{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:40:22Z","timestamp":1790221222663,"version":"4.1.0"},"reference-count":301,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.bcp.2016.09.029","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T05:11:58Z","timestamp":1475730718000},"page":"97-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Antivirals against animal viruses"],"prefix":"10.1016","volume":"133","author":[{"given":"T.G.","family":"Villa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Feijoo-Siota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.R.","family":"Rama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Ageitos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2016.09.029_b0005","series-title":"Antibiot. Curr. Innov. Futur. Trends","first-page":"331","article-title":"Antiviral compounds of natural origin","author":"Veiga-Crespo","year":"2015"},{"key":"10.1016\/j.bcp.2016.09.029_b0010","first-page":"137","article-title":"Antiviral chemotherapy; flavones and related compounds","volume":"7","author":"Cutting","year":"1949","journal-title":"Stanford Med. Bull."},{"key":"10.1016\/j.bcp.2016.09.029_b0015","first-page":"73","article-title":"Antiviral activity of several quinone and isoquinoline derivatives","volume":"4","author":"Kuroya","year":"1953","journal-title":"Yokohama Med. Bull."},{"key":"10.1016\/j.bcp.2016.09.029_b0020","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1476-5381.1953.tb00767.x","article-title":"The antiviral action of phenanthridinium compounds","volume":"8","author":"Dickinson","year":"1953","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0031-6997(25)06964-9","article-title":"The chemotherapy of virus diseases, with brief consideration of the influence of dietary, hormonal and other factors in virus infections","volume":"8","author":"Hurst","year":"1956","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2016.09.029_b0030","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1248\/cpb1953.2.403","article-title":"Researches on chemotherapeutic drugs against viruses. XVII. Synthesis and antiviral properties of urazoles and related compounds","volume":"2","author":"Tsuji","year":"1954","journal-title":"Pharm. Bull."},{"key":"10.1016\/j.bcp.2016.09.029_b0035","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0003-9861(58)90282-0","article-title":"The inhibition of ribonuclease by acidic polymers and their use as possible antiviral agents","volume":"73","author":"Gulick","year":"1958","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2016.09.029_b0040","first-page":"1571","article-title":"Effect of aristolochic acid on herpes simplex infection of the rabbit eye","volume":"30","author":"M\u00f6se","year":"1980","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bcp.2016.09.029_b0045","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/BF02974043","article-title":"Anti-herpetic activity of various medicinal plant extracts","volume":"20","author":"Woo","year":"1997","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0050","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/095632020101200206","article-title":"Enhancement of anti-herpetic activity of glycyrrhizic acid by physiological proteins","volume":"12","author":"Lampi","year":"2001","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0055","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/infdis\/137.2.122","article-title":"A method for testing for synergy with any number of agents","volume":"137","author":"Berenbaum","year":"1978","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b0060","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0166-3542(97)00051-X","article-title":"Synergistic effects of triterpenic compounds with prostaglandin A1 on vaccinia virus infected L929 cells","volume":"36","author":"Lampis","year":"1997","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0065","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/nbt0609-510","article-title":"Extrapolating from sequence\u2013the 2009 H1N1 \u201cswine\u201d influenza virus","volume":"27","author":"Soundararajan","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bcp.2016.09.029_b0070","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0005-2736(99)00197-2","article-title":"Why and how are peptide\u2013lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes","volume":"1462","author":"Matsuzaki","year":"1999","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.bcp.2016.09.029_b0075","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1432-1033.1993.tb18182.x","article-title":"Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7\u201342), diazepam-binding inhibitor (32\u201386) and a novel factor, peptide 3910","volume":"216","author":"Agerberth","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0080","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.peptides.2003.12.006","article-title":"Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin","volume":"25","author":"van der Kraan","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.bcp.2016.09.029_b0085","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1098\/rspb.1957.0048","article-title":"Virus interference. I. The interferon","volume":"147","author":"Isaacs","year":"1957","journal-title":"Proc. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0090","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0042-6822(59)90100-X","article-title":"Action of interferon on the growth of sublethally irradiated virus","volume":"9","author":"Isaacs","year":"1959","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b0095","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/oxfordjournals.bmb.a069760","article-title":"Viral interference and interferon","volume":"15","author":"Isaacs","year":"1959","journal-title":"Br. Med. Bull."},{"issue":"Suppl","key":"10.1016\/j.bcp.2016.09.029_b0100","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/184452a0","article-title":"Interferon produced by cultures of calf kidney cells","volume":"184","author":"Tyrrell","year":"1959","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b0105","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0140-6736(59)91361-3","article-title":"Inhibition by interferon of the growth of vaccinia virus in the rabbit skin","volume":"2","author":"Isaacs","year":"1959","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bcp.2016.09.029_b0110","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1146\/annurev.immunol.23.021704.115633","article-title":"IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors","volume":"23","author":"Liu","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0115","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.coviro.2011.11.001","article-title":"Induction and function of type I and III interferon in response to viral infection","volume":"1","author":"Levy","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b0120","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fcimb.2014.00050","article-title":"The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons","volume":"4","author":"Dussurget","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b0125","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/eji.1830071014","article-title":"Immune interferon. I. Production by lymphokine-activated murine macrophages","volume":"7","author":"Neumann","year":"1977","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0130","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4049\/jimmunol.114.1_Part_2.435","article-title":"Immune specific production of interferon by human T cells in combined macrophage-lymphocyte cultures in response to Herpes simplex antigen","volume":"114","author":"Valle","year":"1975","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0135","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors","volume":"202","author":"Pestka","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bcp.2016.09.029_b0140","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nri1684","article-title":"The yin and yang of type I interferon activity in bacterial infection","volume":"5","author":"Decker","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0145","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.4049\/jimmunol.111.6.1914","article-title":"Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity","volume":"111","author":"Youngner","year":"1973","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0150","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0008-8749(76)90100-3","article-title":"The nature of the suppressive effect of interferon and interferon inducers on the in vitro immune response","volume":"25","author":"Johnson","year":"1976","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0155","first-page":"699","article-title":"Affinity chromatographic analysis of murine interferons induced by viruses and by T and B cell stimulants","volume":"128C","author":"Wietzerbin","year":"1977","journal-title":"Ann. Immunol. (Paris)"},{"key":"10.1016\/j.bcp.2016.09.029_b0160","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1056\/NEJM196507222730404","article-title":"Circulating virus, interferon and antibody after vaccination with the 17-D strain of yellow-fever virus","volume":"273","author":"Wheelock","year":"1965","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0165","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.coi.2011.07.007","article-title":"IFN-\u03bbs","volume":"23","author":"Kotenko","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0170","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/ni873","article-title":"IL-28, IL-29 and their class II cytokine receptor IL-28R","volume":"4","author":"Sheppard","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0175","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/ni1253","article-title":"Are innate immune signaling pathways in plants and animals conserved?","volume":"6","author":"Ausubel","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0180","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1007\/s00018-005-5032-4","article-title":"Innate and acquired plasticity of the intestinal immune system","volume":"62","author":"Didierlaurent","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0185","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense","volume":"25","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2016.09.029_b0190","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1111\/j.1462-5822.2010.01478.x","article-title":"Induction of type I interferons by bacteria","volume":"12","author":"Monroe","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b0195","doi-asserted-by":"crossref","first-page":"25589","DOI":"10.1016\/S0021-9258(19)74081-2","article-title":"Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes","volume":"267","author":"Weisz","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0200","first-page":"613","article-title":"Action du \u201cBacillus subtilis\u201d sur diverses bact\u00e9ries","volume":"21","author":"Nicolle","year":"1907","journal-title":"Ann. Inst. Pasteur (Paris)"},{"key":"10.1016\/j.bcp.2016.09.029_b0205","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/BF02216170","article-title":"Uber die keimt\u00f6tende und entwicklungshemmende Wirkung von H\u00fchnereiwei\u00df","volume":"64","author":"Laschtschenko","year":"1909","journal-title":"Zeitschr. Hyg. Infekt."