{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:36:07Z","timestamp":1764603367363,"version":"3.40.5"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1024817"],"award-info":[{"award-number":["APP1024817"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001043","name":"CASS Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001043","id-type":"DOI","asserted-by":"publisher"}]},{"name":"St. Vincent\u2019s Hospital"},{"name":"Stafford Fox Medical Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.bcp.2016.02.012","type":"journal-article","created":{"date-parts":[[2016,2,21]],"date-time":"2016-02-21T02:46:54Z","timestamp":1456022814000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Harnessing the secretome of cardiac stem cells as therapy for ischemic heart disease"],"prefix":"10.1016","volume":"113","author":[{"given":"Ramin","family":"Khanabdali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-2101","authenticated-orcid":false,"given":"Ayeshah A.","family":"Rosdah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Dusting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiang Y.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2016.02.012_b0005","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics\u20142012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2016.02.012_b0010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrcardio.2014.9","article-title":"Cell therapy for cardiac repair\u2014lessons from clinical trials","volume":"11","author":"Behfar","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0015","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5966\/sctm.2011-0015","article-title":"Increased potency of cardiac stem cells compared with bone marrow mesenchymal stem cells in cardiac repair","volume":"1","author":"Oskouei","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bcp.2016.02.012_b0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/CS20120641","article-title":"Stem cell stimulation of endogenous myocyte regeneration","volume":"125","author":"Weil","year":"2013","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bcp.2016.02.012_b0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/CRD.0b013e318289d7a9","article-title":"The existence of myocardial repair: mechanistic insights and enhancements","volume":"21","author":"Schoenfeld","year":"2013","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.bcp.2016.02.012_b0030","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1253\/circj.CJ-15-0557","article-title":"The quest for the adult cardiac stem cell","volume":"79","author":"Noseda","year":"2015","journal-title":"Circ. J."},{"key":"10.1016\/j.bcp.2016.02.012_b0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","article-title":"Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts","volume":"510","author":"Chong","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/stem.2205","article-title":"Concise review: pluripotent stem cell-derived cardiac cells, a promising cell source for therapy of heart failure: where do we stand?","volume":"34","author":"Gouadon","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2016.02.012_b0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","article-title":"Stem cell therapies in clinical trials: progress and challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0050","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0055","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI44635","article-title":"Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells","volume":"121","author":"Narsinh","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2016.02.012_b0060","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jacc.2014.04.056","article-title":"Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells","volume":"64","author":"Sanchez-Freire","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0065","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/524756","article-title":"Mesenchymal stem cells for cardiac regenerative therapy: optimization of cell differentiation strategy","volume":"2015","author":"Shen","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bcp.2016.02.012_b0070","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5581\/1516-8484.20130017","article-title":"Immunological characteristics of mesenchymal stem cells","volume":"35","author":"Machado Cde","year":"2013","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"10.1016\/j.bcp.2016.02.012_b0075","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1161\/CIRCRESAHA.116.304386","article-title":"Meta-analysis of cell therapy trials for patients with heart failure","volume":"116","author":"Fisher","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.amjcard.2013.03.021","article-title":"Meta-analysis of stem cell therapy in chronic ischemic cardiomyopathy","volume":"112","author":"Kandala","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0085","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/CIRCRESAHA.116.304346","article-title":"Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data","volume":"116","author":"Gyongyosi","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0090","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/CIRCRESAHA.111.243154","article-title":"Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology","volume":"109","author":"Leri","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0095","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.scr.2014.09.008","article-title":"Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells","volume":"13","author":"Chong","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0100","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","article-title":"Adult cardiac stem cells are multipotent and support myocardial regeneration","volume":"114","author":"Beltrami","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0105","doi-asserted-by":"crossref","first-page":"14068","DOI":"10.1073\/pnas.0706760104","article-title":"Human cardiac stem cells","volume":"104","author":"Bearzi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.02.012_b0110","first-page":"58","article-title":"C-kit-positive cardiac stem cells and myocardial regeneration","volume":"2","author":"Hosoda","year":"2012","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"10.1016\/j.bcp.2016.02.012_b0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCRESAHA.108.178525","article-title":"Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function","volume":"103","author":"Rota","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/CIRCHEARTFAILURE.115.002210","article-title":"Effects of intracoronary infusion of escalating doses of cardiac stem cells in rats