{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:38:36Z","timestamp":1776843516011,"version":"3.51.2"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bcp.2017.11.011","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:17:19Z","timestamp":1511237839000},"page":"20-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["The role of hydrogen sulfide in cyclic nucleotide signaling"],"prefix":"10.1016","volume":"149","author":[{"given":"Xu","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siping","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-song","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2017.11.011_b0005","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1042\/bst0030316","article-title":"Inhibition of cytochrome c oxidase by sulphide","volume":"3","author":"Nicholls","year":"1975","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bcp.2017.11.011_b0010","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2017.11.011_b0015","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2017.11.011_b0020","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine \u03b3-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bcp.2017.11.011_b0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","article-title":"Neuroprotective effects of hydrogen sulfide on Parkinson\u2019s disease rat models","volume":"9","author":"Hu","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2017.11.011_b0030","doi-asserted-by":"crossref","first-page":"e21077","DOI":"10.1371\/journal.pone.0021077","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2017.11.011_b0035","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine \u03b2-synthetase\/hydrogen sulfide inhibition in cancer","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0040","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fphar.2016.00385","article-title":"The role of hydrogen sulfide in renal system","volume":"7","author":"Cao","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0045","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0050","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2017.11.011_b0055","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0060","first-page":"1","article-title":"A new hope for a devastating disease: hydrogen sulfide in Parkinson\u2019s disease","author":"Cao","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.niox.2014.06.003","article-title":"Working with \u201cH2S\u201d: facts and apparent artifacts","volume":"41","author":"Wedmann","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bcp.2017.11.011_b0070","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.freeradbiomed.2010.10.705","article-title":"Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest","volume":"50","author":"Carballal","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2017.11.011_b0075","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/tx100266a","article-title":"Rapid reaction of hydrogen sulfide with the neutrophil oxidant hypochlorous acid to generate polysulfides","volume":"23","author":"Nagy","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bcp.2017.11.011_b0080","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/ars.2009.2882","article-title":"Novel insights into hydrogen sulfide-mediated cytoprotection","volume":"12","author":"Calvert","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0085","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.011_b0090","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1113\/expphysiol.2011.057455","article-title":"Hydrogen sulfide: its production and functions","volume":"96","author":"Kimura","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2014.05.012","article-title":"Controversies and conundrums in hydrogen sulfide biology","volume":"41","author":"Olson","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bcp.2017.11.011_b0100","doi-asserted-by":"crossref","first-page":"11441","DOI":"10.1021\/jacs.6b05886","article-title":"Spontaneous and selective formation of HSNO, a crucial intermediate linking H2S and nitroso chemistries","volume":"138","author":"Nava","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2017.11.011_b0105","doi-asserted-by":"crossref","first-page":"E4651","DOI":"10.1073\/pnas.1509277112","article-title":"Key bioactive reaction products of the NO\/H2S interaction are S\/N-hybrid species, polysulfides, and nitroxyl","volume":"112","author":"Cortese-Krott","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.011_b0110","doi-asserted-by":"crossref","first-page":"45995","DOI":"10.1038\/srep45995","article-title":"Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels","volume":"7","author":"Miyamoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2017.11.011_b0115","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1038\/ncomms5381","article-title":"H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway","volume":"5","author":"Eberhardt","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2017.11.011_b0120","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cvr\/cvq248","article-title":"Hydrogen sulfide interacts with nitric oxide in the heart: possible involvement of nitroxyl","volume":"88","author":"Yong","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0125","series-title":"Sulfide Inhibition of and Metabolism by Cytochrome c Oxidase","author":"Nicholls","year":"2013"},{"key":"10.1016\/j.bcp.2017.11.011_b0130","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/bph.12769","article-title":"Interactions of hydrogen sulfide with myeloperoxidase","volume":"172","author":"P\u00e1link\u00e1s","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0135","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0140","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0145","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1089\/ars.2013.5604","article-title":"Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect of hydrogen