},{"key":"10.1016\/j.bcp.2016.09.029_b0210","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1098\/rspb.1922.0023","article-title":"On a remarkable bacteriolytic element found in tissues and secretions","volume":"93","author":"Fleming","year":"1922","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0215","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/0006-3002(54)90246-2","article-title":"Amino acid sequences in lysozyme","volume":"14","author":"Thompson","year":"1954","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.09.029_b0220","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1073\/pnas.77.10.5759","article-title":"Exons encode functional and structural units of chicken lysozyme","volume":"77","author":"Jung","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0225","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1073\/pnas.89.13.5887","article-title":"Functional conversion of the homologous proteins alpha-lactalbumin and lysozyme by exon exchange","volume":"89","author":"Kumagai","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0230","first-page":"390","article-title":"Changes in lysozyme formation in the human colon in various emotional states., Bull. N. Y","volume":"24","author":"Grace","year":"1948","journal-title":"Acad. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0235","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0022-3476(51)80101-X","article-title":"The occurrence of lysozyme in the cerebrospinal fluid and serum of infants and children","volume":"38","author":"Rabe","year":"1951","journal-title":"J. Pediatr."},{"issue":"1985","key":"10.1016\/j.bcp.2016.09.029_b0240","first-page":"457","article-title":", Lysozyme-mediated aggregation and lysis of the periodontal microorganism Capnocytophaga gingivalis","volume":"47","author":"Iacono","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2016.09.029_b0245","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF00389289","article-title":"Lysozyme and chitinase in blood and lymphomyeloid tissues of marine fish","volume":"36","author":"F\u00e4nge","year":"1976","journal-title":"Mar. Biol."},{"key":"10.1016\/j.bcp.2016.09.029_b0250","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/183548a0","article-title":"Antiviral activity of lysozyme","volume":"183","author":"Ferrari","year":"1959","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b0255","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1073\/pnas.96.6.2678","article-title":"Lysozyme and RNases as anti-HIV components in beta-core preparations of human chorionic gonadotropin","volume":"96","author":"Lee-Huang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0260","doi-asserted-by":"publisher","first-page":"e0131894","DOI":"10.1371\/journal.pone.0131894","article-title":"The Effects of the Recombinant CCR5 T4 Lysozyme Fusion Protein on HIV-1 Infection","volume":"10","author":"Jin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2016.09.029_b0265","first-page":"431","article-title":"Research on the action of lysozyme on some strains of influenza virus and their receptors","volume":"5","author":"Colucci","year":"1950","journal-title":"Acta Med. Ital. Mal. Infett. Parassit."},{"key":"10.1016\/j.bcp.2016.09.029_b0270","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF02100084","article-title":"Comparison of goose-type, chicken-type, and phage-type lysozymes illustrates the changes that occur in both amino acid sequence and three-dimensional structure during evolution","volume":"21","author":"Weaver","year":"1984","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.bcp.2016.09.029_b0275","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/BF01576045","article-title":"Inhibition of herpes simplex virus-induced cytopathic effect by modified hen egg-white lysozymes","volume":"10","author":"Cisani","year":"1984","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b0280","first-page":"73","article-title":"Cell fusion induced by herpes simplex is inhibited by hen egg-white lysozyme","volume":"59","author":"Cisani","year":"1989","journal-title":"Microbios"},{"key":"10.1016\/j.bcp.2016.09.029_b0285","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0006-2952(96)00876-3","article-title":"Inhibition of influenza virus fusion by polyanionic proteins","volume":"53","author":"Schoen","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2016.09.029_b0290","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1006\/bbrc.1999.1804","article-title":"Lysozyme association with nucleic acids","volume":"266","author":"Steinrauf","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2016.09.029_b0295","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.yrtph.2008.03.007","article-title":"28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats","volume":"51","author":"Cerven","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.bcp.2016.09.029_b0300","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/nutrit\/nuv009","article-title":"Clinical applications of bioactive milk components","volume":"73","author":"Hill","year":"2015","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bcp.2016.09.029_b0305","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/1471-2148-11-166","article-title":"Evolution of the mammalian lysozyme gene family","volume":"11","author":"Irwin","year":"2011","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.bcp.2016.09.029_b0310","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0065-3233(08)60198-9","article-title":"Lysozyme and alpha-lactalbumin: structure, function, and interrelationships","volume":"41","author":"McKenzie","year":"1991","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0315","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1432-1033.1989.tb14806.x","article-title":"The evolution of lysozyme and alpha-lactalbumin","volume":"182","author":"Nitta","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0320","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/324084a0","article-title":"Alpha-lactalbumin possesses a novel calcium binding loop","volume":"324","author":"Stuart","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b0325","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1080\/07853890802502614","article-title":"Can misfolded proteins be beneficial? The HAMLET case","volume":"41","author":"Pettersson-Kastberg","year":"2009","journal-title":"Ann. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0330","first-page":"89","article-title":"Milk-derived proteins and peptides of potential therapeutic and nutritive value","volume":"6","author":"Zimecki","year":"2007","journal-title":"J. Exp. Ther. Oncol."},{"key":"10.1016\/j.bcp.2016.09.029_b0335","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1089\/aid.1997.13.1101","article-title":"Structural and functional analysis of negatively charged milk proteins with anti-HIV activity","volume":"13","author":"Berkhout","year":"1997","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.bcp.2016.09.029_b0340","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0166-3542(03)00010-X","article-title":"The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification","volume":"59","author":"Oevermann","year":"2003","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0345","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1159\/000104755","article-title":"Anticytomegaloviral activity of esterified milk proteins and L-polylysines","volume":"13","author":"Chobert","year":"2007","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.09.029_b0350","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jmv.1890410503","article-title":"Acyclovir: discovery, mechanism of action, and selectivity","volume":"1","author":"Elion","year":"1993","journal-title":"J. Med. Virol. Suppl."},{"key":"10.1016\/j.bcp.2016.09.029_b0355","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1097\/QCO.0b013e32833229b8","article-title":"Acyclovir: a new use for an old drug","volume":"22","author":"Vanpouille","year":"2009","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b0360","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1086\/515626","article-title":"Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients","volume":"178","author":"Gaudreau","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b0365","doi-asserted-by":"publisher","first-page":"10214","DOI":"10.1021\/jf0724421","article-title":"Antiviral activity of esterified alpha-lactalbumin and beta-lactoglobulin against herpes simplex virus type 1. Comparison with the effect of acyclovir and L-polylysines","volume":"55","author":"Sitohy","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0370","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.gene.2016.02.024","article-title":"Expression of recombinant human \u03b1-lactalbumin in milk of transgenic cloned pigs is sufficient to enhance intestinal growth and weight gain of suckling piglets","volume":"584","author":"Ma","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.bcp.2016.09.029_b0375","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1084\/jem.130.3.643","article-title":"Lactoferrin, an iron-binding protein in neutrophilic leukocytes","volume":"130","author":"Masson","year":"1969","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0380","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1248\/bpb.24.443","article-title":"Characterization