{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:12Z","timestamp":1788870192718,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Swiss National Science Foundation (SNF)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.bcp.2010.02.015","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T09:41:00Z","timestamp":1267695660000},"page":"1815-1826","source":"Crossref","is-referenced-by-count":88,"title":["Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin"],"prefix":"10.1016","volume":"79","author":[{"given":"Marco","family":"Leonti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Casu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Raduner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Cottiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Floris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Gertsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2010.02.015_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.plipres.2006.03.003","article-title":"Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand","volume":"45","author":"Sugiura","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.bcp.2010.02.015_bib2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.drudis.2008.09.001","article-title":"CB1 receptor antagonism: biological basis for metabolic effects","volume":"13","author":"Di Marzo","year":"2008","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bcp.2010.02.015_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrd2553","article-title":"Targeting the endocannabinoid system: to enhance or reduce?","volume":"7","author":"Di Marzo","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bcp.2010.02.015_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tips.2009.05.004","article-title":"The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities","volume":"30","author":"B\u00edr\u00f3","year":"2009","journal-title":"Trends Pharmacol Sci."},{"key":"10.1016\/j.bcp.2010.02.015_bib5","doi-asserted-by":"crossref","first-page":"18488","DOI":"10.1074\/jbc.M413260200","article-title":"Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear","volume":"280","author":"Oka","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib6","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.1142265","article-title":"Attenuation of allergic contact dermatitis through the endocannabinoid system","volume":"316","author":"Karsak","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bcp.2010.02.015_bib7","doi-asserted-by":"crossref","first-page":"8796","DOI":"10.4049\/jimmunol.177.12.8796","article-title":"Involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in oxazolone-induced contact dermatitis in mice","volume":"177","author":"Oka","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2010.02.015_bib8","doi-asserted-by":"crossref","first-page":"33896","DOI":"10.1074\/jbc.M303994200","article-title":"The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase","volume":"278","author":"Maccarrone","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jdermsci.2005.01.007","article-title":"Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin","volume":"38","author":"St\u00e4nder","year":"2005","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.bcp.2010.02.015_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0536.1986.tb01167.x","article-title":"Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola","volume":"14","author":"Hansen","year":"1986","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.bcp.2010.02.015_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0536.1987.tb02634.x","article-title":"Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.)","volume":"17","author":"Hausen","year":"1987","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.bcp.2010.02.015_bib12","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1021\/jf048519s","article-title":"Inhibitory effects of feeding with carrots or (\u2212)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon","volume":"53","author":"Kobaek-Larsen","year":"2005","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib13","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1021\/jf0616154","article-title":"Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosis","volume":"55","author":"Young","year":"2007","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib14","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-Caryophyllene is a Dietary Cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.bcp.2010.02.015_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0031-9422(00)85468-0","article-title":"Polyacetylenes in Araliaceae: Their Chemistry, biosynthesis and biological significance","volume":"25","author":"Hansen","year":"1986","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bcp.2010.02.015_bib16","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1021\/jf048041s","article-title":"Polyacetylenes from Apiaceae vegetables carrot, celery, fennel, parsley and parsnip and their cytotoxic activities","volume":"53","author":"Zidorn","year":"2005","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib17","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1021\/np50070a022","article-title":"Antitumor agents, 115, Seselidiol, a new cytotoxic polyacetylene from Seseli mairei","volume":"53","author":"Hu","year":"1990","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bcp.2010.02.015_bib18","doi-asserted-by":"crossref","first-page":"14192","DOI":"10.1074\/jbc.M601074200","article-title":"Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects","volume":"281","author":"Raduner","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib19","first-page":"236","article-title":"Allergic contact dermatitis from carrot","volume":"42","author":"Murdoch","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.bcp.2010.02.015_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bcp.2004.10.006","article-title":"Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf\/MEK\/ERK and IKK\/I kappa B\/NF-kappa B signal