sulfide","volume":"21","author":"Xie","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0150","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.freeradbiomed.2017.01.026","article-title":"Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formation","volume":"104","author":"Zhou","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2017.11.011_b0155","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1038\/ncomms5776","article-title":"Site-specific mapping and quantification of protein S-sulfenylation in cells","volume":"5","author":"Yang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2017.11.011_b0160","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/anie.201305876","article-title":"Detection of protein S-sulfhydration by a tag-switch technique","volume":"53","author":"Zhang","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bcp.2017.11.011_b0165","doi-asserted-by":"crossref","first-page":"26866","DOI":"10.1074\/jbc.M115.672816","article-title":"Reaction of hydrogen sulfide with disulfide and sulfenic acid to form the strongly nucleophilic persulfide","volume":"290","author":"Cuevasanta","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.011_b0170","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0021-9258(19)77423-7","article-title":"Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles","volume":"232","author":"Sutherland","year":"1958","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.011_b0175","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3390\/cancers6010436","article-title":"The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment","volume":"6","author":"Fajardo","year":"2014","journal-title":"Cancers"},{"key":"10.1016\/j.bcp.2017.11.011_b0180","doi-asserted-by":"crossref","first-page":"a011148","DOI":"10.1101\/cshperspect.a011148","article-title":"The cyclic AMP pathway","volume":"4","author":"Sassone-Corsi","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bcp.2017.11.011_b0185","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cellsig.2004.12.017","article-title":"Ca2+-calmodulin-dependent phosphodiesterase (PDE1): current perspectives","volume":"17","author":"Goraya","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0190","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/physrev.00008.2002","article-title":"Cyclic nucleotide-gated ion channels","volume":"82","author":"Kaupp","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2017.11.011_b0195","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.niox.2014.12.004","article-title":"Role of cGMP in hydrogen sulfide signaling","volume":"46","author":"Bibli","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bcp.2017.11.011_b0200","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.91.16.7583","article-title":"Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase","volume":"91","author":"Archer","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.011_b0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.embor.7400627","article-title":"cGMP signalling: from bench to bedside","volume":"7","author":"Feil","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bcp.2017.11.011_b0210","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.1995.75.4.725","article-title":"Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms","volume":"75","author":"Beavo","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2017.11.011_b0215","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation","volume":"100","author":"Omori","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/bbrc.1999.1915","article-title":"Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor","volume":"267","author":"Kimura","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2017.11.011_b0225","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.neuroscience.2008.08.025","article-title":"Endogenous hydrogen sulfide is involved in regulation of respiration in medullary slice of neonatal rats","volume":"156","author":"Hu","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2017.11.011_b0230","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exer.2012.03.001","article-title":"Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells","volume":"98","author":"Njie-Mbye","year":"2012","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0235","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1159\/000129686","article-title":"Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells","volume":"45","author":"Muzaffar","year":"2008","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0240","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1248\/bpb.b13-00018","article-title":"Inhibition by hydrogen sulfide of rabbit platelet aggregation and calcium mobilization","volume":"36","author":"Nishikawa","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bcp.2017.11.011_b0245","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/ars.2015.6369","article-title":"Decreased gluconeogenesis in the absence of cystathionine gamma-lyase and the underlying mechanisms","volume":"24","author":"Untereiner","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0250","series-title":"In African American Type 2 Diabetic Patients, is Vitamin D Deficiency Associated with Lower Blood Levels of Hydrogen Sulfide and Cyclic Adenosine Monophosphate, and Elevated Oxidative Stress?","author":"Jain","year":"2013"},{"key":"10.1016\/j.bcp.2017.11.011_b0255","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuroscience.2015.07.036","article-title":"Mechanisms of hydrogen sulfide (H2S) action on synaptic transmission at the mouse neuromuscular junction","volume":"303","author":"Gerasimova","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2017.11.011_b0260","doi-asserted-by":"crossref","first-page":"C59","DOI":"10.1152\/ajpcell.00341.2010","article-title":"Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells","volume":"302","author":"Lu","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0265","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.yjmcc.2008.01.007","article-title":"Negative regulation of \u03b2-adrenergic