{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:47:58Z","timestamp":1787161678229,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.bcp.2007.08.027","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T07:14:41Z","timestamp":1188544481000},"page":"383-394","source":"Crossref","is-referenced-by-count":33,"title":["KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells"],"prefix":"10.1016","volume":"75","author":[{"given":"Ki Deok","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Rim","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hee","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Mook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung-Mog","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Cho","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2007.08.027_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1568011053352569","article-title":"Targeting microtubules for cancer chemotherapy","volume":"5","author":"Zhou","year":"2005","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"10.1016\/j.bcp.2007.08.027_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bcp.2007.08.027_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1025513106330","article-title":"Microtubules, microtubule-interfering agents and apoptosis","volume":"8","author":"Mollinedo","year":"2003","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2007.08.027_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ccr.2005.06.011","article-title":"Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death","volume":"8","author":"Weaver","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2007.08.027_bib5","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1038\/sj.onc.1207374","article-title":"The spindle checkpoint, aneuploidy, and cancer","volume":"23","author":"Bharadwaj","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2007.08.027_bib6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1083\/jcb.200102093","article-title":"Checkpoint inhibition of the APC\/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2","volume":"154","author":"Sudakin","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bcp.2007.08.027_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1534-5807(01)00019-3","article-title":"Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1","volume":"1","author":"Tang","year":"2001","journal-title":"Dev Cell"},{"key":"10.1016\/j.bcp.2007.08.027_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/356397a0","article-title":"Social controls on cell survival and cell death","volume":"356","author":"Raff","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2007.08.027_bib9","first-page":"1960","article-title":"High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells","volume":"8","author":"Tang","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2007.08.027_bib10","first-page":"2651","article-title":"Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2\u2032,3\u2032,4\u2032-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest","volume":"60","author":"Gajate","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2007.08.027_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1097-2765(00)80456-6","article-title":"The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex","volume":"3","author":"Puthalakath","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/j.bcp.2007.08.027_bib12","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1126\/science.1062257","article-title":"Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis","volume":"293","author":"Puthalakath","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bcp.2007.08.027_bib13","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1128\/MCB.22.11.3577-3589.2002","article-title":"Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis","volume":"22","author":"Marani","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2007.08.027_bib14","first-page":"2212","article-title":"Mechanism of inhibition of cell proliferation by Vinca alkaloids","volume":"51","author":"Jordan","year":"1991","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2007.08.027_bib15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/277665a0","article-title":"Promotion of microtubule assembly in vitro by taxol","volume":"277","author":"Schiff","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2007.08.027_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0163-7258(84)90025-1","article-title":"Taxol: an antimitotic agent with a new mechanism of action","volume":"25","author":"Manfredi","year":"1984","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bcp.2007.08.027_bib17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1200\/JCO.1999.17.3.1061","article-title":"Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death","volume":"17","author":"Dumontet","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bcp.2007.08.027_bib18","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0306-3623(96)00081-X","article-title":"The P-glycoprotein multidrug transporter","volume":"27","author":"Fardel","year":"1996","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.bcp.2007.08.027_bib19","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/(SICI)1521-1878(199811)20:11<931::AID-BIES8>3.0.CO;2-J","article-title":"Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP","volume":"20","author":"Cole","year":"1998","journal-title":"Bioessays"},{"key":"10.1016\/j.bcp.2007.08.027_bib20","doi-asserted-by":"crossref","first-page":"41439","DOI":"10.1074\/jbc.M507209200","article-title":"Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation","volume":"280","author":"Shin","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.08.027_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/(SICI)1097-0215(19970904)72:5<871::AID-IJC26>3.0.CO;2-A","article-title":"Comparison of tumor growth between hsp25- and hsp27-transfected murine L929 cells in nude mice","volume":"72","author":"Blackburn","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bcp.2007.08.027_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3835(00)00601-7","article-title":"Heat shock protein expression in human tumours grown in severe combined immunodeficient mice","volume":"161","author":"Katoh","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2007.08.027_bib23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/bjc.1994.140","article-title":"A 27kDa heat shock protein that has anomalous prognostic powers in early and advanced breast cancer","volume":"69","author":"Love","year":"1994","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bcp.2007.08.027_bib24","first-page":"4443","article-title":"The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines","volume":"53","author":"Oesterreich","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2007.08.027_bib25","first-page":"7099","article-title":"Heat shock protein expression independently predicts clinical outcome in prostate cancer","volume":"60","author":"Cornford","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2007.08.027_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0960-7404(10)80036-2","article-title":"Heat shock proteins are differentially expressed in human gastrointestinal cancers","volume":"4","author":"Ehrenfried","year":"1995","journal-title":"Surg Oncol"},{"key":"10.1016\/j.bcp.2007.08.027_bib27","first-page":"1603","article-title":"Expression of the heat shock protein HSP27 in human ovarian cancer","volume":"1","author":"Langdon","year":"1995","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bcp.2007.08.027_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/(SICI)1097-0215(19990621)84:3<234::AID-IJC6>3.0.CO;2-9","article-title":"Heat-shock-protein-27 (hsp27) expression in ovarian carcinoma: relation in response to chemotherapy and prognosis","volume":"84","author":"Arts","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bcp.2007.08.027_bib29","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1074\/jbc.M309708200","article-title":"2\u2032-Benzoyloxycinnamaldehyde induces apoptosis in human carcinoma via reactive oxygen species","volume":"279","author":"Han","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.08.027_bib30","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1074\/jbc.273.17.10777","article-title":"Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations","volume":"273","author":"Hsu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2007.08.027_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ccr.2005.06.003","article-title":"Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage","volume":"8","author":"Tao","year":"2005","journal-title":"Cancer Cell"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295207005886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295207005886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T16:54:59Z","timestamp":1546620899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295207005886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0006295207005886"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2007.08.027","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}