with acute myocardial infarction","volume":"8","author":"Tang","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.bcp.2016.02.012_b0125","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/CIRCULATIONAHA.109.871905","article-title":"Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction","volume":"121","author":"Tang","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2016.02.012_b0130","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1161\/CIRCULATIONAHA.112.092627","article-title":"Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance","volume":"126","author":"Chugh","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2016.02.012_b0135","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0140-6736(14)60608-5","article-title":"Expression of concern: the SCIPIO trial","volume":"383","author":"The Lancet","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2016.02.012_b0140","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.ahj.2011.06.019","volume":"162","author":"Traverse","year":"2011","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bcp.2016.02.012_b0145","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.0000147315.71699.51","article-title":"Isolation and expansion of adult cardiac stem cells from human and murine heart","volume":"95","author":"Messina","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0150","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","article-title":"Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens","volume":"115","author":"Smith","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2016.02.012_b0155","doi-asserted-by":"crossref","first-page":"e7195","DOI":"10.1371\/journal.pone.0007195","article-title":"Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue","volume":"4","author":"Davis","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2016.02.012_b0160","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/stem.413","article-title":"Human cardiospheres are a source of stem cells with cardiomyogenic potential","volume":"28","author":"Davis","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2016.02.012_b0165","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.108.816058","article-title":"Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy","volume":"120","author":"Johnston","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2016.02.012_b0170","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(12)60195-0","article-title":"Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial","volume":"379","author":"Makkar","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2016.02.012_b0175","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jacc.2013.08.724","article-title":"Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction)","volume":"63","author":"Malliaras","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0180","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.116.304671","article-title":"Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial","volume":"116","author":"Ishigami","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0185","doi-asserted-by":"crossref","first-page":"12313","DOI":"10.1073\/pnas.2132126100","article-title":"Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction","volume":"100","author":"Oh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.02.012_b0190","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1634\/stemcells.2005-0386","article-title":"The role of the sca-1+\/CD31\u2212 cardiac progenitor cell population in postinfarction left ventricular remodeling","volume":"24","author":"Wang","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2016.02.012_b0195","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1074\/jbc.M310822200","article-title":"Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes","volume":"279","author":"Matsuura","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2016.02.012_b0200","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF03086138","article-title":"Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy","volume":"16","author":"van Vliet","year":"2008","journal-title":"Neth. Heart J."},{"key":"10.1016\/j.bcp.2016.02.012_b0205","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nprot.2008.229","article-title":"Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology","volume":"4","author":"Smits","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bcp.2016.02.012_b0210","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.147.4.869","article-title":"Skeletal myogenic progenitors originating from embryonic dorsal aorta coexpress endothelial and myogenic markers and contribute to postnatal muscle growth and regeneration","volume":"147","author":"De Angelis","year":"1999","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.bcp.2016.02.012_b0215","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/cdd.2008.75","article-title":"Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricle","volume":"15","author":"Galvez","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2016.02.012_b0220","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/cvr\/cvp159","article-title":"Human cardiac mesoangioblasts isolated from hypertrophic cardiomyopathies are greatly reduced in proliferation and differentiation potency","volume":"83","author":"Galvez","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0225","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-5793(02)03477-4","article-title":"The post-natal heart contains a myocardial stem cell population","volume":"530","author":"Hierlihy","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2016.02.012_b0230","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.200603014","article-title":"Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo","volume":"176","author":"Oyama","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2016.02.012_b0235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/01.RES.0000173297.53793.fa","article-title":"CD31\u2212 but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation","volume":"97","author":"Pfister","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0240","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0245","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1089\/scd.2009.0483","article-title":"Islet-1 cells are cardiac progenitors present during the entire lifespan: from the embryonic stage to