{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:51:48Z","timestamp":1781463108753,"version":"3.54.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bcp.2017.11.006","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T15:30:26Z","timestamp":1510846226000},"page":"153-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors"],"prefix":"10.1016","volume":"147","author":[{"given":"Nawid","family":"Madjroh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Rie","family":"Olander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Bundgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pella Cecilia","family":"S\u00f6derhielm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders A.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2017.11.006_b0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/pr.108.00505","article-title":"International Union of Pharmacology. LXX. Subtypes of \u03b3-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function. Update","volume":"60","author":"Olsen","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2017.11.006_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.apha.2017.03.003","article-title":"GABAA receptors and the diversity in their structure and pharmacology","volume":"79","author":"Chua","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0015","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2174\/156802611795371350","article-title":"GABAA receptor subtype-selective modulators. I. \u03b12\/\u03b13-selective agonists as non-sedating anxiolytics","volume":"11","author":"Atack","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bcp.2017.11.006_b0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/gbb.12321","article-title":"GABAA receptor subtype involvement in addictive behaviour","volume":"16","author":"Stephens","year":"2017","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bcp.2017.11.006_b0025","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2174\/156802611795371314","article-title":"GABAA receptor subtype-selective modulators. II. \u03b15-selective inverse agonists for cognition enhancement","volume":"11","author":"Atack","year":"2011","journal-title":"Curr. Top Med. Chem."},{"key":"10.1016\/j.bcp.2017.11.006_b0030","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev-pharmtox-011613-135947","article-title":"GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism","volume":"54","author":"Rudolph","year":"2014","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.bcp.2017.11.006_b0035","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.neuron.2015.03.042","article-title":"The GABAA receptor as a therapeutic target for neurodevelopmental disorders","volume":"86","author":"Braat","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2017.11.006_b0040","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.pharmthera.2005.04.014","article-title":"Treating insomnia: current and investigational pharmacological approaches","volume":"112","author":"Ebert","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2017.11.006_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuron.2011.12.012","article-title":"Extrasynaptic GABAA receptors: their function in the CNS and implications for disease","volume":"73","author":"Brickley","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2017.11.006_b0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrn1625","article-title":"Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors","volume":"6","author":"Farrant","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bcp.2017.11.006_b0055","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1523\/JNEUROSCI.2679-05.2005","article-title":"Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics","volume":"25","author":"Belelli","year":"2005","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.bcp.2017.11.006_b0060","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1113\/jphysiol.2007.146746","article-title":"The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells","volume":"586","author":"Herd","year":"2008","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.006_b0065","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1124\/mol.107.042481","article-title":"Atomic force microscopy reveals the stoichiometry and subunit arrangement of the \u03b14\u03b23\u03b4 GABAA receptor","volume":"73","author":"Barrera","year":"2008","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2017.11.006_b0070","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2009.06387.x","article-title":"Structure of \u03b16\u03b23\u03b4 GABAA receptors and their lack of ethanol sensitivity","volume":"111","author":"Baur","year":"2009","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.bcp.2017.11.006_b0075","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1074\/jbc.M806484200","article-title":"Unanticipated structural and functional properties of \u03b4-subunit-containing GABAA receptors","volume":"284","author":"Kaur","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.006_b0080","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1111\/j.1476-5381.2011.01690.x","article-title":"Characteristics of concatemeric GABAA receptors containing \u03b14\/\u03b4 subunits expressed in Xenopus oocytes","volume":"165","author":"Shu","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0085","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1124\/mol.114.094813","article-title":"GABAA \u03b14, \u03b22 and \u03b4 subunits assemble to produce more than one functionally distinct receptor type","volume":"86","author":"Eaton","year":"2014","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2017.11.006_b0090","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/bph.12514","article-title":"Stoichiometry of \u03b4 subunit containing GABAA receptors","volume":"171","author":"Patel","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0095","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature13293","article-title":"Crystal structure of a human GABAA