{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:41:59Z","timestamp":1789180919861,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 97-2323-B-002-006"],"award-info":[{"award-number":["NSC 97-2323-B-002-006"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["93-K001"],"award-info":[{"award-number":["93-K001"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.bcp.2009.08.022","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T04:14:42Z","timestamp":1251778482000},"page":"162-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways"],"prefix":"10.1016","volume":"79","author":[{"given":"Po-Cheng","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ssu-Chia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiow-Lin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hua","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Lin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Tien","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Che","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peini","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih-Hwa","family":"Guh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2009.08.022_bib1","first-page":"227","article-title":"LKB1 and AMPK and the regulation of skeletal muscle metabolism","volume":"11","author":"Koh","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.bcp.2009.08.022_bib2","first-page":"415","article-title":"Therapeutic perspectives for type 2 diabetes mellitus: molecular and clinical insights","volume":"27","author":"Mauvais-Jarvis","year":"2001","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.bcp.2009.08.022_bib3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4161\/auto.4240","article-title":"AMP-activated protein kinase: a universal regulator of autophagy?","volume":"3","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2009.08.022_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tips.2004.12.011","article-title":"AMPK, the metabolic syndrome and cancer","volume":"26","author":"Luo","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bcp.2009.08.022_bib5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1081\/CNV-200027144","article-title":"The tuberous sclerosis complex genes in tumor development","volume":"22","author":"Mak","year":"2004","journal-title":"Cancer Invest"},{"key":"10.1016\/j.bcp.2009.08.022_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0959-8049(03)00659-2","article-title":"Genetic analysis of the LKB1\/STK11 gene in hepatocellular carcinomas","volume":"40","author":"Kim","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.bcp.2009.08.022_bib7","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","article-title":"Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression","volume":"23","author":"Fingar","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2009.08.022_bib8","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.febslet.2006.04.068","article-title":"The amino acid sensitive TOR pathway from yeast to mammals","volume":"580","author":"Dann","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2009.08.022_bib9","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"Sarbassov","year":"2004","journal-title":"Curr Biol"},{"key":"10.1016\/j.bcp.2009.08.022_bib10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.devcel.2006.10.007","article-title":"Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1","volume":"11","author":"Guertin","year":"2006","journal-title":"Dev Cell"},{"key":"10.1016\/j.bcp.2009.08.022_bib11","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bcp.2009.08.022_bib12","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1158\/1078-0432.CCR-04-0941","article-title":"mTOR and P70 S6 kinase expression in primary liver neoplasms","volume":"10","author":"Sahin","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bcp.2009.08.022_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbagen.2006.07.016","article-title":"Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70(S6K) in HepG2 and HepG2 cells overexpressing constitutively active Akt\/PKB","volume":"1770","author":"Varma","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2009.08.022_bib14","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1158\/0008-5472.CAN-06-3640","article-title":"Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth","volume":"67","author":"Parent","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2009.08.022_bib15","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jhep.2006.11.021","article-title":"Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma","volume":"46","author":"Semela","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.bcp.2009.08.022_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1586\/14737140.9.2.247","article-title":"mTOR inhibitors for hepatocellular cancer: a forward-moving target","volume":"9","author":"Treiber","year":"2009","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.bcp.2009.08.022_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2407-6-232","article-title":"Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction","volume":"6","author":"Schulze-Bergkamen","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcp.2009.08.022_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/01635580701268360","article-title":"Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells","volume":"57","author":"Chen","year":"2007","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.bcp.2009.08.022_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jep.2006.07.009","article-title":"Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells","volume":"109","author":"Peng","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bcp.2009.08.022_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.canlet.2005.02.004","article-title":"Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata","volume":"231","author":"Yang","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2009.08.022_bib21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-2004-818941","article-title":"Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata","volume":"70","author":"Shen","year":"2004","journal-title":"Planta