adulthood","volume":"19","author":"Genead","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bcp.2016.02.012_b0250","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature03215","article-title":"Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages","volume":"433","author":"Laugwitz","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0255","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2006.10.029","article-title":"Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification","volume":"127","author":"Moretti","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0260","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature07060","article-title":"Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart","volume":"454","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0265","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature05383","article-title":"Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization","volume":"445","author":"Smart","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0270","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature10188","article-title":"De novo cardiomyocytes from within the activated adult heart after injury","volume":"474","author":"Smart","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0275","first-page":"393","article-title":"The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells","volume":"3","author":"Friedenstein","year":"1970","journal-title":"Cell Tissue Kinet."},{"key":"10.1016\/j.bcp.2016.02.012_b0280","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.stem.2011.10.002","article-title":"Adult cardiac-resident MSC-like stem cells with a proepicardial origin","volume":"9","author":"Chong","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0285","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1089\/scd.2012.0542","article-title":"Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart","volume":"22","author":"Chong","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bcp.2016.02.012_b0290","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1196\/annals.1392.000","article-title":"Novel markers for the prospective isolation of human MSC","volume":"1106","author":"Buhring","year":"2007","journal-title":"Ann. NY. Acad. Sci."},{"key":"10.1016\/j.bcp.2016.02.012_b0295","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/stem.2101","article-title":"Cardiac repair with a novel population of mesenchymal stem cells resident in the human heart","volume":"33","author":"Zhang","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2016.02.012_b0300","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nm1618","article-title":"Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury","volume":"13","author":"Hsieh","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2016.02.012_b0305","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cell.2013.07.039","article-title":"Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair","volume":"154","author":"Ellison","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2016.02.012_b0310","doi-asserted-by":"crossref","first-page":"13380","DOI":"10.1073\/pnas.1208114109","article-title":"c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart","volume":"109","author":"Jesty","year":"2012","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.02.012_b0315","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature11682","article-title":"Mammalian heart renewal by pre-existing cardiomyocytes","volume":"493","author":"Senyo","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0320","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13309","article-title":"c-kit+ cells minimally contribute cardiomyocytes to the heart","volume":"509","author":"van Berlo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0325","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/cr.2015.143","article-title":"Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes","volume":"26","author":"Liu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0330","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.yjmcc.2010.08.005","article-title":"Paracrine mechanisms of stem cell reparative and regenerative actions in the heart","volume":"50","author":"Mirotsou","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0335","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3727\/096368913X667709","article-title":"Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives","volume":"23","author":"Liang","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bcp.2016.02.012_b0340","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stemcr.2014.04.006","article-title":"Exosomes as critical agents of cardiac regeneration triggered by cell therapy","volume":"2","author":"Ibrahim","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bcp.2016.02.012_b0345","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvu167","article-title":"Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction","volume":"103","author":"Barile","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/CIRCRESAHA.116.304360","article-title":"Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology","volume":"116","author":"Gray","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0355","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/cvr\/cvv168","article-title":"Human epicardial cell-conditioned medium contains HGF\/IgG complexes that phosphorylate RYK and protect against vascular injury","volume":"107","author":"Rao","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0360","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature15372","article-title":"Epicardial FSTL1 reconstitution regenerates the adult mammalian heart","volume":"525","author":"Wei","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.02.012_b0365","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pharmthera.2013.12.002","article-title":"Ischemic preconditioning for cell-based therapy and tissue engineering","volume":"142","author":"Hsiao","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2016.02.012_b0370","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jchf.2013.08.008","article-title":"Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair","volume":"2","author":"Cheng","year":"2014","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.bcp.2016.02.012_b0375","doi-asserted-by":"crossref","first-page":"H1529","DOI":"10.1152\/ajpheart.01087.2009","article-title":"Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury","volume":"298","author":"Abarbanell","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0380","doi-asserted-by":"crossref","first-page":"H1772","DOI":"10.1152\/ajpheart.00557.2010","article-title":"Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival","volume":"299","author":"Li","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0385","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2011.11.029","article-title":"Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells","volume":"59","author":"Li","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0390","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCRESAHA.109.210682","article-title":"Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice","volume":"106","author":"Chimenti","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0395","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1016\/j.yexcr.2009.09.026","article-title":"Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K\/Akt