receptor","volume":"512","author":"Miller","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2017.11.006_b0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tips.2009.12.005","article-title":"Binding, activation and modulation of Cys-loop receptors","volume":"31","author":"Miller","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2017.11.006_b0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.apha.2014.10.002","article-title":"Allosteric modulation of GABAA receptors via multiple drug-binding sites","volume":"72","author":"Sieghart","year":"2015","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/bs.apha.2014.11.005","article-title":"Allosteric ligands and their binding sites define \u03b3-aminobutyric acid (GABA) type A receptor subtypes","volume":"73","author":"Olsen","year":"2015","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1124\/mol.115.099291","article-title":"A multifaceted GABAA receptor modulator: functional properties and molecular mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)","volume":"88","author":"Hammer","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0120","series-title":"Drugs The Straight Facts: Qualuudes","author":"Gass","year":"2008"},{"key":"10.1016\/j.bcp.2017.11.006_b0125","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1471-4159.2004.02801.x","article-title":"Functional characterization of mouse \u03b14\u03b22 nicotinic acetylcholine receptors stably expressed in HEK293T cells","volume":"91","author":"Karadsheh","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2017.11.006_b0130","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1124\/mol.54.2.322","article-title":"Rat \u03b13\/\u03b24 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function","volume":"54","author":"Xiao","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0135","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1074\/jbc.M109.079319","article-title":"Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors","volume":"285","author":"Jensen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.006_b0140","doi-asserted-by":"crossref","first-page":"16256","DOI":"10.1523\/JNEUROSCI.1495-14.2014","article-title":"Probing \u03b14\u03b2\u03b4 GABAA receptor heterogeneity: differential regional effects of a functionally selective \u03b14\u03b21\u03b4\/\u03b14\u03b23\u03b4 receptor agonist on tonic and phasic inhibition in rat brain","volume":"34","author":"Hoestgaard-Jensen","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2017.11.006_b0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuropharm.2008.08.004","article-title":"Novel compounds selectively enhance \u03b4 subunit containing GABAA receptors and increase tonic currents in thalamus","volume":"56","author":"Wafford","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2017.11.006_b0150","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1124\/jpet.105.092403","article-title":"Pharmacological characterization of agonists at \u03b4-containing GABAA receptors: Functional selectivity for extrasynaptic receptors is dependent on the absence of \u03b32","volume":"316","author":"Storustovu","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2017.11.006_b0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuropharm.2015.12.009","article-title":"P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in vivo","volume":"103","author":"Bundgaard","year":"2016","journal-title":"Neuropharmacology"},{"issue":"16","key":"10.1016\/j.bcp.2017.11.006_b0160","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1007\/s00213-014-3492-7","article-title":"In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia","volume":"231","author":"Redrobe","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bcp.2017.11.006_b0165","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00726-012-1456-y","article-title":"Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review","volume":"44","author":"Karim","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.bcp.2017.11.006_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2012.00001","article-title":"GABA potency at GABAA receptors found in synaptic and extrasynaptic zones","volume":"6","author":"Mortensen","year":"2012","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.bcp.2017.11.006_b0175","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1073\/pnas.91.10.4569","article-title":"The modulatory action of loreclezole at the \u03b3-aminobutyric acid type A receptor is determined by a single amino acid in the \u03b22 and \u03b23 subunit","volume":"91","author":"Wingrove","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.006_b0180","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.1073\/pnas.94.20.11031","article-title":"The interaction of the general anesthetic etomidate with the \u03b3-aminobutyric acid type A receptor is influenced by a single amino acid","volume":"94","author":"Belelli","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.006_b0185","doi-asserted-by":"crossref","first-page":"11599","DOI":"10.1523\/JNEUROSCI.3467-06.2006","article-title":"Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog","volume":"26","author":"Li","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2017.11.006_b0190","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.0022-3042.2001.00682.x","article-title":"Molecular determinants for the action of general anesthetics at recombinant \u03b12\u03b23\u03b32 \u03b3-aminobutyric acidA receptors","volume":"80","author":"Siegwart","year":"2002","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.006_b0195","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1124\/mol.53.3.530","article-title":"Propofol and other intravenous anesthetics have sites of action on the \u03b3-aminobutyric acid type A receptor distinct from that for isoflurane","volume":"53","author":"Krasowski","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0200","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S0028-3908(01)00141-1","article-title":"Methionine 286 in transmembrane domain 3 of the GABAA receptor \u03b2 subunit controls a binding cavity for propofol and other alkylphenol general anesthetics","volume":"41","author":"Krasowski","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2017.11.006_b0205","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1124\/mol.108.050500","article-title":"Tryptophan mutations at azi-etomidate photo-incorporation sites on \u03b11 or \u03b22 subunits enhance GABAA receptor gating and reduce etomidate modulation","volume":"74","author":"Stewart","year":"2008","journal-title":"Mol. Pharmacol."