{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:47:16Z","timestamp":1790380036635,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["\u2013 168248\/2014-0"],"award-info":[{"award-number":["\u2013 168248\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bcp.2016.12.018","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T12:17:22Z","timestamp":1482495442000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Antileishmanial activity of verbascoside: Selective arginase inhibition of intracellular amastigotes of Leishmania (Leishmania) amazonensis with resistance induced by LPS plus IFN-\u03b3"],"prefix":"10.1016","volume":"127","author":[{"given":"Claudia do Carmo","family":"Maquiaveli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina L\u00e1zaro","family":"Rochetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidge","family":"Fukumasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Cezar","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson Roberto","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2016.12.018_b0005","unstructured":"WHO, Leishmaniasis, 2016. http:\/\/www.who.int\/leishmaniasis\/en\/. (Accessed 05\/04\/2016 2016)."},{"issue":"19","key":"10.1016\/j.bcp.2016.12.018_b0010","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1073\/pnas.93.19.10383","article-title":"Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania","volume":"93","author":"Mukhopadhyay","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2016.12.018_b0015","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1128\/AAC.01563-07","article-title":"Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials","volume":"52","author":"Wyllie","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2016.12.018_b0020","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev.mi.46.100192.003403","article-title":"Metabolism and functions of trypanothione in the Kinetoplastida","volume":"46","author":"Fairlamb","year":"1992","journal-title":"Annu. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.bcp.2016.12.018_b0025","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1096\/fj.09-146407","article-title":"Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites","volume":"24","author":"Bocedi","year":"2010","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bcp.2016.12.018_b0030","doi-asserted-by":"crossref","first-page":"e0004373","DOI":"10.1371\/journal.pntd.0004373","article-title":"Deprivation of L-arginine induces oxidative stress mediated apoptosis in Leishmania donovani promastigotes: contribution of the polyamine pathway","volume":"10","author":"Mandal","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bcp.2016.12.018_b0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.phytochem.2013.01.014","article-title":"Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement","volume":"89","author":"Cruz","year":"2013","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.bcp.2016.12.018_b0040","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.foodchem.2013.05.025","article-title":"Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection","volume":"141","author":"Manjolin","year":"2013","journal-title":"Food Chem."},{"issue":"5","key":"10.1016\/j.bcp.2016.12.018_b0045","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/cbdd.12566","article-title":"Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase","volume":"86","author":"da Silva","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"issue":"5","key":"10.1016\/j.bcp.2016.12.018_b0050","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ijpara.2010.12.006","article-title":"Inhibition profile of Leishmania mexicana arginase reveals differences with human arginase I","volume":"41","author":"Riley","year":"2011","journal-title":"Int. J. Parasitol."},{"issue":"10","key":"10.1016\/j.bcp.2016.12.018_b0055","doi-asserted-by":"crossref","first-page":"798","DOI":"10.2174\/1389557515666150511153852","article-title":"The promise of plant-derived substances as inhibitors of arginase","volume":"15","author":"Girard-Thernier","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bcp.2016.12.018_b0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/S0102-311X2002000100019","article-title":"N\u00edvel de conhecimentos sobre Leishmaniose Tegumentar Americana (LTA) e uso de terapias alternativas por popula\u00e7\u00f5es de uma \u00e1rea end\u00eamica da Amaz\u00f4nia do Maranh\u00e3o, Brasil","volume":"18","author":"Moreira","year":"2002","journal-title":"Cadernos de Sa\u00fade P\u00fablica"},{"issue":"5","key":"10.1016\/j.bcp.2016.12.018_b0065","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/acs.jnatprod.5b00875","article-title":"Verbascoside inhibits promastigote growth and arginase activity of Leishmania amazonensis","volume":"79","author":"Maquiaveli","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcp.2016.12.018_b0070","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0021-9258(18)51085-1","article-title":"Colorimetric determination of urea","volume":"157","author":"Archibald","year":"1945","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2016.12.018_b0075","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"Suppl. 