{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:59:22Z","timestamp":1773176362897,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Departamento de Educaci\u00f3n, Universidades e Investigaci\u00f3n del Gobierno Vasco (GV\/EJ, Spain)","award":["IT-705-13"],"award-info":[{"award-number":["IT-705-13"]}]},{"name":"Departamento de Industria, Comercio y Turismo del Gobierno Vasco (Basque Government, GV\/EJ, Spain)","award":["S-PE12UN040"],"award-info":[{"award-number":["S-PE12UN040"]}]},{"name":"Departamento de Industria, Comercio y Turismo del Gobierno Vasco (Basque Government, GV\/EJ, Spain)","award":["S-PE13UN017"],"award-info":[{"award-number":["S-PE13UN017"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.bcp.2014.10.005","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T09:31:25Z","timestamp":1413624685000},"page":"642-650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration"],"prefix":"10.1016","volume":"92","author":[{"given":"Alberto","family":"Ouro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lide","family":"Arana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Io-Guan\u00e9","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ordo\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gomez-Larrauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Presa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Trueba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Gangoiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bittman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gomez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2014.10.005_bib0005","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jbior.2013.08.006","article-title":"Phosphatidic acid, phospholipase D and tumorigenesis","volume":"54C","author":"Gomez-Cambronero","year":"2014","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.bcp.2014.10.005_bib0010","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/boc.201300011","article-title":"Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays","volume":"105","author":"Willier","year":"2013","journal-title":"Biol Cell"},{"key":"10.1016\/j.bcp.2014.10.005_bib0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1165\/rcmb.2010-0019OC","article-title":"An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils","volume":"44","author":"Sitrin","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.bcp.2014.10.005_bib0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nri2974","article-title":"The outs and the ins of sphingosine-1-phosphate in immunity","volume":"11","author":"Spiegel","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bcp.2014.10.005_bib0025","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.plipres.2010.02.004","article-title":"Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease","volume":"49","author":"Gangoiti","year":"2010","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cellsig.2008.11.003","article-title":"Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor","volume":"21","author":"Granado","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.bcp.2014.10.005_bib0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1152\/ajpendo.00480.2012","article-title":"Ceramide 1-phosphate (C1P) induces macrophage chemoattractant protein-1 release: involvement in C1P-stimulated cell migration","volume":"304","author":"Arana","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.bcp.2014.10.005_bib0040","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/mi.5.6.8","article-title":"Ceramide-1-phosphate: the missing\u201d link in eicosanoid biosynthesis and inflammation","volume":"5","author":"Lamour","year":"2005","journal-title":"Mol Interv"},{"key":"10.1016\/j.bcp.2014.10.005_bib0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.imlet.2004.09.001","article-title":"The role of sphingosine and ceramide kinases in inflammatory responses","volume":"96","author":"Baumruker","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1016\/j.bcp.2014.10.005_bib0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/978-1-4419-6741-1_8","article-title":"Ceramide-1-phosphate in cell survival and inflammatory signaling","author":"Gomez-Munoz","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bcp.2014.10.005_bib0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.prostaglandins.2007.11.002","article-title":"Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages","volume":"85","author":"Hammad","year":"2008","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.bcp.2014.10.005_bib0060","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcb.2011.09.003","article-title":"Sphingosine-1-phosphate signaling and its role in disease","volume":"22","author":"Maceyka","year":"2012","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.bcp.2014.10.005_bib0065","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1194\/jlr.D008532","article-title":"Blood sphingolipidomics in healthy humans: impact of sample collection methodology","volume":"51","author":"Hammad","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0070","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/stem.1291","article-title":"Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells\u2014implications for tissue regeneration","volume":"31","author":"Kim","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2014.10.005_bib0075","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1757-2215-6-95","article-title":"Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy","volume":"6","author":"Ratajczak","year":"2013","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0080","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1021\/jo902076w","article-title":"Caged ceramide 1-phosphate analogues: synthesis and properties","volume":"74","author":"Lankalapalli","year":"2009","journal-title":"J Org Chem"},{"key":"10.1016\/j.bcp.2014.10.005_bib0085","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.cellsig.2007.12.008","article-title":"Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase\/PKB, JNK and ERK1\/2 