{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:12:07Z","timestamp":1791331927960,"version":"4.3.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000350","name":"Core","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bcp.2014.07.035","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:36:37Z","timestamp":1411346197000},"page":"299-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks"],"prefix":"10.1016","volume":"92","author":[{"given":"Anne","family":"Tr\u00e9cul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Morceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthoula","family":"Gaigneaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schnekenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Diederich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2014.07.035_bib0005","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0278-5846(82)80172-3","article-title":"Sodium valproate: kinetic profile and effects on GABA levels in various brain areas of the rat","volume":"6","author":"Mesdjian","year":"1982","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bcp.2014.07.035_bib0010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1528-1157.1986.tb03525.x","article-title":"Valproate reduces excitability by blockage of sodium and potassium conductance","volume":"27","author":"VanDongen","year":"1986","journal-title":"Epilepsia"},{"key":"10.1016\/j.bcp.2014.07.035_bib0015","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.bcp.2014.07.035_bib0020","first-page":"2010","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","author":"Chateauvieux","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0025","series-title":"Encyclopedia of Toxicology","first-page":"905","article-title":"Valproic Acid","author":"Chateauvieux","year":"2014"},{"key":"10.1016\/j.bcp.2014.07.035_bib0030","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/088307380001500713","article-title":"Temporary pure red-cell aplasia during valproate monotherapy: clinical observations and spectral electroencephalographic aspects","volume":"15","author":"Farkas","year":"2000","journal-title":"J Child Neurol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0035","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1528-1167.2006.00587.x","article-title":"Valproate-associated coagulopathies are frequent and variable in children","volume":"47","author":"Gerstner","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.bcp.2014.07.035_bib0040","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/j.1528-1167.2006.00596.x","article-title":"Risk of aplastic anemia in patients using antiepileptic drugs","volume":"47","author":"Handoko","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.bcp.2014.07.035_bib0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/08880010390158496","article-title":"Increase of fetal hemoglobin synthesis indicating differentiation induction in children receiving valproic acid","volume":"20","author":"Kieslich","year":"2003","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0050","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1371\/journal.pmed.0010051","article-title":"Pure red cell aplasia after 13 years of sodium valproate, and bone marrow suppression after 17 years of carbamazepine","volume":"1","author":"The","year":"2004","journal-title":"PLoS Med"},{"key":"10.1016\/j.bcp.2014.07.035_bib0055","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bcp.2010.11.011","article-title":"Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway","volume":"81","author":"Chateauvieux","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0060","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bcp.2011.06.045","article-title":"Erythropoietin, erythropoiesis and beyond","volume":"82","author":"Chateauvieux","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0065","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1128\/MCB.25.4.1215-1227.2005","article-title":"GATA1 function, a paradigm for transcription factors in hematopoiesis","volume":"25","author":"Ferreira","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1196\/annals.1329.064","article-title":"GATA-1: friends, brothers, and coworkers","volume":"1030","author":"Morceau","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.bcp.2014.07.035_bib0075","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1182\/blood.V96.8.2641","article-title":"PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding","volume":"96","author":"Zhang","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2014.07.035_bib0080","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000065660","article-title":"Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage","volume":"108","author":"Ohneda","year":"2002","journal-title":"Acta Haematol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0085","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood.V89.10.3636","article-title":"Transcription factor GATA-2 is required for proliferation\/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation","volume":"89","author":"Tsai","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2014.07.035_bib0090","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1128\/MCB.00482-09","article-title":"GATA-2 reinforces megakaryocyte development in the absence of GATA-1","volume":"29","author":"Huang","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0095","doi-asserted-by":"crossref","first-page":"14744","DOI":"10.3390\/ijms140714744","article-title":"Long and short non-coding RNAs as regulators of hematopoietic differentiation","volume":"14","author":"Morceau","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bcp.2014.07.035_bib0100","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/ajh.21863","article-title":"MicroRNAs: emerging key regulators of hematopoiesis","volume":"85","author":"Havelange","year":"2010","journal-title":"Am J Hematol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0105","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1038\/leu.2012.137","article-title":"MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment","volume":"26","author":"Zhang","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2014.07.035_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2217\/epi.11.104","article-title":"Involvement of miRNA in erythroid differentiation","volume":"4","author":"Bianchi","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.bcp.2014.07.035_bib0115","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1073\/pnas.0712312105","article-title":"A GATA-1-regulated microRNA locus essential for erythropoiesis","volume":"105","author":"Dore","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bcp.2014.07.035_bib0120","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.7314\/APJCP.2013.14.6.3631","article-title":"MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k\/Akt pathway","volume":"14","author":"Li","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.bcp.2014.07.035_bib0125","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2010.08.074","article-title":"MiRNA-451 plays a role as tumor suppressor in human glioma cells","volume":"1359","author":"Nan","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0130","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/carcin\/bgt206","article-title":"miR-451 inhibits cell proliferation in human hepatocellular carcinoma through direct suppression of IKK-beta","volume":"34","author":"Li","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2014.07.035_bib0135","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1084\/jem.20102384","article-title":"Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL","volume":"208","author":"Li","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.bcp.2014.07.035_bib0140","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1074\/jbc.M110.177063","article-title":"NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155\/PU.1 pathway","volume":"286","author":"Thompson","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.07.035_bib0145","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1365-2141.2008.07382.x","article-title":"Marziali G. MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors","volume":"143","author":"Romania","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0150","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1073\/pnas.0811466106","article-title":"A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis","volume":"106","author":"Ben-Ami","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bcp.2014.07.035_bib0155","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1593\/neo.10482","article-title":"Down-regulation of microRNAs 222\/221 in acute myelogenous leukemia with deranged core-binding factor subunits","volume":"12","author":"Brioschi","year":"2010","journal-title":"Neoplasia"},{"key":"10.1016\/j.bcp.2014.07.035_bib0160","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/nar\/gkt848","article-title":"A