{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:49:13Z","timestamp":1787971753006,"version":"build-2784847793"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Instituto de Salud Carlos"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.bcp.2015.12.012","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T14:18:05Z","timestamp":1450534685000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":154,"special_numbering":"C","title":["Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-1545","authenticated-orcid":false,"given":"Sergio","family":"Portal-N\u00fa\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Esbrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Alcaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-2944","authenticated-orcid":false,"given":"Raquel","family":"Largo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2015.12.012_bib0005","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bcp.2015.12.012_bib0010","series-title":"Osteoarthritis: Pathogenesis, Clinical Aspects and Diagnosis","author":"Sellam","year":"2009"},{"key":"10.1016\/j.bcp.2015.12.012_bib0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semarthrit.2009.03.006","article-title":"Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics","volume":"39","author":"Herrero-Beaumont","year":"2009","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22203\/eCM.v021a16","article-title":"Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis","volume":"21","author":"Goldring","year":"2011","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bcp.2015.12.012_bib0025","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0030","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.joca.2009.03.002","article-title":"Aging and Osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix","volume":"17","author":"Loeser","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0035","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0040","doi-asserted-by":"crossref","first-page":"20560","DOI":"10.3390\/ijms160920560","article-title":"Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis","volume":"16","author":"Musumeci","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2015.12.012_bib0045","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.maturitas.2014.12.003","article-title":"Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis","volume":"80","author":"Mobasheri","year":"2015","journal-title":"Maturitas"},{"key":"10.1016\/j.bcp.2015.12.012_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7243\/2055-091X-2-1","article-title":"Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes","volume":"30","author":"Musumeci","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0055","first-page":"1","article-title":"Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis","volume":"21","author":"Martin","year":"2001","journal-title":"Iowa Orthop. J."},{"key":"10.1016\/j.bcp.2015.12.012_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/rheumatology\/ket247","article-title":"Osteoarthritis: a progressive disease with changing phenotypes","volume":"53","author":"Casta\u00f1eda","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bcp.2015.12.012_bib0065","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrrheum.2013.113","article-title":"Osteoarthritis: osteoporotic OA: a reasonable target for bone-acting agents","volume":"9","author":"Herrero-Beaumont","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40266-015-0243-3","article-title":"Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis","volume":"32","author":"Bruy\u00e8re","year":"2015","journal-title":"Drugs Aging"},{"key":"10.1016\/j.bcp.2015.12.012_bib0075","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1517\/13543784.2015.1091880","article-title":"Investigational drugs for the treatment of osteoarthritis","volume":"24","author":"Wang","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bcp.2015.12.012_bib0080","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2174\/138161209789058110","article-title":"An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging","volume":"15","author":"De la Fuente","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bcp.2015.12.012_bib0085","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10522-009-9234-2","article-title":"Origin and evolution of the free radical theory of aging: a brief personal history, 1954\u20132009","volume":"10","author":"Harman","year":"2009","journal-title":"Biogerontology"},{"key":"10.1016\/j.bcp.2015.12.012_bib0090","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0531-5565(80)90010-8","article-title":"Mitochondrial role in cell aging","volume":"15","author":"Miquel","year":"1980","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0095","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joca.2005.04.002","article-title":"Oxygen and reactive oxygen species in cartilage degradation: friends or foes?","volume":"13","author":"Henrotin","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrrheum.2014.162","article-title":"Emerging regulators of the inflammatory process in osteoarthritis","volume":"11","author":"Liu-Bryan","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0105","doi-asserted-by":"crossref","first-page":"31156","DOI":"10.1074\/jbc.M501069200","article-title":"Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0110","first-page":"CR238","article-title":"Oxidative equilibrium in the prophylaxis of degenerative joint changes: an analysis of pre- and postoperative activity of antioxidant enzymes in patients with hip and knee osteoarthritis","volume":"16","author":"Olszewska-S\u0142onina","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bcp.2015.12.012_bib0115","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1136\/ard.2009.119966","article-title":"Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease","volume":"69","author":"Scott","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bcp.2010.02.017","article-title":"New molecular targets for the treatment of osteoarthritis","volume":"80","author":"Alcaraz","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0125","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/cs1010593","article-title":"Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis","volume":"101","author":"Mazzetti","year":"2001","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bcp.2015.12.012_bib0130","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00002281-200309000-00016","article-title":"AGEing and osteoarthritis: a different perspective","volume":"15","author":"Verzijl","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11926-001-0069-3","article-title":"Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis","volume":"3","author":"Abramson","year":"2001","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bcp.2015.12.012_bib0140","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage."