{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:40:04Z","timestamp":1791085204049,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"10","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.bcp.2013.03.002","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T06:52:31Z","timestamp":1363157551000},"page":"1417-1423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies"],"prefix":"10.1016","volume":"85","author":[{"given":"Pedro","family":"Esbrit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Alcaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2013.03.002_bib0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrrheum.2009.260","article-title":"Osteoporosis: impact on health and economics","volume":"6","author":"Harvey","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0010","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jbmr.262","article-title":"The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed","volume":"26","author":"Khosla","year":"2011","journal-title":"J Bone Mineral Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0015","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/er.2009-0024","article-title":"From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis","volume":"31","author":"Manolagas","year":"2010","journal-title":"Endocr Rev"},{"key":"10.1016\/j.bcp.2013.03.002_bib0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s002239900619","article-title":"Influence of skeletal site of origin and donor age on osteoblastic cell growth and differentiation","volume":"64","author":"Mart\u00ednez","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bcp.2013.03.002_bib0025","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.exger.2006.09.008","article-title":"Fracture healing in the elderly patient","volume":"41","author":"Gruber","year":"2006","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0030","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrendo.2011.233","article-title":"Bone, sweet bone\u2013osteoporotic fractures in diabetes mellitus","volume":"8","author":"Hamann","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0035","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2013.03.002_bib0040","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1172\/JCI33612","article-title":"Building bone to reverse osteoporosis and repair fractures","volume":"118","author":"Khosla","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2013.03.002_bib0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0050","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.bcp.2013.03.002_bib0055","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.bcp.2013.03.002_bib0060","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","article-title":"Molecular and cellular mechanisms of the anabolic effect of intermittent PTH","volume":"40","author":"Jilka","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0065","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1582-4934.2010.01224.x","article-title":"Bone regeneration and stem cells","volume":"15","author":"Arvidson","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bcp.2013.03.002_bib0070","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.bone.2006.04.024","article-title":"Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation","volume":"39","author":"Vaes","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/art.30135","article-title":"Should bisphosphonates be used for long-term treatment of glucocorticoid-induced osteoporosis?","volume":"63","author":"Teitelbaum","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bcp.2013.03.002_bib0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4239\/wjd.v2.i3.41","article-title":"Osteoporosis in diabetes mellitus: possible cellular and molecular mechanisms","volume":"2","author":"Wongdee","year":"2011","journal-title":"World J Diabetes"},{"key":"10.1016\/j.bcp.2013.03.002_bib0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.molmed.2009.07.002","article-title":"Mechanisms of bone repair and regeneration","volume":"15","author":"Deschaseaux","year":"2009","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bcp.2013.03.002_bib0090","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/BOT.0b013e3181ed1361","article-title":"Trauma-induced inflammation and fracture healing","volume":"24","author":"Pape","year":"2010","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.bcp.2013.03.002_bib0095","first-page":"559","article-title":"Role of angiogenesis in bone formation","volume":"27","author":"Portal-N\u00fa\u00f1ez","year":"2012","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0100","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1210\/en.2003-1185","article-title":"Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments","volume":"145","author":"Sneddon","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0105","first-page":"801","article-title":"Catabolic and anabolic actions of parathyroid hormone on the skeleton","volume":"34","author":"Silva","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.bcp.2013.03.002_bib0110","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1359\/JBMR.051109","article-title":"A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide","volume":"21","author":"Lindsay","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0115","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.bone.2006.09.008","article-title":"Skeletal actions of intermittent parathyroid hormone: Effects on bone remodelling and structure","volume":"40","author":"Compston","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.rdc.2011.08.002","article-title":"Teriparatide update","volume":"37","author":"Silverman","year":"2011","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.bcp.2013.03.002_bib0125","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.2165\/00003495-200666180-00008","article-title":"Recombinant full-length parathyroid hormone (1-84)","volume":"66","author":"Moen","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.bcp.2013.03.002_bib0130","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1359\/jbmr.080208","article-title":"On the interpretation of rat carcinogenicity studies for human PTH (1\u201334) and human PTH (1\u201384)","volume":"23","author":"Tashjian","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0135","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2131\/jts.37.617","article-title":"Osteosarcoma in Sprague-Dawley rats after long-term treatment with teriparatide (human parathyroid hormone (1\u201334))","volume":"37","author":"Watanabe","year":"2012","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.bcp.2013.03.002_bib0140","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.abb.2008.03.003","article-title":"Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone","volume":"473","author":"Goltzman","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bcp.2013.03.002_bib0145","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1185\/03007995.2011.599837","article-title":"Combination antiresorptive and osteoanabolic therapy for osteoporosis: we are not there yet","volume":"27","author":"Cusano","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.bcp.2013.03.002_bib0150","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cellsig.2009.02.012","article-title":"PTH and PTHrP signaling in osteoblasts","volume":"21","author":"Datta","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.bcp.2013.03.002_bib0155","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1210\/en.2003-1695","article-title":"Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice","volume":"145","author":"Miao","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0160","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1359\/jbmr.2000.15.8.1517","volume":"15","author":"Stewart","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0165","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1210\/en.2008-1108","article-title":"Role of parathyroid hormone-related protein in the decreased osteoblast function in diabetes-related osteopenia","volume":"150","author":"Lozano","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0170","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/ten.tea.2009.0355","article-title":"Role of the N- and C-terminal fragments of parathyroid hormone-related protein as putative therapies to improve bone regeneration under high glucocorticoid treatment","volume":"16","author":"de Castro","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.bcp.2013.03.002_bib0175","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/jcp.22902","article-title":"Comparison of the skeletal effects induced by daily administration of PTHrP (1-36) and PTHrP (107-139) to ovariectomized mice","volume":"227","author":"de Castro","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0180","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1210\/jc.2002-021122","article-title":"Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis","volume":"88","author":"Horwitz","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2013.03.002_bib0185","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.bone.2011.07.017","article-title":"Issues in modern bone histomorphometry","volume":"49","author":"Recker","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0190","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1210\/me.2007-0274","article-title":"Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH\/PTHrP receptor","volume":"22","author":"Dean","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0195","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives","volume":"97","author":"Baron","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2013.03.002_bib0200","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1210\/en.138.3.1299","article-title":"Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo","volume":"138","author":"Cornish","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0205","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1476-5381.2010.01155.x","article-title":"The C-terminal fragment of parathyroid hormone-related peptide promotes bone formation in diabetic mice with low turnover osteopenia","volume":"162","author":"Lozano","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0210","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1359\/jbmr.070328","article-title":"Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells","volume":"22","author":"Datta","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0215","doi-asserted-by":"crossref","first-page":"19374","DOI":"10.1074\/jbc.M108913200","article-title":"Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells","volume":"277","author":"Chen","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.03.002_bib0220","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1359\/jbmr.1999.14.6.915","article-title":"Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone-related protein","volume":"14","author":"Cornish","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0225","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.bone.2006.06.010","article-title":"Intermittent treatment with parathyroid hormone [PTH] as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells","volume":"39","author":"Rickard","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0380","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11357-011-9372-8","article-title":"Characterization of skeletal alterations in a model of prematurely aging mice","volume":"35","author":"Portal-N\u00fa\u00f1ez","year":"2013","journal-title":"Age"},{"key":"10.1016\/j.bcp.2013.03.002_bib0235","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00223-006-0099-y","article-title":"Transient exposure to PTHrP (107\u2013139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro","volume":"79","author":"De Gort\u00e1zar","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.bcp.2013.03.002_bib0240","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jcp.21547","article-title":"Parathyroid hormone-related protein (107\u2013139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2","volume":"217","author":"Alonso","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0245","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1210\/me.2002-0225","article-title":"PTH bone anabolic action requires Cbfa1\/Runx2-dependent signaling","volume":"17","author":"Krishnan","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0250","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1097-4652(199601)166:1<94::AID-JCP11>3.0.CO;2-P","article-title":"Expression of parathyroid hormone-related protein in cells of osteoblast lineage","volume":"166","author":"Suda","year":"1996","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0255","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s001980200120","article-title":"Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells","volume":"13","author":"Mart\u00ednez","year":"2002","journal-title":"Osteoporosis Int"},{"key":"10.1016\/j.bcp.2013.03.002_bib0260","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/en.136.8.3632","article-title":"Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells","volume":"136","author":"Dobnig","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0265","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1476-5381.2011.01450.x","article-title":"Biasing