{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:26:47Z","timestamp":1772036807516,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["93-K001"],"award-info":[{"award-number":["93-K001"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["93-2323-B-002-003"],"award-info":[{"award-number":["93-2323-B-002-003"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["94-2323-B-002 -006"],"award-info":[{"award-number":["94-2323-B-002 -006"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.bcp.2007.03.015","type":"journal-article","created":{"date-parts":[[2007,3,25]],"date-time":"2007-03-25T06:51:00Z","timestamp":1174805460000},"page":"10-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways"],"prefix":"10.1016","volume":"74","author":[{"given":"Ying-Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin-Hsuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiow-Lin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che-Ming","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Chu","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Ping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunn-Fang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jih-Hwa","family":"Guh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2007.03.015_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/scientificamerican0880-66","article-title":"Microtubules","volume":"243","author":"Dustin","year":"1980","journal-title":"Sci Am"},{"key":"10.1016\/j.bcp.2007.03.015_bib2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/1074-5521(95)90119-1","article-title":"Microtubule dynamics: taking aim at a moving target","volume":"2","author":"Wilson","year":"1995","journal-title":"Chem Biol"},{"key":"10.1016\/j.bcp.2007.03.015_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1083\/jcb.94.3.688","article-title":"Taxol binds to cellular microtubules","volume":"94","author":"Manfredi","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bcp.2007.03.015_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.med.48.1.353","article-title":"The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents","volume":"48","author":"Rowinsky","year":"1997","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.bcp.2007.03.015_bib5","first-page":"309","article-title":"Tubulin and microtubules as targets for anticancer drugs","volume":"5","author":"Hadfield","year":"2003","journal-title":"Prog Cell Cycle Res"},{"key":"10.1016\/j.bcp.2007.03.015_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0960-9822(01)00150-6","article-title":"Axoneme-specific \u03b2-tubulin specialization: a conserved C-terminal motif specifies the central pair","volume":"11","author":"Nielsen","year":"2001","journal-title":"Curr Biol"},{"issue":"Pt 19","key":"10.1016\/j.bcp.2007.03.015_bib7","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1242\/jcs.02550","article-title":"Direct involvement of the isotype-specific C-terminus of \u03b2 tubulin in ciliary beating","volume":"118","author":"Vent","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bcp.2007.03.015_bib8","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1158\/1535-7163.MCT-05-0244","article-title":"Class III \u03b2-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel","volume":"4","author":"Seve","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bcp.2007.03.015_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/088307380301801205","article-title":"Class III \u03b2-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology","volume":"18","author":"Katsetos","year":"2003","journal-title":"J Child Neurol"},{"key":"10.1016\/j.bcp.2007.03.015_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s002800050989","article-title":"The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review","volume":"44","author":"Wang","year":"1999","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.bcp.2007.03.015_bib11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/sj.cdd.4401130","article-title":"Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe","volume":"9","author":"Castedo","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bcp.2007.03.015_bib12","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1242\/jcs.108.8.2897","article-title":"Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage","volume":"108","author":"Ongkeko","year":"1995","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bcp.2007.03.015_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1097-2765(00)80157-4","article-title":"Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase","volume":"2","author":"Yu","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.bcp.2007.03.015_bib14","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1038\/sj.onc.1206039","article-title":"Chemotherapy: Targeting the mitochondrial cell death pathway","volume":"21","author":"Debatin","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2007.03.015_bib15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijantimicag.2005.06.003","article-title":"Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds","volume":"26","author":"Adams","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bcp.2007.03.015_bib16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1055\/s-2004-832614","article-title":"Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa","volume":"70","author":"Adams","year":"2004","journal-title":"Planta Med"},{"key":"10.1016\/j.bcp.2007.03.015_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1248\/cpb.51.409","article-title":"1-methyl-2-undecyl-4(1H)-quinolone as an irreversible and selective inhibitor of type B monoamine oxidase","volume":"51","author":"Lee","year":"2003","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.bcp.2007.03.015_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/carcin\/bgg192","article-title":"Sulforaphane: A naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization","volume":"25","author":"Jackson","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2007.03.015_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0006-291X(03)00621-1","article-title":"Mitochondrial intermembrane proteins in cell death","volume":"304","author":"Van Gurp","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2007.03.015_bib20","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/0006-2952(94)90580-0","article-title":"Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers","volume":"48","author":"Wils","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2007.03.015_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.canlet.2005.05.016","article-title":"Induction of p53 and drug resistance following treatment with cisplatin or paclitaxel in ovarian cancer cell lines","volume":"236","author":"Metzinger","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2007.03.015_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4781(01)00204-4","article-title":"Checking out the G2\/M transition","volume":"1519","author":"Smits","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2007.03.015_bib23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl-2 family: Regulators of the cellular life-or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bcp.2007.03.015_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/sj.neo.7900131","article-title":"Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1","volume":"3","author":"Pathan","year":"2001","journal-title":"Neoplasia"},{"key":"10.1016\/j.bcp.2007.03.015_bib25","doi-asserted-by":"crossref","first-page":"18984","DOI":"10.1074\/jbc.273.30.18984","article-title":"Phosphorylation of bcl-2 is a marker of M phase events and not a determinant of apoptosis","volume":"273","author":"Ling","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.03.015_bib26","doi-asserted-by":"crossref","first-page":"30777","DOI":"10.1074\/jbc.273.46.30777","article-title":"Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest","volume":"273","author":"Scatena","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.03.015_bib27","first-page":"3331","article-title":"Bcl-xL is phosphorylated in malignant cells following microtubule disruption","volume":"58","author":"Poruchynsky","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2007.03.015_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.biocel.2004.04.007","article-title":"Mcl-1","volume":"37","author":"Michels","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bcp.2007.03.015_bib29","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1128\/MCB.21.9.3025-3036.2001","article-title":"Caspase cleavage enhances the apoptosis-inducing effects of BAD","volume":"21","author":"Condorelli","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2007.03.015_bib30","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/81343","article-title":"Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation","volume":"6","author":"Zheng","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.bcp.2007.03.015_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.189.2.381","article-title":"Mitochondrial release of caspase-2 and -9 during the apoptotic process","volume":"189","author":"Susin","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.bcp.2007.03.015_bib32","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1038\/sj.onc.1207517","article-title":"Role of AIF in caspase-dependent and caspase-independent cell death","volume":"23","author":"Cregan","year":"2004","journal-title":"Oncogene"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295207001530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295207001530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:48:46Z","timestamp":1757767726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295207001530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0006295207001530"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2007.03.015","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2007.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}