},{"key":"10.1016\/j.bcp.2015.12.012_bib0145","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1139\/y11-055","article-title":"Physiology and pathophysiology of nitrosative and oxidative stress in osteoarthritic joint destruction","volume":"89","author":"Ziskoven","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0150","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/eji.201040868","article-title":"Modulation of human T-cell functions by reactive nitrogen species","volume":"41","author":"Kasic","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0155","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-\u03baB signaling: multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bcp.2015.12.012_bib0160","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1084\/jem.20062525","article-title":"Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification","volume":"204","author":"Morita","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2015.12.012_bib0165","doi-asserted-by":"crossref","first-page":"31972","DOI":"10.1074\/jbc.M109.056838","article-title":"Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways","volume":"284","author":"Yin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0170","doi-asserted-by":"crossref","first-page":"14100","DOI":"10.1074\/jbc.M601820200","article-title":"Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs","volume":"281","author":"Nelson","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0175","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tig.2008.10.002","article-title":"Autophagy and aging: keeping that old broom working","volume":"24","author":"Cuervo","year":"2008","journal-title":"Trends Genet."},{"key":"10.1016\/j.bcp.2015.12.012_bib0180","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1242\/jcs.064576","article-title":"The regulation of autophagy\u2014unanswered questions","volume":"124","author":"Chen","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bcp.2015.12.012_bib0185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.bcp.2015.12.012_bib0190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000129697","article-title":"Senescence, apoptosis or autophagy? When a damaged cell must decide its path\u2014a mini-review","volume":"54","author":"Vicencio","year":"2008","journal-title":"Gerontology"},{"key":"10.1016\/j.bcp.2015.12.012_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2015.09.021","article-title":"Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation","author":"Mattiolo","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0200","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00418-008-0406-y","article-title":"Autophagy\u2013physiology and pathophysiology","volume":"129","author":"Uchiyama","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0205","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4161\/auto.26679","article-title":"Boning up on autophagy: the role of autophagy in skeletal biology","volume":"10","author":"Shapiro","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2015.12.012_bib0210","doi-asserted-by":"crossref","first-page":"12297","DOI":"10.1074\/jbc.M900573200","article-title":"ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy","volume":"284","author":"Ganley","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0215","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrrheum.2011.109","article-title":"Autophagy and cartilage homeostasis mechanism in joint health, aging and osteoarthritis","volume":"7","author":"Lotz","year":"2012","journal-title":"Nat Rev Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0220","doi-asserted-by":"crossref","first-page":"398483","DOI":"10.1155\/2015\/398483","article-title":"Cellular and molecular connections between autophagy and inflammation","volume":"2015","author":"Lapaquette","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bcp.2015.12.012_bib0225","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.redox.2014.12.010","article-title":"Autophagy in lung disease pathogenesis and therapeutics","volume":"4","author":"Ryter","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0230","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"Rubinsztein","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2015.12.012_bib0235","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI73946","article-title":"Essential role for autophagy in life span extension","volume":"125","author":"Madeo","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2015.12.012_bib0240","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.27305","article-title":"Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis","volume":"62","author":"Caram\u00e9s","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0245","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10495-010-0458-z","article-title":"Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model","volume":"15","author":"Almonte-Becerril","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2015.12.012_bib0250","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/art.24444","article-title":"Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy","volume":"60","author":"Bohensky","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0255","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/art.39073","article-title":"The relationship of autophagy defects to cartilage damage during joint aging in a mouse model","volume":"67","author":"Caram\u00e9s","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0260","article-title":"Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis","author":"Bouderlique","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0265","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/art.33444","article-title":"Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection","volume":"64","author":"Caram\u00e9s","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0270","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/art.34323","article-title":"Autophagy modulates osteoarthritis-related gene expression in human chondrocytes","volume":"64","author":"Sasaki","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0275","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10495-013-0811-0","article-title":"Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation","volume":"18","author":"Zhang","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2015.12.012_bib0280","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2015.12.012_bib0285","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nbt.1678","article-title":"Epigenetic modifications as therapeutic targets","volume":"28","author":"Kelly","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0290","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/acel.12349","article-title":"DNA methylation and healthy human