{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:47:44Z","timestamp":1790009264777,"version":"4.0.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.bcp.2007.05.017","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T11:11:02Z","timestamp":1180177862000},"page":"623-638","source":"Crossref","is-referenced-by-count":69,"title":["The \u03c9-atracotoxins: Selective blockers of insect M-LVA and HVA calcium channels"],"prefix":"10.1016","volume":"74","author":[{"given":"Youmie","family":"Chong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Sollod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Hains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne C.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Broady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham M.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2007.05.017_bib1","unstructured":"World Health Organisation. Vector resistance to insecticides. 15th Report of the WHO Expert Committee on Vector Biology and Control. World Health Org Tech Rep Ser 1992;818:1\u201362."},{"key":"10.1016\/j.bcp.2007.05.017_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/bk-1990-0421.ch002","article-title":"Overview of insecticide resistance","volume":"421","author":"Georghiou","year":"1990","journal-title":"ACS Symp Ser"},{"key":"10.1016\/j.bcp.2007.05.017_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cropro.2003.10.001","article-title":"Safeguarding production-losses in major crops and the role of crop protection","volume":"23","author":"Oerke","year":"2004","journal-title":"Crop Protect"},{"key":"10.1016\/j.bcp.2007.05.017_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3201\/eid0403.980326","article-title":"Resurgent vector-borne diseases as a global health problem","volume":"4","author":"Gubler","year":"1998","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bcp.2007.05.017_bib5","series-title":"Comprehensive molecular insect science","first-page":"175","article-title":"Bacillus thuringiensis mechanisms and use","author":"Bravo","year":"2005"},{"key":"10.1016\/j.bcp.2007.05.017_bib6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/370138a0","article-title":"Field trial of a genetically improved baculovirus insecticide","volume":"370","author":"Cory","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2007.05.017_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11248-006-0007-2","article-title":"Spider venom toxin protects plants from insect attack","volume":"15","author":"Khan","year":"2006","journal-title":"Transgenic Res"},{"key":"10.1016\/j.bcp.2007.05.017_bib8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.toxicon.2005.10.011","article-title":"Orally active acaricidal peptide toxins from spider venom","volume":"47","author":"Mukherjee","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.bcp.2007.05.017_bib9","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1432-1327.1999.00646.x","article-title":"Structure-function studies of \u03c9-atracotoxin, a potent antagonist of insect voltage-gated calcium channels","volume":"264","author":"Wang","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.bcp.2007.05.017_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nsb0797-559","article-title":"The structure of a novel insecticidal neurotoxin, \u03c9-atracotoxin-HV1, from the venom of an Australian funnel web spider","volume":"4","author":"Fletcher","year":"1997","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib11","doi-asserted-by":"crossref","first-page":"26568","DOI":"10.1074\/jbc.M102199200","article-title":"Functional significance of the \u03b2 hairpin in the insecticidal neurotoxin \u03c9-atracotoxin-Hv1a","volume":"276","author":"Tedford","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.05.017_bib12","doi-asserted-by":"crossref","first-page":"44133","DOI":"10.1074\/jbc.M404006200","article-title":"Scanning mutagenesis of \u03c9-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels","volume":"279","author":"Tedford","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.05.017_bib13","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","article-title":"A common structural motif incorporating a cystine knot and a triple-stranded \u03b2-sheet in toxic and inhibitory polypeptides","volume":"3","author":"Pallaghy","year":"1994","journal-title":"Protein Sci"},{"key":"10.1016\/j.bcp.2007.05.017_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1034\/j.1399-3011.1999.00040.x","article-title":"Refined solution structure of \u03c9-conotoxin GVIA: implications for calcium channel binding","volume":"53","author":"Pallaghy","year":"1999","journal-title":"J Pept Res"},{"key":"10.1016\/j.bcp.2007.05.017_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0041-0101(00)00160-4","article-title":"The cystine knot motif in toxins and implications for drug design","volume":"39","author":"Craik","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.bcp.2007.05.017_bib16","unstructured":"Atkinson RK, Tyler MI, Vonarx EJ, Howden MEH. Insecticidal toxins derived from funnel web (Atrax or Hadronyche) spiders. International Patent WO 93\/15108; 1993, August 5."