{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:17:54Z","timestamp":1791271074976,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.bcp.2006.02.001","type":"journal-article","created":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T14:50:08Z","timestamp":1142002208000},"page":"1449-1458","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacological characterization of protease activated receptor-1 by a serum responsive element-dependent reporter gene assay: Major role of calmodulin"],"prefix":"10.1016","volume":"71","author":[{"given":"Luc","family":"De Vries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Palmier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Finana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Le Grand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Cussac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2006.02.001_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/35025229","article-title":"Thrombin signalling and protease-activated receptors","volume":"407","author":"Coughlin","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2006.02.001_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0031-6997(24)01493-5","article-title":"Proteinase-activated receptors","volume":"53","author":"Macfarlane","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bcp.2006.02.001_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/mol.104.003103","article-title":"The cardiovascular actions of protease-activated receptors","volume":"67","author":"Steinberg","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2006.02.001_bib4","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0092-8674(91)90261-V","article-title":"Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation","volume":"64","author":"Vu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2006.02.001_bib5","doi-asserted-by":"crossref","first-page":"13146","DOI":"10.1016\/S0021-9258(18)42184-9","article-title":"Tethered ligand agonist peptides","volume":"267","author":"Scarborough","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/386502a0","article-title":"Protease-activated receptor-3 is a second thrombin receptor in humans","volume":"386","author":"Ishihara","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2006.02.001_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/35007085","article-title":"PAR3 is a cofactor for PAR4 activation by thrombin","volume":"404","author":"Nakanishi-Matsui","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2006.02.001_bib8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1432-1033.1995.tb20784.x","article-title":"Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2","volume":"232","author":"Nysted","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.bcp.2006.02.001_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1172\/JCI116206","article-title":"Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor","volume":"91","author":"McNamara","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2006.02.001_bib10","doi-asserted-by":"crossref","first-page":"25672","DOI":"10.1074\/jbc.M100914200","article-title":"G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation","volume":"276","author":"Gilchrist","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib11","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/sj.onc.1202186","article-title":"Cell growth control by G protein-coupled receptors: from signal transduction to signal integration","volume":"17","author":"Gutkind","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2006.02.001_bib12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0968-0004(92)90013-Y","article-title":"The serum response element","volume":"17","author":"Treisman","year":"1992","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.bcp.2006.02.001_bib13","doi-asserted-by":"crossref","first-page":"24470","DOI":"10.1074\/jbc.M908449199","article-title":"G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha-induced serum response element-dependent transcription","volume":"275","author":"Shi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib14","doi-asserted-by":"crossref","first-page":"40789","DOI":"10.1074\/jbc.M202745200","article-title":"Serum response factor activation by muscarinic receptors via rhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2","volume":"277","author":"Lin","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib15","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1091\/mbc.7.11.1679","article-title":"Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells","volume":"7","author":"Post","year":"1996","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.bcp.2006.02.001_bib16","doi-asserted-by":"crossref","first-page":"27118","DOI":"10.1074\/jbc.273.42.27118","article-title":"Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors","volume":"273","author":"Mao","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib17","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1124\/mol.64.5.1199","article-title":"Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes","volume":"64","author":"Sorensen","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2006.02.001_bib18","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1182\/blood-2002-02-0415","article-title":"The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells","volume":"100","author":"Wu","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2006.02.001_bib19","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0960-894X(99)00339-X","article-title":"Structure\u2013activity relationships of pyrroloquinazolines as thrombin receptor antagonists","volume":"9","author":"Ahn","year":"1999","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bcp.2006.02.001_bib20","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.1074\/jbc.270.14.8367","article-title":"Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor","volume":"270","author":"Vouret-Craviari","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bcp.2006.02.001_bib22","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1074\/jbc.272.7.4043","article-title":"Interactions of mast cell tryptase with thrombin receptors and PAR-2","volume":"272","author":"Molino","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1124\/mol.56.5.1025","article-title":"Human dopamine