aging","volume":"14","author":"Jones","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0295","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bcp.2015.12.012_bib0300","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.21300","article-title":"Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions","volume":"52","author":"Roach","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0305","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.joca.2008.09.006","article-title":"DNA methylation is not responsible for p21WAF1\/CIP1 down-regulation in osteoarthritic chondrocytes","volume":"17","author":"Sesselmann","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0310","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1136\/annrheumdis-2014-205980","article-title":"Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches","volume":"73","author":"den Hollander","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0315","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/art.38762","article-title":"Genome-wide dna methylation s tudy identifies significant epigenomic changes in osteoarthritic cartilage","volume":"66","author":"Jeffries","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0320","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/jor.22722","article-title":"Epigenetic differences in human cartilage between mild and severe OA","volume":"32","author":"Moazedi-Fuerst","year":"2014","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0325","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1002\/art.38713","article-title":"Characterization of the cartilage DNA methylome in knee and hip osteoarthritis","volume":"66","author":"Rushton","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0330","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/art.39162","article-title":"Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage","volume":"67","author":"den Hollander","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0335","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1002\/art.24882","article-title":"DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes","volume":"60","author":"Hashimoto","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0340","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1074\/jbc.M113.512269","article-title":"Modulation of ten-eleven translocation 1 (TET1), tsocitrate dehydrogenase (IDH) expression, \u03b1-ketoglutarate (\u03b1-KG), and DNA hydroxymethylation levels by interleukin-1\u03b2 in primary human chondrocytes","volume":"289","author":"Haseeb","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0345","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.joca.2015.02.168","article-title":"Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis","volume":"23","author":"Takahashi","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0350","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.37806","article-title":"Loss of methylation in CpG sites in the NF-\u03baB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes","volume":"65","author":"de Andr\u00e9s","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0355","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1002\/art.38774","article-title":"Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation","volume":"66","author":"Imagawa","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0360","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/ard.2004.022509","article-title":"DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage","volume":"64","author":"P\u00f6schl","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0365","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00439-014-1447-z","article-title":"CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383","volume":"133","author":"Reynard","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bcp.2015.12.012_bib0370","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0375","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/art.27762","article-title":"Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes","volume":"63","author":"El Mansouri","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0380","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/jbmr.397","article-title":"Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation","volume":"26","author":"Rodova","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0385","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/jbmr.1843","article-title":"Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage","volume":"28","author":"Kim","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0390","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1136\/ard.2007.069377","article-title":"Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention","volume":"66","author":"Iliopoulos","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0395","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1128\/MCB.25.8.2873-2884.2005","article-title":"Class II histone deacetylases: from sequence to function, regulation, and clinical implication","volume":"25","author":"Yang","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0400","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/jcb.24089","article-title":"Ski inhibits TGF-\u03b2\/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes","volume":"113","author":"Kim","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0405","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1096\/fj.09-133215","article-title":"A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes","volume":"23","author":"Hong","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2015.12.012_bib0410","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/s10165-009-0224-7","article-title":"Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis","volume":"20","author":"Higashiyama","year":"2010","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0415","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s13075-014-0491-3","article-title":"Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human ost","volume":"16","author":"Cao","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bcp.2015.12.012_bib0420","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2005.01.029","article-title":"Calorie restriction\u2014the SIR2 connection","volume":"120","author":"Guarente","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0425","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2015.12.012_bib0430","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/art.37750","article-title":"Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model","volume":"65","author":"Gabay","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0435","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jbspin.2013.01.001","article-title":"Sirt1-deficient mice exhibit an altered cartilage