{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:02:45Z","timestamp":1787497365505,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 102-2320-B-038-047"],"award-info":[{"award-number":["NSC 102-2320-B-038-047"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan","award":["101TMU-WFH-01-4"],"award-info":[{"award-number":["101TMU-WFH-01-4"]}]},{"name":"Taipei Medical University, Taipei, Taiwan","award":["TMU-R-100-05"],"award-info":[{"award-number":["TMU-R-100-05"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.bcp.2014.02.004","type":"journal-article","created":{"date-parts":[[2014,2,16]],"date-time":"2014-02-16T09:46:25Z","timestamp":1392543985000},"page":"372-383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells"],"prefix":"10.1016","volume":"88","author":[{"given":"Yu-Fan","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Ling","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joen-Rong","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2014.02.004_bib0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1742-2094-8-26","article-title":"Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease","volume":"8","author":"Grammas","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.bcp.2014.02.004_bib0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2009.07.031","article-title":"The blood\u2013brain barrier and immune function and dysfunction","volume":"37","author":"Banks","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bcp.2014.02.004_bib0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12026-007-0069-0","article-title":"Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells","volume":"39","author":"Gioannini","year":"2007","journal-title":"Immunol Res"},{"key":"10.1016\/j.bcp.2014.02.004_bib0025","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1038\/sj.onc.1203286","article-title":"The role of cyclooxygenases in inflammation, cancer, and development","volume":"18","author":"Williams","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2014.02.004_bib0030","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1096\/fj.02-1078fje","article-title":"Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death","volume":"17","author":"Ejima","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.bcp.2014.02.004_bib0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"Dong","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0045","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.molimm.2011.08.026","article-title":"Coactivation of TLR4 and TLR2\/6 coordinates an additive augmentation on IL-6 gene transcription via p38MAPK pathway in U937 mononuclear cells","volume":"49","author":"Jin","year":"2011","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0050","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.bbagen.2011.08.015","article-title":"MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide","volume":"1810","author":"Hsu","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2014.02.004_bib0055","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1189\/jlb.1009668","article-title":"Apoptosis signal-regulating kinase 1 in peptidoglycan-induced COX-2 expression in macrophages","volume":"87","author":"Hsu","year":"2010","journal-title":"J Leukocyte Biol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0060","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/jpet.109.157438","article-title":"Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells","volume":"333","author":"Turpeinen","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bcp.2014.02.004_bib0065","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cellsig.2003.12.008","article-title":"Structure and regulation of MAPK phosphatases","volume":"16","author":"Farooq","year":"2004","journal-title":"Cell Signalling"},{"key":"10.1016\/j.bcp.2014.02.004_bib0070","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1084\/jem.20060336","article-title":"Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1","volume":"203","author":"Abraham","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.bcp.2014.02.004_bib0075","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1073\/pnas.0510965103","article-title":"Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses","volume":"103","author":"Chi","year":"2006","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2014.02.004_bib0080","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.4049\/jimmunol.0804343","article-title":"Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice","volume":"183","author":"Frazier","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0085","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1172\/JCI39054","article-title":"MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice","volume":"119","author":"Roth","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2014.02.004_bib0090","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd2289","article-title":"Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses","volume":"6","author":"Jeffrey","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bcp.2014.02.004_bib0095","doi-asserted-by":"crossref","first-page":"L622","DOI":"10.1152\/ajplung.00477.2005","article-title":"NF-kappa B activation as a pathological mechanism of septic shock and inflammation","volume":"290","author":"Liu","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0100","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.4049\/jimmunol.173.3.2011","article-title":"Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis","volume":"173","author":"Shishodia","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0105","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1074\/jbc.M207470200","article-title":"Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity","volume":"278","author":"Wu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0110","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.4049\/jimmunol.176.8.5015","article-title":"Histone hyperacetylation is associated with amelioration of experimental colitis in mice","volume":"176","author":"Glauben","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0163-7258(02)00299-1","article-title":"Lithium and valproic acid: parallels and contrasts in diverse signaling contexts","volume":"96","author":"Gurvich","year":"2002","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bcp.2014.02.004_bib0120","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0125","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuroscience.2012.07.013","article-title":"Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats","volume":"221","author":"Zhang","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2014.02.004_bib0130","article-title":"Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells","author":"Huang","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bcp.2014.02.004_bib0135","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2165\/00023210-200216100-00004","article-title":"Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience","volume":"16","author":"Perucca","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.bcp.2014.02.004_bib0140","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acid-mediated cellular differentiation","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2014.02.004_bib0145","doi-asserted-by":"crossref","first-page":"8111","DOI":"10.4049\/jimmunol.177.11.8111","article-title":"Cyclooxygenase-2 