{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:19:23Z","timestamp":1778159963483,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.bcp.2013.06.006","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T11:02:02Z","timestamp":1371639722000},"page":"548-560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["7-Ketocholesterol induces P-glycoprotein through PI3K\/mTOR signaling in hepatoma cells"],"prefix":"10.1016","volume":"86","author":[{"given":"Sheng-Fan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Ching","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmal","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Jen","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie D.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Peter","family":"Guengerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Chen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Shan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yune-Fang","family":"Ueng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2013.06.006_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000086183","article-title":"Mechanisms of drug resistance in cancer chemotherapy","volume":"14","author":"Luqmani","year":"2005","journal-title":"Med Princ Pract"},{"issue":"Suppl. 4","key":"10.1016\/j.bcp.2013.06.006_bib0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1634\/theoncologist.2010-S4-42","article-title":"Treatment of intermediate\/advanced hepatocellular carcinoma in the clinic: how can outcomes be improved","volume":"15","author":"Lencioni","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.bcp.2013.06.006_bib0015","first-page":"531","article-title":"Chemosensitization of human hepatocellular carcinoma cells with cyclosporine A in poat-liver transplant patient plasma","volume":"2","author":"Tong","year":"1996","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bcp.2013.06.006_bib0020","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/jcp.49.6.470","article-title":"Expression of P-glycoprotein in hepatocellular carcinoma: a potential marker of prognosis","volume":"49","author":"Soini","year":"1994","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.bcp.2013.06.006_bib0025","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/1097-0142(19940115)73:2<298::AID-CNCR2820730211>3.0.CO;2-4","article-title":"Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma","volume":"73","author":"Itsubo","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2013.06.006_bib0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3835(02)00155-6","article-title":"MDR1 gene expression in hepatocellular carcinoma and the peritumoral liver of patients with and without cirrhosis","volume":"186","author":"Grud\u00e9","year":"2002","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2013.06.006_bib0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0168-8278(95)80429-3","article-title":"Overexpression of P-glycoprotein in adenomatous hyperplasia of human liver with cirrhosis","volume":"22","author":"Nagasue","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.bcp.2013.06.006_bib0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbrc.2006.12.202","article-title":"Cholesterol: coupling between membrane microenvironment and ABC transporter activity","volume":"354","author":"Meyer dos Santos","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2013.06.006_bib0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1440-1746.1992.tb01026.x","article-title":"Hypercholesterolaemia in patients with hepatocellular carcinoma","volume":"7","author":"Hwang","year":"1992","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.bcp.2013.06.006_bib0050","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1590\/S0100-879X2008000700001","article-title":"Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis","volume":"41","author":"Vejux","year":"2008","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.bcp.2013.06.006_bib0055","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/lt.20524","article-title":"High preoperative recipient plasma 7\u03b2-hydroxycholesterol is associated with initial poor graft function after liver transplantation","volume":"11","author":"Corradini","year":"2005","journal-title":"Liver Transplant"},{"key":"10.1016\/j.bcp.2013.06.006_bib0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1620\/tjem.140.245","article-title":"The regulating effect of cholesterol derivatives isolated from human sera on lymphocyte response to phytohemagglutinin","volume":"140","author":"Saito","year":"1983","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.bcp.2013.06.006_bib0065","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1530-0277.1990.tb00509.x","article-title":"Oxysterols and alcoholic liver disease","volume":"14","author":"Ryzlak","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.bcp.2013.06.006_bib0070","first-page":"549","article-title":"Uniformity of liver density and nonheme (storage) iron distribution","volume":"111","author":"Overmoyer","year":"1987","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.bcp.2013.06.006_bib0075","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/hep.21291","article-title":"Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol","volume":"44","author":"Hirayama","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.bcp.2013.06.006_bib0080","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.freeradbiomed.2006.12.013","article-title":"Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy","volume":"42","author":"Arca","year":"2007","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.bcp.2013.06.006_bib0085","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.bbagen.2006.08.003","article-title":"Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells","volume":"1760","author":"Rodrigues","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2013.06.006_bib0090","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1634\/stemcells.2004-0324","article-title":"Metabolic changes in mesenchymal stem cells in osteogenic medium measured by autofluorescence spectroscopy","volume":"245","author":"Reyes","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2013.06.006_bib0095","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1158\/0008-5472.CAN-04-3922","article-title":"Metabolic mapping of MCF10A human breast cells via multiphoton fluorescence lifetime imaging of the coenzyme NADH","volume":"65","author":"Bird","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2013.06.006_bib0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jhep.2006.08.018","article-title":"Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes","volume":"46","author":"Aly","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.bcp.2013.06.006_bib0105","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jconrel.2011.03.017","article-title":"Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7\/ADR cells","volume":"152","author":"Shieh","year":"2011","journal-title":"J Control Release"},{"key":"10.1016\/j.bcp.2013.06.006_bib0110","doi-asserted-by":"crossref","first-page":"39615","DOI":"10.1074\/jbc.M304095200","article-title":"Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1","volume":"278","author":"Lee","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.06.006_bib0115","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.toxlet.2008.12.007","article-title":"Suppressive