of bovine angiogenin-1 and lactogenin-like protein as glycyrrhizin-binding proteins and their in vitro phosphorylation by C-kinase","volume":"24","author":"Tanigawa","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bcp.2016.09.029_b0385","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1651-2227.1997.tb08896.x","article-title":"Effect of human milk prostaglandins and lactoferrin on respiratory syncytial virus and rotavirus","volume":"86","author":"Grover","year":"1997","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.bcp.2016.09.029_b0390","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1172\/JCI118056","article-title":"Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro","volume":"96","author":"McNeely","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2016.09.029_b0395","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0166-3542(01)00195-4","article-title":"Antiviral activities of lactoferrin","volume":"52","author":"van der Strate","year":"2001","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0400","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s004300050049","article-title":"Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29","volume":"186","author":"Superti","year":"1997","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0405","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1016\/S0024-3205(00)00853-5","article-title":"First demonstration of an inhibitory activity of milk proteins against human immunodeficiency virus-1 reverse transcriptase and the effect of succinylation","volume":"67","author":"Wang","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0410","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0168-1702(99)00121-5","article-title":"Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells","volume":"66","author":"Ikeda","year":"2000","journal-title":"Virus Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0415","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1007\/s00018-005-5373-z","article-title":"Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties","volume":"62","author":"Gifford","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0420","first-page":"55","article-title":"The proteins in whey","volume":"23","author":"Sorensen","year":"1939","journal-title":"Comptes Rendus Des Trav. Du Lab."},{"key":"10.1016\/j.bcp.2016.09.029_b0425","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.07.020","article-title":"Lactoferrin: structure, function and applications","volume":"33","author":"Gonz\u00e1lez-Ch\u00e1vez","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bcp.2016.09.029_b0430","doi-asserted-by":"publisher","first-page":"6997","DOI":"10.1007\/s00253-015-6818-4","article-title":"Antiviral activities of whey proteins","volume":"99","author":"Ng","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.09.029_b0435","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/S0024-3205(01)01311-X","article-title":"Inhibition of human immunodeficiency virus type 1 reverse transcriptase, protease and integrase by bovine milk proteins","volume":"69","author":"Ng","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0440","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1089\/aid.1996.12.769","article-title":"Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro","volume":"12","author":"Swart","year":"1996","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.bcp.2016.09.029_b0445","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/1743-422X-7-330","article-title":"Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1)","volume":"7","author":"Taha","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.bcp.2016.09.029_b0450","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.3168\/jds.S0022-0302(91)78608-6","article-title":"Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin","volume":"74","author":"Tomita","year":"1991","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0455","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1016\/j.bbamem.2007.04.018","article-title":"Solution structures and model membrane interactions of lactoferrampin, an antimicrobial peptide derived from bovine lactoferrin","volume":"1768","author":"Haney","year":"2007","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.bcp.2016.09.029_b0460","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/00365549850161557","article-title":"Lactoferricin of bovine origin is more active than lactoferricins of human, murine and caprine origin","volume":"30","author":"Vorland","year":"1998","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b0465","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1128\/AAC.41.1.54","article-title":"Antibacterial activity in bovine lactoferrin-derived peptides","volume":"41","author":"Hoek","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0470","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.2174\/1566524014666141015151749","article-title":"Recent studies on the antimicrobial peptides lactoferricin and lactoferrampin","volume":"14","author":"Yin","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0475","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1006\/bbrc.1999.1091","article-title":"Isolation and characterization of angiogenin-1 and a novel protein designated lactogenin from bovine milk","volume":"263","author":"Ye","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2016.09.029_b0480","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jconrel.2010.12.009","article-title":"Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei","volume":"155","author":"Wang","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2016.09.029_b0485","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0024-3205(00)00423-9","article-title":"Purification and characterization of glycolactin, a novel glycoprotein from bovine milk","volume":"66","author":"Ye","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0490","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1042\/bj0370372","article-title":"The dicarboxylic and basic amino-acids of edestin, egg albumin and beta-lactoglobulin","volume":"37","author":"Chibnall","year":"1943","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2016.09.029_b0495","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1021\/ja01209a008","article-title":"Monolayers of B-lactoglobulin; film molecular weight","volume":"68","author":"Bull","year":"1946","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2016.09.029_b0500","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0304-4165(01)00116-7","article-title":"Isolation and characterization of four bactericidal domains in the bovine beta-lactoglobulin","volume":"1526","author":"Pellegrini","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.09.029_b0505","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3168\/jds.S0022-0302(95)76713-3","article-title":"Interaction of beta-lactoglobulin with retinol and fatty acids and its role as a possible biological function for this protein: a review","volume":"78","author":"P\u00e9rez","year":"1995","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0510","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nm0296-230","article-title":"Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV","volume":"2","author":"Neurath","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0515","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/095632029800900209","article-title":"3-Hydroxyphthaloyl beta-lactoglobulin. III. Antiviral activity against herpesviruses","volume":"9","author":"Neurath","year":"1998","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0520","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1177\/095632029800900407","article-title":"3-Hydroxyphthaloyl beta-lactoglobulin. IV Antiviral activity in the mouse model of genital herpesvirus infection","volume":"9","author":"Kokuba","year":"1998","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0525","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s12602-010-9036-5","article-title":"Antiviral Action of Methylated \u03b2-Lactoglobulin on the Human Influenza Virus A Subtype H3N2","volume":"2","author":"Sitohy","year":"2010","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.bcp.2016.09.029_b0530","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1017\/S0022029910000592","article-title":"Influenza virus A subtype H1N1 is inhibited by methylated \u03b2-lactoglobulin","volume":"77","author":"Sitohy","year":"2010","journal-title":"J. Dairy Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0535","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.fct.2013.06.026","article-title":"Preliminary assessment of potential toxicity of methylated soybean protein and methylated \u03b2-lactoglobulin in male Wistar rats","volume":"59","author":"Sitohy","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2016.09.029_b0540","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/jmv.24439","article-title":"Safety evaluation of chemically modified beta-lactoglobulin administered intravaginally","volume":"88","author":"Guo","year":"2016","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b0545","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.3168\/jds.2013-7792","article-title":"Bovine \u03ba-casein inhibits human rotavirus (HRV) infection via direct binding of glycans to HRV","volume":"97","author":"Inagaki","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0550","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0304-4165(81)90215-4","article-title":"The chemical structure of neutral and acidic sugar chains obtained from bovine colostrum kappa-casein","volume":"678","author":"Saito","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.09.029_b0555","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10719-006-5435-y","article-title":"Role of sialic acids in rotavirus infection","volume":"23","author":"Isa","year":"2006","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.bcp.2016.09.029_b0560","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0003-9861(63)90250-9","article-title":"Radiation Chemistry Of Proteins. I. Modified Lysozyme Substances","volume":"102","author":"Stevens","year":"1963","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2016.09.029_b0565","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1016\/S0021-9258(18)94475-3","article-title":"The