},{"key":"10.1016\/j.bcp.2007.05.017_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10158-003-0027-z","article-title":"Mode of action of atracotoxin at central and peripheral synapses of insects","volume":"5","author":"Bloomquist","year":"2003","journal-title":"Invert Neurosci"},{"key":"10.1016\/j.bcp.2007.05.017_bib18","first-page":"215","article-title":"Characterization of insecticidal peptides from venom of Australian funnel-web spiders","volume":"12","author":"Vonarx","year":"2006","journal-title":"J Venom Anim Toxins"},{"key":"10.1016\/j.bcp.2007.05.017_bib19","first-page":"410","article-title":"The isolated chick biventer cervicis nerve-muscle preparation","volume":"15","author":"Ginsborg","year":"1960","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2007.05.017_bib20","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0076-6879(93)18026-9","article-title":"Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: thermal RACE","volume":"218","author":"Frohman","year":"1993","journal-title":"Meth Enzymol"},{"key":"10.1016\/j.bcp.2007.05.017_bib21","doi-asserted-by":"crossref","first-page":"8998","DOI":"10.1073\/pnas.85.23.8998","article-title":"Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer","volume":"85","author":"Frohman","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bcp.2007.05.017_bib22","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1152\/jn.1996.76.2.963","article-title":"Two distinct low-voltage-activated Ca2+ currents contribute to the pacemaker mechanism in cockroach dorsal unpaired median neurons","volume":"76","author":"Grolleau","year":"1996","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/jn.1997.77.1.186","article-title":"Ca2+ currents in central insect neurons: electrophysiological and pharmacological properties","volume":"77","author":"Wicher","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1096-9861(19960325)367:1<147::AID-CNE9>3.0.CO;2-3","article-title":"Anatomy and targets of dorsal unpaired median neurones in the terminal abdominal ganglion of the male cockroach Periplaneta americana L","volume":"367","author":"Sinakevitch","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bcp.2007.05.017_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0165-0270(94)90031-0","article-title":"JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements","volume":"51","author":"Barry","year":"1994","journal-title":"J Neurosci Meth"},{"key":"10.1016\/j.bcp.2007.05.017_bib26","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1085\/jgp.70.5.549","article-title":"Inactivation of sodium channels. I. Sodium current experiments","volume":"70","author":"Bezanilla","year":"1977","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1242\/jeb.144.1.535","article-title":"Ionic species involved in the electrical activity of single adult aminergic neurones isolated from the sixth abdominal ganglion of the cockroach Periplaneta americana","volume":"144","author":"Lapied","year":"1989","journal-title":"J Exp Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib28","first-page":"113","article-title":"Effects of whole venom and venom fractions from several Australian spiders, including Atrax (Hadronyche) species, when injected into insects","volume":"114C","author":"Atkinson","year":"1996","journal-title":"Comp Biochem Physiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.toxicon.2004.02.010","article-title":"Australian funnel-web spiders: master insecticide chemists","volume":"43","author":"Tedford","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.bcp.2007.05.017_bib31","doi-asserted-by":"crossref","first-page":"40306","DOI":"10.1074\/jbc.M105206200","article-title":"Biopesticide panning: discovery of a potent and highly specific peptide antagonist of insect calcium channels","volume":"276","author":"Wang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.05.017_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.peptides.2004.07.016","article-title":"Were arachnids the first to use combinatorial peptide libraries?","volume":"26","author":"Sollod","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.bcp.2007.05.017_bib33","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00001756-199405000-00001","article-title":"Ca2+ currents in cockroach neurones: properties and modulation by neurohormone D","volume":"5","author":"Wicher","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.bcp.2007.05.017_bib34","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.neuropharm.2007.03.012","article-title":"CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons","volume":"51","author":"Kubista","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2007.05.017_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(03)02084-3","article-title":"SNX482 selectively blocks P\/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells","volume":"475","author":"Arroyo","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bcp.2007.05.017_bib36","first-page":"355","article-title":"\u03c9-Toxins affect Na+ currents in neurosecretory insect neurons","volume":"5","author":"Wicher","year":"1998","journal-title":"Receptors Channels"},{"key":"10.1016\/j.bcp.2007.05.017_bib37","doi-asserted-by":"crossref","first-page":"14734","DOI":"10.1021\/bi026546a","article-title":"Two tarantula peptides inhibit activation of multiple sodium channels","volume":"41","author":"Middleton","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2007.05.017_bib38","first-page":"623","article-title":"Modulation of alpha1G and alpha1C Ca channels by the spider toxin ProTx-II","author":"Kraus","year":"2000","journal-title":"Soc Neurosci Abstr"},{"key":"10.1016\/j.bcp.2007.05.017_bib39","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.bi.63.070194.004135","article-title":"Calcium channel diversity and neurotransmitter release: the \u03c9-conotoxins and \u03c9-agatoxins","volume":"63","author":"Olivera","year":"1994","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.bcp.2007.05.017_bib40","first-page":"301","article-title":"Toxicology, mode of action and target site-mediated resistance to insecticides acting on chloride channels","volume":"106","author":"Bloomquist","year":"1993","journal-title":"Comp Biochem Physiol C"},{"key":"10.1016\/j.bcp.2007.05.017_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/(SICI)1520-6327(1998)38:1<19::AID-ARCH3>3.0.CO;2-Q","article-title":"Novel insecticidal