effect of tobacco smoke extracts on oral P-glycoprotein function and its impact in smoke-induced insult to oral epidermal cells","volume":"185","author":"Pan","year":"2009","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bcp.2013.06.006_bib0120","doi-asserted-by":"crossref","first-page":"15826","DOI":"10.1074\/jbc.M808641200","article-title":"7-Ketocholesterol incorporation into sphingolipid\/cholesterol-enriched (lipid raft) domains is impaired by vitamin E","volume":"284","author":"Royer","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.06.006_bib0125","doi-asserted-by":"crossref","first-page":"33021","DOI":"10.1074\/jbc.M111.282434","article-title":"Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate","volume":"286","author":"Shinkyo","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.06.006_bib0130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","article-title":"Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2\u2032,7\u2032-dichlorofluorescein","volume":"47","author":"Rothe","year":"1990","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.bcp.2013.06.006_bib0135","doi-asserted-by":"crossref","first-page":"024016","DOI":"10.1117\/1.2718582","article-title":"Application of fluorescence resonance energy transfer resolved by fluorescence lifetime imaging microscopy for the detection of enterovirus 71 infection in cells","volume":"12","author":"Ghukasyan","year":"2007","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.bcp.2013.06.006_bib0140","first-page":"762","article-title":"Kinetic analysis of p-glycoprotein-mediated doxorubicin efflux","volume":"263","author":"Dordal","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2013.06.006_bib0145","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1021\/bi0506425","article-title":"The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I","volume":"44","author":"Massey","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2013.06.006_bib0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.placenta.2010.12.007","article-title":"Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors","volume":"32","author":"Aye","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.bcp.2013.06.006_bib0155","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cellsig.2010.11.002","article-title":"A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression","volume":"23","author":"Huwait","year":"2011","journal-title":"Cell Signal"},{"key":"10.1016\/j.bcp.2013.06.006_bib0160","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1038\/onc.2010.30","article-title":"Liver X receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells","volume":"29","author":"Pommier","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2013.06.006_bib0165","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cellsig.2006.12.003","article-title":"Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signaling","volume":"19","author":"Arcaro","year":"2007","journal-title":"Cell Signal"},{"key":"10.1016\/j.bcp.2013.06.006_bib0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-9150(01)00504-4","article-title":"7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells","volume":"159","author":"Phillips","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bcp.2013.06.006_bib0175","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.leukres.2008.06.010","article-title":"PI3K\/Akt inhibition modulates multidrug resistance and activates NF-\u03baB in murine lymphoma cell lines","volume":"33","author":"Garc\u00eda","year":"2009","journal-title":"Leukemia Res"},{"key":"10.1016\/j.bcp.2013.06.006_bib0180","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1158\/1535-7163.MCT-07-0148","article-title":"Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein","volume":"6","author":"Katayama","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bcp.2013.06.006_bib0185","doi-asserted-by":"crossref","first-page":"14056","DOI":"10.1074\/jbc.M700906200","article-title":"RAS\/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation","volume":"282","author":"Roux","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.06.006_bib0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/187152013804487380","article-title":"New insight into P-glycoprotein as a drug target","volume":"13","author":"Breier","year":"2013","journal-title":"Anti-cancer Agent Med Chem"},{"key":"10.1016\/j.bcp.2013.06.006_bib0195","first-page":"178","article-title":"Therapeutic implications of targeting the PI3Kinase\/AKT\/mTOR signaling module in melanoma therapy","volume":"2","author":"Jazirehi","year":"2012","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.bcp.2013.06.006_bib0200","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/carcin\/14.5.987","article-title":"p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines","volume":"14","author":"Hsu","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2013.06.006_bib0205","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1074\/jbc.M008495200","article-title":"Aromatic hydrocarbon receptor (AhR)-, AhR nuclear translocator- and p53-mediated induction of murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells","volume":"276","author":"Mathieu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2013.06.006_bib0210","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1053\/jhep.2001.24667","article-title":"Induction of Mdr1b expression by tumor necrosis factor-\u03b1 in rat liver cells is independent of p53 but requires NF-\u03baB signaling","volume":"33","author":"Ros","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.bcp.2013.06.006_bib0215","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1073\/pnas.1014769108","article-title":"Mammalian target of rapamycin up-regulation of pyruvate kinase type M2 is critical for aerobic glycolysis and tumor growth","volume":"108","author":"Sun","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bcp.2013.06.006_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.2717503","article-title":"In vivo multiphoton fluorescence lifetime imaging of protein-bound and free NADH in normal and pre-cancerous epithelia","volume":"12","author":"Skala","year":"2007","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.bcp.2013.06.006_bib0225","first-page":"1029","article-title":"On the origin of cancer cells","volume":"324","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bcp.2013.06.006_bib0230","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/jcb.22422","article-title":"Glycolytic pyruvate regulates p-glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state","volume":"109","author":"Wartenberg","year":"2010","journal-title":"J Cell Biochem"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295213003778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295213003778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:09:32Z","timestamp":1715530172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295213003778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0006295213003778"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2013.06.006","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"7-Ketocholesterol induces P-glycoprotein through PI3K\/mTOR signaling in hepatoma cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2013.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}