{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:07:46Z","timestamp":1791472066835,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"11","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bcp.2013.09.019","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T03:46:08Z","timestamp":1380685568000},"page":"1594-1602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development"],"prefix":"10.1016","volume":"86","author":[{"given":"Marco","family":"van der Stoep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaosha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Calpe-Berdiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"van der Sluis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peshtiwan","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.A.","family":"Korporaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo J.C.","family":"Van Berkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Van Eck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"Hoekstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcp.2013.09.019_bib0005","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.ajpath.2011.05.020","article-title":"Stage-specific remodeling of atherosclerotic lesions upon cholesterol lowering in LDL receptor knockout mice","volume":"179","author":"Zhao","year":"2011","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.bcp.2013.09.019_bib0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1067\/mva.2001.115963","article-title":"Dramatic remodeling of advanced atherosclerotic plaques of the apolipoprotein E-deficient mouse in a novel transplantation model","volume":"34","author":"Reis","year":"2001","journal-title":"J Vasc Surg"},{"issue":"5","key":"10.1016\/j.bcp.2013.09.019_bib0015","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1172\/JCI43802","article-title":"Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe\u2212\/\u2212 mice during disease regression","volume":"121","author":"Potteaux","year":"2011","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.bcp.2013.09.019_bib0020","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00109-011-0722-x","article-title":"Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies","volume":"89","author":"Van Craeyveld","year":"2011","journal-title":"J Mol Med (Berl)"},{"issue":"9","key":"10.1016\/j.bcp.2013.09.019_bib0025","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/CIRCULATIONAHA.110.984146","article-title":"Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques","volume":"123","author":"Feig","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bcp.2013.09.019_bib0030","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/01.ATV.0000152613.83243.12","article-title":"Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels","volume":"25","author":"Raffai","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"22","key":"10.1016\/j.bcp.2013.09.019_bib0035","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis","volume":"14","author":"Schultz","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.bcp.2013.09.019_bib0040","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/383728a0","article-title":"An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha","volume":"383","author":"Janowski","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2013.09.019_bib0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/01.ATV.0000152727.69018.61","article-title":"Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists","volume":"25","author":"Bradley","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.bcp.2013.09.019_bib0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling","volume":"116","author":"Zelcer","year":"2006","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.bcp.2013.09.019_bib0055","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.bcp.2008.11.026","article-title":"Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis","volume":"77","author":"Fievet","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.bcp.2013.09.019_bib0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.ATV.0000150044.84012.68","article-title":"Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists","volume":"25","author":"Levin","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.bcp.2013.09.019_bib0065","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1194\/jlr.M800374-JLR200","article-title":"LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms","volume":"50","author":"Verschuren","year":"2009","journal-title":"J Lipid Res"},{"issue":"12","key":"10.1016\/j.bcp.2013.09.019_bib0070","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1172\/JCI38911","article-title":"LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression","volume":"120","author":"Feig","year":"2010","journal-title":"J Clin Invest"},{"issue":"37","key":"10.1016\/j.bcp.2013.09.019_bib0075","doi-asserted-by":"crossref","first-page":"34182","DOI":"10.1074\/jbc.M204887200","article-title":"Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles","volume":"277","author":"Grefhorst","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.bcp.2013.09.019_bib0080","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1194\/jlr.M700254-JLR200","article-title":"The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential","volume":"49","author":"Zanotti","year":"2008","journal-title":"J Lipid Res"},{"issue":"5200","key":"10.1016\/j.bcp.2013.09.019_bib0085","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1126\/science.7863332","article-title":"Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation","volume":"267","author":"Linton","year":"1995","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.bcp.2013.09.019_bib0090","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1161\/01.ATV.17.11.3117","article-title":"Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis","volume":"17","author":"Van Eck","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.bcp.2013.09.019_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2011.03.001","article-title":"ATP binding cassette transporter A-I and HDL metabolism: effects of fatty acids","volume":"23","author":"Lee","year":"2012","journal-title":"J Nutr Biochem"},{"issue":"4","key":"10.1016\/j.bcp.2013.09.019_bib0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bcp.2005.11.004","article-title":"Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype","volume":"71","author":"Lund","year":"2006","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"10.1016\/j.bcp.2013.09.019_bib0105","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/01.ATV.20.10.2261","article-title":"Effect of macrophage-derived apolipoprotein E on established atherosclerosis in apolipoprotein E-deficient mice","volume":"20","author":"Shi","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.bcp.2013.09.019_bib0110","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/CIRCULATIONAHA.105.560177","article-title":"Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo","volume":"113","author":"Naik","year":"2006","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.bcp.2013.09.019_bib0115","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1161\/hc4501.098952","article-title":"Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content","volume":"104","author":"Rong","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bcp.2013.09.019_bib0120","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ajpath.2010.11.007","article-title":"The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice","volume":"178","author":"Ye","year":"2011","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1016\/j.bcp.2013.09.019_bib0125","doi-asserted-by":"crossref","first-page":"e28534","DOI":"10.1371\/journal.pone.0028534","article-title":"Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages","volume":"6","author":"Feig","year":"2011","journal-title":"PLoS One"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295213006242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295213006242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T04:24:52Z","timestamp":1564287892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295213006242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0006295213006242"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2013.09.019","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2013.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}