{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:34:56Z","timestamp":1762144496579,"version":"3.44.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["93-2321-B-038-001","94-2321-B-038-001"],"award-info":[{"award-number":["93-2321-B-038-001","94-2321-B-038-001"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.bcp.2006.11.009","type":"journal-article","created":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T10:42:50Z","timestamp":1164019370000},"page":"682-693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neuroprotective effects of PMC, a potent \u03b1-tocopherol derivative, in brain ischemia-reperfusion: Reduced neutrophil activation and anti-oxidant actions"],"prefix":"10.1016","volume":"73","author":[{"given":"George","family":"Hsiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Jen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiing-Harn","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duen-Suey","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joen-Rong","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2006.11.009_bib1","first-page":"199","article-title":"Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows","volume":"4","author":"Kuroda","year":"1997","journal-title":"Clin Neurosci"},{"key":"10.1016\/j.bcp.2006.11.009_bib2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/01.STR.31.6.1402","article-title":"Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia","volume":"31","author":"Abumiya","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.bcp.2006.11.009_bib3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1161\/01.STR.25.7.1469","article-title":"Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rats","volume":"25","author":"Matsuo","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.bcp.2006.11.009_bib4","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/01.STR.27.8.1373","article-title":"Indicible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia","volume":"27","author":"Iadecola","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.bcp.2006.11.009_bib5","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","article-title":"Ischemic cell death in brain neurons","volume":"79","author":"Lipton","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bcp.2006.11.009_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2003.08.026","article-title":"Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production","volume":"992","author":"Liou","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.bcp.2006.11.009_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0006-8993(99)02117-4","article-title":"Nitrotyrosine generation via inducible nitric oxide synthase in vascular wall in focal ischemia-reperfusion","volume":"852","author":"Hirabayashi","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.bcp.2006.11.009_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-8993(02)03796-4","article-title":"Protective effect of a new nonpeptidyl mimetic of SOD, M40401, against focal cerebral ischemia in the rat","volume":"963","author":"Shimizu","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.bcp.2006.11.009_bib9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004647-200101000-00002","article-title":"Reactive oxygen radicals in signaling and damage in the ischemic brain","volume":"21","author":"Chan","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.bcp.2006.11.009_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/bbrc.1993.1620","article-title":"Inhibition of NF-kappa B activation by vitamine E derivatives","volume":"193","author":"Suzuki","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2006.11.009_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0024-3205(99)00236-2","article-title":"Comparison of the relative activities of \u03b1-tocopherol and PMC on platelet aggregation and antioxidative activity","volume":"65","author":"Sheu","year":"1999","journal-title":"Life Sci"},{"key":"10.1016\/j.bcp.2006.11.009_bib12","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.bcp.2003.12.010","article-title":"Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages","volume":"67","author":"Hsiao","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2006.11.009_bib13","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1161\/01.ATV.0000174798.25085.d6","article-title":"Protective mechanisms of inosine in platelet activation and cerebral ischemic damage","volume":"25","author":"Hsiao","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bcp.2006.11.009_bib14","first-page":"223","article-title":"Neuronal damage following transient cerebral ischemia and its restoration by neural transplant","volume":"2","author":"Nishino","year":"1994","journal-title":"Neurobiology"},{"key":"10.1016\/j.bcp.2006.11.009_bib15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/jcbfm.1990.47","article-title":"A semiautomated method for measuring brain infarct volume","volume":"10","author":"Swanson","year":"1990","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.bcp.2006.11.009_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0006-8993(01)02613-0","article-title":"Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation","volume":"909","author":"Rodrigo","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.bcp.2006.11.009_bib17","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1523\/JNEUROSCI.22-10-03921.2002","article-title":"Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation","volume":"22","author":"Han","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.bcp.2006.11.009_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-4165(00)00173-2","article-title":"Cinnamophilin as a novel antiperoxidative cytoprotectant and free radical scavenger","volume":"1525","author":"Hsiao","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2006.11.009_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1172\/JCI200421655","article-title":"Neutrophil protein kinase C as a mediator of stroke-reperfusion