{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:55:48Z","timestamp":1793213748990,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.bcp.2008.11.002","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T09:59:22Z","timestamp":1226570362000},"page":"1117-1124","source":"Crossref","is-referenced-by-count":94,"title":["Adenosine receptor agonists for promotion of dermal wound healing"],"prefix":"10.1016","volume":"77","author":[{"given":"Mar\u00eda D.","family":"Valls","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce N.","family":"Cronstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Montesinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2008.11.002_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.med.46.1.467","article-title":"Pharmacologic enhancement of wound healing","volume":"46","author":"Pierce","year":"1995","journal-title":"Ann Rev Med"},{"issue":"7","key":"10.1016\/j.bcp.2008.11.002_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm0796-725a","article-title":"Plasminogen and wound healing","volume":"2","author":"Romer","year":"1996","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.bcp.2008.11.002_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clindermatol.2006.10.002","article-title":"Stem cells in cutaneous wound healing","volume":"25","author":"Cha","year":"2007","journal-title":"Clin Dermatol"},{"issue":"3","key":"10.1016\/j.bcp.2008.11.002_bib4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol Rev"},{"issue":"9498","key":"10.1016\/j.bcp.2008.11.002_bib5","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2008.11.002_bib6","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1002\/dmrr.825","article-title":"A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes","volume":"24","author":"Hinchliffe","year":"2008","journal-title":"Diabetes Metab Res Rev"},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2008.11.002_bib7","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1002\/dmrr.847","article-title":"The biology of chronic foot ulcers in persons with diabetes","volume":"24","author":"Gary Sibbald","year":"2008","journal-title":"Diabetes Metab Res Rev"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib8","doi-asserted-by":"crossref","first-page":"B354","DOI":"10.1093\/gerona\/51A.5.B354","article-title":"Sensory peptides as neuromodulators of wound healing in aged rats","author":"Khalil","year":"1996","journal-title":"J Gerontol Ser A, Biol"},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2008.11.002_bib9","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1002\/dmrr.862","article-title":"Neurovascular control and neurogenic inflammation in diabetes","volume":"24","author":"Schaper","year":"2008","journal-title":"Diabetes Metab Res Rev"},{"issue":"1","key":"10.1016\/j.bcp.2008.11.002_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0031-6997(24)01482-0","article-title":"International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits","volume":"53","author":"Khakh","year":"2001","journal-title":"Pharmacol Rev"},{"issue":"4","key":"10.1016\/j.bcp.2008.11.002_bib11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol Rev"},{"issue":"9","key":"10.1016\/j.bcp.2008.11.002_bib12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0898-6568(03)00058-5","article-title":"Signalling from adenosine receptors to mitogen-activated protein kinases","volume":"15","author":"Schulte","year":"2003","journal-title":"Cell Signal"},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2008.11.002_bib13","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1038\/sj.bjp.0706429","article-title":"Purinergic signalling","volume":"147","author":"Burnstock","year":"2006","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.bcp.2008.11.002_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrd1983","article-title":"Adenosine receptors as therapeutic targets","volume":"5","author":"Jacobson","year":"2006","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/01.RES.0000012203.21416.14","article-title":"Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation","volume":"90","author":"Feoktistov","year":"2002","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.bcp.2008.11.002_bib16","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.4049\/jimmunol.167.7.4026","article-title":"Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells","volume":"167","author":"Khoa","year":"2001","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.bcp.2008.11.002_bib17","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/art.21974","article-title":"Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma","volume":"54","author":"Chan","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib18","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/S0002-9440(10)61151-0","article-title":"Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors","volume":"160","author":"Montesinos","year":"2002","journal-title":"Am J Pathol"},{"issue":"8","key":"10.1016\/j.bcp.2008.11.002_bib19","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.4049\/jimmunol.171.8.3991","article-title":"Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells","volume":"171","author":"Nguyen","year":"2003","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.bcp.2008.11.002_bib20","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1124\/mol.105.016857","article-title":"Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane","volume":"69","author":"Khoa","year":"2006","journal-title":"Mol