4","key":"10.1016\/j.bcp.2016.12.018_b0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1078\/1433-187X-00307","article-title":"Pharmacological profile of extracts of Pelargonium sidoides and their constituents","volume":"10","author":"Kolodziej","year":"2003","journal-title":"Phytomedicine"},{"issue":"17","key":"10.1016\/j.bcp.2016.12.018_b0085","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.phytochem.2005.01.011","article-title":"Antileishmanial activity and immune modulatory effects of tannins and related compounds on Leishmania parasitised RAW 264.7 cells","volume":"66","author":"Kolodziej","year":"2005","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.bcp.2016.12.018_b0090","doi-asserted-by":"crossref","first-page":"e0004442","DOI":"10.1371\/journal.pntd.0004442","article-title":"Oral efficacy of apigenin against cutaneous leishmaniasis: Involvement of reactive oxygen species and autophagy as a mechanism of action","volume":"10","author":"Fonseca-Silva","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2016.12.018_b0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.niox.2012.04.004","article-title":"Leishmania chagasi naturally resistant to nitric oxide isolated from humans and dogs with visceral leishmaniasis in Brazil","volume":"27","author":"Santos","year":"2012","journal-title":"Nitric Oxide"},{"issue":"7","key":"10.1016\/j.bcp.2016.12.018_b0100","doi-asserted-by":"crossref","first-page":"e3000","DOI":"10.1371\/journal.pntd.0003000","article-title":"Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and fosters parasite virulence","volume":"8","author":"Henard","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"2","key":"10.1016\/j.bcp.2016.12.018_b0105","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.4238\/2015.June.29.4","article-title":"Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide","volume":"14","author":"Rios","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2016.12.018_b0110","doi-asserted-by":"crossref","first-page":"e0003411","DOI":"10.1371\/journal.pntd.0003411","article-title":"Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB\/c and BALB\/c Nude Mice","volume":"9","author":"Teixeira","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.bcp.2016.12.018_b0115","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.193.6.777","article-title":"The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages","volume":"193","author":"Iniesta","year":"2001","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.bcp.2016.12.018_b0120","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1462-5822.2007.01096.x","article-title":"The Leishmania\u2013macrophage interaction: a metabolic perspective","volume":"10","author":"Naderer","year":"2008","journal-title":"Cell. Microbiol."},{"issue":"7","key":"10.1016\/j.bcp.2016.12.018_b0125","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nm.3221","article-title":"Inflammasome-derived IL-1[beta] production induces nitric oxide-mediated resistance to Leishmania","volume":"19","author":"Lima-Junior","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bcp.2016.12.018_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-7-7","article-title":"Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis","volume":"7","author":"Giudice","year":"2007","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2016.12.018_b0135","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/bbrc.1994.1909","article-title":"Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase","volume":"202","author":"Daghigh","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.bcp.2016.12.018_b0140","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1128\/IAI.73.9.6085-6090.2005","article-title":"Arginase I induction during Leishmania major infection mediates the development of disease","volume":"73","author":"Iniesta","year":"2005","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.bcp.2016.12.018_b0145","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2165\/00003495-199040020-00002","article-title":"Therapy and prophylaxis of systemic protozoan infections","volume":"40","author":"Van Voorhis","year":"1990","journal-title":"Drugs"},{"key":"10.1016\/j.bcp.2016.12.018_b0150","series-title":"Polyamines in Cancer: Basic Mechanisms and Clinical Approaches, Polyamine inhibitors and analogs","first-page":"151","author":"Kramer","year":"1996"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216304981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295216304981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T18:10:09Z","timestamp":1655489409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295216304981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":30,"alternative-id":["S0006295216304981"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2016.12.018","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antileishmanial activity of verbascoside: Selective arginase inhibition of intracellular amastigotes of Leishmania (Leishmania) amazonensis with resistance induced by LPS plus IFN-\u03b3","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2016.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}