Med"},{"key":"10.1016\/j.bcp.2009.08.022_bib22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0024-3205(02)01686-7","article-title":"Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes","volume":"71","author":"Hseu","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.bcp.2009.08.022_bib23","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1021\/jf0209701","article-title":"Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats","volume":"51","author":"Song","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bcp.2009.08.022_bib24","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1055\/s-2007-990232","article-title":"A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata","volume":"73","author":"Lee","year":"2007","journal-title":"Planta Med"},{"key":"10.1016\/j.bcp.2009.08.022_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/jcp.1041040318","article-title":"Protein synthesis and the presence of absence of a measurable G1 in cultured Chinese hamster cells","volume":"104","author":"Liskay","year":"1980","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2009.08.022_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0304-3835(86)90037-6","article-title":"Inhibition of mitochondrial protein synthesis leads to proliferation arrest in the G1-phase of the cell cycle","volume":"32","author":"van den Bogert","year":"1986","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2009.08.022_bib27","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.bcp.2007.08.009","article-title":"Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis","volume":"74","author":"Tsai","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2009.08.022_bib28","doi-asserted-by":"crossref","first-page":"11591","DOI":"10.1074\/jbc.M110367200","article-title":"The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites","volume":"277","author":"Herbert","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2009.08.022_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1139\/y04-107","article-title":"Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy","volume":"83","author":"Chan","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.bcp.2009.08.022_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","article-title":"Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis","volume":"121","author":"Ma","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2009.08.022_bib31","first-page":"3107","article-title":"Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma","volume":"54","author":"Nishida","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2009.08.022_bib32","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1073\/pnas.88.8.3470","article-title":"High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer","volume":"88","author":"el-Deiry","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bcp.2009.08.022_bib33","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1158\/0008-5472.CAN-07-0529","article-title":"Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4\/6-pRb-E2F1 pathway","volume":"67","author":"Jung","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2009.08.022_bib34","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1074\/jbc.273.26.16621","article-title":"Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies","volume":"273","author":"Weng","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2009.08.022_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0014-5793(97)00323-2","article-title":"The modular phosphorylation and activation of p70s6k","volume":"410","author":"Pullen","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2009.08.022_bib36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/363170a0","article-title":"p70s6k function is essential for G1 progression","volume":"363","author":"Lane","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2009.08.022_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1357-2725(98)00131-9","article-title":"eIF4E activity is regulated at multiple levels","volume":"31","author":"Raught","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bcp.2009.08.022_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.canlet.2008.08.018","article-title":"Inhibition of mTOR enhances chemosensitivity in hepatocellular carcinoma","volume":"273","author":"Tam","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2009.08.022_bib39","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cellsig.2009.01.004","article-title":"Akt-dependent and -independent mechanisms of mTOR regulation in cancer","volume":"21","author":"Memmott","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.bcp.2009.08.022_bib40","doi-asserted-by":"crossref","first-page":"27713","DOI":"10.1074\/jbc.M703037200","article-title":"Signaling pathways regulating TC21-induced tumorigenesis","volume":"282","author":"Erdogan","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2009.08.022_bib41","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1242\/jcs.01540","article-title":"The AMP-activated protein kinase pathway\u2014new players upstream and downstream","volume":"117","author":"Hardie","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bcp.2009.08.022_bib42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/bbrc.2001.5627","article-title":"Cell cycle regulation via p53 phosphorylation by a 5\u2032-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line","volume":"287","author":"Imamura","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2009.08.022_bib43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.2006.108324","article-title":"AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer","volume":"574","author":"Motoshima","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.bcp.2009.08.022_bib44","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/01.CIR.0000136025.96811.76","article-title":"AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation","volume":"110","author":"Nagata","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2009.08.022_bib45","doi-asserted-by":"crossref","first-page":"E148","DOI":"10.1152\/ajpendo.00211.2007","article-title":"Berberine improves glucose metabolism through induction of glycolysis","volume":"294","author":"Yin","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295209007023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295209007023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:51:41Z","timestamp":1757767901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295209007023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0006295209007023"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2009.08.022","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2009.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}