reaction of phenylglyoxal with arginine residues in proteins","volume":"243","author":"Takahashi","year":"1968","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0570","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1021\/bi00832a012","article-title":"Enzymic and immunochemical properties of lysozyme. I. Derivatives modified at tyrosine. Influence of nature of modification on activity","volume":"8","author":"Atassi","year":"1969","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2016.09.029_b0575","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/0019-2791(69)90195-5","article-title":"Enzymic and immunochemical properties of lysozyme. II. Conformation, immunochemistry and enzymic activity of a derivative modified at tryptophan","volume":"6","author":"Habeeb","year":"1969","journal-title":"Immunochemistry"},{"key":"10.1016\/j.bcp.2016.09.029_b0580","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/0019-2791(71)90493-9","article-title":"Enzymic and immunochemical properties of lysozyme. V. Derivatives modified at lysine residues by guanidination, acetylation, succinylation or maleylation","volume":"8","author":"Habeeb","year":"1971","journal-title":"Immunochemistry"},{"key":"10.1016\/j.bcp.2016.09.029_b0585","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/S0021-9258(18)62226-4","article-title":"Conformational studies on modified proteins and peptides. IV. Conformation of lysozyme derivatives modified at tyrosine or at tryptophan residues","volume":"246","author":"Atassi","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0590","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/oxfordjournals.jbchem.a130181","article-title":"Preparation and properties of lysozyme modified by fluorescein-isothiocyanate","volume":"73","author":"Hiramatsu","year":"1973","journal-title":"J. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0595","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1073\/pnas.71.5.1658","article-title":"Chemical conversion of aspartic acid 52, a catalytic residue in hen egg-white lysozyme, to homoserine","volume":"71","author":"Eshdat","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0600","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/oxfordjournals.jbchem.a130951","article-title":"Oxidation of tryptophan in lysozyme by ozone in aqueous solution","volume":"78","author":"Kuroda","year":"1975","journal-title":"J. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0605","first-page":"1015","article-title":"Binding of substrate analogs to hen lysozyme in which Trp 62 is modified to kynurenine","volume":"87","author":"Teshima","year":"1980","journal-title":"J. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0610","doi-asserted-by":"publisher","DOI":"10.1021\/bi00520a005","article-title":"Selective modification of aspartic acid-101 in lysozyme by carbodiimide reaction","volume":"20","author":"Yamada","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2016.09.029_b0615","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1021\/bi00538a030","article-title":"Modification of catalytic groups in lysozyme with ethylenimine","volume":"21","author":"Yamada","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2016.09.029_b0620","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1432-1033.1981.tb05336.x","article-title":"ADP-ribosylation of proteins in non-infected Escherichia coli cells","volume":"116","author":"Sk\u00f3rko","year":"1981","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0625","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/S0140-6736(87)90681-7","article-title":"Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine","volume":"1","author":"Ueno","year":"1987","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bcp.2016.09.029_b0630","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.4049\/jimmunol.143.4.1149","article-title":"Dextran sulfate and heparin interact with CD4 molecules to inhibit the binding of coat protein (gp120) of HIV","volume":"143","author":"Lederman","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0635","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0944-5013(00)80040-3","article-title":"Effect of lysozyme or modified lysozyme fragments on DNA and RNA synthesis and membrane permeability of Escherichia coli","volume":"155","author":"Pellegrini","year":"2000","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0640","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0304-4165(98)00165-2","article-title":"Isolation and identification of three bactericidal domains in the bovine alpha-lactalbumin molecule","volume":"1426","author":"Pellegrini","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.09.029_b0645","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.67.6.471","article-title":"Antiviral properties of ehrlichin, an antibiotic produced by Streptomyces lavendulae","volume":"67","author":"Groupe","year":"1951","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b0650","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/JB.55.5.615-621.1948","article-title":"Antibiotic agents separated from the root of lace-leaved leptotaenia","volume":"55","author":"Carlson","year":"1948","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bcp.2016.09.029_b0655","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF02160840","article-title":"On the chemical nature of acerin and the virucidal and antiviral effects of some vegetable tannins","volume":"10","author":"Fischer","year":"1954","journal-title":"Experientia"},{"key":"10.1016\/j.bcp.2016.09.029_b0660","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0042-6822(62)90010-7","article-title":"Purification and characteristics of a virus inhibitor from Dianthus caryophyllus L. II. Characterization and mode of action","volume":"18","author":"Ragetli","year":"1962","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b0665","first-page":"608","article-title":"[On the antiviral properties of some plant extracts. Experiments in vitro with poliomyelitis viruses and ECHO viruses]","volume":"41","author":"Albano","year":"1962","journal-title":"Boll. Ist. Sieroter. Milan."},{"key":"10.1016\/j.bcp.2016.09.029_b0670","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/0042-6822(62)90153-8","article-title":"Occurrence of antiviral factor in virus-infected plants","volume":"17","author":"Sela","year":"1962","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b0675","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3181\/00379727-117-29600","article-title":"Antiviral Activity of Melissa officinalis (Lemon Balm) Extract","volume":"117","author":"Cohen","year":"1964","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0680","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1021\/ja00968a057","article-title":"Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata 1,2","volume":"88","author":"Wall","year":"1966","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2016.09.029_b0685","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/0042-6822(72)90153-5","article-title":"Camptothecin: mechanism of inhibition of adenovirus formation","volume":"48","author":"Horwitz","year":"1972","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b0690","doi-asserted-by":"publisher","first-page":"865","DOI":"10.3181\/00379727-124-31872","article-title":"Antiviral substances in plants of the mint family (labiatae). I. Tannin of Melissa officinalis","volume":"124","author":"Kucera","year":"1967","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0695","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3181\/00379727-124-31873","article-title":"Antiviral substances in plants of the mint family (labiatae). II. Nontannin polyphenol of Melissa officinalis","volume":"124","author":"Herrmann","year":"1967","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0700","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000220538","article-title":"Antiviral effects of alkaloid fraction of Narcissus","volume":"13","author":"Ramanathan","year":"1968","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bcp.2016.09.029_b0705","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/BF02152834","article-title":"Isolation and antiviral activity of the hymnemic acids","volume":"24","author":"Sinsheimer","year":"1968","journal-title":"Experientia"},{"key":"10.1016\/j.bcp.2016.09.029_b0710","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/jps.2600610945","article-title":"Cryptopleurine, an active antiviral alkaloid from Boehmeria cylindrica (L.) Sw. (Urticaceae)","volume":"61","author":"Krmpotic","year":"1972","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b0715","first-page":"463","article-title":"Screening of higher plants for biological activities. II. Antiviral activity","volume":"41","author":"Van Den Berghe","year":"1978","journal-title":"Lloydia"},{"key":"10.1016\/j.bcp.2016.09.029_b0720","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1002\/biot.200700084","article-title":"Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health","volume":"2","author":"Ververidis","year":"2007","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.bcp.2016.09.029_b0725","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/jmv.1890150110","article-title":"Antiviral effect of flavonoids on human viruses","volume":"15","author":"Kaul","year":"1985","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b0730","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/0278-6915(95)00077-1","article-title":"Review of the biology of Quercetin and related bioflavonoids","volume":"33","author":"Formica","year":"1995","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2016.09.029_b0735","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1093\/jac\/dkg291","article-title":"In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids","volume":"52","author":"Chiang","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0740","doi-asserted-by":"publisher","first-page":"11334","DOI":"10.1128\/JVI.78.20.11334-11339.2004","article-title":"Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells","volume":"78","author":"Yi","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b0745","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1021\/np030470h","article-title":"Antiviral flavonoids from the seeds of Aesculus