function by hydrogen sulphide in the rat hearts","volume":"44","author":"Yong","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0270","doi-asserted-by":"crossref","first-page":"C1261","DOI":"10.1152\/ajpcell.00195.2008","article-title":"Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells","volume":"295","author":"Lim","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0275","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.taap.2015.10.021","article-title":"H2S induces vasoconstriction of rat cerebral arteries via cAMP\/adenylyl cyclase pathway","volume":"289","author":"Li","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0280","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.2009090949","article-title":"Hydrogen sulfide inhibits plasma renin activity","volume":"21","author":"Lu","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bcp.2017.11.011_b0285","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ars.2012.4888","article-title":"Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats","volume":"20","author":"Liu","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0290","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/ars.2012.5119","article-title":"Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase\/cAMP pathway","volume":"20","author":"Yang","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0295","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1017\/S1461145714000583","article-title":"Hydrogen sulfide inhibits opioid withdrawal-induced pain sensitization in rats by down-regulation of spinal calcitonin gene-related peptide expression in the spine","volume":"17","author":"Yang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0300","doi-asserted-by":"crossref","first-page":"R636","DOI":"10.1152\/ajpregu.00489.2014","article-title":"Hydrogen sulfide decreases \u03b2-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption","volume":"308","author":"Agn\u00e9","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0305","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12031-010-9464-4","article-title":"H2S protects hippocampal neurons from anoxia\u2013reoxygenation through cAMP-mediated PI3K\/Akt\/p70S6K cell-survival signaling pathways","volume":"43","author":"Shao","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bcp.2017.11.011_b0310","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00424-013-1366-1","article-title":"Sodium\/calcium exchanger is upregulated by sulfide signaling, forms complex with the \u03b21 and \u03b23 but not \u03b22 adrenergic receptors, and induces apoptosis","volume":"466","author":"Markova","year":"2014","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.bcp.2017.11.011_b0315","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous K ATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2017.11.011_b0320","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2017.11.011_b0325","doi-asserted-by":"crossref","first-page":"H163","DOI":"10.1152\/ajpheart.1988.254.1.H163","article-title":"Vascular relaxation and cGMP in hypertension","volume":"254","author":"Otsuka","year":"1988","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0330","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","article-title":"H2S-induced vasorelaxation and underlying cellular and molecular mechanisms","volume":"283","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0335","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.vph.2010.04.004","article-title":"4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery","volume":"53","author":"San Cheang","year":"2010","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0340","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1161\/ATVBAHA.110.209783","article-title":"Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity","volume":"30","author":"Bucci","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2017.11.011_b0345","doi-asserted-by":"crossref","first-page":"e53319","DOI":"10.1371\/journal.pone.0053319","article-title":"cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation","volume":"7","author":"Bucci","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2017.11.011_b0350","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.011_b0355","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.phrs.2016.08.026","article-title":"Regulation and role of endogenously produced hydrogen sulfide in angiogenesis","volume":"113","author":"Katsouda","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0360","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.phrs.2016.06.029","article-title":"Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide","volume":"111","author":"Zhou","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0365","doi-asserted-by":"crossref","first-page":"G330","DOI":"10.1152\/ajpgi.00161.2017","article-title":"Augmentation of cGMP\/PKG pathway and colonic motility by hydrogen sulfide","volume":"313","author":"Nalli","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0370","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bcp.2013.08.064","article-title":"Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A","volume":"86","author":"M\u00f3dis","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0375","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.niox.2015.02.095","article-title":"Selectivity of hydrogen sulfide toward cyclic nucleotide phosphodiesterases","volume":"47","author":"Panagiotis","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bcp.2017.11.011_b0380","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1097\/HJH.0b013e32829b8fd0","article-title":"The novel gaseous vasorelaxant hydrogen sulfide inhibits angiotensin-converting enzyme activity of endothelial cells","volume":"25","author":"Laggner","year":"2007","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bcp.2017.11.011_b0385","doi-asserted-by":"crossref","unstructured":"M.R. Filipovic Persulfidation (S-sulfhydration) and H2S Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide