{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:35:12Z","timestamp":1791250512139,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"\u201cRecherche Cancer et Sang\u201d Foundation"},{"name":"\u201cRecherches Scienti\ufb01ques Luxembourg\u201d Association"},{"name":"\u201cEen H\u00e4erz firkriibskrank Kanner\u201d Association"},{"DOI":"10.13039\/501100006672","name":"Action Lions \u201cVaincre le Cancer\u201d Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006672","id-type":"DOI","asserted-by":"crossref"}]},{"name":"T\u00e9l\u00e9vie Luxembourg"},{"DOI":"10.13039\/501100001866","name":"National Research Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001866","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.bcp.2010.10.013","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T08:13:00Z","timestamp":1288599180000},"page":"364-378","source":"Crossref","is-referenced-by-count":96,"title":["Sustained exposure to the DNA demethylating agent, 2\u2032-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy"],"prefix":"10.1016","volume":"81","author":[{"given":"Michael","family":"Schnekenburger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Grandjenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ghelfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Karius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Foliguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Diederich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2010.10.013_bib0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.45.120403.095832","article-title":"Aberrant DNA methylation as a cancer-inducing mechanism","volume":"45","author":"Esteller","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0010","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/jnci\/dji311","article-title":"DNA methyltransferase inhibitors and the development of epigenetic cancer therapies","volume":"97","author":"Lyko","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.bcp.2010.10.013_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ijc.23607","article-title":"Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine","volume":"123","author":"Stresemann","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bcp.2010.10.013_bib0020","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1182\/blood-2003-03-0687","article-title":"Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2\u2032-deoxycytidine (decitabine) in hematopoietic malignancies","volume":"103","author":"Issa","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0025","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/cncr.11543","article-title":"Results of decitabine (5-aza-2\u2032deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia","volume":"98","author":"Kantarjian","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2010.10.013_bib0030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/sj.leu.2403552","article-title":"Induction of gene expression by 5-aza-2\u2032-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms","volume":"19","author":"Schmelz","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2010.10.013_bib0035","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.biopha.2007.07.015","article-title":"5-Aza-2\u2032-deoxycytidine increases the expression of anti-angiogenic vascular endothelial growth factor 189b variant in human lung microvascular endothelial cells","volume":"62","author":"Miller-Kasprzak","year":"2008","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bcp.2010.10.013_bib0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/B:CLIN.0000017180.19881.c1","article-title":"5-Aza-2\u2032-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis","volume":"21","author":"Nam","year":"2004","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.bcp.2010.10.013_bib0045","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1182\/blood.V64.4.922.922","article-title":"5-Aza-2\u2032-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias","volume":"64","author":"Pinto","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0050","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1182\/blood.V84.4.1036.1036","article-title":"Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells","volume":"84","author":"Selvakumaran","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0055","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ctrv.2008.07.001","article-title":"Apoptosis and non-apoptotic deaths in cancer development and treatment response","volume":"34","author":"de Bruin","year":"2008","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.bcp.2010.10.013_bib0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000129697","article-title":"Senescence, apoptosis or autophagy? When a damaged cell must decide its path \u2013 a mini-review","volume":"54","author":"Vicencio","year":"2008","journal-title":"Gerontology"},{"key":"10.1016\/j.bcp.2010.10.013_bib0065","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2147","article-title":"Chronic myeloid leukaemia as a model of disease evolution in human cancer","volume":"7","author":"Melo","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bcp.2010.10.013_bib0070","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0021-9258(19)68144-5","article-title":"Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2\u2032-deoxycytidine","volume":"257","author":"Creusot","year":"1982","journal-title":"J Biol Chem"},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2010.10.013_bib0075","first-page":"9","article-title":"Effects of 5-aza-2\u2032-deoxycytidine on differentiation and oncogene expression in the human monoblastic leukemia cell line U-937","volume":"7","author":"Attadia","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2010.10.013_bib0080","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/0-306-46843-3_66","article-title":"Inhibition of dna methylation by 5-aza-2\u2032-deoxycytidine correlates with induction of K562 cells