pathways","volume":"20","author":"Gangoiti","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.bcp.2014.10.005_bib0090","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0026-895X(25)08599-2","article-title":"Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides","volume":"47","author":"Gomez-Munoz","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bcp.2014.10.005_bib0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1194\/jlr.M300158-JLR200","article-title":"Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages","volume":"45","author":"Gomez-Munoz","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0100","doi-asserted-by":"crossref","first-page":"14917","DOI":"10.1016\/S0021-9258(18)77204-9","article-title":"Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin","volume":"265","author":"Dressler","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.10.005_bib0105","doi-asserted-by":"crossref","first-page":"24399","DOI":"10.1074\/jbc.M209179200","article-title":"Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels","volume":"278","author":"Hundal","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.10.005_bib0110","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.2000.2111","article-title":"Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid","volume":"268","author":"Sliva","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bcp.2014.10.005_bib0115","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1081\/CNV-100107739","article-title":"Effect of phosphatidic acid on human breast cancer cells exposed to doxorubicin","volume":"19","author":"Sliva","year":"2001","journal-title":"Cancer Invest"},{"key":"10.1016\/j.bcp.2014.10.005_bib0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/01902148.2012.719282","article-title":"Phospholipase D participates in H(2)O(2)-induced A549 alveolar epithelial cell migration","volume":"38","author":"Shao","year":"2012","journal-title":"Exp Lung Res"},{"issue":"Suppl.","key":"10.1016\/j.bcp.2014.10.005_bib0125","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1194\/jlr.R800055-JLR200","article-title":"Lipid phosphate phosphatases and signaling","volume":"50","author":"Brindley","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0130","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1016\/S0006-3495(96)79454-7","article-title":"Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes","volume":"71","author":"Leikin","year":"1996","journal-title":"Biophys J"},{"key":"10.1016\/j.bcp.2014.10.005_bib0135","doi-asserted-by":"crossref","first-page":"45117","DOI":"10.1074\/jbc.M303789200","article-title":"Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway","volume":"278","author":"Lim","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.10.005_bib0140","doi-asserted-by":"crossref","first-page":"36636","DOI":"10.1074\/jbc.M804633200","article-title":"Role of phosphatidic acid in the coupling of the ERK cascade","volume":"283","author":"Kraft","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.10.005_bib0145","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-5793(02)03483-X","article-title":"The role of phosphatidic acid in the regulation of the Ras\/MEK\/Erk signaling cascade","volume":"531","author":"Andresen","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2014.10.005_bib0150","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbalip.2013.02.001","article-title":"New insights on the role of ceramide 1-phosphate in inflammation","volume":"1831","author":"Gomez-Munoz","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bcp.2014.10.005_bib0155","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.biochi.2011.09.009","article-title":"Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts","volume":"94","author":"Gangoiti","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.bcp.2014.10.005_bib0160","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1016\/j.febslet.2005.05.067","article-title":"Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase\/protein kinase B pathway","volume":"579","author":"Gomez-Munoz","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bcp.2014.10.005_bib0165","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/leu.2011.185","article-title":"Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors","volume":"26","author":"Kim","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2014.10.005_bib0170","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1089\/scd.2012.0488","article-title":"Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction","volume":"22","author":"Karapetyan","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.bcp.2014.10.005_bib0175","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1194\/jlr.M048207","article-title":"Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts","volume":"55","author":"Wijesinghe","year":"2014","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0180","doi-asserted-by":"crossref","first-page":"e102526","DOI":"10.1371\/journal.pone.0102526","article-title":"Visualization of phosphatidic acid fluctuations in the plasma membrane of living cells","volume":"9","author":"Ferraz-Nogueira","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bcp.2014.10.005_bib0185","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1128\/MCB.00121-12","article-title":"Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12\/CXCR4 pathway","volume":"32","author":"Asano","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bcp.2014.10.005_bib0190","doi-asserted-by":"crossref","first-page":"8517","DOI":"10.1074\/jbc.M707107200","article-title":"Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin","volume":"283","author":"Boath","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2014.10.005_bib0195","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1194\/jlr.M700083-JLR200","article-title":"Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis","volume":"48","author":"Lamour","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0200","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1158\/0008-5472.CAN-04-1853","article-title":"Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1\/epidermal growth factor paracrine loop","volume":"65","author":"Goswami","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0205","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0022-2275(20)31669-2","article-title":"GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex","volume":"42","author":"Deeg","year":"2001","journal-title":"J Lipid Res"},{"key":"10.1016\/j.bcp.2014.10.005_bib0210","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1091\/mbc.E03-09-0673","article-title":"Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis","volume":"15","author":"Du","year":"2004","journal-title":"Mol Biol Cell"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295214005905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295214005905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T06:16:20Z","timestamp":1746425780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295214005905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0006295214005905"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2014.10.005","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2014.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}