chinensis","volume":"67","author":"Wei","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcp.2016.09.029_b0750","doi-asserted-by":"publisher","first-page":"7806","DOI":"10.1128\/JVI.00896-14","article-title":"A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans","volume":"88","author":"Colpitts","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b0755","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1039\/b515312n","article-title":"Pharmacological activities of natural triterpenoids and their therapeutic implications","volume":"23","author":"Dzubak","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.09.029_b0760","first-page":"731","article-title":"Production of triterpenoids with cell and tissue cultures","volume":"60","author":"Malinowska","year":"2013","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.bcp.2016.09.029_b0765","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1021\/np50052a022","article-title":"In vitro antiviral activity of dammar resin triterpenoids","volume":"50","author":"Poehland","year":"1987","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcp.2016.09.029_b0770","first-page":"BR254","article-title":"Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives","volume":"8","author":"Chowdhury","year":"2002","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bcp.2016.09.029_b0775","first-page":"2866","article-title":"Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation","volume":"9","author":"Tan","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0780","first-page":"4956","article-title":"Betulinic acid triggers CD95 (APO-1\/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors","volume":"57","author":"Fulda","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0785","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1002\/hed.10231","article-title":"Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells","volume":"25","author":"Thurnher","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.bcp.2016.09.029_b0790","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1021\/np50104a008","article-title":"Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids","volume":"57","author":"Fujioka","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcp.2016.09.029_b0795","first-page":"79","article-title":"\u201cIn vitro\u201d antiviral activity of neem (Azadirachta indica. A. Juss) leaf extract against group B coxsackieviruses","volume":"31","author":"Badam","year":"1999","journal-title":"J. Commun. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b0800","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1016\/S0968-0896(02)00072-X","article-title":"Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax","volume":"10","author":"Jiang","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0805","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1248\/cpb.52.153","article-title":"3-epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation","volume":"52","author":"Akihisa","year":"2004","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.bcp.2016.09.029_b0810","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.phytochem.2007.06.016","article-title":"Flavaglines and triterpenoids from the leaves of Aglaia forbesii","volume":"69","author":"Joycharat","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bcp.2016.09.029_b0815","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ejmech.2012.03.035","article-title":"Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription","volume":"52","author":"Osorio","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0820","first-page":"1415","article-title":"Anti-human coronavirus (anti-HCoV) triterpenoids from the leaves of Euphorbia neriifolia","volume":"7","author":"Chang","year":"2012","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.bcp.2016.09.029_b0825","first-page":"43","article-title":"Triterpenoids from Argania spinosa: 20 years of research","volume":"8","author":"Chafchaouni-Moussaoui","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.bcp.2016.09.029_b0830","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1086\/592988","article-title":"Enterovirus-associated encephalitis in the California encephalitis project, 1998\u20132005","volume":"198","author":"Fowlkes","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b0835","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.bbrc.2014.05.019","article-title":"Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection","volume":"449","author":"Zhang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2016.09.029_b0840","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1080\/14786419.2015.1007456","article-title":"Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication","volume":"29","author":"\u00c1lvarez","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0845","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1039\/C5NP00015G","article-title":"Pentacyclic triterpenoids with nitrogen- and sulfur-containing heterocycles: synthesis and medicinal significance","volume":"32","author":"Kvasnica","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.09.029_b0850","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.procbio.2010.07.015","article-title":"Biotransformation of triterpenes","volume":"46","author":"Muffler","year":"2011","journal-title":"Process Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b0855","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1104\/pp.104.044859","article-title":"Tobacco mosaic virus regulates the expression of its own resistance gene N","volume":"135","author":"Levy","year":"2004","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bcp.2016.09.029_b0860","first-page":"653","article-title":"Inheritance of pathogenicity in Melampsora lini","volume":"32","author":"Flor","year":"1942","journal-title":"Phytopathology"},{"key":"10.1016\/j.bcp.2016.09.029_b0865","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1146\/annurev.py.09.090171.001423","article-title":"Current status of the gene-for-gene concept","volume":"9","author":"Flor","year":"1971","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.bcp.2016.09.029_b0870","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0042-6822(78)90034-X","article-title":"The mechanism of stimulation of the antiviral factor (AVF) in Nicotiana leaves. The involvement of phosphorylation and the role of the N-gene","volume":"89","author":"Sela","year":"1978","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b0875","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1073\/pnas.79.7.2278","article-title":"Human interferons protect plants from virus infection","volume":"79","author":"Orchansky","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0880","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1126\/science.6178155","article-title":"Multiplication of tobacco mosaic virus in tobacco leaf disks is inhibited by (2\u2032\u20135) oligoadenylate","volume":"216","author":"Devash","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bcp.2016.09.029_b0885","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1073\/pnas.87.2.588","article-title":"Two antiviral proteins from tobacco: purification and characterization by monoclonal antibodies to human beta-interferon","volume":"87","author":"Edelbaum","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0890","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/BF00036825","article-title":"Two antiviral proteins, gp35 and gp22, correspond to beta-1,3-glucanase and an isoform of PR-5","volume":"17","author":"Edelbaum","year":"1991","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.bcp.2016.09.029_b0895","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/BF01315128","article-title":"The purification and nature of an antiviral protein from Cuscuta reflexa plants","volume":"70","author":"Awasthi","year":"1981","journal-title":"Arch. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b0900","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/0167-4838(84)90342-X","article-title":"Dodecandrin, a new ribosome-inhibiting protein from Phytolacca dodecandra","volume":"791","author":"Ready","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.09.029_b0905","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1073\/pnas.83.14.5053","article-title":"Extracellular localization of pokeweed antiviral protein","volume":"83","author":"Ready","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0910","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1104\/pp.111.186197","article-title":"Expression of an entire bacterial operon in plants","volume":"158","author":"Mozes-Koch","year":"2012","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bcp.2016.09.029_b0915","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1084\/jem.97.5.601","article-title":"An antiviral substance from Penicillium funiculosum. I. Effect upon infection in mice with swine influenza virus and Columbia SK encephalomyelitis virus","volume":"97","author":"Shope","year":"1953","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0920","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1084\/jem.97.5.627","article-title":"An antiviral substance from Penicillium funiculosum. II. Effect of helenine upon infection in mice with Semliki Forest virus","volume":"97","author":"Shope","year":"1953","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0925","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1084\/jem.97.5.639","article-title":"An antiviral substance from Penicillium funiculosum. III. General properties and characteristics of helenine","volume":"97","author":"Shope","year":"1953","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b0930","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1073\/pnas.52.3.741","article-title":"Interferon Production Induced by Statolon","volume":"52","author":"Kleinschmidt","year":"1964","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b0935","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.7164\/antibiotics.31.1079","article-title":"Isolation and characterization of a new antitumor polysaccharide, KS-2, extracted from culture mycelia of Lentinus edodes","volume":"31","author":"Fujii","year":"1978","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.bcp.2016.09.029_b0940","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.2174\/092986710791698495","article-title":"Lentinus edodes: a macrofungus with pharmacological