Pharmacol"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib21","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.4049\/jimmunol.162.6.3607","article-title":"IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation","volume":"162","author":"Xaus","year":"1999","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.bcp.2008.11.002_bib22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.yexmp.2007.03.005","article-title":"Diabetes-induced alterations of adenosine receptors expression level in rat liver","volume":"83","author":"Grden","year":"2007","journal-title":"Exp Mol Pathol"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib23","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.bcp.2008.11.002_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/HJH.0b013e3282f331fb","article-title":"The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning","volume":"26","author":"Lafuente","year":"2008","journal-title":"J Hypertens"},{"key":"10.1016\/j.bcp.2008.11.002_bib25","series-title":"Handbook of Experimental Pharmacology, Vol 151\/II: Purinergic and Pyrmidinergic Signalling II Cardiovascular, Respiratory, Immune, Metabolic and Gastrointestinal Tract Function","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-3-642-56921-0_9","article-title":"Role of P1 receptors in inflammation","author":"Montesinos","year":"2001"},{"issue":"9","key":"10.1016\/j.bcp.2008.11.002_bib26","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrd2638","article-title":"Adenosine receptors: therapeutic aspects for inflammatory and immune diseases","volume":"7","author":"Hasko","year":"2008","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1272\/jnms1923.65.351","article-title":"Extracellular purines and their receptors in immunoregulation. Review of recent advances","volume":"65","author":"Sitkovsky","year":"1998","journal-title":"Nippon Ika Daigaku Zasshi"},{"key":"10.1016\/j.bcp.2008.11.002_bib28","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1172\/JCI116884","article-title":"The antiinflammatory mechanism of methotrexate: increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation","volume":"92","author":"Cronstein","year":"1993","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.bcp.2008.11.002_bib29","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1073\/pnas.96.11.6377","article-title":"Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB","volume":"96","author":"Cronstein","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1172\/JCI1554","article-title":"Methotrexate and Sulfasalazine Promote Adenosine Release by a Mechanism that Requires Ecto-5\u2032-nucleotidase-mediated Conversion of Adenine Nucleotides","volume":"101","author":"Morabito","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2008.11.002_bib31","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1172\/JCI114547","article-title":"The adenosine\/neutrophil paradox resolved. Human neutrophils possess both A1 and A2 receptors which promote chemotaxis and inhibit O2-generation, respectively","volume":"85","author":"Cronstein","year":"1990","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib32","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.4049\/jimmunol.151.5.2775","article-title":"Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function","volume":"151","author":"Salmon","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2008.11.002_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF01993227","article-title":"The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function","volume":"34","author":"Lesch","year":"1991","journal-title":"Agents Act"},{"key":"10.1016\/j.bcp.2008.11.002_bib34","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1172\/JCI119104","article-title":"Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors","volume":"98","author":"Bong","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2008.11.002_bib35","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1084\/jem.158.4.1160","article-title":"Adenosine: a physiological modulator of superoxide anion generation by human neutrophils","volume":"158","author":"Cronstein","year":"1983","journal-title":"J Exp Med"},{"issue":"9","key":"10.1016\/j.bcp.2008.11.002_bib36","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.4049\/jimmunol.153.9.4159","article-title":"Differential regulatory effects of adenosine on cytokine release by activated human monocytes","volume":"153","author":"Bouma","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2008.11.002_bib37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/art.1780370207","article-title":"Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression","volume":"37","author":"Firestein","year":"1994","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.bcp.2008.11.002_bib38","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1084\/jem.188.8.1433","article-title":"Neutrophil-derived 5\u2032-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation","volume":"188","author":"Lennon","year":"1998","journal-title":"J Exp Med"},{"issue":"11","key":"10.1016\/j.bcp.2008.11.002_bib39","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.20040915","article-title":"Crucial role for ecto-5\u2032-nucleotidase (CD73) in vascular leakage during hypoxia","volume":"200","author":"Thompson","year":"2004","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib40","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1074\/jbc.275.6.4429","article-title":"Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells","volume":"275","author":"Salvatore","year":"2000","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.bcp.2008.11.002_bib41","first-page":"469","article-title":"Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models","volume":"32","author":"Baharav","year":"2005","journal-title":"J