{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:07:40Z","timestamp":1773421660424,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"SAAD Trading and Contracting Company"},{"name":"University of Ulster Strategic Research Funding"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.bcp.2010.08.010","type":"journal-article","created":{"date-parts":[[2010,8,23]],"date-time":"2010-08-23T04:22:04Z","timestamp":1282537324000},"page":"1727-1735","source":"Crossref","is-referenced-by-count":51,"title":["(d-Ser2)Oxm[mPEG-PAL]: A novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions"],"prefix":"10.1016","volume":"80","author":[{"given":"Barry D.","family":"Kerr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A.","family":"Gault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2010.08.010_bib0005","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0065-2423(08)60089-X","article-title":"Gut hormones","volume":"21","author":"Bloom","year":"1980","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.bcp.2010.08.010_bib0010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.physiol.59.1.257","article-title":"Enteroglucagon","volume":"59","author":"Holst","year":"1997","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ncpendmet0017","article-title":"Biologic actions and therapeutic potential of the proglucagon-derived peptides","volume":"1","author":"Drucker","year":"2005","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1016\/j.bcp.2010.08.010_bib0020","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1210\/en.2003-1338","article-title":"Peripheral oxyntomodulin reduces food intake and bodyweight gain in rats","volume":"145","author":"Dakin","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2010.08.010_bib0025","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1038\/sj.ijo.0803344","article-title":"Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomized controlled trial","volume":"30","author":"Wynne","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.bcp.2010.08.010_bib0030","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1210\/jc.2003-030421","article-title":"Oxyntomodulin suppresses appetite and reduces food intake in humans","volume":"88","author":"Cohen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2010.08.010_bib0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2009.06.010","article-title":"The role of gut hormones in the regulation of body weight and energy homeostasis","volume":"316","author":"Karra","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0040","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1210\/en.2008-0336","article-title":"The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances \u03b2-cell function but does not inhibit gastric emptying in mice","volume":"149","author":"Maida","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2010.08.010_bib0045","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1053\/j.gastro.2004.04.063","article-title":"Oxyntomodulin and glucagon-like peptide 1 differentially regulate murine food intake and energy expenditure","volume":"127","author":"Baggio","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2010.08.010_bib0050","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.2337\/db09-0278","article-title":"GLP-1\/GCGR dual agonism reverses obesity in mice","volume":"58","author":"Pocai","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2010.08.010_bib0055","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0300-595X(72)80045-8","article-title":"Glucagon","volume":"1","author":"Marks","year":"1972","journal-title":"Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2010.08.010_bib0060","doi-asserted-by":"crossref","first-page":"E199","DOI":"10.1152\/ajpendo.00545.2003","article-title":"Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans","volume":"287","author":"Holst","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bcp.2010.08.010_bib0065","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/endo.133.2.8102095","article-title":"Glucagon-like peptide-1-(7\u201336) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line","volume":"133","author":"Gros","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2010.08.010_bib0070","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nchembio.209","article-title":"A new glucagon and GLP-1 co-agonist eliminates obesity in rodents","volume":"5","author":"Day","year":"2009","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0075","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1210\/en.2008-0828","article-title":"Investigation of structure\u2013activity relationships of oxyntomodulin (Oxm) using Oxm analogs","volume":"150","author":"Druce","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2010.08.010_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0167-0115(99)00089-0","article-title":"Dipeptidyl-peptidase IV (CD26)\u2014role of inactivation of regulatory peptides","volume":"85","author":"Mentlein S R","year":"1999","journal-title":"Regul Pept"},{"key":"10.1016\/j.bcp.2010.08.010_bib0085","first-page":"61","article-title":"GIP-based therapeutics for diabetes and obesity","volume":"2","author":"Irwin","year":"2008","journal-title":"Curr Chem Biol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0090","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.beem.2009.03.008","article-title":"Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)\u2014preclinical and clinical results","volume":"23","author":"Madsbad","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2010.08.010_bib0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s001250050903","article-title":"Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity","volume":"41","author":"Deacon","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.bcp.2010.08.010_bib0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1677\/joe.0.1760133","article-title":"Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotropic polypeptide","volume":"176","author":"Gault","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0105","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2337\/diabetes.51.3.652","article-title":"Dipeptidyl peptidase IV-resistant [d-Ala(2)]glucose-dependent insulontropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats","volume":"51","author":"Hinke","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2010.08.010_bib0110","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1124\/jpet.105.097824","article-title":"Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob\/ob) mice","volume":"318","author":"Green","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2010.08.010_bib0115","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1021\/jm9909645","article-title":"Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration","volume":"43","author":"Knudsen","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.bcp.2010.08.010_bib0120","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1016\/j.bcp.2008.03.011","article-title":"C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes","volume":"75","author":"Gault","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0125","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1515\/BC.2004.035","article-title":"Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues","volume":"385","author":"Green","year":"2004","journal-title":"Biol Chem"},{"key":"10.1016\/j.bcp.2010.08.010_bib0130","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s00125-006-0234-3","article-title":"PEGylated glucagon-like peptide-1 displays preserved effects on insulin release in isolated pancreatic islets and improved biological activity in db\/db mice","volume":"49","author":"Lee","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.bcp.2010.08.010_bib0135","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.bcp.2009.05.037","article-title":"Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties","volume":"78","author":"Kerr","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2010.08.010_bib0140","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/diab.45.8.1132","article-title":"Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electro-fusion","volume":"45","author":"McClenaghan","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2010.08.010_bib0145","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.2337\/diab.42.11.1678","article-title":"Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9\u201339) an antagonist of the receptor","volume":"42","author":"Thorens","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2010.08.010_bib0150","doi-asserted-by":"crossref","first-page":"13413","DOI":"10.1073\/pnas.212519199","article-title":"Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants","volume":"99","author":"Reeves","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bcp.2010.08.010_bib0155","first-page":"11","article-title":"Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob\/ob mice","volume":"6","author":"Bailey","year":"1982","journal-title":"Int J Obes"},{"key":"10.1016\/j.bcp.2010.08.010_bib0160","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00252768","article-title":"Abnormal plasma glucose and insulin responses in heterozygous lean (ob\/+) mice","volume":"20","author":"Flatt","year":"1981","journal-title":"Diabetologia"},{"key":"10.1016\/j.bcp.2010.08.010_bib0165","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ecl.2008.07.001","article-title":"Role of gut hormones in obesity","volume":"37","author":"Jayasena","year":"2008","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.bcp.2010.08.010_bib0170","doi-asserted-by":"crossref","first-page":"E1173","DOI":"10.1152\/ajpendo.00233.2002","article-title":"Repeated ICV administration of oxyntomodulin causes a greater reduction in bodyweight gain than in pair-fed rats","volume":"283","author":"Dakin","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bcp.2010.08.010_bib0175","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.2741\/2956","article-title":"Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes","volume":"13","author":"Flatt","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.bcp.2010.08.010_bib0180","doi-asserted-by":"crossref","first-page":"S288","DOI":"10.1055\/s-2001-18589","article-title":"The entero-insular axis in type 2 diabetes-incretins as therapeutic agents","volume":"109","author":"Creutzfeldt","year":"2001","journal-title":"Exp Clin Endocrinol Diabetes"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210006192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210006192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T02:06:18Z","timestamp":1559441178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295210006192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0006295210006192"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2010.08.010","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}