{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:13:22Z","timestamp":1790727202901,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Basic Research and Development Project of China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.bcp.2011.04.001","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T07:24:55Z","timestamp":1303284295000},"page":"148-155","source":"Crossref","is-referenced-by-count":56,"title":["Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K\/Akt activation and PKC inhibition"],"prefix":"10.1016","volume":"82","author":[{"given":"Tao-Hua","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Kang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2011.04.001_bib0005","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully","year":"1969","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: a perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2011.04.001_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI118771","article-title":"Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia","volume":"98","author":"Lentz","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2011.04.001_bib0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbapap.2008.10.001","article-title":"Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells","volume":"1794","author":"Liu","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2011.04.001_bib0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.freeradbiomed.2008.11.002","article-title":"Homocysteine and inflammation as main determinants of oxidative stress in the elderly","volume":"46","author":"Ventura","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bcp.2011.04.001_bib0030","first-page":"187","article-title":"Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease","volume":"10","author":"Zhou","year":"2004","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.bcp.2011.04.001_bib0035","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jvs.2005.01.054","article-title":"Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries","volume":"41","author":"Zhou","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.bcp.2011.04.001_bib0040","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.ATV.19.8.1899","article-title":"Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia","volume":"19","author":"Ungvari","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0045","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria","volume":"52","author":"Jaffe","year":"1973","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.bcp.2011.04.001_bib0050","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2011.04.001_bib0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ddmec.2005.05.029","article-title":"Mechanisms in homocysteine-induced vascular disease","volume":"2","author":"Wang","year":"2005","journal-title":"Drug Discov Today (Dis Mech)"},{"key":"10.1016\/j.bcp.2011.04.001_bib0060","first-page":"103","article-title":"Hyperhomocysteinemia and atherosclerosis","volume":"57","author":"Yang","year":"2005","journal-title":"Acta Physiol Sin"},{"key":"10.1016\/j.bcp.2011.04.001_bib0065","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI108520","article-title":"Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis","volume":"58","author":"Harker","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2011.04.001_bib0070","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/blood.V75.4.895.895","article-title":"Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells","volume":"75","author":"Rodgers","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2011.04.001_bib0075","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherothrombosis","volume":"338","author":"Welch","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bcp.2011.04.001_bib0080","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1161\/01.ATV.0000189559.87328.e4","article-title":"Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation","volume":"25","author":"Jiang","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9150(01)00626-8","article-title":"Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians","volume":"161","author":"Weyer","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bcp.2011.04.001_bib0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00001199-200303000-00009","volume":"18","author":"Glenn","year":"2003","journal-title":"Head Trauma Rehabil"},{"issue":"12","key":"10.1016\/j.bcp.2011.04.001_bib0095","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1248\/bpb.29.2425","article-title":"Ginseng saponins diminish adverse vascular effects associated with chronic methronine-induced hyperhomocysteinemia","volume":"29","author":"Kim","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bcp.2011.04.001_bib0100","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1016\/S0024-3205(00)00880-8","article-title":"Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells","volume":"67","author":"Li","year":"2000","journal-title":"Life Sci"},{"key":"10.1016\/j.bcp.2011.04.001_bib0105","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1440-1681.1996.tb01767.x","article-title":"Cardiovascular protection by ginsenosides and their nitric oxide releasing action","volume":"23","author":"Chen","year":"1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0110","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1248\/cpb.14.595","article-title":"Chemical studies on oriental plant drugs XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins","volume":"14","author":"Shibata","year":"1966","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.bcp.2011.04.001_bib0115","first-page":"903","article-title":"Effect of ginsenoside Rb1 and astragalus polysaccharide on the excretion of NO IL-6 and TNF-\u03b1 in micro-vascular endothelial cells","volume":"37","author":"Xie","year":"2006","journal-title":"Acta Vet Zool Sin"},{"key":"10.1016\/j.bcp.2011.04.001_bib0120","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bbrc.2006.12.119","article-title":"Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor","volume":"353","author":"Yu","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2011.04.001_bib0125","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jss.2005.09.016","article-title":"Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production","volume":"133","author":"Ohashi","year":"2006","journal-title":"J Surg Res"},{"key":"10.1016\/j.bcp.2011.04.001_bib0130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.1250","article-title":"Protective role of endothelial nitric oxide synthase","volume":"199","author":"Albrecht","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.7326\/0003-4819-120-3-199402010-00009","article-title":"Nitric oxide: a physiologic messenger","volume":"120","author":"Lowenstein","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bcp.2011.04.001_bib0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","author":"Knowles","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.bcp.2011.04.001_bib0145","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1152\/ajpregu.00323.2002","article-title":"Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase","volume":"284","author":"Fleming","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0150","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.yjmcc.2006.05.023","article-title":"Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation","volume":"42","author":"Mount","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0155","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2011.04.001_bib0160","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/01.HYP.0000049624.99844.3D","article-title":"Wall stiffness suppresses Akt\/eNOS and cytoprotection in pulse-perfused endothelium","volume":"41","author":"Peng","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.bcp.2011.04.001_bib0165","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1161\/hh1101.092677","article-title":"Phosphorylation of Thr495 regulates Ca2+\/calmodulin-dependent endothelial nitric oxide synthase activity","volume":"88","author":"Fleming","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2011.04.001_bib0170","doi-asserted-by":"crossref","first-page":"17625","DOI":"10.1074\/jbc.C100122200","article-title":"Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase","volume":"276","author":"Michell","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2011.04.001_bib0175","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.RES.0000179775.04114.45","article-title":"AlphaPKC activates eNOS and increases arterial blood flow in vivo","volume":"97","author":"Partovian","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2011.04.001_bib0180","doi-asserted-by":"crossref","first-page":"H460","DOI":"10.1152\/ajpheart.00116.2009","article-title":"Periadventitial adipose tissue impairs coronary endothelial function via PKC-beta-dependent phosphorylation of nitric oxide synthase","volume":"297","author":"Payne","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.bcp.2011.04.001_bib0185","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1182\/blood-2008-12-196584","article-title":"Phosphorylation of endothelial nitric oxide synthase by atypicalPKC{zeta} contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro","volume":"114","author":"Oubaha","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2011.04.001_bib0190","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.yjmcc.2009.11.002","article-title":"\u03b4PKC inhibition or \u025bPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification","volume":"48","author":"Monti","year":"2010","journal-title":"J Mol Cell Cardiol"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295211002206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295211002206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T11:45:48Z","timestamp":1592480748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295211002206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0006295211002206"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2011.04.001","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}