Rheumatol"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib42","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/ar1914","article-title":"Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis","volume":"8","author":"Montesinos","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"13","key":"10.1016\/j.bcp.2008.11.002_bib43","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1096\/fj.99-0508com","article-title":"Adenosine inhibits IL-12 and TNF-alpha production via adenosine A2a receptor-dependent and independent mechanisms [In Process Citation]","volume":"14","author":"Hasko","year":"2000","journal-title":"FASEB J"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib44","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1524-475X.2007.00271.x","article-title":"Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1","volume":"15","author":"Mi","year":"2007","journal-title":"Wound Repair Regen"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1743-6109.2006.00105.x","article-title":"Purinergic substances promote murine keratinocyte proliferation and enhance impaired wound healing in mice","volume":"14","author":"Braun","year":"2006","journal-title":"Wound Repair Regen"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib46","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/1523-1747.ep12606228","article-title":"Adenosine and adenine nucleotides inhibit the autonomous and epidermal growth factor-mediated proliferation of cultured human keratinocytes","volume":"104","author":"Cook","year":"1995","journal-title":"J Invest Dermatol"},{"issue":"18","key":"10.1016\/j.bcp.2008.11.002_bib47","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0024-3205(99)00104-6","article-title":"Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes","volume":"64","author":"Thellung","year":"1999","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.bcp.2008.11.002_bib48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/jsre.1999.5716","article-title":"Cyclopentyladenosine improves cell proliferation, wound healing, and hair growth","volume":"87","author":"Sun","year":"1999","journal-title":"J Surg Res"},{"issue":"9","key":"10.1016\/j.bcp.2008.11.002_bib49","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1084\/jem.186.9.1615","article-title":"Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors","volume":"186","author":"Montesinos","year":"1997","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib50","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.2353\/ajpath.2008.070952","article-title":"Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine","volume":"172","author":"Fernandez","year":"2008","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib51","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10753-008-9078-y","article-title":"Adenosine A(2A) receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis","volume":"31","author":"Katebi","year":"2008","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.bcp.2008.11.002_bib52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/jpet.105.096016","article-title":"Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor","volume":"317","author":"Kreckler","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"5302","key":"10.1016\/j.bcp.2008.11.002_bib53","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib54","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1182\/blood-2003-04-1114","article-title":"Signaling through JAM-1 and {alpha}v{beta}3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and {alpha}v{beta}3 complex","volume":"102","author":"Naik","year":"2003","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bcp.2008.11.002_bib55","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/hq0701.093685","article-title":"Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis","volume":"21","author":"Pepper","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib56","first-page":"702","article-title":"Synergistic induction of t-PA by vascular endothelial growth factor and basic fibroblast growth factor and localization of t-PA to Weibel-Palade bodies in bovine microvascular endothelial cells","volume":"86","author":"Pepper","year":"2001","journal-title":"Thromb Haemost"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib57","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.thromres.2007.03.024","article-title":"VEGF increases the fibrinolytic activity of endothelial cells within fibrin matrices: involvement of VEGFR-2, tissue type plasminogen activator and matrix metalloproteinases","volume":"121","author":"Ratel","year":"2007","journal-title":"Thromb Res"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib58","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/02713689808951232","article-title":"Adenosine stimulates canine retinal microvascular endothelial cell migration and tube formation","volume":"17","author":"Lutty","year":"1998","journal-title":"Curr Eye