{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:25:20Z","timestamp":1785439520710,"version":"3.56.0"},"reference-count":142,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1A2A1A05005078"],"award-info":[{"award-number":["2016R1A2A1A05005078"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1A2A2A01002524"],"award-info":[{"award-number":["2015R1A2A2A01002524"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MISP","award":["20110031961"],"award-info":[{"award-number":["20110031961"]}]},{"name":"Advanced Production Technology Development Program and High Value-added Food Technology Development Program"},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["PJ011066"],"award-info":[{"award-number":["PJ011066"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.bcp.2016.10.009","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T23:31:03Z","timestamp":1477438263000},"page":"56-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics"],"prefix":"10.1016","volume":"134","author":[{"given":"Je Won","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Jip","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo Joon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2016.10.009_b0005","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1146\/annurev-chembioeng-061010-114209","article-title":"Metabolic engineering for the production of natural products","volume":"2","author":"Pickens","year":"2011","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"10.1016\/j.bcp.2016.10.009_b0010","first-page":"3670","article-title":"Natural products: a continuing source of novel drug leads","volume":"2013","author":"Cragg","year":"1830","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.10.009_b0015","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1021\/ja909118a","article-title":"Natural products version 2.0: connecting genes to molecules","volume":"132","author":"Walsh","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"2016","key":"10.1016\/j.bcp.2016.10.009_b0020","first-page":"629","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"1981","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcp.2016.10.009_b0025","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1126\/science.1168243","article-title":"Drug discovery and natural products: end of an era or an endless frontier?","volume":"325","author":"Li","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bcp.2016.10.009_b0030","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bcp.2016.10.009_b0035","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/2047-2994-1-11","article-title":"Participants of the 3rd World Healthcare-Associated Infection Forum, Ready for a world without antibiotics? the pensieres antibiotic resistance call to action","volume":"1","author":"Carlet","year":"2012","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"10.1016\/j.bcp.2016.10.009_b0040","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/ja.2012.27","article-title":"Thoughts and facts about antibiotics: where we are now and where we are heading","volume":"65","author":"Berdy","year":"2012","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bcp.2016.10.009_b0045","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.sbi.2013.06.012","article-title":"Engineering polyketide synthases and nonribosomal peptide synthetases","volume":"23","author":"Williams","year":"2013","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0050","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1039\/C5NP00099H","article-title":"Recent advances in engineering nonribosomal peptide assembly lines","volume":"33","author":"Winn","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0055","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.2174\/156802609789941906","article-title":"Biosynthesis of bacterial aromatic polyketides","volume":"9","author":"Zhan","year":"2009","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bcp.2016.10.009_b0060","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1039\/b911956f","article-title":"Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis","volume":"27","author":"Olano","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0065","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1021\/sb300092n","article-title":"Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity","volume":"4","author":"Thaker","year":"2015","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0070","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cbpa.2016.01.012","article-title":"On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems","volume":"31","author":"Sundaram","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0075","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.1007\/s00253-013-4978-7","article-title":"Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes","volume":"97","author":"Song","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0080","doi-asserted-by":"publisher","first-page":"7591","DOI":"10.1039\/C4CS00426D","article-title":"A comprehensive review of glycosylated bacterial natural products","volume":"44","author":"Elshahawi","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bcp.2016.10.009_b0085","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cbpa.2012.01.018","article-title":"Combinatorial biosynthesis of polyketides \u2013 a perspective","volume":"16","author":"Wong","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0090","first-page":"823","article-title":"Recent advances in combinatorial biosynthesis for drug discovery","volume":"9","author":"Sun","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bcp.2016.10.009_b0095","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.copbio.2011.12.016","article-title":"Synthetic biological approaches to natural product biosynthesis","volume":"23","author":"Winter","year":"2012","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0100","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/10408419409113554","article-title":"The genetics of chemical diversity","volume":"20","author":"Cerda-Olmedo","year":"1994","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0105","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/375549a0","article-title":"Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits","volume":"375","author":"McDaniel","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.10.009_b0110","doi-asserted-by":"publisher","first-page":"7749","DOI":"10.1021\/ja9803658","article-title":"Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases","volume":"120","author":"Yu","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2016.10.009_b0115","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1073\/pnas.96.5.1846","article-title":"Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel \u201cunnatural\u201d natural products","volume":"96","author":"McDaniel","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.10.009_b0120","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.copbio.2016.03.008","article-title":"Metabolic engineering of natural product biosynthesis in actinobacteria","volume":"42","author":"Bilyk","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0125","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1039\/C5NP00109A","article-title":"Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology","volume":"33","author":"Weissman","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0130","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1021\/cr0301189","article-title":"Genetic approaches to polyketide antibiotics. 1","volume":"105","author":"McDaniel","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bcp.2016.10.009_b0135","doi-asserted-by":"publisher","first-page":"9814","DOI":"10.1002\/anie.200801204","article-title":"Natural-product sugar biosynthesis and enzymatic glycodiversification","volume":"47","author":"Thibodeaux","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bcp.2016.10.009_b0140","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.cbpa.2009.02.003","article-title":"Indolocarbazole antitumour compounds by combinatorial biosynthesis","volume":"13","author":"Salas","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0145","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1751-7915.2010.00231.x","article-title":"Molecular insights on the biosynthesis of antitumour compounds by actinomycetes","volume":"4","author":"Olano","year":"2011","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0150","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00253-009-2326-8","article-title":"Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects","volume":"85","author":"Park","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0155","first-page":"1231","article-title":"Radical SAM enzymes in the biosynthesis of sugar-containing natural products","volume":"2012","author":"Ruszczycky","year":"1824","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2016.10.009_b0160","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1039\/C2NP20092A","article-title":"2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways","volume":"30","author":"Park","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0165","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.cbpa.2012.03.007","article-title":"Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology","volume":"16","author":"Kharel","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0170","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.tim.2014.10.007","article-title":"Nucleoside antibiotics: biosynthesis, regulation, and biotechnology","volume":"23","author":"Niu","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0175","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cbpa.2009.02.004","article-title":"Combinatorial biosynthesis of plant medicinal polyketides by microorganisms","volume":"13","author":"Horinouchi","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0180","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1039\/c1np00049g","article-title":"Combinatorial biosynthesis in plants: a (p)review on its potential and future exploitation","volume":"28","author":"Pollier","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0185","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1039\/C001463J","article-title":"Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis","volume":"28","author":"Sussmuth","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0190","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cbpa.2015.11.016","article-title":"Combinatorial biosynthesis of RiPPs: docking with marine life","volume":"31","author":"Sardar","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0195","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1039\/C4NP00057A","article-title":"Microbial biosynthesis of medicinally important plant secondary metabolites","volume":"31","author":"Song","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0200","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1021\/sb3000673","article-title":"Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways","volume":"3","author":"Baltz","year":"2014","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0205","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1002\/anie.200806121","article-title":"The biosynthetic logic of polyketide diversity","volume":"48","author":"Hertweck","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bcp.2016.10.009_b0210","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1039\/C5NP00095E","article-title":"Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines","volume":"33","author":"Pang","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0215","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.sbi.2016.05.009","article-title":"Structure and mechanism of assembly line polyketide synthases","volume":"41","author":"Robbins","year":"2016","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0220","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1039\/B507395M","article-title":"Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork","volume":"24","author":"Hertweck","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0225","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1039\/b911518h","article-title":"Cyclization of aromatic polyketides from bacteria and fungi","volume":"27","author":"Zhou","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0230","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.chembiol.2011.02.013","article-title":"Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase","volume":"18","author":"Harle","year":"2011","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0235","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1021\/cb100267k","article-title":"Recombinant E. coli prototype strains for in vivo glycorandomization","volume":"6","author":"Williams","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0240","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1039\/c1np00045d","article-title":"Enzymatic methods for glyco(diversification\/randomization) of