},{"issue":"51","key":"10.1016\/j.bcp.2017.11.006_b0210","doi-asserted-by":"crossref","first-page":"26529","DOI":"10.1074\/jbc.M116.753335","article-title":"General anesthetic binding sites in human \u03b14\u03b23\u03b4 \u03b3-aminobutyric acid type A receptors (GABAARs)","volume":"291","author":"Chiara","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.006_b0215","doi-asserted-by":"crossref","first-page":"25943","DOI":"10.1038\/srep25943","article-title":"Novel positive allosteric modulators of GABAA receptors with anesthetic activity","volume":"6","author":"Maldifassi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2017.11.006_b0220","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1124\/mol.65.1.68","article-title":"Defining the propofol binding site location on the GABAA receptor","volume":"65","author":"Bali","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0225","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature05324","article-title":"Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites","volume":"444","author":"Hosie","year":"2006","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bcp.2017.11.006_b0230","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2174\/1570159X14666160202121319","article-title":"Multiple non-equivalent interfaces mediate direct activation of GABAA receptors by propofol","volume":"14","author":"Eaton","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2017.11.006_b0235","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1213\/ANE.0000000000001368","article-title":"Mapping general anesthetic sites in heteromeric \u03b3-aminobutyric acid type A receptors reveals a potential for targeting receptor subtypes","volume":"123","author":"Forman","year":"2016","journal-title":"Anesthesia Analgesia"},{"key":"10.1016\/j.bcp.2017.11.006_b0240","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00213-014-3568-4","article-title":"11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABA receptors","volume":"231","author":"Chen","year":"2014","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.bcp.2017.11.006_b0245","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cpt.557","article-title":"Psychedelics as Medicines: An Emerging New Paradigm","volume":"101","author":"Nichols","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2017.11.006_b0250","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.2174\/13816128113196660137","article-title":"Novel Therapeutic Strategies in Major Depression: Focus on RNAi and Ketamine","volume":"20","author":"Bortolozzi","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bcp.2017.11.006_b0255","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1124\/mol.104.002543","article-title":"Pentobarbital differentially modulates \u03b11\u03b23\u03b4 and \u03b11\u03b23\u03b32L GABAA receptor currents","volume":"66","author":"Feng","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0260","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.phrs.2016.05.014","article-title":"A pharmacological assessment of agonists and modulators at \u03b14\u03b22\u03b32 and \u03b14\u03b22\u03b4 GABAA receptors: The challenge in comparing apples with oranges","volume":"111","author":"Ahring","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.006_b0265","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/bph.12507","article-title":"Etomidate produces similar allosteric modulation in \u03b11\u03b23\u03b4 and \u03b11\u03b23\u03b32L GABAA receptors","volume":"171","author":"Feng","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0270","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/bph.12001","article-title":"A study of subunit selectivity, mechanism and site of action of the \u03b4 selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors","volume":"168","author":"Jensen","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.006_b0275","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/bi201772m","article-title":"Mapping general anesthetic binding site(s) in human \u03b11\u03b23 \u03b3-aminobutyric acid type A receptors with [3H]TDBzl-etomidate, a photoreactive etomidate analogue","volume":"51","author":"Chiara","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2017.11.006_b0280","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuropharm.2016.01.003","article-title":"Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital","volume":"105","author":"Maldifassi","year":"2016","journal-title":"Neuropharmacology"},{"issue":"23","key":"10.1016\/j.bcp.2017.11.006_b0285","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1111\/bph.12861","article-title":"The neurosteroid 5\u03b2-pregnan-3\u03b1-ol-20-one enhances actions of etomidate as a positive allosteric modulator of \u03b11\u03b22\u03b32L GABAA receptors","volume":"171","author":"Li","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.006_b0290","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1097\/ALN.0b013e318289bcd3","article-title":"The benzodiazepine diazepam potentiates responses of \u03b11\u03b22\u03b32L \u03b3-aminobutyric acid type A receptors activated by either \u03b3-aminobutyric acid or allosteric agonists","volume":"118","author":"Li","year":"2013","journal-title":"Anesthesiology"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217306706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217306706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:00:48Z","timestamp":1757768448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295217306706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":58,"alternative-id":["S0006295217306706"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2017.11.006","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}