Springer 2015 29 59","DOI":"10.1007\/978-3-319-18144-8_2"},{"key":"10.1016\/j.bcp.2017.11.011_b0390","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0005-2728(99)00024-9","article-title":"Guanylate cyclase and the\u22c5 NO\/cGMP signaling pathway","volume":"1411","author":"Denninger","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2017.11.011_b0395","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The gasotransmitter role of hydrogen sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0400","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.011_b0405","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1016\/j.thromres.2013.07.010","article-title":"The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthases","volume":"132","author":"Kram","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0410","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ijir.2012.39","article-title":"Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by enhancing expression of endothelial nitric oxide synthase","volume":"25","author":"Meng","year":"2013","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0415","doi-asserted-by":"crossref","first-page":"ra87","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bcp.2017.11.011_b0420","doi-asserted-by":"crossref","unstructured":"D. Polhemus K. Kondo S. Bhushan S.C. Bir C.G. Kevil T. Murohara et al. Hydrogen sulfide attenuates cardiac dysfunction following heart failure via induction of angiogenesis Circ. Heart Fail. 2013 10.1161\/CIRCHEARTFAILURE.113.000299","DOI":"10.1161\/CIRCHEARTFAILURE.113.000299"},{"key":"10.1016\/j.bcp.2017.11.011_b0425","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H2S protects against pressure overload induced heart failure via upregulation of endothelial nitric oxide synthase (eNOS)","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2017.11.011_b0430","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/CIRCULATIONAHA.108.833491","article-title":"Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice","volume":"120","author":"Minamishima","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2017.11.011_b0435","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2017.11.011_b0440","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ajh.2011.149","article-title":"Interdependency of cystathione \u03b3-lyase and cystathione \u03b2-synthase in hydrogen sulfide-induced blood pressure regulation in rats","volume":"25","author":"Roy","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.bcp.2017.11.011_b0445","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/hr.2014.125","article-title":"Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice","volume":"38","author":"Al-Magableh","year":"2015","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0450","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1681\/ASN.2013030291","article-title":"Hydrogen sulfide attenuates sFlt1-induced hypertension and renal damage by upregulating vascular endothelial growth factor","volume":"25","author":"Holwerda","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bcp.2017.11.011_b0455","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/0886022X.2011.643365","article-title":"Exogenous hydrogen sulfide (H2S) reduces blood pressure and prevents the progression of diabetic nephropathy in spontaneously hypertensive rats","volume":"34","author":"Ahmad","year":"2012","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bcp.2017.11.011_b0460","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/jpet.105.092023","article-title":"Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes","volume":"316","author":"Bian","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2017.11.011_b0465","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvv129","article-title":"Cardioprotection by H2S engages a cGMP-dependent protein kinase G\/phospholamban pathway","volume":"106","author":"Bibli","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0470","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2017.11.011_b0475","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.11.011_b0480","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.niox.2010.11.001","article-title":"Cardioprotective effects of hydrogen sulfide","volume":"25","author":"Szab\u00f3","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bcp.2017.11.011_b0485","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2017.11.011_b0490","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1161\/CIRCULATIONAHA.108.843979","article-title":"Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia\/reperfusion through protein-kinase G-dependent generation of hydrogen sulfide","volume":"120","author":"Salloum","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2017.11.011_b0495","doi-asserted-by":"crossref","first-page":"H1347","DOI":"10.1152\/ajpheart.00544.2011","article-title":"Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia\/reperfusion injury: role of hydrogen sulfide","volume":"302","author":"Salloum","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2017.11.011_b0500","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00395-015-0500-y","article-title":"Hydrogen sulfide mediates the cardioprotective effects of gene therapy with PKG-I\u03b1","volume":"110","author":"Das","year":"2015","journal-title":"Basic Res. Cardiol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217306925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217306925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T19:07:25Z","timestamp":1659899245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295217306925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":100,"alternative-id":["S0006295217306925"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2017.11.011","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of hydrogen sulfide in cyclic nucleotide signaling","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2017.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}