{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:58:59Z","timestamp":1789754339403,"version":"4.0.1"},"reference-count":89,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T00:00:00Z","timestamp":1309996800000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2006\/00995-9"],"award-info":[{"award-number":["2006\/00995-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2008\/01724-4"],"award-info":[{"award-number":["2008\/01724-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.bcp.2010.06.052","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T04:27:59Z","timestamp":1278563279000},"page":"1284-1295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca2+ dependence, and cyt c release"],"prefix":"10.1016","volume":"80","author":[{"given":"Thiago S.","family":"Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila A.","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora P.","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otaciro R.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Cerchiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Curti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iseli L.","family":"Nantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5381","key":"10.1016\/j.bcp.2010.06.052_bib1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"issue":"5684","key":"10.1016\/j.bcp.2010.06.052_bib2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0003-9861(79)90371-0","article-title":"The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms","volume":"195","author":"Hunter","year":"1979","journal-title":"Arch Biochem Biophys"},{"issue":"12","key":"10.1016\/j.bcp.2010.06.052_bib4","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.febslet.2010.04.023","article-title":"The mitochondrial permeability transition from yeast to mammals","volume":"584","author":"Azzolin","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2010.06.052_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1196\/annals.1420.023","article-title":"The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown","volume":"1123","author":"Juhaszova","year":"2008","journal-title":"Ann NY Acad Sci"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1432-1033.1988.tb14475.x","article-title":"Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress. A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload","volume":"178","author":"Crompton","year":"1988","journal-title":"Eur J Biochem"},{"issue":"32","key":"10.1016\/j.bcp.2010.06.052_bib7","doi-asserted-by":"crossref","first-page":"19955","DOI":"10.1016\/S0021-9258(17)45467-6","article-title":"Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants","volume":"265","author":"Fagian","year":"1990","journal-title":"J Biol Chem"},{"issue":"24","key":"10.1016\/j.bcp.2010.06.052_bib8","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1016\/S0021-9258(19)89437-1","article-title":"The voltage sensor of the mitochondrial permeability transition is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents","volume":"269","author":"Petronilli","year":"1994","journal-title":"J Biol Chem"},{"issue":"Pt2","key":"10.1016\/j.bcp.2010.06.052_bib9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/bj20011672","article-title":"Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore","volume":"367","author":"McStay","year":"2002","journal-title":"Biochem J"},{"issue":"10","key":"10.1016\/j.bcp.2010.06.052_bib10","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1742-4658.2006.05213.x","article-title":"The mitochondrial permeability transition from in vitro artifact to disease target","volume":"273","author":"Bernardi","year":"2006","journal-title":"FEBS J"},{"issue":"5","key":"10.1016\/j.bcp.2010.06.052_bib11","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bcp.2008.11.003","article-title":"Inhibitory modulation of the mitochondrial permeability transition by minocycline","volume":"77","author":"Gieseler","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/070674379704200205","article-title":"The history of the psychopharmacology of schizophrenia","volume":"42","author":"Lehmann","year":"1997","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.bcp.2010.06.052_bib13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1476-5381.1963.tb02011.x","article-title":"Anti-emetic activity of phenothiazines in relation to their chemical structure","volume":"21","author":"Bhargava","year":"1963","journal-title":"Br J Pharmacol Chemother"},{"issue":"6D","key":"10.1016\/j.bcp.2010.06.052_bib14","first-page":"5209","article-title":"Subcutaneous levomepromazine rescue (SLR) for high grade delayed chemotherapy-induced emesis (DCIE)","volume":"23","author":"McCabe","year":"2003","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0268-960X(87)90019-1","article-title":"Mechanisms and management of chemotherapy-induced nausea and vomiting","volume":"1","author":"Allan","year":"1987","journal-title":"Blood Rev"},{"key":"10.1016\/j.bcp.2010.06.052_bib16","first-page":"CD001944","article-title":"Thioridazine for schizophrenia","volume":"3","author":"Fenton","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bcp.2010.06.052_bib17","first-page":"565","article-title":"Extrapyramidal