D(3) receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism","volume":"56","author":"Cussac","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2006.02.001_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.bcp.2006.02.001_bib25","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1124\/mol.58.6.1178","article-title":"Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide","volume":"58","author":"Blackhart","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2006.02.001_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1124\/mol.62.3.578","article-title":"Differential activation of Gq\/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking","volume":"62","author":"Cussac","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2006.02.001_bib27","first-page":"539","article-title":"Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s)","volume":"294","author":"Brink","year":"2000","journal-title":"J Exp Pharmacol Ther"},{"key":"10.1016\/j.bcp.2006.02.001_bib28","doi-asserted-by":"crossref","first-page":"25048","DOI":"10.1074\/jbc.M414090200","article-title":"Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1","volume":"280","author":"McLaughlin","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib29","doi-asserted-by":"crossref","first-page":"34253","DOI":"10.1074\/jbc.274.48.34253","article-title":"G protein selectivity is a determinant of RGS2 function","volume":"274","author":"Heximer","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.pharmtox.40.1.235","article-title":"The regulator of G protein signaling family","volume":"40","author":"De Vries","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bcp.2006.02.001_bib31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1083\/jcb.200203126","article-title":"LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics","volume":"157","author":"Geneste","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bcp.2006.02.001_bib32","doi-asserted-by":"crossref","first-page":"39042","DOI":"10.1074\/jbc.M504341200","article-title":"Radixin stimulates Rac1 and Ca2+\/calmodulin-dependent kinase, CaMKII","volume":"280","author":"Liu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/01.RES.78.4.553","article-title":"Thrombin receptor actions in neonatal rat ventricular myocytes","volume":"78","author":"Jiang","year":"1996","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2006.02.001_bib34","doi-asserted-by":"crossref","first-page":"22081","DOI":"10.1074\/jbc.274.31.22081","article-title":"Calmodulin binding to G protein-coupling domain of opioid receptors","volume":"274","author":"Wang","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib35","doi-asserted-by":"crossref","first-page":"32672","DOI":"10.1074\/jbc.M002780200","article-title":"Binding of calmodulin to the D2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch","volume":"275","author":"Bofill-Cardona","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib36","doi-asserted-by":"crossref","first-page":"17027","DOI":"10.1074\/jbc.M313919200","article-title":"Calmodulin interacts with the third intracellular loop of the serotonin 5-hydroxytryptamine1A receptor at two distinct sites: putative role in receptor phosphorylation by protein kinase C","volume":"279","author":"Turner","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib37","doi-asserted-by":"crossref","first-page":"33708","DOI":"10.1074\/jbc.M301940200","article-title":"Calmodulin is a phospholipase C-beta interacting protein","volume":"278","author":"McCullar","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib38","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1093\/emboj\/19.18.4955","article-title":"SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation","volume":"19","author":"Poser","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.bcp.2006.02.001_bib39","first-page":"513","article-title":"Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells","volume":"9","author":"Wang","year":"1998","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.bcp.2006.02.001_bib40","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1074\/jbc.M308753200","article-title":"Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2","volume":"279","author":"Goel","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib41","doi-asserted-by":"crossref","first-page":"22807","DOI":"10.1074\/jbc.270.39.22807","article-title":"Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets","volume":"270","author":"Zhang","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib42","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1074\/jbc.M210578200","article-title":"Negative regulation of ERK and Elk by protein kinase B modulates c-fos transcription","volume":"270","author":"Galetic","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib43","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1124\/jpet.104.068569","article-title":"Signaling mechanisms involved in protease-activated receptor-1-mediated interleukin-6 production by human gingival fibroblasts","volume":"311","author":"Tanaka","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2006.02.001_bib44","article-title":"Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF","volume":"22","author":"Bebien","year":"1836","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2006.02.001_bib45","doi-asserted-by":"crossref","first-page":"46814","DOI":"10.1074\/jbc.M305709200","article-title":"Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation","volume":"278","author":"Marinissen","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib46","doi-asserted-by":"crossref","first-page":"18434","DOI":"10.1074\/jbc.M409710200","article-title":"G alpha 12\/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes","volume":"280","author":"Nishida","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.02.001_bib47","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bcp.2006.02.001_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.ATV.0000099880.09014.7D","article-title":"Thrombin and phenotypic modulation of the endothelium","volume":"24","author":"Minami","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629520600089X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629520600089X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T23:51:35Z","timestamp":1736293895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629520600089X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S000629520600089X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2006.02.001","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}