{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:23:54Z","timestamp":1773285834303,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.bcp.2009.07.003","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T04:54:23Z","timestamp":1247806463000},"page":"1340-1349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: Comparison with in vivo studies"],"prefix":"10.1016","volume":"78","author":[{"given":"S.J.S.","family":"Flora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2009.07.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(02)00084-X","article-title":"Arsenic toxicity and potential mechanism of action","volume":"133","author":"Hughes","year":"2002","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bcp.2009.07.003_bib2","first-page":"617","article-title":"Arsenic-induced skin lesions among Atacameno people in Northern Chile despite good nutrition and centuries of exposure","volume":"108","author":"Smith","year":"2000","journal-title":"Environ Health Persp"},{"key":"10.1016\/j.bcp.2009.07.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/ESE-120016590","article-title":"The spatial pattern of risk from arsenic poisoning: a Bangladesh case study","volume":"38","author":"Hassan","year":"2003","journal-title":"J Environ Sci Health A. Tox Hazard Subst Environ Eng"},{"key":"10.1016\/j.bcp.2009.07.003_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1021\/tx700315a","article-title":"Reversal of arsenic-induced hepatic apoptosis with combined administration of DMSA and its analogues in guinea pigs: role of glutathione and linked enzymes","volume":"21","author":"Mishra","year":"2008","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.envres.2004.10.003","article-title":"The temporal stability of arsenic concentrations in well water in western Nevada","volume":"99","author":"Steinmaus","year":"2005","journal-title":"Environ Res"},{"key":"10.1016\/j.bcp.2009.07.003_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/1097-0142(196802)21:2<312::AID-CNCR2820210222>3.0.CO;2-K","article-title":"Arsenical cancer of skin. Histological study with special reference to Bowen's disease","volume":"21","author":"Yeh","year":"1968","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2009.07.003_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/096032718300200110","article-title":"Chronic arsenic poisoning in the north of Mexico","volume":"2","author":"Cebri\u00e1n","year":"1983","journal-title":"Hum Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib8","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.lfs.2005.04.016","article-title":"Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats","volume":"77","author":"Flora","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.bcp.2009.07.003_bib9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1046\/j.1440-1681.1999.03157.x","article-title":"Arsenic induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats","volume":"26","author":"Flora","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.bcp.2009.07.003_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.pa.30.040190.001431","article-title":"Meso-2, 3-dimercapto-succinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent","volume":"30","author":"Aposhian","year":"1990","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib11","first-page":"4","article-title":"Chronic arsenic toxicity in West Bengal \u2013 the worst calamity in the world","volume":"96","author":"Guha Mazumder","year":"1998","journal-title":"J Ind Med Ass"},{"key":"10.1016\/j.bcp.2009.07.003_bib12","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1600-0773.1992.tb00483.x","article-title":"Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso 2,3-dimercaptosuccinic acid","volume":"70","author":"Jones","year":"1992","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10565-006-0135-8","article-title":"Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats","volume":"23","author":"Bhadauria","year":"2007","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4161\/oxim.1.1.6481","article-title":"Combined administration of taurine and monoisoamyl DMSA protects arsenic induced oxidative injury in rats","volume":"1","author":"Flora","year":"2008","journal-title":"Oxid Med Cell Long"},{"key":"10.1016\/j.bcp.2009.07.003_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1124\/jpet.107.121996","article-title":"Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca2+","volume":"322","author":"Flora","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2009.07.003_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cbi.2007.08.003","article-title":"Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA","volume":"170","author":"Flora","year":"2007","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bcp.2009.07.003_bib17","series-title":"Developmental biology","author":"Gilbert","year":"2003"},{"key":"10.1016\/j.bcp.2009.07.003_bib18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tiv.2007.07.013","article-title":"First steps in establishing a developmental toxicity test method based on human embryonic stem cells","volume":"22","author":"Adler","year":"2008","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.bcp.2009.07.003_bib19","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bcp.2009.07.003_bib20","first-page":"70","article-title":"Embryonic stem cells in drug discovery","volume":"3","author":"McNeish","year":"2004","journal-title":"Nat Rev"},{"key":"10.1016\/j.bcp.2009.07.003_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000016700","article-title":"Embryotoxicity screening using embryonic stem cells in vitro: correlation to in vivo teratogenicity","volume":"165","author":"Scholz","year":"1999","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.bcp.2009.07.003_bib22","first-page":"119","article-title":"The embryonic stem cell test, an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblast and embryonic stem cells","volume":"10","author":"Spielmann","year":"1997","journal-title":"In Vitro Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib23","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cellbi.2008.08.012","article-title":"Assessment of developmental toxicity using human embryonic stem cells","volume":"32","author":"Mehta","year":"2008","journal-title":"Cell Biol Inter"},{"key":"10.1016\/j.bcp.2009.07.003_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-0436.2006.00051.x","article-title":"Characterization and in vitro differentiation potential of a new human embryonic stem cell line, ReliCellhES1","volume":"74","author":"Mandal","year":"2006","journal-title":"Differentiation"},{"key":"10.1016\/j.bcp.2009.07.003_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.reprotox.2005.05.008","article-title":"Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation","volume":"21","author":"Mehta","year":"2006","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2005.05.026","article-title":"Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats","volume":"214","author":"Saxena","year":"2005","journal-title":"Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0278-6915(01)00046-1","article-title":"Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats","volume":"39","author":"Mehta","year":"2002","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jat.871","article-title":"Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats","volume":"22","author":"Mehta","year":"2002","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jat.890","article-title":"Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats","volume":"23","author":"Flora","year":"2003","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.bcp.2009.07.003_bib30","doi-asserted-by":"crossref","first-page":"10496","DOI":"10.1103\/PhysRevB.43.10496","volume":"43","author":"Tajima","year":"1991","journal-title":"Phy Rev"},{"key":"10.1016\/j.bcp.2009.07.003_bib31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1021\/tx00019a015","article-title":"Synthesis and properties of the monomethyl ester of meso-dimercaptosuccinic acid and its chelates of lead (II), cadmium (II), and mercury(II)","volume":"4","author":"Rivera","year":"1991","journal-title":"Chem Res Toxicol"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295209006339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295209006339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:50:50Z","timestamp":1757767850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295209006339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0006295209006339"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2009.07.003","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: Comparison with in vivo studies","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2009.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}