the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass","volume":"164","author":"Gesty-Palmer","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0270","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1016\/j.actbio.2012.04.002","article-title":"Osteostatin improves the osteogenic activity of fibroblast growth factor-2 immobilized on Si-doped hydroxyapatite in osteoblastic cells","volume":"8","author":"Lozano","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.bcp.2013.03.002_bib0275","doi-asserted-by":"crossref","first-page":"50259","DOI":"10.1074\/jbc.M307444200","article-title":"Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts","volume":"278","author":"Bellido","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.03.002_bib0280","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1096\/fj.09-147033","article-title":"The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice","volume":"24","author":"Toribio","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.bcp.2013.03.002_bib0285","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.febslet.2010.05.047","article-title":"Alterations of the Wnt\/\u03b2-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice","volume":"584","author":"Portal-N\u00fa\u00f1ez","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2013.03.002_bib0290","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1210\/en.2009-1488","article-title":"Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice","volume":"151","author":"Weinstein","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0295","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1002\/jcb.23208","article-title":"Connexin43 interacts with beta-arrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone","volume":"112","author":"Bivi","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.bcp.2013.03.002_bib0300","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bone.2006.09.002","article-title":"Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells","volume":"40","author":"Yamamoto","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0305","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1074\/jbc.M409846200","article-title":"Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase","volume":"280","author":"Qin","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.03.002_bib0310","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bone.2009.05.006","article-title":"Parathyroid hormone suppresses osteoblast apoptosis by augmenting DNA repair","volume":"45","author":"Schnoke","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2013.03.002_bib0315","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1474-9726.2010.00616.x","article-title":"Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration","volume":"9","author":"Jilka","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2013.03.002_bib0320","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1210\/en.2006-1372","article-title":"In vivo analysis of Wnt signaling in bone","volume":"148","author":"Glass","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2013.03.002_bib0325","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/jcb.20506","article-title":"Effects of parathyroid hormone on Wnt signaling pathway in bone","volume":"95","author":"Kulkarni","year":"2005","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.bcp.2013.03.002_bib0330","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1101\/gad.1702708","article-title":"Parathyroid hormone signaling through low-density lipoprotein-related protein 6","volume":"22","author":"Wan","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.bcp.2013.03.002_bib0335","doi-asserted-by":"crossref","first-page":"e2942","DOI":"10.1371\/journal.pone.0002942","article-title":"Control of bone mass and remodeling by PTH receptor signaling in osteocytes","volume":"3","author":"O\u2018Brien","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bcp.2013.03.002_bib0340","doi-asserted-by":"crossref","first-page":"52240","DOI":"10.1074\/jbc.M302566200","article-title":"Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts","volume":"278","author":"Sowa","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.03.002_bib0345","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1138\/20110521","article-title":"Insulin-like growth factor-I and bone","volume":"8","author":"Bikle","year":"2011","journal-title":"IBMS BoneKEy"},{"key":"10.1016\/j.bcp.2013.03.002_bib0350","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jcp.21661","article-title":"Endogenous FGF-2 is critically important in PTH anabolic effects on bone","volume":"219","author":"Sabbieti","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0355","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00441-011-1188-4","article-title":"Endogenous tissue engineering: PTH therapy for skeletal repair","volume":"347","author":"Takahata","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0360","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1359\/jbmr.070724","article-title":"Enhanced chondrogenesis and Wnt-signaling in parathyroid hormone treated fractures","volume":"22","author":"Kakar","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bcp.2013.03.002_bib0365","doi-asserted-by":"crossref","unstructured":"Salinas AJ, Esbrit P, Vallet-Reg\u00ed M. A tissue engineering approach based on the use of bioceramics for bone repair. Biomat Sci 2012; http:\/\/dx.doi.org\/10.1039\/c2bm00071g.","DOI":"10.1039\/C2BM00071G"},{"key":"10.1016\/j.bcp.2013.03.002_bib0370","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jcp.22986","article-title":"Constitutively active PTH\/PTHrP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation","volume":"227","author":"Ono","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.bcp.2013.03.002_bib0375","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1016\/j.biomaterials.2010.07.103","article-title":"The osteoinductive properties of mesoporous silicate coated with osteostatin in a rabbit femur cavity defect model","volume":"31","author":"Trejo","year":"2010","journal-title":"Biomaterials"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295213001585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295213001585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:33:44Z","timestamp":1539822824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295213001585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":75,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0006295213001585"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2013.03.002","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2013.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}