peptides from Tegenaria agrestis spider venom may have a direct effect on the insect central nervous system","volume":"38","author":"Johnson","year":"1998","journal-title":"Arch Insect Biochem Physiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib42","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0965-1748(95)00029-U","article-title":"Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguetia canities","volume":"25","author":"Krapcho","year":"1995","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1081\/TXR-120014409","article-title":"Structure and function of insecticidal neurotoxins from Australian funnel-web spiders","volume":"21","author":"King","year":"2002","journal-title":"J Toxicol-Toxin Rev"},{"key":"10.1016\/j.bcp.2007.05.017_bib44","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL: an automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.bcp.2007.05.017_bib45","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bcp.2007.05.017_bib46","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.toxicon.2006.11.012","article-title":"Modulation of insect Cav channels by peptidic spider toxins","volume":"49","author":"King","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bcp.2007.05.017_bib47","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/jn.1995.73.1.160","article-title":"Separation and identification of multiple potassium currents regulating the pacemaker activity of insect neurosecretory cells (DUM neurons)","volume":"73","author":"Grolleau","year":"1995","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib48","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1242\/jeb.203.5.841","article-title":"The molecular biology of invertebrate voltage-gated Ca2+ channels","volume":"203","author":"Jeziorski","year":"2000","journal-title":"J Exp Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib49","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1242\/jeb.203.11.1633","article-title":"Dorsal unpaired median neurones in the insect central nervous system: towards a better understanding of the ionic mechanisms underlying spontaneous electrical activity","volume":"203","author":"Grolleau","year":"2000","journal-title":"J Exp Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib50","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1152\/jn.2001.86.5.2353","article-title":"Peptidergic modulation of insect voltage-gated Ca2+ currents: role of resting Ca2+ current and protein kinases A and C","volume":"86","author":"Wicher","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib51","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10158-005-0003-x","article-title":"Role of a novel maintained low-voltage-activated inward current permeable to sodium and calcium in pacemaking of insect neurosecretory neurons","volume":"5","author":"Defaix","year":"2005","journal-title":"Invert Neurosci"},{"key":"10.1016\/j.bcp.2007.05.017_bib52","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1242\/jeb.170.1.93","article-title":"Analysis of repolarization of presynaptic motor terminals in Drosophila larvae using potassium-channel-blocking drugs and mutations","volume":"170","author":"Gho","year":"1992","journal-title":"J Exp Biol"},{"key":"10.1016\/j.bcp.2007.05.017_bib53","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1523\/JNEUROSCI.12-01-00297.1992","article-title":"Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels","volume":"12","author":"Robitaille","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.bcp.2007.05.017_bib54","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0896-6273(93)90076-4","article-title":"Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release","volume":"11","author":"Robitaille","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2007.05.017_bib55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/jphysiol.2004.062661","article-title":"BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampus","volume":"557","author":"Raffaelli","year":"2004","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.bcp.2007.05.017_bib56","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/jn.00904.2005","article-title":"Peptidergic counter-regulation of Ca2+- and Na+-dependent K+ currents modulates the shape of action potentials in neurosecretory insect neurons","volume":"95","author":"Wicher","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bcp.2007.05.017_bib57","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1046\/j.1460-9568.2003.02550.x","article-title":"The large conductance Ca2+-activated potassium channel (pSlo) of the cockroach Periplaneta americana: structure, localization in neurons and electrophysiology","volume":"17","author":"Derst","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bcp.2007.05.017_bib58","doi-asserted-by":"crossref","first-page":"15353","DOI":"10.1021\/bi981255g","article-title":"Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas","volume":"37","author":"Newcomb","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2007.05.017_bib59","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.toxicon.2006.11.028","article-title":"Fighting the global pest problem: preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control","volume":"49","author":"Nicholson","year":"2007","journal-title":"Toxicon"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295207003279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295207003279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T07:34:13Z","timestamp":1628926453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295207003279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0006295207003279"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2007.05.017","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}