regulatory circuit comprising GATA1\/2 switch and microRNA-27a\/24 promotes erythropoiesis","volume":"42","author":"Wang","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0165","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.leu.2401689","article-title":"FLI-1 is a suppressor of erythroid differentiation in human hematopoietic cells","volume":"14","author":"Athanasiou","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2014.07.035_bib0170","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1182\/blood-2011-09-380634","article-title":"Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis","volume":"119","author":"Dore","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2014.07.035_bib0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(00)00017-0","article-title":"Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia","volume":"13","author":"Hart","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2014.07.035_bib0180","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1182\/blood-2006-04-019760","article-title":"Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins","volume":"108","author":"Pang","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2014.07.035_bib0185","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bcp.2011.03.030","article-title":"Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1\/GATA-2 balance impairment and PU.1 over-expression","volume":"82","author":"Grigorakaki","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0190","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acid-mediated cellular differentiation","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0195","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.yexcr.2006.01.017","article-title":"HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers","volume":"312","author":"Vulcano","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0200","doi-asserted-by":"crossref","first-page":"e84515","DOI":"10.1371\/journal.pone.0084515","article-title":"Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2014.07.035_bib0205","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with \u2018mini-extracts\u2019, prepared from a small number of cells","volume":"17","author":"Schreiber","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0210","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1471-4159.2010.06612.x","article-title":"Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription","volume":"113","author":"Nunes","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.bcp.2014.07.035_bib0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.canlet.2013.06.023","article-title":"Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3\/STAT5 inactivation and apoptosis induction in human leukemia cells","volume":"340","author":"Trecul","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bcp.2014.07.035_bib0220","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0006-2952(95)02240-6","article-title":"Evidence for distinct regulation processes in the aclacinomycin- and doxorubicin-mediated differentiation of human erythroleukemic cells","volume":"51","author":"Morceau","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0225","first-page":"1023","article-title":"Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells","volume":"7","author":"Morceau","year":"1996","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.bcp.2014.07.035_bib0230","doi-asserted-by":"crossref","first-page":"31087","DOI":"10.1074\/jbc.R110.159079","article-title":"GATA switches as developmental drivers","volume":"285","author":"Bresnick","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.07.035_bib0235","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.1565607","article-title":"A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway","volume":"21","author":"O\u2018Carroll","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.bcp.2014.07.035_bib0240","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature09092","article-title":"A dicer-independent miRNA biogenesis pathway that requires Ago catalysis","volume":"465","author":"Cheloufi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2014.07.035_bib0245","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.bcp.2008.08.025","article-title":"Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation","volume":"76","author":"Buck","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0250","first-page":"853","article-title":"The inhibitory effect of the proinflammatory cytokine TNFalpha on erythroid differentiation involves erythroid transcription factor modulation","volume":"34","author":"Buck","year":"2009","journal-title":"Int J Oncol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0255","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.biocel.2005.06.017","article-title":"GATA-1: one protein, many partners","volume":"38","author":"Lowry","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0260","doi-asserted-by":"crossref","first-page":"16334","DOI":"10.1074\/jbc.M109.011601","article-title":"MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)","volume":"284","author":"Martinez-Nunez","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.07.035_bib0265","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"Vigorito","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2014.07.035_bib0270","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1038\/sj.emboj.7600834","article-title":"PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure","volume":"24","author":"Stopka","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.bcp.2014.07.035_bib0275","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/25166","article-title":"Regulation of activity of the transcription factor GATA-1 by acetylation","volume":"396","author":"Boyes","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2014.07.035_bib0280","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1128\/MCB.19.5.3496","article-title":"CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites","volume":"19","author":"Hung","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0285","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.leukres.2007.03.012","article-title":"Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia","volume":"31","author":"Cheng","year":"2007","journal-title":"Leuk Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0290","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jhep.2004.10.020","article-title":"Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357","volume":"42","author":"Armeanu","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0295","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2119\/2007-00084.Bokelmann","article-title":"Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins","volume":"14","author":"Bokelmann","year":"2008","journal-title":"Mol Med"},{"key":"10.1016\/j.bcp.2014.07.035_bib0300","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.exphem.2010.03.019","article-title":"A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis","volume":"38","author":"Liu","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0305","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/dvdy.23906","article-title":"Regulation of primitive hematopoiesis by class I histone deacetylases","volume":"242","author":"Shah","year":"2013","journal-title":"Dev Dyn"},{"key":"10.1016\/j.bcp.2014.07.035_bib0310","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.exphem.2005.08.007","article-title":"Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo","volume":"33","author":"Cao","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0315","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10577-008-9005-y","article-title":"Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation","volume":"17","author":"Popova","year":"2009","journal-title":"Chromosome Res"},{"key":"10.1016\/j.bcp.2014.07.035_bib0320","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.exphem.2012.02.004","article-title":"Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation","volume":"40","author":"Iancu-Rubin","year":"2012","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bcp.2014.07.035_bib0325","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/ajh.20676","article-title":"Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin","volume":"81","author":"Cao","year":"2006","journal-title":"Am J Hematol"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295214005267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295214005267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T19:40:29Z","timestamp":1717357229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295214005267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0006295214005267"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2014.07.035","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2014.07.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}