side effects and clinical response to the phenothiazines","volume":"20","author":"Cole","year":"1961","journal-title":"Rev Can Biol"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/014107689809100310","article-title":"Thioridazine, diarrhoea and torsades de pointe","volume":"91","author":"Denvir","year":"1998","journal-title":"J R Soc Med"},{"issue":"11","key":"10.1016\/j.bcp.2010.06.052_bib19","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1176\/appi.ajp.158.11.1774","article-title":"Antipsychotic drugs: prolonged QTc interval, Torsade de Pointes, and sudden death","volume":"158","author":"Glassman","year":"2001","journal-title":"Am J Psychiatry"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjp.0705283","article-title":"The antipsychotic drug chlorpromazine inhibits HERG potassium channels","volume":"139","author":"Thomas","year":"2003","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.1967.03120140139038","article-title":"Thioridazine agranulocytosis","volume":"200","author":"Rosenthal","year":"1967","journal-title":"J Am Med Assoc"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000246080","article-title":"Phototoxic properties of neuroleptic drugs","volume":"194","author":"Eberlein-Konig","year":"1997","journal-title":"Dermatology"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1562\/0031-8655(2002)075<0011:ESPAIV>2.0.CO;2","article-title":"Excited-state properties and in vitro phototoxicity studies of three phenothiazine derivatives","volume":"75","author":"Elisei","year":"2002","journal-title":"Photochem Photobiol"},{"issue":"6","key":"10.1016\/j.bcp.2010.06.052_bib24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/hep.1840200610","article-title":"Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis","volume":"20","author":"Moradpour","year":"1994","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1089-3261(02)00011-9","article-title":"Drug hepatotoxicity","volume":"6","author":"Goodman","year":"2002","journal-title":"Clin Liver Dis"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3748\/wjg.v13.i3.329","article-title":"Assessment of drug-induced hepatotoxicity in clinical practice: a challenge for gastroenterologists","volume":"13","author":"Andrade","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.bcp.2010.06.052_bib27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.mpmed.2006.10.005","article-title":"Drugs that damage the liver","volume":"35","author":"Brind","year":"2007","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.bcp.2010.06.052_bib28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1001\/jama.1973.03220170044011","article-title":"Thioridazine toxicity. Agranulocytosis and hepatitis with encephalopathy","volume":"224","author":"Weiden","year":"1973","journal-title":"J Am Med Assoc"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0021-9258(18)89700-9","article-title":"Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria","volume":"260","author":"Broekemeier","year":"1985","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib30","first-page":"357","article-title":"Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress","volume":"255","author":"Crompton","year":"1988","journal-title":"Biochem J"},{"key":"10.1016\/j.bcp.2010.06.052_bib31","series-title":"Catalysis and photochemistry in heterogeneous media","first-page":"75","article-title":"Chemical and photochemical behavior of phenothiazines in heterogeneous media related to a diversity of biological effects","author":"Rodrigues","year":"2007"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-4274(01)00411-8","article-title":"Induction of apoptosis by phenothiazine derivates in V79 cells","volume":"125","author":"Karmakar","year":"2001","journal-title":"Toxicol Lett"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00280-003-0738-1","article-title":"Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes","volume":"53","author":"Zhelev","year":"2004","journal-title":"Cancer Chemother Pharmacol"},{"issue":"9","key":"10.1016\/j.bcp.2010.06.052_bib34","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/1529-0131(200009)43:9<1994::AID-ANR10>3.0.CO;2-7","article-title":"Chlorpromazine induces apoptosis in activated human lymphoblasts","volume":"43","author":"Hieronymus","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0006-291X(78)90398-4","article-title":"Considerations in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5,5-dimethyl-1-pyrroline-1-oxide","volume":"83","author":"Buettner","year":"1978","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2010.06.052_bib36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0091-679X(08)62030-0","article-title":"Preparation and characterization of mitochondria and submitochondrial particles of rat liver and liver-derived tissues","volume":"20","author":"Pedersen","year":"1978","journal-title":"Meth Cell Biol"},{"key":"10.1016\/j.bcp.2010.06.052_bib37","series-title":"Biochemical toxicology","first-page":"217","article-title":"Preparation and use of mitochondria in toxicological research","author":"Cain","year":"1987"},{"issue":"2\u20133","key":"10.1016\/j.bcp.2010.06.052_bib38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0005-2728(97)00078-9","article-title":"Ca2+ acting at the external side of the inner mitochondrial membrane can stimulate mitochondrial permeability transition induced by phenylarsine oxide","volume":"1322","author":"Kowaltowski","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2010.06.052_bib39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0076-6879(87)43013-9","article-title":"Spectrophotometric assay of thiols","volume":"143","author":"Jocelyn","year":"1987","journal-title":"Methods Enzymol"},{"issue":"18","key":"10.1016\/j.bcp.2010.06.052_bib40","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/bi00637a020","article-title":"Spontaneous, reversible protein cross-linking in the human erythrocyte membrane. Temperature and pH dependence","volume":"16","author":"Liu","year":"1977","journal-title":"Biochemistry"},{"issue":"5259","key":"10.1016\/j.bcp.2010.06.052_bib41","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2010.06.052_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/elps.1150080203","article-title":"Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels","volume":"8","author":"Blum","year":"1987","journal-title":"Electrophoresis"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0162-0134(03)00314-3","article-title":"A proposed sequence of events for cadmium-induced mitochondrial impairment","volume":"97","author":"Dorta","year":"2003","journal-title":"J Inorg Biochem"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1179\/135100009X392520","article-title":"Hydroxyl radical oxidation of guanosine 5\u2032-triphosphate (GTP): requirement for a GTP-Cu(II) complex","volume":"14","author":"Cerchiaro","year":"2009","journal-title":"Redox Rep"},{"key":"10.1016\/j.bcp.2010.06.052_bib45","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1021\/om060560s","article-title":"Organic tellurium-centered radicals evidenced by EPR spin trapping and mass spectrometry experiments: insights into the mechanism of the hydrotelluration reaction","volume":"25","author":"Keppler","year":"2006","journal-title":"Organometallics"},{"key":"10.1016\/j.bcp.2010.06.052_bib46","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0076-6879(79)56030-3","article-title":"Measurements of cation transport with metallochromic indicators","author":"Scarpa","year":"1979"},{"issue":"14","key":"10.1016\/j.bcp.2010.06.052_bib47","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1021\/bi027370f","article-title":"Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status","volume":"42","author":"Nulton-Persson","year":"2003","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/sj.bjp.0704672","article-title":"Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis\u2014potentially implicated mechanisms","volume":"136","author":"Rodrigues","year":"2002","journal-title":"Brit J Pharmacol"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-4157(95)00003-A","article-title":"The mitochondrial permeability transition","volume":"1241","author":"Zoratti","year":"1995","journal-title":"Biochim Biophys Acta"},{"issue":"25","key":"10.1016\/j.bcp.2010.06.052_bib50","doi-asserted-by":"crossref","first-page":"12257","DOI":"10.1021\/jp0605404","article-title":"Photochemically generated stable cation radical of phenothiazine aggregates in mildly acid buffered solutions","volume":"110","author":"Rodrigues","year":"2006","journal-title":"J Phys Chem B"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib51","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0005-2728(96)00111-9","article-title":"Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition","volume":"1318","author":"Kowaltowski","year":"1997","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"10.1016\/j.bcp.2010.06.052_bib52","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbabio.2009.06.009","article-title":"Mitochondrial calcium and the permeability transition in cell death","volume":"1787","author":"Lemasters","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abbi.1993.1551","article-title":"The participation of reactive oxygen species and protein thiols in the mechanism of mitochondrial inner membrane permeabilization by calcium plus prooxidants","volume":"307","author":"Valle","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"10.1016\/j.bcp.2010.06.052_bib54","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02110442","article-title":"The irreversibility of inner mitochondrial membrane permeabilization by Ca2+ plus prooxidants is determined by the extent of membrane protein thiol cross-linking","volume":"28","author":"Castilho","year":"1996","journal-title":"J Bioenerg Biomembr"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib55","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/BJ20080972","article-title":"Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis","volume":"417","author":"Santana","year":"2009","journal-title":"Biochem J"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0891-5849(94)00166-H","article-title":"Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria","volume":"18","author":"Castilho","year":"1995","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"10.1016\/j.bcp.2010.06.052_bib57","first-page":"1081","article-title":"Thioridazine