drugs and small molecules","volume":"28","author":"Gantt","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0245","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/348176a0","article-title":"An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea","volume":"348","author":"Cortes","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2016.10.009_b0250","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1126\/science.2024119","article-title":"Modular organization of genes required for complex polyketide biosynthesis","volume":"252","author":"Donadio","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.bcp.2016.10.009_b0255","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.2174\/15680266113136660223","article-title":"Structure-activity relationships and mechanism of action of macrolides derived from erythromycin as antibacterial agents","volume":"13","author":"Liang","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bcp.2016.10.009_b0260","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.chembiol.2010.09.013","article-title":"Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host","volume":"17","author":"Zhang","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0265","doi-asserted-by":"publisher","first-page":"12259","DOI":"10.1021\/ja304682q","article-title":"Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket","volume":"134","author":"Harvey","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2016.10.009_b0270","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ymben.2013.09.005","article-title":"Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli","volume":"20","author":"Jiang","year":"2013","journal-title":"Metab. Eng."},{"key":"10.1016\/j.bcp.2016.10.009_b0275","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1021\/cb300505w","article-title":"Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase","volume":"8","author":"Sundermann","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0280","doi-asserted-by":"publisher","first-page":"8402","DOI":"10.1128\/AEM.02403-15","article-title":"Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis","volume":"81","author":"Fayed","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0285","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1007\/s00253-015-7036-9","article-title":"In vivo investigation to the macrolide-glycosylating enzyme pair DesVII\/DesVIII in Saccharopolyspora erythraea","volume":"100","author":"Wu","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0290","doi-asserted-by":"publisher","first-page":"12111","DOI":"10.1073\/pnas.95.21.12111","article-title":"A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity","volume":"95","author":"Xue","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.10.009_b0295","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s00253-011-3592-9","article-title":"Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities","volume":"93","author":"Han","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0300","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jbiotec.2013.05.014","article-title":"Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17","volume":"168","author":"Shinde","year":"2013","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0305","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1002\/adsc.201500250","article-title":"Chemoenzymatic synthesis of glycosylated macrolactam analogues of the macrolide antibiotic YC-17","volume":"357","author":"Shinde","year":"2015","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.bcp.2016.10.009_b0310","doi-asserted-by":"publisher","first-page":"853","DOI":"10.2174\/138920112800399095","article-title":"History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents","volume":"13","author":"Campbell","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0315","article-title":"Ivermectin: a reflection on simplicity (Nobel lecture)","author":"Campbell","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bcp.2016.10.009_b0320","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/biot.201200383","article-title":"Synthetic biology of avermectin for production improvement and structure diversification","volume":"9","author":"Zhuo","year":"2014","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.bcp.2016.10.009_b0325","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1016\/j.bmcl.2011.04.008","article-title":"Production of doramectin by rational engineering of the avermectin biosynthetic pathway","volume":"21","author":"Wang","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bcp.2016.10.009_b0330","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12934-015-0337-y","article-title":"Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase","volume":"14","author":"Zhang","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.bcp.2016.10.009_b0335","doi-asserted-by":"publisher","first-page":"5326","DOI":"10.1128\/AEM.01025-15","article-title":"Gene replacement for the generation of designed novel avermectin derivatives with enhanced acaricidal and nematicidal activities","volume":"81","author":"Huang","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0340","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00253-010-2890-y","article-title":"Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae","volume":"21","author":"Han","year":"2011","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0345","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/ja.2015.121","article-title":"PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A","volume":"69","author":"Perez","year":"2016","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bcp.2016.10.009_b0350","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1021\/np200580g","article-title":"Langkolide, a 32-membered macrolactone antibiotic produced by Streptomyces sp. Acta 3062","volume":"75","author":"Helaly","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcp.2016.10.009_b0355","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12934-016-0443-5","article-title":"Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative","volume":"15","author":"Salcedo","year":"2016","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.bcp.2016.10.009_b0360","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.canlet.2015.10.002","article-title":"Anthracyclines potentiate anti-tumor immunity: a new opportunity for chemoimmunotherapy","volume":"369","author":"Zhang","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2016.10.009_b0365","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2174\/1389200216888150915112039","article-title":"Role