{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:03:52Z","timestamp":1792065832402,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.bcp.2011.05.014","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T01:33:37Z","timestamp":1306373617000},"page":"548-555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)"],"prefix":"10.1016","volume":"82","author":[{"given":"Manuel","family":"Mata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepcion","family":"Gimeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Cortijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2011.05.014_bib0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-7-53","article-title":"Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema","volume":"7","author":"Demedts","year":"2006","journal-title":"Respir Res"},{"issue":"4","key":"10.1016\/j.bcp.2011.05.014_bib0010","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1378\/chest.130.4.1203","article-title":"How viral infections causes exacerbations of airway diseases","volume":"130","author":"Malia","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.bcp.2011.05.014_bib0015","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"issue":"22","key":"10.1016\/j.bcp.2011.05.014_bib0020","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1183\/09031936.03.00038303","article-title":"Longitudinal changes in the nature, severity and frequency of COPD exacerbations","author":"Donaldson","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.bcp.2011.05.014_bib0025","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"The relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.bcp.2011.05.014_bib0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1513\/pats.2306030","article-title":"Role of viruses in exacerbations of chronic obstructive pulmonary disease","volume":"1","author":"Wedzycha","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.bcp.2011.05.014_bib0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.7326\/0003-4819-130-5-199903020-00003","article-title":"Relation between vaccination and out patient visits, hospitalization and mortality in elderly persons with chronic lung disease","volume":"130","author":"Nichol","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.bcp.2011.05.014_bib0040","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI114499","article-title":"Dependence on O2-generation by xanthine oxidase of pathogenesis of influenza virus infection in mice","volume":"85","author":"Akaike","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2011.05.014_bib0045","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0891-5849(94)90198-8","article-title":"Influenza virus infection induces differential expression of antioxidant genes in human airway epithelial cells","volume":"6","author":"Jacoby","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bcp.2011.05.014_bib0050","first-page":"L708","article-title":"Release of reactive oxygen species by guinea pig tracheal epithelial cells in vitro","volume":"262","author":"Kinnula","year":"1992","journal-title":"Am J Physiol"},{"issue":"5 (Suppl. 1)","key":"10.1016\/j.bcp.2011.05.014_bib0055","doi-asserted-by":"crossref","first-page":"303S","DOI":"10.1378\/chest.117.5_suppl_1.303S-a","article-title":"Oxidants\/antioxidants and COPD","volume":"117","author":"MacNee","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.bcp.2011.05.014_bib0060","first-page":"357","article-title":"The isoenzymes of glutathione transferase","volume":"57","author":"Mannervik","year":"1985","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"10.1016\/j.bcp.2011.05.014_bib0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1465-9921-7-130","article-title":"The genetics of chronic obstructive pulmonary disease","volume":"7","author":"Wood","year":"2006","journal-title":"Respir Res"},{"issue":"5","key":"10.1016\/j.bcp.2011.05.014_bib0070","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/thx.2005.048512","article-title":"Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function","volume":"61","author":"Young","year":"2006","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.bcp.2011.05.014_bib0075","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1165\/rcmb.2008-0330OC","article-title":"Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes","volume":"41","author":"Hosakote","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bcp.2011.05.014_bib0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2334-2-5","article-title":"Respiratory syncytial virus and TNF alpha induction of chemokine gene expression involves differential activation of Rel A and NF-kappa B1","volume":"2","author":"Carpenter","year":"2002","journal-title":"BMC Infect Dis"},{"issue":"3","key":"10.1016\/j.bcp.2011.05.014_bib0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s10753-009-9170-y","article-title":"Therapeutic effect of recombinant human catalase on H1N1 influenza-induced pneumonia in mice","volume":"33","author":"Shi","year":"2010","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.bcp.2011.05.014_bib0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.freeradbiomed.2010.11.025","article-title":"Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge","volume":"50","author":"Case","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.bcp.2011.05.014_bib0095","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1093\/toxsci\/kfi141","article-title":"Diesel exhaust enhances influenza virus infections in respiratory epithelial cells","volume":"85","author":"Jaspers","year":"2005","journal-title":"Toxicol Sci"},{"issue":"February (3)","key":"10.1016\/j.bcp.2011.05.014_bib0100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bcp.2009.08.025","article-title":"N-acetyl-l-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus","volume":"79","author":"Geiler","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.bcp.2011.05.014_bib0105","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1164\/ajrccm.163.2.2001038","article-title":"Relationship of epidermal growth factor receptors to goblet cell production in human bronchi","volume":"163","author":"Takeyama","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"5 (Suppl.)","key":"10.1016\/j.bcp.2011.05.014_bib0110","doi-asserted-by":"crossref","first-page":"166S","DOI":"10.1378\/chest.121.5_suppl.166S","article-title":"Mucin apoprotein expression in COPD","volume":"121","author":"Leikauf","year":"2002","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.bcp.2011.05.014_bib0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1165\/rcmb.2008-0223OC","article-title":"Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway","volume":"40","author":"Zhu","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"February (4)","key":"10.1016\/j.bcp.2011.05.014_bib0120","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1128\/JVI.80.4.1629-1636.2006","article-title":"Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner","volume":"80","author":"Avadhanula","year":"2006","journal-title":"J Virol"},{"issue":"August (3)","key":"10.1016\/j.bcp.2011.05.014_bib0125","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1164\/rccm.200301-030OC","article-title":"Respiratory syncytial virus in allergic lung inflammation increases MUC5AC and gob-5","volume":"170","author":"Hashimoto","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.bcp.2011.05.014_bib0130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/thx.2004.025692","article-title":"Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human epithelial cells","volume":"60","author":"Mata","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.bcp.2011.05.014_bib0135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-3589(08)60985-0","article-title":"N-acetylcysteine: pharmacological considerations and experimental and clinical applications","volume":"38","author":"Cotgreave","year":"1997","journal-title":"Adv Pharmacol"},{"issue":"2","key":"10.1016\/j.bcp.2011.05.014_bib0140","first-page":"99","article-title":"The role for N-acetylcysteine in the management of COPD","volume":"1","author":"Dekhuijzen","year":"2006","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"3","key":"10.1016\/j.bcp.2011.05.014_bib0145","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1476-5381.1994.tb17093.x","article-title":"Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone","volume":"113","author":"Mitchell","year":"1994","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.bcp.2011.05.014_bib0150","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1183\/09031936.03.00018003","article-title":"Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin MUC5AC expression in rats","volume":"22","author":"Mata","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.bcp.2011.05.014_bib0155","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0891-5849(00)00424-X","article-title":"Evidence of a defective thiol status of alveolar macrophages from COPD patients and smokers","volume":"29","author":"T\u00e4ger","year":"2000","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"10.1016\/j.bcp.2011.05.014_bib0160","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.200609074","article-title":"The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production","volume":"177","author":"Bell","year":"2007","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.bcp.2011.05.014_bib0165","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1183\/09031936.03.00039602","article-title":"Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen","volume":"21","author":"Blesa","year":"2003","journal-title":"Eur Respir J"},{"issue":"21","key":"10.1016\/j.bcp.2011.05.014_bib0170","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1016\/j.vaccine.2009.02.087","article-title":"Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate","volume":"27","author":"Wressnigg","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.bcp.2011.05.014_bib0175","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/1471-2334-10-308","article-title":"Co-infection of influenza B and Streptococci causing severe pneumonia and septic shock in healthy women","volume":"10","author":"Aebi","year":"2010","journal-title":"BMC Infect Dis"},{"issue":"January (1)","key":"10.1016\/j.bcp.2011.05.014_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2010.09.011","article-title":"The role of cytokines and chemokines in severe respiratory syncytial virus infection and subsequent asthma","volume":"53","author":"Zeng","year":"2011","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.bcp.2011.05.014_bib0185","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/15412550902724024","article-title":"Recognizing the importance of respiratory syncytial virus in chronic obstructive pulmonary disease","volume":"6","author":"Ramaswamy","year":"2009","journal-title":"COPD"},{"issue":"January (1)","key":"10.1016\/j.bcp.2011.05.014_bib0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1165\/rcmb.2009-0120OC","article-title":"Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells","volume":"44","author":"Xing","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10.1016\/j.bcp.2011.05.014_bib0195","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1128\/JVI.01420-06","article-title":"Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growth","volume":"81","author":"Bitko","year":"2007","journal-title":"J Virol"},{"issue":"13","key":"10.1016\/j.bcp.2011.05.014_bib0200","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.phymed.2010.03.016","article-title":"Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation","volume":"17","author":"Gangehei","year":"2010","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.bcp.2011.05.014_bib0205","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1034\/j.1399-3003.2000.16b12.x","article-title":"The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review","volume":"16","author":"Stey","year":"2000","journal-title":"Eur Respir J"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295211003273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295211003273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:54:34Z","timestamp":1773251674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295211003273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0006295211003273"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2011.05.014","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2011.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}