{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:21:28Z","timestamp":1791030088161,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.bcp.2010.12.006","type":"journal-article","created":{"date-parts":[[2010,12,12]],"date-time":"2010-12-12T09:04:48Z","timestamp":1292144688000},"page":"636-648","source":"Crossref","is-referenced-by-count":73,"title":["Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation"],"prefix":"10.1016","volume":"81","author":[{"given":"Daniela","family":"Impellizzeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Mazzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Paterniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Di Paola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2010.12.006_bib0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.bjp.0702866","article-title":"Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation","volume":"128","author":"Nantel","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0010","doi-asserted-by":"crossref","first-page":"H303","DOI":"10.1152\/ajpheart.2000.279.1.H303","article-title":"Effect of the NADPH oxidase inhibitor apocynin on ischemia\u2013reperfusion lung injury","volume":"279","author":"Dodd","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0015","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils","volume":"320","author":"Weiss","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bcp.2010.12.006_bib0020","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0026-895X(24)05652-9","article-title":"Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure\u2013activity relationships","volume":"66","author":"Chen","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0025","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S1567-5769(02)00058-9","article-title":"The role of NF-kappaB in the regulation of cell stress responses","volume":"2","author":"Wang","year":"2002","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0030","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.bcp.2010.12.006_bib0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-8741(98)00150-0","article-title":"Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil","volume":"65","author":"Shinde","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejphar.2005.11.061","article-title":"Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice","volume":"531","author":"Hougee","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/10623320213638","article-title":"Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols","volume":"9","author":"Johnson","year":"2002","journal-title":"Endothelium"},{"key":"10.1016\/j.bcp.2010.12.006_bib0050","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0891-5849(01)00725-0","article-title":"Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics","volume":"31","author":"Peters","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bcp.2010.12.006_bib0055","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/sj.bjp.0703401","article-title":"Apocynin inhibits peroxynitrite formation by murine macrophages","volume":"130","author":"Muijsers","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0060","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1164\/ajrccm.153.5.8630623","article-title":"Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo","volume":"153","author":"Sadeghi-Hashjin","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bcp.2010.12.006_bib0065","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.4049\/jimmunol.168.8.3974","article-title":"Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox\u2212\/\u2212 and gp91phox\u2212\/\u2212 mice","volume":"168","author":"Gao","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0070","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1074\/jbc.M610248200","article-title":"Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation","volume":"282","author":"Gao","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2010.12.006_bib0075","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/bjp.2008.202","article-title":"Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice","volume":"154","author":"Wang","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0080","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1189\/jlb.0605341","article-title":"The role of the peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in the regulation of acute inflammation","volume":"79","author":"Cuzzocrea","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0085","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/sj.bjp.0706902","article-title":"Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice","volume":"149","author":"Cuzzocrea","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0090","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1476-5381.1996.tb15472.x","article-title":"Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy","volume":"118","author":"Saleh","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0095","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainres.2006.03.060","article-title":"Apocynin protects against global cerebral ischemia\u2013reperfusion-induced oxidative stress and injury in the gerbil hippocampus","volume":"1090","author":"Wang","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.bcp.2010.12.006_bib0100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0160-5402(85)90029-4","article-title":"Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium","volume":"14","author":"Mullane","year":"1985","journal-title":"J Pharmacol Methods"},{"key":"10.1016\/j.bcp.2010.12.006_bib0105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bcp.2010.12.006_bib0110","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.18-09-03251.1998","article-title":"Traumatic spinal cord injury induces nuclear factor-kappaB activation","volume":"18","author":"Bethea","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.bcp.2010.12.006_bib0115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bcp.2010.12.006_bib0120","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1172\/JCI114496","article-title":"Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation","volume":"85","author":"Clark","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2010.12.006_bib0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0006-2952(99)00296-8","article-title":"Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries","volume":"59","author":"Bowie","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI25711","article-title":"ERK1\/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo","volume":"116","author":"Lee","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2010.12.006_bib0135","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.imbio.2008.12.001","article-title":"Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro","volume":"214","author":"Klink","year":"2009","journal-title":"Immunobiology"},{"issue":"Pt 