of drug metabolism in the cytotoxicity and clinical efficacy of anthracyclines","volume":"16","author":"Edwardson","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.bcp.2016.10.009_b0370","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jphotobiol.2016.02.032","article-title":"Review on the binding of anticancer drug doxorubicin with DNA and tRNA: structural models and antitumor activity","volume":"158","author":"Agudelo","year":"2016","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.bcp.2016.10.009_b0375","doi-asserted-by":"publisher","first-page":"4912","DOI":"10.1128\/AEM.02527-10","article-title":"Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates","volume":"77","author":"Han","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0380","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.breast.2011.12.012","article-title":"Epirubicin: is it like doxorubicin in breast cancer? a clinical review","volume":"21","author":"Khasraw","year":"2012","journal-title":"Breast"},{"key":"10.1016\/j.bcp.2016.10.009_b0385","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1007\/s10529-014-1542-1","article-title":"Bioconversion of deoxysugar moieties to the biosynthetic intermediates of daunorubicin in an engineered strain of Streptomyces coeruleobidus","volume":"36","author":"Yuan","year":"2014","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.bcp.2016.10.009_b0390","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cbpa.2016.03.011","article-title":"Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics","volume":"32","author":"Liu","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0395","doi-asserted-by":"publisher","first-page":"17677","DOI":"10.1021\/ja907852c","article-title":"Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575","volume":"131","author":"Pickens","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2016.10.009_b0400","doi-asserted-by":"publisher","first-page":"41539","DOI":"10.1074\/jbc.M111.299859","article-title":"Structural and biochemical characterization of the salicylyl-acyltranferase SsfX3 from a tetracycline biosynthetic pathway","volume":"286","author":"Pickens","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2016.10.009_b0405","doi-asserted-by":"publisher","first-page":"11136","DOI":"10.1002\/anie.201205426","article-title":"Heterologous expression and manipulation of three tetracycline biosynthetic pathways","volume":"51","author":"Wang","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bcp.2016.10.009_b0410","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ab.2015.09.015","article-title":"Kinetic characterization of small DNA-binding molecules interacting with a DNA strand on a quartz crystal microbalance","volume":"492","author":"Furusawa","year":"2016","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bcp.2016.10.009_b0415","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/cbic.201100637","article-title":"Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin","volume":"13","author":"Siitonen","year":"2012","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bcp.2016.10.009_b0420","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1021\/acschembio.6b00245","article-title":"Characterization of three tailoring enzymes in dutomycin biosynthesis and generation of a potent antibacterial analogue","volume":"11","author":"Sun","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0425","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1128\/AEM.01774-10","article-title":"Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties","volume":"77","author":"Shepherd","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0430","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1002\/cbic.201402426","article-title":"Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent","volume":"15","author":"Chen","year":"2014","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bcp.2016.10.009_b0435","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ygyno.2010.03.020","article-title":"Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts","volume":"118","author":"Previdi","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bcp.2016.10.009_b0440","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s11060-010-0266-x","article-title":"Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma","volume":"101","author":"Seznec","year":"2011","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.bcp.2016.10.009_b0445","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1517\/13543776.2014.877443","article-title":"Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature","volume":"24","author":"Lavecchia","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bcp.2016.10.009_b0450","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.1021\/jm300234t","article-title":"A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis","volume":"55","author":"Nunez","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2016.10.009_b0455","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2624","article-title":"Identification of mithramycin analogs with improved targeting of the EWS\/FLI1 transcription factor","author":"Osgood","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2016.10.009_b0460","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.8817","article-title":"Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma","author":"Tornin","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2016.10.009_b0465","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1039\/C5NP00035A","article-title":"Insights into the chemical logic and enzymatic machinery of NRPS assembly lines","volume":"33","author":"Walsh","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0470","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1016\/j.clinthera.2015.11.007","article-title":"Beyond vancomycin: the tail of the lipoglycopeptides","volume":"37","author":"Klinker","year":"2015","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bcp.2016.10.009_b0475","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/ja.2010.131","article-title":"Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase","volume":"64","author":"Oh","year":"2011","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bcp.2016.10.009_b0480","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1039\/c0mb00320d","article-title":"Regioselective deacetylation based on teicoplanin-complexed Orf2\u2217 crystal