pathway","volume":"315","author":"Tang","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0400","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.healun.2014.07.010","article-title":"Ex vivo paracrine properties of cardiac tissue: effects of chronic heart failure","volume":"34","author":"Boucek","year":"2015","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.bcp.2016.02.012_b0405","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/scd.2009.0041","article-title":"Characterization of long-term cultured c-kit+ cardiac stem cells derived from adult rat hearts","volume":"19","author":"Miyamoto","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bcp.2016.02.012_b0410","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1073\/pnas.0502678102","article-title":"Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function","volume":"102","author":"Linke","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.02.012_b0415","doi-asserted-by":"crossref","first-page":"e14297","DOI":"10.1371\/journal.pone.0014297","article-title":"c-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling","volume":"5","author":"Kawaguchi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2016.02.012_b0420","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7653489","article-title":"Exosomes and their therapeutic potentials of stem cells","volume":"2016","author":"Han","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bcp.2016.02.012_b0425","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1530\/JOE-15-0201","article-title":"Microvesicles and exosomes: new players in metabolic and cardiovascular disease","volume":"228","author":"Lawson","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bcp.2016.02.012_b0430","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/CIRCULATIONAHA.104.500447","article-title":"Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy","volume":"112","author":"Nagaya","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2016.02.012_b0435","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/pmic.200900515","article-title":"Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes","volume":"10","author":"Stastna","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.bcp.2016.02.012_b0440","doi-asserted-by":"crossref","first-page":"g2688","DOI":"10.1136\/bmj.g2688","article-title":"Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis","volume":"348","author":"Nowbar","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.bcp.2016.02.012_b0445","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm.3627","article-title":"Translational strategies and challenges in regenerative medicine","volume":"20","author":"Dimmeler","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2016.02.012_b0450","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jacc.2010.05.039","article-title":"Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease","volume":"56","author":"Beohar","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2016.02.012_b0455","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.addr.2015.04.023","article-title":"Self-assembling peptide-based delivery of therapeutics for myocardial infarction","volume":"96","author":"French","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bcp.2016.02.012_b0460","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jconrel.2015.02.009","article-title":"Heart regeneration after myocardial infarction using synthetic biomaterials","volume":"203","author":"Pascual-Gil","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2016.02.012_b0465","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0140-6736(11)61590-0","article-title":"Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial","volume":"378","author":"Bolli","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2016.02.012_b0470","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1172\/JCI81321","article-title":"Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction","volume":"125","author":"de Couto","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2016.02.012_b0475","doi-asserted-by":"crossref","first-page":"e88590","DOI":"10.1371\/journal.pone.0088590","article-title":"Angiogenesis, cardiomyocyte proliferation and anti-fibrotic effects underlie structural preservation post-infarction by intramyocardially-injected cardiospheres","volume":"9","author":"Tseliou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2016.02.012_b0480","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.3727\/096368914X685771","article-title":"Cardiosphere conditioned media influence the plasticity of human mediastinal adipose tissue-derived mesenchymal stem cells","volume":"24","author":"Siciliano","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bcp.2016.02.012_b0485","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1161\/CIRCRESAHA.115.306146","article-title":"Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair","volume":"116","author":"Avolio","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2016.02.012_b0490","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.surg.2014.04.002","article-title":"Estradiol treatment promotes cardiac stem cell (CSC)-derived growth factors, thus improving CSC-mediated cardioprotection after acute ischemia\/reperfusion","volume":"156","author":"Wang","year":"2014","journal-title":"Surgery"},{"key":"10.1016\/j.bcp.2016.02.012_b0495","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2013.01.015","article-title":"Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia\/reperfusion injury","volume":"431","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216001118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216001118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T19:49:26Z","timestamp":1654372166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295216001118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":99,"alternative-id":["S0006295216001118"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2016.02.012","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing the secretome of cardiac stem cells as therapy for ischemic heart disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2016.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}