differentiation","volume":"486","author":"Fabianowska-Majewska","year":"2000","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0085","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bcp.2004.03.047","article-title":"Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells","volume":"68","author":"Schnekenburger","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0090","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1182\/blood-2008-05-158535","article-title":"15-Deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes","volume":"112","author":"O\u2019Brien","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0095","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.pharmthera.2003.09.002","article-title":"Mechanisms involved in the induced differentiation of leukemia cells","volume":"100","author":"Tsiftsoglou","year":"2003","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bcp.2010.10.013_bib0100","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2010.10.013_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2009.12.020","article-title":"Mitochondrial calpain system: an overview","volume":"495","author":"Kar","year":"2010","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bcp.2010.10.013_bib0110","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00280-002-0563-y","article-title":"Phase I trial of continuous infusion 5-aza-2\u2032-deoxycytidine","volume":"51","author":"Aparicio","year":"2003","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0115","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1182\/blood-2007-05-088500","article-title":"Historical review: megakaryopoiesis and thrombopoiesis","volume":"111","author":"Kaushansky","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0120","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1002\/j.1460-2075.1992.tb05557.x","article-title":"GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line","volume":"11","author":"Visvader","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.bcp.2010.10.013_bib0125","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0301-472X(00)00553-1","article-title":"Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation","volume":"28","author":"Ikonomi","year":"2000","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0130","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1128\/MCB.22.12.4268-4279.2002","article-title":"Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation","volume":"22","author":"Cantor","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1620\/tjem.192.259","article-title":"Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin","volume":"192","author":"Terui","year":"2000","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.bcp.2010.10.013_bib0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0962-8924(93)90148-T","article-title":"Cell adhesion molecules as tumour suppressors","volume":"3","author":"Hedrick","year":"1993","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0145","first-page":"5195","article-title":"E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas","volume":"55","author":"Graff","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2010.10.013_bib0150","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1182\/blood-2002-03-0686","article-title":"Platelet formation is the consequence of caspase activation within megakaryocytes","volume":"100","author":"De Botton","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0155","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1073\/pnas.92.19.8690","article-title":"Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2","volume":"92","author":"Shivdasani","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bcp.2010.10.013_bib0160","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1182\/blood-2003-08-2870","article-title":"Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development","volume":"103","author":"Fujiwara","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0165","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1182\/blood-2003-05-1738","article-title":"Effects of 5-aza-2\u2032-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease","volume":"102","author":"Saunthararajah","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.193.2.247","article-title":"Caspase activation is required for terminal erythroid differentiation","volume":"193","author":"Zermati","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.bcp.2010.10.013_bib0175","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1182\/blood.V87.9.3837.bloodjournal8793837","article-title":"Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL","volume":"87","author":"Benito","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2010.10.013_bib0180","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(00)81013-2","article-title":"Fetal anemia and apoptosis of red cell progenitors in Stat5a\u2212\/\u22125b\u2212\/\u2212 mice: a direct role for Stat5 in Bcl-X(L) induction","volume":"98","author":"Socolovsky","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2010.10.013_bib0185","doi-asserted-by":"crossref","first-page":"25441","DOI":"10.1074\/jbc.M109.038174","article-title":"Calpain-1 cleaves and activates caspase-7","volume":"284","author":"Gafni","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2010.10.013_bib0190","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4161\/cc.9.4.10637","article-title":"DNA damage response links calpain to cellular senescence","volume":"9","author":"Demarchi","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2010.10.013_bib0195","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ncb1482","article-title":"Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis","volume":"8","author":"Yousefi","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bcp.2010.10.013_bib0200","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.519709","article-title":"Autophagy mediates the mitotic senescence transition","volume":"23","author":"Young","year":"2009","journal-title":"Genes Dev"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210007926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210007926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T22:39:04Z","timestamp":1636756744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295210007926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0006295210007926"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2010.10.013","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}