structures","volume":"7","author":"Chan","year":"2011","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.bcp.2016.10.009_b0485","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nchembio.556","article-title":"Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0490","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1093\/cid\/civ522","article-title":"Telavancin: the long and winding road from discovery to Food and Drug Administration approvals and future directions","volume":"61","author":"Wenzler","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bcp.2016.10.009_b0495","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1080\/17425255.2016.1187599","article-title":"Pharmacodynamics, pharmacokinetics and clinical efficacy of telavancin in the treatment of pneumonia","volume":"12","author":"Adamantia","year":"2016","journal-title":"Expert Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.bcp.2016.10.009_b0500","doi-asserted-by":"publisher","first-page":"15661","DOI":"10.1021\/ja105825a","article-title":"Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products","volume":"132","author":"Banik","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2016.10.009_b0505","doi-asserted-by":"publisher","first-page":"11797","DOI":"10.1073\/pnas.1222159110","article-title":"Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products","volume":"110","author":"Owen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2016.10.009_b0510","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/tcr.201500210","article-title":"Aminoglycoside antibiotics: new insights into the biosynthetic machinery of old drugs","volume":"16","author":"Kudo","year":"2016","journal-title":"Chem. Rec."},{"key":"10.1016\/j.bcp.2016.10.009_b0515","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1021\/cb3005116","article-title":"Aminoglycoside antibiotics in the 21st century","volume":"8","author":"Becker","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0520","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1038\/mt.2013.150","article-title":"A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM Gene","volume":"21","author":"Du","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bcp.2016.10.009_b0525","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1021\/cb400498n","article-title":"Structure-guided discovery of a novel aminoglycoside conjugate targeting HIV-1 RNA viral genome","volume":"8","author":"Ennifar","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0530","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1039\/C4MD00078A","article-title":"Antifungal amphiphilic aminoglycosides","volume":"5","author":"Chang","year":"2014","journal-title":"Medchemcomm."},{"key":"10.1016\/j.bcp.2016.10.009_b0535","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1039\/C5MD00453E","article-title":"A review of patents (2011\u20132015) towards combating resistance to and toxicity of aminoglycosides","volume":"7","author":"Chandrika","year":"2016","journal-title":"Medchemcomm."},{"key":"10.1016\/j.bcp.2016.10.009_b0540","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/cbic.200900779","article-title":"The future of aminoglycosides: the end or renaissance?","volume":"11","author":"Houghton","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bcp.2016.10.009_b0545","first-page":"139","article-title":"Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens","volume":"6","author":"Matsumoto","year":"2014","journal-title":"Clin. Pharmacol."},{"key":"10.1016\/j.bcp.2016.10.009_b0550","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1111\/j.1365-2672.2009.04582.x","article-title":"Biosynthesis of paromamine derivatives in engineered Escherichia coli by heterologous expression","volume":"108","author":"Kurumbang","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0555","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.resmic.2010.04.013","article-title":"Heterologous production of ribostamycin derivatives in engineered Escherichia coli","volume":"161","author":"Kurumbang","year":"2010","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0560","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s12010-010-9045-6","article-title":"Biosynthesis of ribostamycin derivatives by reconstitution and heterologous expression of required gene sets","volume":"163","author":"Kurumbang","year":"2011","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0565","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/cbic.200900584","article-title":"Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides","volume":"11","author":"Green","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bcp.2016.10.009_b0570","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nchembio.671","article-title":"Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation","volume":"7","author":"Park","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0575","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1586\/eri.11.170","article-title":"Susceptibility of Gram-negative bacteria to isepamicin: a systematic review","volume":"10","author":"Falagas","year":"2012","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"10.1016\/j.bcp.2016.10.009_b0580","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-015-0402-6","article-title":"Assembly of a novel biosynthetic pathway for gentamicin B production in Micromonospora echinospora","volume":"15","author":"Ni","year":"2016","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.bcp.2016.10.009_b0585","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1039\/B816215H","article-title":"Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis","volume":"27","author":"Winn","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0590","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.funbio.2013.11.001","article-title":"Nikkomycin Z is an effective inhibitor of the chytrid fungus linked to global amphibian declines","volume":"118","author":"Holden","year":"2014","journal-title":"Fungal Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0595","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ejmech.2015.11.027","article-title":"Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents","volume":"108","author":"Ji","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2016.10.009_b0600","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ymben.2011.01.002","article-title":"Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties","volume":"13","author":"Li","year":"2011","journal-title":"Metab. Eng."