activities","volume":"17","author":"Bisen","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b0945","series-title":"Enzybiotics Antibiot. Enzym. as Drugs Ther.","first-page":"75","article-title":"Phylogeny of enzybiotics","author":"Veiga-Crespo","year":"2010"},{"key":"10.1016\/j.bcp.2016.09.029_b0950","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1016\/j.carres.2003.08.013","article-title":"Chain conformation of sulfated derivatives of beta-glucan from sclerotia of Pleurotus tuber-regium","volume":"338","author":"Zhang","year":"2003","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0955","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.antiviral.2011.07.009","article-title":"Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia","volume":"92","author":"Cardozo","year":"2011","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b0960","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1128\/AAC.02250-12","article-title":"In vivo anti-herpes simplex virus activity of a sulfated derivative of Agaricus brasiliensis mycelial polysaccharide","volume":"57","author":"Cardozo","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b0965","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3892\/br.2015.470","article-title":"Auricularia auricular-judae polysaccharide attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and inflammation","volume":"3","author":"Zhuan-Yun","year":"2015","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.bcp.2016.09.029_b0970","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1023\/A:1023951525250","article-title":"Beta-1,3-glucanase from unfertilized eggs of the sea urchin Strongylocentrotus intermedius. Comparison with beta-1,3-glucanases of marine and terrestrial mollusks","volume":"68","author":"Sova","year":"2003","journal-title":"Biochem. Biokhimiia"},{"key":"10.1016\/j.bcp.2016.09.029_b0975","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1439-0450.2004.00732.x","article-title":"Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide","volume":"51","author":"Jung","year":"2004","journal-title":"J. Vet. Med. B. Infect. Dis. Vet. Public Health."},{"key":"10.1016\/j.bcp.2016.09.029_b0980","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1006\/viro.1995.1034","article-title":"Identification of structural features of heparin required for inhibition of herpes simplex virus type 1 binding","volume":"206","author":"Herold","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b0985","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.fm.2012.04.008","article-title":"Effectiveness of chitosan on the inactivation of enteric viral surrogates","volume":"32","author":"Davis","year":"2012","journal-title":"Food Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b0990","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ijpharm.2007.08.017","article-title":"Effect of chitosan, benzalkonium chloride and ethylenediaminetetraacetic acid on permeation of acyclovir across isolated rabbit cornea","volume":"348","author":"Majumdar","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2016.09.029_b0995","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1021\/bm200970x","article-title":"Carbohydrate-functionalized chitosan fiber for influenza virus capture","volume":"12","author":"Li","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bcp.2016.09.029_b1000","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1128\/AAC.02183-15","article-title":"Novel Polyanions Inhibiting Replication of Influenza Viruses","volume":"60","author":"Ciejka","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1005","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1743-422X-8-141","article-title":"In vitro evaluation of antiviral and virucidal activity of a high molecular weight hyaluronic acid","volume":"8","author":"Cermelli","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.bcp.2016.09.029_b1010","doi-asserted-by":"publisher","first-page":"J27","DOI":"10.3314\/mmj.57.J27","article-title":"Mechanism of Cryptococcus meningoencephalitis","volume":"57","author":"Miyazato","year":"2016","journal-title":"Med. Mycol. J."},{"key":"10.1016\/j.bcp.2016.09.029_b1015","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/206263a0","article-title":"Isolation of Vivomycin and Borrelidin, Two Antibiotics with Anti-Viral Activity, from a Species of Streptomyces (C2989)","volume":"206","author":"Lumb","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b1020","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1099\/ijs.0.041483-0","article-title":"Streptomyces heilongjiangensis sp. nov., a novel actinomycete that produces borrelidin isolated from the root surface of soybean [Glycine max (L.) Merr]","volume":"63","author":"Liu","year":"2013","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b1025","doi-asserted-by":"publisher","first-page":"331","DOI":"10.7883\/yoken1948.4.331","article-title":"An antiviral substance, abikoviromycin, produced by Streptomyces species","volume":"4","author":"Umezawa","year":"1951","journal-title":"Jpn. J. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b1030","first-page":"18","article-title":"[A new antiviral antibiotic violarin produced by Actinomyces violaceus]","volume":"3","author":"Krasil\u2019nikov","year":"1958","journal-title":"Antibiotiki"},{"key":"10.1016\/j.bcp.2016.09.029_b1035","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1348-0421.1958.tb00060.x","article-title":"Studies on antiviral antibiotics from streptomyces. X. Effect of myxoviromycin upon infection with influenza virus in mice","volume":"2","author":"Hinuma","year":"1958","journal-title":"Jpn. J. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b1040","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1620\/tjem.70.95","article-title":"Studies on antiviral antibiotics from streptomyces. XII. Further studies on the antiviral antibiotic, myxoviromycin","volume":"70","author":"Kobayashi","year":"1959","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b1045","first-page":"138","article-title":"Virocidin, a new antiviral and antibacterial antibiotic","volume":"11","author":"Funaki","year":"1958","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.bcp.2016.09.029_b1050","first-page":"97","article-title":"Screening studies of antiviral substances produced by actinomycetes and new antiviral substances, niromycins","volume":"13","author":"Osato","year":"1960","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.bcp.2016.09.029_b1055","first-page":"623","article-title":"Antiviral extracts from Propionibacteria","volume":"10","author":"Cutting","year":"1960","journal-title":"Antibiot. Chemother. (Northfield, Ill.)"},{"key":"10.1016\/j.bcp.2016.09.029_b1060","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/206263a0","article-title":"Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity, from a species of Streptomyces (C2989)","volume":"206","author":"Lumb","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b1065","first-page":"1152","article-title":"Borrelidin and vivomycin","volume":"1","author":"Pask","year":"1965","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bcp.2016.09.029_b1070","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1128\/IAI.13.3.763-767.1976","article-title":"Antiviral activity of Brucella abortus preparations; separation of active components","volume":"13","author":"Feingold","year":"1976","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2016.09.029_b1075","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.4049\/jimmunol.116.6.1512","article-title":"Augmentation of cell-mediated cytotoxicity against syngeneic Gross virus-induced lymphoma in rats by phytohemagglutinin and endotoxin","volume":"116","author":"Glaser","year":"1976","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b1080","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1084\/jem.166.5.1300","article-title":"Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts","volume":"166","author":"Helfgott","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b1085","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jlb.57.4.569","article-title":"Induction of macrophage binding to virally infected cells by low levels of lipopolysaccharide","volume":"57","author":"Derrick","year":"1995","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bcp.2016.09.029_b1090","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1179\/2047773215Y.0000000018","article-title":"VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria","volume":"109","author":"Canavese","year":"2015","journal-title":"Pathog. Glob. Health."},{"key":"10.1016\/j.bcp.2016.09.029_b1095","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.it.2014.12.007","article-title":"Caspases come together over LPS","volume":"36","author":"Smith","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b1100","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1128\/IAI.65.9.3520-3528.1997","article-title":"Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1","volume":"65","author":"Sasaki","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2016.09.029_b1105","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1007\/s00018-008-8228-6","article-title":"Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant","volume":"65","author":"Casella","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2016.09.029_b1110","doi-asserted-by":"publisher","first-page":"e36812","DOI":"10.1371\/journal.pone.0036812","article-title":"Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice","volume":"7","author":"Kamphuis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2016.09.029_b1115","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jconrel.2013.11.013","article-title":"Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine","volume":"174","author":"Patil","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2016.09.029_b1120","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1146\/annurev.bi.57.070188.002445","article-title":"Tumor necrosis, cachexia, shock, and inflammation: a common mediator","volume":"57","author":"Beutler","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bcp.2016.09.029_b1125","doi-asserted-by":"publisher","first-page":"510","DOI":"10.4062\/biomolther.2015.117","article-title":"Lipid A as a Drug Target and Therapeutic Molecule","volume":"23","author":"Joo","year":"2015","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.bcp.2016.09.029_b1130","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0166-3542(90)90016-Z","article-title":"Effect of acyl substituents of synthetic lipid A-subunit analogues on their immunomodulating antiviral activity","volume":"13","author":"Ikeda","year":"1990","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b1135","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.femsim.2004.05.002","article-title":"Bacillus alcalophilus peptidoglycan induces IFN-alpha-mediated inhibition of vaccinia virus replication","volume":"42","author":"Liu","year":"2004","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b1140","first-page":"233","article-title":"Immunomodulation by Bordetella pertussis: antiviral effects","volume":"61","author":"Winters","year":"1985","journal-title":"Dev. Biol. Stand."