gene transcription in a macrophage model of inflammation","volume":"177","author":"Kang","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0150","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids--new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bcp.2014.02.004_bib0155","doi-asserted-by":"crossref","first-page":"26803","DOI":"10.1074\/jbc.M109.028381","article-title":"Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK","volume":"284","author":"King","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0160","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1084\/jem.20071728","article-title":"Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling","volume":"205","author":"Cao","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.bcp.2014.02.004_bib0165","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/med.10017","article-title":"Anti-tumor mechanisms of valproate: a novel role for an old drug","volume":"22","author":"Blaheta","year":"2002","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bcp.2014.02.004_bib0170","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2007.06.053","article-title":"Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity","volume":"149","author":"Chen","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2014.02.004_bib0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2174\/138945010790711923","article-title":"Valproic acid in the complex therapy of malignant tumors","volume":"11","author":"Hrebackova","year":"2010","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.bcp.2014.02.004_bib0180","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.nbd.2007.02.006","article-title":"Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation","volume":"26","author":"Sinn","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bcp.2014.02.004_bib0185","doi-asserted-by":"crossref","first-page":"7802","DOI":"10.1128\/MCB.22.22.7802-7811.2002","article-title":"Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38","volume":"22","author":"Lasa","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0190","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4049\/jimmunol.176.3.1899","article-title":"Essential role of MAPK phosphatase-1 in the negative control of innate immune responses","volume":"176","author":"Salojin","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0195","doi-asserted-by":"crossref","first-page":"7366","DOI":"10.4049\/jimmunol.178.11.7366","article-title":"Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells","volume":"178","author":"Issa","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-811X-11-8","article-title":"Up-regulation of COX-2\/PGE2 by endothelin-1 via MAPK-dependent NF-kappaB pathway in mouse brain microvascular endothelial cells","volume":"11","author":"Lin","year":"2013","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.bcp.2014.02.004_bib0205","doi-asserted-by":"crossref","first-page":"L614","DOI":"10.1152\/ajplung.00215.2002","article-title":"Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells","volume":"284","author":"Chen","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0210","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.yexcr.2005.06.022","article-title":"Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK","volume":"309","author":"Liu","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.bcp.2014.02.004_bib0215","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/sj.cdd.4401759","article-title":"Valproic acid induces extracellular signal-regulated kinase 1\/2 activation and inhibits apoptosis in endothelial cells","volume":"13","author":"Michaelis","year":"2006","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bcp.2014.02.004_bib0220","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1074\/jbc.M411200200","article-title":"Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival","volume":"280","author":"Wu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0225","doi-asserted-by":"crossref","first-page":"16461","DOI":"10.1074\/jbc.M501762200","article-title":"Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling","volume":"280","author":"Wu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0230","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nri2035","article-title":"MAPK phosphatases\u2014regulating the immune response","volume":"7","author":"Liu","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bcp.2014.02.004_bib0235","doi-asserted-by":"crossref","first-page":"35212","DOI":"10.1074\/jbc.M112.400671","article-title":"Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1)","volume":"287","author":"Vollmer","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0240","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/mc.20652","article-title":"Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion","volume":"49","author":"Lin","year":"2010","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.bcp.2014.02.004_bib0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/nar\/gks916","article-title":"The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-kappaB","volume":"41","author":"Ziesche","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bcp.2014.02.004_bib0250","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1062374","article-title":"Duration of nuclear NF-kappaB action regulated by reversible acetylation","volume":"293","author":"Chen","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bcp.2014.02.004_bib0255","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pupt.2012.05.003","article-title":"Smoke exposure of human macrophages reduces HDAC3 activity, resulting in enhanced inflammatory cytokine production","volume":"25","author":"Winkler","year":"2012","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.bcp.2014.02.004_bib0260","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1046\/j.1471-4159.2003.01701.x","article-title":"Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain","volume":"85","author":"Bosetti","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0265","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1042\/BST0360543","article-title":"Complexity of COX-2 gene regulation","volume":"36","author":"Harper","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.bcp.2014.02.004_bib0270","doi-asserted-by":"crossref","first-page":"32992","DOI":"10.1074\/jbc.M203218200","article-title":"Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA","volume":"277","author":"Monick","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.02.004_bib0275","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1074\/jbc.M710137200","article-title":"Two distinct pathways for cyclooxygenase-2 protein degradation","volume":"283","author":"Mbonye","year":"2008","journal-title":"J Biol Chem"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295214000987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295214000987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T07:52:41Z","timestamp":1597477961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295214000987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0006295214000987"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2014.02.004","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2014.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}