},{"key":"10.1016\/j.bcp.2016.10.009_b0605","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1475-2859-11-135","article-title":"Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes","volume":"11","author":"Li","year":"2012","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.bcp.2016.10.009_b0610","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1475-2859-13-59","article-title":"Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes","volume":"13","author":"Feng","year":"2014","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.bcp.2016.10.009_b0615","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1002\/bit.25594","article-title":"Metabolic engineering of an industrial polyoxin producer for the targeted overproduction of designer nucleoside antibiotics","volume":"112","author":"Qi","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bcp.2016.10.009_b0620","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/biom5031652","article-title":"Inhibition of topoisomerase (DNA) I (TOP1): DNA damage repair and anticancer therapy","volume":"5","author":"Xu","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2016.10.009_b0625","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1021\/cr300410v","article-title":"Kinase inhibitors of marine origin","volume":"113","author":"Bharate","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bcp.2016.10.009_b0630","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1039\/b905068j","article-title":"Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles","volume":"27","author":"Sanchez","year":"2009","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bcp.2016.10.009_b0635","doi-asserted-by":"publisher","first-page":"27923","DOI":"10.18632\/oncotarget.4736","article-title":"Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer","volume":"6","author":"Cuenca-Lopez","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2016.10.009_b0640","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1002\/anie.201308272","article-title":"Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues","volume":"53","author":"Singh","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bcp.2016.10.009_b0645","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/1439-7633(20020301)3:2\/3<124::AID-CBIC124>3.0.CO;2-J","article-title":"Combinatorial biosynthesis of antibiotics: challenges and opportunities","volume":"3","author":"Walsh","year":"2002","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bcp.2016.10.009_b0650","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jbiotec.2005.12.001","article-title":"Combinatorial biosynthesis \u2013 potential and problems","volume":"124","author":"Floss","year":"2006","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0655","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nchembio.1893","article-title":"Reinvigorating natural product combinatorial biosynthesis with synthetic biology","volume":"11","author":"Kim","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0660","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.copbio.2016.02.010","article-title":"Recent progress in therapeutic natural product biosynthesis using Escherichia coli","volume":"42","author":"Ahmadi","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0665","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/nchembio.970","article-title":"Systems metabolic engineering of microorganisms for natural and non-natural chemicals","volume":"8","author":"Lee","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2016.10.009_b0670","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fbioe.2015.00199","article-title":"Systems biology approaches to understand natural products biosynthesis","volume":"3","author":"Licona-Cassani","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0675","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nrmicro.2015.24","article-title":"Synthetic biology to access and expand nature\u2019s chemical diversity","volume":"14","author":"Smanski","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0680","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7311.1","article-title":"Accessing Nature\u2019s diversity through metabolic engineering and synthetic biology","volume":"5","author":"King","year":"2016","journal-title":"F1000Res."},{"key":"10.1016\/j.bcp.2016.10.009_b0685","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fmicb.2014.00021","article-title":"Expression of codon optimized genes in microbial systems: current industrial applications and perspectives","volume":"5","author":"Elena","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bcp.2016.10.009_b0690","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1007\/s12272-015-0638-z","article-title":"Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery","volume":"38","author":"Kim","year":"2015","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.bcp.2016.10.009_b0695","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jbiotec.2015.12.028","article-title":"Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites","volume":"219","author":"Song","year":"2016","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bcp.2016.10.009_b0700","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1039\/C5NP00085H","article-title":"New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters","volume":"33","author":"Luo","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2016.10.009_b0705","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrg3645","article-title":"Ribosome profiling: new views of translation, from single codons to genome scale","volume":"15","author":"Ingolia","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bcp.2016.10.009_b0710","doi-asserted-by":"publisher","first-page":"11605","DOI":"10.1038\/ncomms11605","article-title":"The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)","volume":"7","author":"Jeong","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216303781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216303781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T21:29:35Z","timestamp":1568496575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295216303781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":142,"alternative-id":["S0006295216303781"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2016.10.009","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726901899.793532052","asserted-by":"object"}]},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2016.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}