induces erythrocyte stomatocytosis due to interactions with negatively charged lipids","volume":"7","author":"Hendrich","year":"2002","journal-title":"Cell Mol Biol Lett"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib58","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-5793(81)80297-9","article-title":"Identification of free hydroxyl radicals in respiring rat-heart mitochondria by spin trapping with the nitrone DMPO","volume":"123","author":"Nohl","year":"1981","journal-title":"FEBS Lett"},{"issue":"9","key":"10.1016\/j.bcp.2010.06.052_bib59","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.freeradbiomed.2003.12.013","article-title":"EPR spin trapping of protein radicals","volume":"36","author":"Davies","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"10.1016\/j.bcp.2010.06.052_bib60","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00726-006-0429-4","article-title":"EPR spin-trapping of protein radicals to investigate biological oxidative mechanisms","volume":"32","author":"Augusto","year":"2007","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2004.10.005","article-title":"Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH","volume":"151","author":"Eghbal","year":"2004","journal-title":"Chem Biol Interact"},{"issue":"14","key":"10.1016\/j.bcp.2010.06.052_bib62","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1021\/bi002715k","article-title":"Substrate specificity characterization of recombinant metallo oligopeptidases, thimet oligopeptidase and neurolysin","volume":"40","author":"Oliveira","year":"2001","journal-title":"Biochemistry"},{"issue":"50","key":"10.1016\/j.bcp.2010.06.052_bib63","doi-asserted-by":"crossref","first-page":"39474","DOI":"10.1074\/jbc.M003370200","article-title":"Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax","volume":"275","author":"Kim","year":"2000","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2010.06.052_bib64","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbabio.2004.10.006","article-title":"Mitochondrial permeability transitions: how many doors to the house?","volume":"1076","author":"Zoratti","year":"2005","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib65","first-page":"391","article-title":"Role of calcium ions in regulation of mammalian intramitochondrial metabolism","volume":"70","author":"McCormack","year":"1990","journal-title":"Physiol Ver"},{"issue":"6","key":"10.1016\/j.bcp.2010.06.052_bib66","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/sj.bjp.0703667","article-title":"Effects of nimesulide and its reduced metabolite on mitochondria","volume":"131","author":"Mingatto","year":"2000","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.bcp.2010.06.052_bib67","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0022-3565(25)33233-7","article-title":"Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships","volume":"222","author":"Prozialeck","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"10.1016\/j.bcp.2010.06.052_bib68","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0006-2952(01)00585-8","article-title":"Inhibition of T-cell invasion across cultured fibroblast monolayers by phenothiazine-related calmodulin inhibitors: impairment of lymphocyte motility by trifluoperazine and chlorpromazine, and alteration of the monolayer by pimozide","volume":"61","author":"Grabski","year":"2001","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"10.1016\/j.bcp.2010.06.052_bib69","first-page":"1019","article-title":"Effect of cyclosporin A and trifluoperazine on rat liver mitochondria swelling and lipid peroxidation","volume":"26","author":"Nemopuceno","year":"1993","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib70","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0021-9258(18)54033-3","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability","volume":"268","author":"Bernardi","year":"1993","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib71","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0162-3109(98)00018-6","article-title":"Calmodulin antagonists inhibit apoptosis of CD4+ T-cells from patients with AIDS","volume":"40","author":"Pan","year":"1998","journal-title":"Immunopharmacology"},{"issue":"5B","key":"10.1016\/j.bcp.2010.06.052_bib72","first-page":"4081","article-title":"Relationship between cytotoxic activity and dipole moment for phthalimido- and chloroethyl-phenothiazines","volume":"19","author":"Kurihara","year":"1999","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib73","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(98)00135-6","article-title":"Dose-related inversion of cinnarizine and flunarizine effects on mitochondrial permeability transition","volume":"348","author":"Elimadi","year":"1998","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.bcp.2010.06.052_bib74","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2515\/therapie:2006025","article-title":"The interaction of new plant flavonoids with rat liver mitochondria: relation between the anti- and pro-oxydant effect and flavonoids concentration","volume":"61","author":"Lahouel","year":"2006","journal-title":"Therapie"},{"issue":"11","key":"10.1016\/j.bcp.2010.06.052_bib75","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.bbabio.2008.12.017","article-title":"The