Res"},{"issue":"8","key":"10.1016\/j.bcp.2008.11.002_bib59","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/01.RES.85.8.699","article-title":"Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells","volume":"85","author":"Grant","year":"1999","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib60","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/S0002-9440(10)61170-4","article-title":"Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin","volume":"160","author":"Leibovich","year":"2002","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib61","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1161\/01.HYP.0000144800.21037.a5","article-title":"Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype","volume":"44","author":"Feoktistov","year":"2004","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.bcp.2008.11.002_bib62","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/CIRCRESAHA.107.150110","article-title":"A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes","volume":"101","author":"Clark","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2008.11.002_bib63","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6793-5-10","article-title":"Adenosine infusion increases plasma levels of VEGF in humans","volume":"5","author":"Adair","year":"2005","journal-title":"BMC Physiol"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib64","doi-asserted-by":"crossref","first-page":"R283","DOI":"10.1152\/ajpregu.00840.2004","article-title":"Growth regulation of the vascular system: an emerging role for adenosine","volume":"289","author":"Adair","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.RES.0000061572.10929.2D","article-title":"Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors","volume":"92","author":"Feoktistov","year":"2003","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib66","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1124\/mol.104.007807","article-title":"Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1","volume":"67","author":"Desai","year":"2005","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.bcp.2008.11.002_bib67","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nm0396-287","article-title":"Impaired wound healing in mice with a disrupted plasminogen gene [see comments]","volume":"2","author":"Romer","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.bcp.2008.11.002_bib68","first-page":"264","article-title":"Adenosine receptors on rabbit alveolar macrophages: binding characteristics and effects on cellular function","volume":"110","author":"Hasday","year":"1987","journal-title":"J Lab Clin Med"},{"issue":"4","key":"10.1016\/j.bcp.2008.11.002_bib69","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1055\/s-0037-1615077","article-title":"Adenosine 3\u2032:5\u2032-cyclic monophosphate induces regulated secretion of tissue-type plasminogen activator and von Willebrand factor from cultured human endothelial cells","volume":"79","author":"Hegeman","year":"1998","journal-title":"Thromb Haemost"},{"issue":"32","key":"10.1016\/j.bcp.2008.11.002_bib70","doi-asserted-by":"crossref","first-page":"16802","DOI":"10.1016\/S0021-9258(18)37462-3","article-title":"Cyclic AMP potentiates phorbol ester stimulation of tissue plasminogen activator release and inhibits secretion of plasminogen activator inhibitor-1 from human endothelial cells","volume":"263","author":"Santell","year":"1988","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.bcp.2008.11.002_bib71","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1055\/s-0037-1615762","article-title":"Extracellular nucleotides ATP and UTP induce a marked acute release of tissue-type plasminogen activator in vivo in man","volume":"85","author":"Hrafnkelsdottir","year":"2001","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.bcp.2008.11.002_bib72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1014417728325","article-title":"Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel)","volume":"26","author":"Victor-Vega","year":"2002","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.bcp.2008.11.002_bib73","doi-asserted-by":"crossref","first-page":"H67","DOI":"10.1152\/ajpheart.2001.281.1.H67","article-title":"Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation","volume":"281","author":"Peirce","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.bcp.2008.11.002_bib74","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1524-475X.2008.00361.x","article-title":"Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse","volume":"16","author":"Galeano","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2008.11.002_bib75","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cyto.2006.07.014","article-title":"The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation","volume":"35","author":"Ramakers","year":"2006","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.bcp.2008.11.002_bib76","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.2353\/ajpath.2007.061048","article-title":"Wound healing is impaired in MyD88-deficient mice: A role for MyD88 in the regulation of wound healing by adenosine A2A receptors","volume":"171","author":"Macedo","year":"2007","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.bcp.2008.11.002_bib77","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0006-2952(00)00570-0","article-title":"Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells","volume":"61","author":"Fredholm","year":"2001","journal-title":"Biochem Pharmacol"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295208007892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295208007892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T18:38:20Z","timestamp":1738521500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295208007892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0006295208007892"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2008.11.002","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}