phenotype","volume":"80","author":"Gabay","year":"2013","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.bcp.2015.12.012_bib0440","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bone.2013.10.020","article-title":"Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt\/\u03b2-catenin activity","volume":"59","author":"Abed","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bcp.2015.12.012_bib0445","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/art.27369","article-title":"SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway","volume":"62","author":"Gagarina","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0450","doi-asserted-by":"crossref","first-page":"36300","DOI":"10.1074\/jbc.M803196200","article-title":"Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase","volume":"283","author":"Dvir-Ginzberg","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0455","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jor.22268","article-title":"The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1\u03b2 in human chondrocytes","volume":"31","author":"Matsushita","year":"2013","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0460","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/jor.22859","article-title":"Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2\u03b1","volume":"33","author":"Li","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0465","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature06736","article-title":"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin","volume":"452","author":"Michishita","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2015.12.012_bib0470","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.joca.2015.03.024","article-title":"Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes","volume":"23","author":"Nagai","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0475","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0480","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0485","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/138920209788185225","article-title":"Epigenetic control of microRNA expression and aging","volume":"10","author":"Liang","year":"2009","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.bcp.2015.12.012_bib0490","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.mad.2008.05.004","article-title":"Murine microRNAs implicated in liver functions and aging process","volume":"129","author":"Maes","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bcp.2015.12.012_bib0495","doi-asserted-by":"crossref","first-page":"e10724","DOI":"10.1371\/journal.pone.0010724","article-title":"microRNA expression patterns reveal differential expression of target genes with age","volume":"5","author":"Noren Hooten","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2015.12.012_bib0500","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1474-9726.2010.00549.x","article-title":"miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging","volume":"9","author":"Hackl","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0505","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/jor.22157","article-title":"MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism","volume":"30","author":"Ukai","year":"2012","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0510","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1073\/pnas.0707900105","article-title":"Dicer-dependent pathways regulate chondrocyte proliferation and differentiation","volume":"105","author":"Kobayashi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2015.12.012_bib0515","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1074\/jbc.M111.302430","article-title":"Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)","volume":"287","author":"Martinez-Sanchez","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0520","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2474-13-144","article-title":"Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes","volume":"13","author":"D\u00edaz-Prado","year":"2012","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bcp.2015.12.012_bib0525","doi-asserted-by":"crossref","first-page":"e3740","DOI":"10.1371\/journal.pone.0003740","article-title":"Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks","volume":"3","author":"Iliopoulos","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2015.12.012_bib0530","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.joca.2008.09.012","article-title":"The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-\u03b1 and MMP13","volume":"17","author":"Jones","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0535","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/17453674.2014.957079","article-title":"The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone","volume":"86","author":"Weilner","year":"2015","journal-title":"Acta Orthop."},{"key":"10.1016\/j.bcp.2015.12.012_bib0540","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1038\/emm.2013.152","article-title":"MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes","volume":"46","author":"Zhang","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bcp.2015.12.012_bib0545","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12891-015-0652-9","article-title":"Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis","volume":"16","author":"Tornero-Esteban","year":"2015","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bcp.2015.12.012_bib0550","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13075-015-0556-y","article-title":"MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes","volume":"17","author":"Kostopoulou","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bcp.2015.12.012_bib0555","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/ar4494","article-title":"p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis","volume":"16","author":"Philipot","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bcp.2015.12.012_bib0560","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-\u03baB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2015.12.012_bib0565","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2011.03.003","article-title":"MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis","volume":"480","author":"Li","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.bcp.2015.12.012_bib0570","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/art.24404","article-title":"Expression of microRNA-146a in osteoarthritis cartilage","volume":"60","author":"Yamasaki","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0575","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/art.27329","article-title":"MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes","volume":"62","author":"Akhtar","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0580","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.joca.2013.11.006","article-title":"Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes","volume":"22","author":"Vonk","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0585","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1101\/gad.1915510","article-title":"MicroRNA-140 