cascades","volume":"69","author":"Matsubara","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2010.02.015_bib21","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.4049\/jimmunol.174.8.5047","article-title":"ERK1\/2 regulates epidermal chemokine expression and skin inflammation","volume":"174","author":"Pastore","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2010.02.015_bib22","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1016\/S0014-2999(00)00653-1","article-title":"2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice","volume":"406","author":"Gallily","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bcp.2010.02.015_bib23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/jcb.1103","article-title":"Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids","volume":"81","author":"Chang","year":"2001","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.bcp.2010.02.015_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0923-1811(01)00147-5","article-title":"Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes","volume":"28","author":"Kohda","year":"2002","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.bcp.2010.02.015_bib25","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1002\/chem.200801579","article-title":"Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues","volume":"14","author":"Egger","year":"2008","journal-title":"Chemistry"},{"key":"10.1016\/j.bcp.2010.02.015_bib26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tips.2006.01.010","article-title":"A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists","volume":"27","author":"Di Marzo","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bcp.2010.02.015_bib27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1055\/s-2008-1034302","article-title":"Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system","volume":"74","author":"Gertsch","year":"2008","journal-title":"Planta Med"},{"key":"10.1016\/j.bcp.2010.02.015_bib28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/187152008783497073","article-title":"Acetylenic anticancer agents","volume":"8","author":"Siddiq","year":"2008","journal-title":"Anticancer Agents in Med Chem"},{"key":"10.1016\/j.bcp.2010.02.015_bib29","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1248\/yakushi1947.84.8_757","article-title":"Studies on the components of Panax ginseng C. A. Meyer. 3. On the ethereal extract of ginseng radix alba. On the structure of a new acetylene derivative \u201cpanaxynol\u201d","volume":"84","author":"Takashi","year":"1964","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.bcp.2010.02.015_bib30","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1002\/cber.19660991122","article-title":"New polyines with a C17-chain","volume":"99","author":"Bohlmann","year":"1966","journal-title":"Chem Ber"},{"key":"10.1016\/j.bcp.2010.02.015_bib31","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/cber.19610940412","article-title":"Polyacetylenverbindungen. XXXI. \u00dcber Polyine aus der Familie der Umbelliferen","volume":"94","author":"Bohlmann","year":"1961","journal-title":"Chem Ber"},{"key":"10.1016\/j.bcp.2010.02.015_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0040-4020(01)83330-5","article-title":"The structure of carotatoxin, a natural toxicant from carrot","volume":"23","author":"Crosby","year":"1967","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bcp.2010.02.015_bib33","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1039\/j39660001220","article-title":"Natural Acetylenes. Part XXIII. A C18 polyacetylenic keto-aldehyde related to falcarinone from an Umbellifer (Pastinaca sativa L.)","author":"Jones","year":"1966","journal-title":"J Chem Soc C"},{"key":"10.1016\/j.bcp.2010.02.015_bib34","first-page":"179","article-title":"Photooxidation of a polyacetylene compound from Panax ginseng C. A. Meyer","volume":"7","author":"Koh","year":"1986","journal-title":"Bull Korean Chem Soc"},{"key":"10.1016\/j.bcp.2010.02.015_bib35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jpba.2006.01.057","article-title":"Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis","volume":"41","author":"Christensen","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.bcp.2010.02.015_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-0536.1988.tb05509.x","article-title":"Human maximization test of falcarinol, the principal contact allergen of English ivy and Algerian ivy (Hedera helix, H. canariensis)","volume":"19","author":"Gafner","year":"1988","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.bcp.2010.02.015_bib37","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1096\/fj.07-104877","article-title":"Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling","volume":"10","author":"Dobrosi","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.bcp.2010.02.015_bib38","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s007020070043","article-title":"Involvement of other neurotransmitters in behaviours induced by the cannabinoid CB1 receptor antagonist SR 141716A in naive mice","volume":"107","author":"Darmani","year":"2000","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bcp.2010.02.015_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00011-003-1162-z","article-title":"Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin","volume":"52","author":"Dvorak","year":"2003","journal-title":"Inflamm Res"},{"key":"10.1016\/j.bcp.2010.02.015_bib40","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1365-2222.1996.tb00538.x","article-title":"Intradermal challenge with interleukin-8 causes tissue oedema and neutrophil accumulation in atopic and non-atopic human subjects","volume":"26","author":"Douglass","year":"1996","journal-title":"Clin Exp Allergy"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210001577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210001577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T16:28:28Z","timestamp":1544632108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295210001577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0006295210001577"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2010.02.015","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}