3","key":"10.1016\/j.bcp.2010.12.006_bib0140","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1042\/bj3440859","article-title":"Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils","volume":"344","author":"Reeves","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.bcp.2010.12.006_bib0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0014-5793(00)01167-4","article-title":"Roles of p38 MAPK, PKC and PI3-K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes","volume":"467","author":"Yamamori","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2010.12.006_bib0150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-8741(00)00268-3","article-title":"Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora","volume":"73","author":"Smit","year":"2000","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/ajrcmb.11.1.8018341","article-title":"Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol","volume":"11","author":"Stolk","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0160","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bcp.2010.12.006_bib0165","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s001090050078","article-title":"The NF-kappa B\/Rel and I kappa B gene families: mediators of immune response and inflammation","volume":"74","author":"Wulczyn","year":"1996","journal-title":"J Mol Med"},{"key":"10.1016\/j.bcp.2010.12.006_bib0170","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/art.1780400207","article-title":"Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes","volume":"40","author":"Crofford","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bcp.2010.12.006_bib0175","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.270.52.31315","article-title":"Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells","volume":"270","author":"Yamamoto","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2010.12.006_bib0180","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcp.21495","article-title":"iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells","volume":"217","author":"Wu","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0185","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0140-6736(05)80083-2","article-title":"Induction of nitric oxide synthase in asthma","volume":"342","author":"Hamid","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2010.12.006_bib0190","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1046\/j.1365-2222.1998.00428.x","article-title":"Peroxynitrite in airway diseases","volume":"28","author":"Sadeghi-Hashjin","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.bcp.2010.12.006_bib0195","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0024-3205(96)00651-0","article-title":"Peroxynitrite: a two-faced metabolite of nitric oxide","volume":"60","author":"Muijsers","year":"1997","journal-title":"Life Sci"},{"key":"10.1016\/j.bcp.2010.12.006_bib0200","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1165\/rcmb.2008-0300OC","article-title":"NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia\u2013reperfusion injury","volume":"40","author":"Yang","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0205","first-page":"803","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat Rev"},{"key":"10.1016\/j.bcp.2010.12.006_bib0210","first-page":"678","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat Rev"},{"key":"10.1016\/j.bcp.2010.12.006_bib0215","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cardiores.2004.03.018","article-title":"Role of NADPH oxidase-mediated superoxide production in the regulation of E-selectin expression by endothelial cells subjected to anoxia\/reoxygenation","volume":"63","author":"Rupin","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bcp.2010.12.006_bib0220","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI118392","article-title":"Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke","volume":"97","author":"Connolly","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2010.12.006_bib0225","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0165-6147(98)01193-6","article-title":"Role of poly(ADP-ribose) synthetase in inflammation and ischaemia\u2013reperfusion","volume":"19","author":"Szabo","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bcp.2010.12.006_bib0230","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1476-5381.1996.tb15475.x","article-title":"Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation","volume":"118","author":"Salvemini","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0235","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(99)00910-3","article-title":"Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy","volume":"390","author":"Cuzzocrea","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0240","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jss.2005.07.030","article-title":"Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas\/FasL","volume":"130","author":"Peng","year":"2006","journal-title":"J Surg Res"},{"key":"10.1016\/j.bcp.2010.12.006_bib0245","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.4049\/jimmunol.167.11.6217","article-title":"Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors","volume":"167","author":"Hohlbaum","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2010.12.006_bib0250","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.shk.0000190825.28783.a4","article-title":"Role of endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha in the development of bleomycin-induced lung injury","volume":"24","author":"Genovese","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.bcp.2010.12.006_bib0255","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2005.08.010","article-title":"NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin","volume":"40","author":"Qin","year":"2006","journal-title":"Free Radic Biol Med"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210008476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295210008476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T18:35:41Z","timestamp":1740767741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295210008476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0006295210008476"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2010.12.006","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}