483X(89)90018-8","article-title":"Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals","volume":"55","author":"Boyer","year":"1989","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2006.01.014_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449609089891","article-title":"Ecotoxicology of organotin compounds","volume":"26","author":"Fent","year":"1996","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.bcp.2006.01.014_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0269-7491(96)00093-0","article-title":"Effects of triphenyltin chloride and five other organotin compounds on the development of imposex in the rock shell, Thais clavigera","volume":"95","author":"Horiguchi","year":"1997","journal-title":"Environ Pollut"},{"key":"10.1016\/j.bcp.2006.01.014_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/etc.5620170106","article-title":"Critical appraisal of the evidence for tributyltin-mediated endocrine disruption in mollusks","volume":"17","author":"Matthiessen","year":"1998","journal-title":"Environ Toxicol Chem"},{"key":"10.1016\/j.bcp.2006.01.014_bib12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF00196029","article-title":"Occurrence of butyltin residues in certain foodstuffs","volume":"55","author":"Kannan","year":"1995","journal-title":"Bull Environ Contam Toxicol"},{"key":"10.1016\/j.bcp.2006.01.014_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0269-7491(95)00028-P","article-title":"Butyltins in muscle and liver of fish collected from certain Asian and Oceanian countries","volume":"90","author":"Kannan","year":"1995","journal-title":"Environ Pollut"},{"key":"10.1016\/j.bcp.2006.01.014_bib14","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1210\/me.2004-0397","article-title":"Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions","volume":"19","author":"Nakanishi","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02367105","article-title":"TBT-induced imposex in marine neogastropods is mediated by an increasing androgen level","volume":"50","author":"Bettin","year":"1996","journal-title":"Helgol Meeresunters"},{"key":"10.1016\/j.bcp.2006.01.014_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0141-1136(95)00069-0","article-title":"The metabolism of testosterone by the periwinkle (Littorina littorea) in vitro and in vivo: effects of tributyltin","volume":"42","author":"Ronis","year":"1996","journal-title":"Mar Environ Res"},{"key":"10.1016\/j.bcp.2006.01.014_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0141-1136(91)90032-4","article-title":"The effects of tributyltin upon steroid titers in the female dogwhelk, Nucella lapillus, and the development of imposex","volume":"32","author":"Spooner","year":"1991","journal-title":"Mar Environ Res"},{"key":"10.1016\/j.bcp.2006.01.014_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-4274(01)00451-9","article-title":"Effect of organotins on human aromatase activity in vitro","volume":"126","author":"Cooke","year":"2002","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bcp.2006.01.014_bib19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0039-128X(01)00108-8","article-title":"Inhibition of human cytochrome P450 aromatase activity by butyltins","volume":"66","author":"Heidrich","year":"2001","journal-title":"Steroids"},{"key":"10.1016\/j.bcp.2006.01.014_bib20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0039-128X(02)00051-X","article-title":"Effects of butyltins on human 5\u03b1-reductase type 1 and type 2 activity","volume":"67","author":"Doering","year":"2002","journal-title":"Steroids"},{"key":"10.1016\/j.bcp.2006.01.014_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0960-0760(03)00074-8","article-title":"Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism","volume":"84","author":"Lo","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.bcp.2006.01.014_bib22","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1210\/jcem.87.6.8540","article-title":"Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells","volume":"87","author":"Nakanishi","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2006.01.014_bib23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/bbrc.2001.5952","article-title":"Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN","volume":"289","author":"Saitoh","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2006.01.014_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0006-291X(03)00914-8","article-title":"Triphenyltin enhances the neutrophilic differentiation of promyelocytic HL-60 cells","volume":"306","author":"Watanabe","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2006.01.014_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0041-008X(89)90060-4","article-title":"Prenatal or postnatal exposure to bis(tri-n-butyltin)oxide in the rat: postnatal evaluation of teratology and behavior","volume":"97","author":"Crofton","year":"1989","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.bcp.2006.01.014_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0300-483X(94)02920-P","article-title":"Further evaluation of the developmental toxicity of tributyltin chloride in rats","volume":"96","author":"Ema","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2006.01.014_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0378-4274(91)90108-I","article-title":"Effects of triphenyltin acetate on pregnancy in rats by oral administration","volume":"56","author":"Noda","year":"1991","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bcp.2006.01.014_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0378-4274(91)90032-2","article-title":"Teratogenicity study of tri-n-butyltin acetate in rats by oral administration","volume":"55","author":"Noda","year":"1991","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bcp.2006.01.014_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.ph.43.030181.001115","article-title":"Endocrine physiology of the placenta","volume":"43","author":"Simpson","year":"1981","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.bcp.2006.01.014_bib30","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1210\/endo.138.7.5258","article-title":"Expression of 17\u03b2-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20\u03b1-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats","volume":"138","author":"Akinola","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2006.01.014_bib31","first-page":"1309","article-title":"P450(17\u03b1) and P450SCC gene expression and regulation in the rat placenta","volume":"130","author":"Durkee","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2006.01.014_bib32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1095\/biolreprod33.2.451","article-title":"The development of placental androstenedione and testosterone production and their utilization by the ovary for aromatization to estrogen during rat pregnancy","volume":"33","author":"Jackson","year":"1985","journal-title":"Biol Reprod"},{"key":"10.1016\/j.bcp.2006.01.014_bib33","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1210\/jcem-72-3-560","article-title":"A new cause of female pseudohermaphroditism: placental aromatase deficiency","volume":"72","author":"Shozu","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2006.01.014_bib34","first-page":"355","article-title":"Regulation of 3\u03b2-hydroxysteroid dehydrogenase and 17\u03b2-hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic adenosine 3\u2032,5\u2032-monophosphate and phorbol myristate acetate in human choriocarcinoma cells","volume":"7","author":"Tremblay","year":"1993","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib35","first-page":"1633","article-title":"Coordination of transcription of the human 17\u03b2-hydroxysteroid dehydrogenase type 1 gene (EDH17B2) by a cell-specific enhancer and a silencer: identification of a retinoic acid response element","volume":"9","author":"Piao","year":"1995","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1677\/joe.0.1720031","article-title":"Retinoic acids promote the action of aromatase and 17\u03b2-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17\u03b2-estradiol in placental cells","volume":"172","author":"Zhu","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bcp.2006.01.014_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jf60209a002","article-title":"Bioorganotin chemistry. Metabolism of organotin compounds in microsomal monooxygenase systems and in mammals","volume":"25","author":"Kimmel","year":"1976","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bcp.2006.01.014_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jat.884","article-title":"Metabolism of a tetraphenyltin compound in rats after a single oral dose","volume":"23","author":"Ohhira","year":"2003","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.bcp.2006.01.014_bib39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s00204-002-0428-5","article-title":"Metabolism of tributyltin and triphenyltin by rat, hamster and human hepatic microsomes","volume":"77","author":"Ohhira","year":"2003","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.bcp.2006.01.014_bib40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.toxlet.2004.10.009","article-title":"Some organotin compounds enhance histone acetyltransferase activity","volume":"155","author":"Osada","year":"2005","journal-title":"Toxicol Lett"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295206000669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295206000669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:59:19Z","timestamp":1762095559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295206000669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0006295206000669"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2006.01.014","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organotin compounds enhance 17\u03b2-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: Potential promotion of 17\u03b2-estradiol biosynthesis in human placenta","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2006.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}