plays dual roles in both cartilage development and homeostasis","volume":"24","author":"Miyaki","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcp.2015.12.012_bib0590","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.febslet.2014.05.033","article-title":"Effect of microRNA-145 on IL-1\u03b2-induced cartilage degradation in human chondrocytes","volume":"588","author":"Yang","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2015.12.012_bib0595","first-page":"2555","article-title":"Decreased expression of microRNA-130a correlates with TNF-\u03b1 in the development of osteoarthritis","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0600","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1093\/rheumatology\/keq247","article-title":"Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro","volume":"49","author":"Abouheif","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.bcp.2015.12.012_bib0605","doi-asserted-by":"crossref","first-page":"261","DOI":"10.5435\/JAAOS-20-04-261","article-title":"A new therapeutic target in cartilage injury and osteoarthritis","volume":"20","author":"Lotz","year":"2012","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.bcp.2015.12.012_bib0610","first-page":"RA9","article-title":"Antioxidant therapy in human endocrine disorders","volume":"16","author":"Golbidi","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bcp.2015.12.012_bib0615","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/01.mco.0000247478.79779.8f","article-title":"Rationale and impact of vitamin C in clinical nutrition","volume":"9","author":"McGregor","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bcp.2015.12.012_bib0620","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.4049\/jimmunol.164.12.6509","article-title":"Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-\u03ba B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation","volume":"164","author":"Manna","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2015.12.012_bib0625","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00011-004-1341-6","article-title":"Effect of resveratrol in experimental osteoarthritis in rabbits","volume":"54","author":"Elmali","year":"2005","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bcp.2015.12.012_bib0630","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1474-9726.2010.00616.x","article-title":"Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration","volume":"9","author":"Jilka","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2015.12.012_bib0635","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1089\/scd.2014.0101","article-title":"Intermittent PTHrP(1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells","volume":"23","author":"Fischer","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bcp.2015.12.012_bib0640","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/annrheumdis-2011-200557","article-title":"Autophagy activation by rapamycin reduces severity of experimental osteoarthritis","volume":"71","author":"Caram\u00e9s","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0645","first-page":"1","article-title":"Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis","author":"Zhang","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0650","first-page":"1","article-title":"Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice","author":"Huang","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2015.12.012_bib0655","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcb.24362","article-title":"Vertical inhibition of the PI3K\/Akt\/mTOR pathway for the treatment of osteoarthritis","volume":"114","author":"Chen","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0660","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.37965","article-title":"Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation","volume":"65","author":"Culley","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0665","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.joca.2008.03.009","article-title":"Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes","volume":"16","author":"Chabane","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0670","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.joca.2012.09.003","article-title":"Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MA PK signaling pathway in cultured human chondrocytes","volume":"21","author":"Saito","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0675","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1525-0016(03)00235-1","article-title":"A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis","volume":"8","author":"Chung","year":"2003","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bcp.2015.12.012_bib0680","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.joca.2007.10.014","article-title":"Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model","volume":"16","author":"Nasu","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bcp.2015.12.012_bib0685","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1007\/s11033-010-0055-9","article-title":"Alleviation of osteoarthritis by trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis","volume":"37","author":"Chen","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2015.12.012_bib0690","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2119\/molmed.2011.00058","article-title":"Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis","volume":"17","author":"Joosten","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.bcp.2015.12.012_bib0695","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/art.30238","article-title":"Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis","volume":"63","author":"Vojinovic","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2015.12.012_bib0700","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1074\/jbc.M114.618454","article-title":"Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo","volume":"290","author":"Li","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2015.12.012_bib0705","article-title":"Circulating microRNAs as novel biomarkers for bone diseases\u2014complex signatures for multifactorial diseases?","author":"Hackl","year":"2015","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295215007674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295215007674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T15:19:34Z","timestamp":1567437574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295215007674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":141,"alternative-id":["S0006295215007674"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2015.12.012","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2015.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}