injury","volume":"114","author":"Chou","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2006.11.009_bib20","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1021\/jf9806762","article-title":"Free radical-scavenging activity of grape seed extract and antioxidants by electron spin resonance spectrometry in an H2O2\/NaOH\/DMSO system","volume":"47","author":"Yamaguchi","year":"1999","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bcp.2006.11.009_bib21","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1161\/01.STR.20.12.1627","article-title":"Rodent models of cerebral ischemia","volume":"20","author":"Ginsberg","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.bcp.2006.11.009_bib22","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.1996.1199","article-title":"In vivo expression of mRNAs encoding hypoxia-inducible factor 1","volume":"225","author":"Wiener","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2006.11.009_bib23","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1084\/jem.182.6.1683","article-title":"A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter","volume":"182","author":"Melillo","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.bcp.2006.11.009_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1460-9568.1998.00028.x","article-title":"Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices","volume":"10","author":"Moro","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bcp.2006.11.009_bib25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1471-4914(01)02090-1","article-title":"Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology","volume":"7","author":"Semenza","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bcp.2006.11.009_bib26","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1471-4159.2004.02483.x","article-title":"HIF-1\u03b1 reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion","volume":"90","author":"Matrone","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.bcp.2006.11.009_bib27","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1523\/JNEUROSCI.17-23-09157.1997","article-title":"Delayed reduction of ischemia brain injury and neurological deficits in mice lacking the nitric oxide synthase gene","volume":"17","author":"Iadecola","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.bcp.2006.11.009_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0014-5793(96)00347-X","article-title":"Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation","volume":"385","author":"Gow","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2006.11.009_bib29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/BF03401871","article-title":"BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways","volume":"7","author":"Gibson","year":"2001","journal-title":"Mol Med"},{"key":"10.1016\/j.bcp.2006.11.009_bib30","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1038\/sj.onc.1204742","article-title":"Dephosphorylated hypoxia-inducible factor 1 alpha as a mediator of p53-dependent apoptosis during hypoxia","volume":"20","author":"Suzuki","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2006.11.009_bib31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1006\/exnr.2001.7835","article-title":"The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?","volume":"173","author":"Emerich","year":"2002","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bcp.2006.11.009_bib32","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.1086\/513849","article-title":"Activation of the neutrophil respiratory burst oxidase","volume":"179","author":"Clark","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bcp.2006.11.009_bib33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1161\/01.STR.23.9.1367","article-title":"Polymorphonuclear leukocytes and monocytes\/macrophages in the pathogenesis of cerebral ischemia and stroke","volume":"23","author":"Kochanek","year":"1992","journal-title":"Stroke"},{"key":"10.1016\/j.bcp.2006.11.009_bib34","series-title":"Biochemistry and physiology of the neutrophil","article-title":"The generation and recognition of neutrophil-activating factors: structure and function of neutrophil receptors","author":"Edwards","year":"1994"},{"key":"10.1016\/j.bcp.2006.11.009_bib35","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1074\/jbc.M001914200","article-title":"Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1\u03b1 during hypoxia. A mechanism of O2 sensing","volume":"275","author":"Chandel","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.11.009_bib36","doi-asserted-by":"crossref","first-page":"26765","DOI":"10.1016\/S0021-9258(19)61441-9","article-title":"Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1\u03b1 in vascular smooth muscle cells","volume":"275","author":"Richard","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2006.11.009_bib37","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.febslet.2005.03.088","article-title":"A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1\u03b1","volume":"579","author":"Sanjuan-Pla","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2006.11.009_bib38","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1096\/fj.02-1086fje","article-title":"Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke","volume":"17","author":"Hurtado","year":"2003","journal-title":"FASEB J"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295206007441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295206007441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:48:37Z","timestamp":1757767717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295206007441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0006295206007441"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2006.11.009","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effects of PMC, a potent \u03b1-tocopherol derivative, in brain ischemia-reperfusion: Reduced neutrophil activation and anti-oxidant actions","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2006.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}