role of the mitochondrial permeability transition pore in heart disease","volume":"1787","author":"Halestrap","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"1\u20133","key":"10.1016\/j.bcp.2010.06.052_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(01)03314-2","article-title":"Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?","volume":"512","author":"He","year":"2002","journal-title":"FEBS Lett"},{"issue":"26","key":"10.1016\/j.bcp.2010.06.052_bib77","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1021\/jp056486t","article-title":"Interaction of phenothiazine compounds with zwitterionic lysophosphatidylcholine micelles: small angle X-ray scattering, electronic absorption spectroscopy, and theoretical calculations","volume":"110","author":"Barbosa","year":"2006","journal-title":"J Phys Chem B"},{"issue":"8","key":"10.1016\/j.bcp.2010.06.052_bib78","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0167-7799(97)01068-8","article-title":"Selective targeting of bioactive compounds to mitochondria","volume":"15","author":"Murphy","year":"1997","journal-title":"Trends Biotechnol"},{"issue":"1","key":"10.1016\/j.bcp.2010.06.052_bib79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/BJ20060919","article-title":"Accumulation of lipophilic dications by mitochondria and cells","volume":"400","author":"Ross","year":"2006","journal-title":"Biochem J"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib80","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1005516115189","article-title":"Inactivation of mitochondrial permeability transition pore by octylguanidine and octylamine","volume":"32","author":"Ch\u00e1vez","year":"2002","journal-title":"J Bioenergy Biomembr"},{"key":"10.1016\/j.bcp.2010.06.052_bib81","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2741\/3303","article-title":"Crosstalk signaling between mitochondrial Ca2+ and ROS","volume":"14","author":"Feissner","year":"2009","journal-title":"Front Biosci"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2010.06.052_bib82","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/A:1006893903113","article-title":"Role of mitochondrial calcium transport in the control of substrate oxidation","volume":"184","author":"Hansford","year":"1998","journal-title":"Mol Cell Biochem"},{"issue":"Pt3","key":"10.1016\/j.bcp.2010.06.052_bib83","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj2780715","article-title":"Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage","volume":"278","author":"Halestrap","year":"1991","journal-title":"Biochem J"},{"issue":"33","key":"10.1016\/j.bcp.2010.06.052_bib84","doi-asserted-by":"crossref","first-page":"23169","DOI":"10.1074\/jbc.274.33.23169","article-title":"Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition","volume":"274","author":"Kristal","year":"1999","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bcp.2010.06.052_bib85","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1046\/j.1432-1327.1998.2580729.x","article-title":"Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore","volume":"258","author":"Crompton","year":"1998","journal-title":"Eur J Biochem"},{"issue":"35","key":"10.1016\/j.bcp.2010.06.052_bib86","doi-asserted-by":"crossref","first-page":"25577","DOI":"10.1074\/jbc.M700009200","article-title":"Protective role of mitochondrial unsaturated lipids on the preservation of the apoptotic ability of cytochrome c exposed to singlet oxygen","volume":"282","author":"Rodrigues","year":"2007","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.bcp.2010.06.052_bib87","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1529\/biophysj.105.080150","article-title":"Cytochrome c interaction with cardiolipin\/phosphatidylcholine model membranes: effect of cardiolipin protonation","volume":"90","author":"Gorbenko","year":"2006","journal-title":"Biophys J"},{"issue":"9","key":"10.1016\/j.bcp.2010.06.052_bib88","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1073\/pnas.95.9.4997","article-title":"Bax directly induces release of cytochrome c from isolated mitochondria","volume":"95","author":"Jurgensmeier","year":"1998","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10.1016\/j.bcp.2010.06.052_bib89","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.cdd.4402072","article-title":"Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis","volume":"14","author":"Zhang","year":"2007","journal-title":"Cell Death Differ"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210004867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210004867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:52:31Z","timestamp":1757767951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295210004867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":89,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0006295210004867"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2010.06.052","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca2+ dependence, and cyt c release","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2010.06.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}