},{"key":"10.1016\/j.bcp.2016.09.029_b1145","doi-asserted-by":"publisher","first-page":"4782","DOI":"10.1128\/AAC.02594-14","article-title":"Highly sulfated K5 Escherichia coli polysaccharide derivatives inhibit respiratory syncytial virus infectivity in cell lines and human tracheal-bronchial histocultures","volume":"58","author":"Cagno","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1150","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1084\/jem.20060136","article-title":"A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression","volume":"203","author":"Macagno","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b1155","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.intimp.2005.07.004","article-title":"Antiviral and immunoregulatory effect of a novel exopolysaccharide from a marine thermotolerant Bacillus licheniformis","volume":"6","author":"Arena","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2016.09.029_b1160","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1128\/JB.141.3.1432-1434.1980","article-title":"Identification of flagellin associated with the Bacillus subtilis folded chromosome","volume":"141","author":"Gu\u00e9rout-Fleury","year":"1980","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bcp.2016.09.029_b1165","doi-asserted-by":"publisher","first-page":"8280","DOI":"10.4049\/jimmunol.180.12.8280","article-title":"Flagellin treatment protects against chemicals, bacteria, viruses, and radiation","volume":"180","author":"Vijay-Kumar","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2016.09.029_b1170","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/MMBR.60.2.316-341.1996","article-title":"Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis","volume":"60","author":"Henderson","year":"1996","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bcp.2016.09.029_b1175","series-title":"Enzybiotics Antibiot. Enzym. as Drugs Ther.","first-page":"1","article-title":"Concluding remarks: the future of enzybiotics","author":"Veiga-Crespo","year":"2010"},{"issue":"Suppl 3","key":"10.1016\/j.bcp.2016.09.029_b1180","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/irv.12174","article-title":"Viral-bacterial interactions-therapeutic implications","volume":"7","author":"Deng","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"10.1016\/j.bcp.2016.09.029_b1185","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jhep.2008.11.015","article-title":"Antiviral therapy increases the risk of bacterial infections in HCV-infected cirrhotic patients awaiting liver transplantation: A retrospective study","volume":"50","author":"Carri\u00f3n","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bcp.2016.09.029_b1190","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.virol.2012.08.007","article-title":"Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120","volume":"433","author":"F\u00e9rir","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b1195","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/S1473-3099(01)00092-5","article-title":"Cationic peptides: effectors in innate immunity and novel antimicrobials","volume":"1","author":"Hancock","year":"2001","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bcp.2016.09.029_b1200","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nrmicro976","article-title":"Primate defensins","volume":"2","author":"Lehrer","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b1205","doi-asserted-by":"publisher","first-page":"28821","DOI":"10.1074\/jbc.M112.375949","article-title":"Multifaceted mechanisms of HIV-1 entry inhibition by human \u03b1-defensin","volume":"287","author":"Demirkhanyan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b1210","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00441-010-1022-4","article-title":"Defensins in innate immunity","volume":"343","author":"Hazlett","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bcp.2016.09.029_b1215","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/prot.20963","article-title":"Small cationic protein from a marine turtle has \u03b2-defensin-like fold and antibacterial and antiviral activity","volume":"64","author":"Chattopadhyay","year":"2006","journal-title":"Proteins Struct. Funct. Bioinf."},{"key":"10.1016\/j.bcp.2016.09.029_b1220","unstructured":"B.H. Olson, C.L. Harvey, A.J. Jnnek, Restkictocin, US3104208 (A), 1963 <https:\/\/www.google.us\/patents\/US3104208>."},{"key":"10.1016\/j.bcp.2016.09.029_b1225","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0076-6879(01)41142-6","article-title":"A natural classification of ribonucleases","volume":"341","author":"Aravind","year":"2001","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bcp.2016.09.029_b1230","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1574-6976.2006.00063.x","article-title":"Fungal ribotoxins: molecular dissection of a family of natural killers","volume":"31","author":"Lacadena","year":"2007","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bcp.2016.09.029_b1235","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s10482-008-9266-7","article-title":"Ribotoxin genes in isolates of Aspergillus section Clavati","volume":"94","author":"Varga","year":"2008","journal-title":"Antonie Van Leeuwenhoek"},{"key":"10.1016\/j.bcp.2016.09.029_b1240","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.1128\/IAI.68.8.4462-4469.2000","article-title":"Antiviral activity of shiga toxin 1: suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation","volume":"68","author":"Ferens","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2016.09.029_b1245","series-title":"Microb. Toxins Curr. Res. Futur. Trends","first-page":"167","article-title":"Fungal ribotoxins: structure, function and evolution","author":"Herrero-Gal\u00e1n","year":"2009"},{"key":"10.1016\/j.bcp.2016.09.029_b1250","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S0014-5793(98)00137-9","article-title":"The cytotoxin alpha-sarcin behaves as a cyclizing ribonuclease","volume":"424","author":"Lacadena","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2016.09.029_b1255","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2174\/138920108784567335","article-title":"The therapeutic potential of fungal ribotoxins","volume":"9","author":"Carreras-Sangr\u00e0","year":"2008","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.bcp.2016.09.029_b1260","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/prot.21910","article-title":"The insecticidal protein hirsutellin A from the mite fungal pathogen Hirsutella thompsonii is a ribotoxin","volume":"72","author":"Herrero-Gal\u00e1n","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.bcp.2016.09.029_b1265","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.biochi.2011.08.010","article-title":"Implication of an Asp residue in the ribonucleolytic activity of hirsutellin A reveals new electrostatic interactions at the active site of ribotoxins","volume":"94","author":"Herrero-Gal\u00e1n","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.bcp.2016.09.029_b1270","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b1275","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nature00873","article-title":"Short interfering RNA confers intracellular antiviral immunity in human cells","volume":"418","author":"Gitlin","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b1280","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1073\/pnas.252783999","article-title":"Interference of hepatitis C virus RNA replication by short interfering RNAs","volume":"100","author":"Kapadia","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b1285","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.antiviral.2004.09.005","article-title":"Inhibition of SARS-CoV replication by siRNA","volume":"65","author":"Wu","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b1290","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1126\/science.1108784","article-title":"A cellular microRNA mediates antiviral defense in human cells","volume":"308","author":"Lecellier","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bcp.2016.09.029_b1295","doi-asserted-by":"publisher","first-page":"5965","DOI":"10.1016\/j.febslet.2005.08.034","article-title":"Antiviral silencing in animals","volume":"579","author":"Li","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2016.09.029_b1300","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/3-540-27262-3_7","article-title":"RNA interference. Its use as antiviral therapy","author":"Haasnoot","year":"2006","journal-title":"RNA Towar. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b1305","doi-asserted-by":"publisher","first-page":"7108","DOI":"10.1073\/pnas.1319635111","article-title":"Drosha as an interferon-independent antiviral factor","volume":"111","author":"Shapiro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b1310","doi-asserted-by":"publisher","first-page":"8267","DOI":"10.1128\/JVI.00766-15","article-title":"Robust Protection against Highly Virulent Foot-and-Mouth Disease Virus in Swine by Combination Treatment with Recombinant Adenoviruses Expressing Porcine Alpha and Gamma Interferons and Multiple Small Interfering RNAs","volume":"89","author":"Kim","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b1315","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2174\/138955751410141020150822","article-title":"Viral M2 ion channel protein: a promising target for anti-influenza drug discovery","volume":"14","author":"Moorthy","year":"2014","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b1320","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1126\/science.144.3620.862","article-title":"Antiviral activity of 1-adamantanamine (amantadine)","volume":"144","author":"Davies","year":"1964","journal-title":"Science (80\u2013)"},{"key":"10.1016\/j.bcp.2016.09.029_b1325","article-title":"Role of virion M2 protein in influenza virus uncoating: specific reduction in the rate of membrane fusion between virus and liposomes by amantadine","volume":"945\u2013948","author":"Wharton","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b1330","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/j.1460-2075.1985.tb04038.x","article-title":"The molecular basis of the specific anti-influenza action of amantadine","volume":"4","author":"Hay","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2016.09.029_b1335","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.1128\/JVI.70.12.8391-8401.1996","article-title":"Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins","volume":"70","author":"Bui","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b1340","doi-asserted-by":"publisher","first-page":"997","DOI":"10.2174\/092986708784049658","article-title":"Arbidol: a broad-spectrum antiviral compound that blocks viral fusion","volume":"15","author":"Boriskin","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b1345","article-title":"The synthetic antiviral drug arbidol inhibits globally prevalent pathogenic viruses","volume":"77\u201315","author":"P\u00e9cheur","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2016.09.029_b1350","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1476-5381.1966.tb01673.x","article-title":"The inhibition of neuraminidase and antiviral action","volume":"27","author":"Edmond","year":"1966","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1355","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1517\/13543784.11.6.859","article-title":"Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza","volume":"11","author":"Smee","year":"2002","journal-title":"Expert Opin. Investig. Drugs."},{"key":"10.1016\/j.bcp.2016.09.029_b1360","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/0042-6822(74)90080-4","article-title":"Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid","volume":"58","author":"Meindl","year":"1974","journal-title":"Virology"},{"key":"10.1016\/j.bcp.2016.09.029_b1365","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/363418a0","article-title":"Rational design of potent sialidase-based inhibitors of influenza virus replication","volume":"363","author":"von Itzstein","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.09.029_b1370","doi-asserted-by":"publisher","first-page":"g2547","DOI":"10.1136\/bmj.g2547","article-title":"Zanamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments","volume":"348","author":"Heneghan","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.bcp.2016.09.029_b1375","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1128\/AAC.00333-08","article-title":"CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity","volume":"53","author":"Yamashita","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1380","series-title":"Virology: Principles and Applications","author":"Carter","year":"2007"},{"key":"10.1016\/j.bcp.2016.09.029_b1385","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1128\/AAC.41.9.1949","article-title":"Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104","volume":"41","author":"Eisenberg","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1390","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1021\/jm0002679","article-title":"BCX-1812 (RWJ-270201): Discovery of a Novel, Highly Potent, Orally Active and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design","volume":"43","author":"Babu","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b1395","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0006-3002(59)90597-9","article-title":"Synthesis and biological activities of iododeoxyuridine, an analog of thymidine","volume":"32","author":"Prusoff","year":"1959","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.09.029_b1400","first-page":"507","article-title":"Antiviral therapy","volume":"50","author":"Stalder","year":"1977","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.bcp.2016.09.029_b1405","first-page":"469","article-title":"Antiviral Agents","volume":"144","author":"Patrick","year":"1974","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1016\/j.bcp.2016.09.029_b1410","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nrmicro975","article-title":"Antivirals and antiviral strategies","volume":"2","author":"De Clercq","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2016.09.029_b1415","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0166-3542(81)90011-5","article-title":"Acyclovir \u2013 a review of the preclinical and early clinical data of a new antiherpes drug","volume":"1","author":"Brigden","year":"1981","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b1420","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/nrd1877","article-title":"Acyclic nucleoside phosphonates: a key class of antiviral drugs","volume":"4","author":"De Clercq","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2016.09.029_b1425","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1126\/science.177.4050.705","article-title":"Broad-spectrum antiviral activity of Virazole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide","volume":"177","author":"Sidwell","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.bcp.2016.09.029_b1430","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nrd4010","article-title":"Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases","volume":"12","author":"Jordheim","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2016.09.029_b1435","doi-asserted-by":"publisher","first-page":"7096","DOI":"10.1073\/pnas.82.20.7096","article-title":"3\u2032-Azido-3\u2032-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III\/lymphadenopathy-associated virus in vitro","volume":"82","author":"Mitsuya","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b1440","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.antiviral.2005.05.001","article-title":"Antiviral drug discovery and development: Where chemistry meets with biomedicine","volume":"67","author":"De Clercq","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bcp.2016.09.029_b1445","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/0006-2952(91)90276-B","article-title":"Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines","volume":"42","author":"De Clercq","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2016.09.029_b1450","series-title":"Proteases as Targets Ther.","first-page":"3","article-title":"The road to fortovase. A history of saquinavir, the first human immunodeficiency virus protease inhibitor","author":"Redshaw","year":"2000"},{"key":"10.1016\/j.bcp.2016.09.029_b1455","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1073\/pnas.83.6.1911","article-title":"Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III\/lymphadenopathy-associated virus (HTLV-III\/LAV) by 2\u2032,3\u2032-dideoxynucleosides","volume":"83","author":"Mitsuya","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b1460","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-405880-4.00009-3","article-title":"The nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors in the treatment of HIV infections (AIDS)","author":"De Clercq","year":"2013","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bcp.2016.09.029_b1465","series-title":"Drug Discov. Dev.","first-page":"353","article-title":"Discovery and development of nevirapine","author":"Grozinger","year":"2006"},{"key":"10.1016\/j.bcp.2016.09.029_b1470","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1128\/AAC.39.12.2602","article-title":"L-743,726 (DMP-266): a Novel, Highly Potent Nonnucleoside Inhibitor of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase","volume":"39","author":"Young","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1475","article-title":"Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents","year":"2016","journal-title":"Dep. Heal. Hum. Serv."},{"key":"10.1016\/j.bcp.2016.09.029_b1480","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1073\/pnas.92.7.2484","article-title":"ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans","volume":"92","author":"Kempf","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.09.029_b1485","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1128\/AAC.42.12.3218","article-title":"ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease","volume":"42","author":"Sham","year":"1998","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.bcp.2016.09.029_b1490","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1021\/jm049560p","article-title":"Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor","volume":"48","author":"Surleraux","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2016.09.029_b1495","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pgen.1005986","article-title":"Exploiting Genetic Interference for Antiviral Therapy","volume":"12","author":"Tanner","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcp.2016.09.029_b1500","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.chom.2012.05.016","article-title":"An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription","volume":"12","author":"Mousseau","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bcp.2016.09.029_b1505","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/irv.12045","article-title":"Newer influenza antivirals, biotherapeutics and combinations","volume":"7","author":"Hayden","year":"2013","journal-title":"Influenza Other Respir. Viruses"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216303306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216303306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T01:25:57Z","timestamp":1749605157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295216303306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":301,"alternative-id":["S0006295216303306"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2016.09.029","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antivirals against animal viruses","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2016.09.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}