{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:45:48Z","timestamp":1790826348281,"version":"4.1.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.bcp.2017.11.018","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T14:17:08Z","timestamp":1512656228000},"page":"188-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target"],"prefix":"10.1016","volume":"151","author":[{"suffix":"Jr.","given":"Warren","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Tew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2017.11.018_b0005","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.39.1.361","article-title":"Biochemical, cellular, and pharmacological aspects of the multidrug transporter","volume":"39","author":"Ambudkar","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2017.11.018_b0010","doi-asserted-by":"crossref","unstructured":"S. Wilkens, Structure and mechanism of ABC transporters, F1000Prime Rep 7 (2015) 14.","DOI":"10.12703\/P7-14"},{"issue":"5","key":"10.1016\/j.bcp.2017.11.018_b0015","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00424-006-0047-8","article-title":"The ABCA subfamily\u2013gene and protein structures, functions and associated hereditary diseases","volume":"453","author":"Albrecht","year":"2007","journal-title":"Pflugers Arch.."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2017.11.018_b0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1388-1981(00)00157-8","article-title":"Tangier disease and ABCA1","volume":"1529","author":"Oram","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.bcp.2017.11.018_b0025","first-page":"1332","article-title":"Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells","volume":"58","author":"Laing","year":"1998","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.018_b0030","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0026-895X(25)08962-X","article-title":"Molecular conformation of estramustine and two analogues","volume":"41","author":"Punzi","year":"1992","journal-title":"Mol. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2017.11.018_b0035","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1200\/JCO.1992.10.11.1754","article-title":"Phase II study of estramustine and vinblastine, two microtubule inhibitors, in hormone-refractory prostate cancer","volume":"10","author":"Hudes","year":"1992","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0040","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1021\/bi961445w","article-title":"Interaction of estramustine with tubulin isotypes","volume":"36","author":"Laing","year":"1997","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0045","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00018-002-8508-5","article-title":"ABCA2: a candidate regulator of neural transmembrane lipid transport","volume":"59","author":"Schmitz","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0050","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/geno.1994.1237","article-title":"Cloning of two novel ABC transporters mapping on human chromosome 9","volume":"21","author":"Luciani","year":"1994","journal-title":"Genomics"},{"issue":"Pt 3","key":"10.1016\/j.bcp.2017.11.018_b0055","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1042\/bj3500865","article-title":"Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2\/ABCA2","volume":"350","author":"Zhao","year":"2000","journal-title":"Biochem. J."},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0060","first-page":"3339","article-title":"Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2)","volume":"61","author":"Vulevic","year":"2001","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0065","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/bbrc.2001.4305","article-title":"Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages","volume":"281","author":"Kaminski","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.018_b0070","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/nar\/gkg192","article-title":"Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors","volume":"31","author":"Davis","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.018_b0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/cne.10493","article-title":"Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain","volume":"455","author":"Tanaka","year":"2003","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neulet.2006.12.028","article-title":"Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve","volume":"414","author":"Saito","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2017.11.018_b0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jns.2005.01.016","article-title":"Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve","volume":"232","author":"Wang","year":"2005","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0090","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1021\/cn300008p","article-title":"Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain","volume":"3","author":"Grunewald","year":"2012","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/MCB.01824-06","article-title":"\u201cSkittish\u201d Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system","volume":"27","author":"Mack","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0100","first-page":"22","article-title":"Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus","volume":"1678","author":"Ile","year":"2004","journal-title":"BBA"},{"issue":"46","key":"10.1016\/j.bcp.2017.11.018_b0105","doi-asserted-by":"crossref","first-page":"48477","DOI":"10.1074\/jbc.M409848200","article-title":"ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities","volume":"279","author":"Fitzgerald","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0110","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.biopha.2012.06.007","article-title":"Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies","volume":"66","author":"Mack","year":"2012","journal-title":"Biomed. Pharmacother."},{"issue":"31","key":"10.1016\/j.bcp.2017.11.018_b0115","first-page":"18","article-title":"Defeating drug resistance in cancer","volume":"6","author":"Gottesman","year":"2006","journal-title":"Discov. Med."},{"issue":"10","key":"10.1016\/j.bcp.2017.11.018_b0120","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1096\/fj.03-1490fje","article-title":"Association of ABCA2 expression with determinants of Alzheimer's disease","volume":"18","author":"Chen","year":"2004","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/138920007779315044","article-title":"The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds","volume":"8","author":"Mack","year":"2007","journal-title":"Curr. Drug Metab."},{"issue":"12","key":"10.1016\/j.bcp.2017.11.018_b0130","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1038\/sj.bjc.6601863","article-title":"Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation","volume":"90","author":"Boonstra","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"24","key":"10.1016\/j.bcp.2017.11.018_b0135","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1158\/0008-5472.CAN-04-1978","article-title":"Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes","volume":"64","author":"Gillet","year":"2004","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0140","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/leu.2008.103","article-title":"Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration","volume":"22","author":"Chapuy","year":"2008","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.bcp.2017.11.018_b0145","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.leukres.2015.02.013","article-title":"Celecoxib sensitizes imatinib-resistant K562 cells to imatinib by inhibiting MRP1-5, ABCA2 and ABCG2 transporters via Wnt and Ras signaling pathways","volume":"39","author":"Dharmapuri","year":"2015","journal-title":"Leuk. Res."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jcb.10724","article-title":"Cholesterol and prostate cancer","volume":"91","author":"Freeman","year":"2004","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0155","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0009-9120(00)00160-0","article-title":"Increased plasma HDL-cholesterol and apo A-I in breast cancer patients undergoing adjuvant tamoxifen therapy","volume":"33","author":"Mastroianni","year":"2000","journal-title":"Clin. Biochem."},{"issue":"12","key":"10.1016\/j.bcp.2017.11.018_b0160","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/jnci\/95.12.844","article-title":"Of cancer and cholesterol: studies elucidate anticancer mechanisms of statins","volume":"95","author":"Brower","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0165","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1158\/0008-5472.CAN-05-0476","article-title":"Lysosomes as targets for cancer therapy","volume":"65","author":"Fehrenbacher","year":"2005","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.bcp.2017.11.018_b0170","first-page":"11218","article-title":"Establishment of pancreatic cancer stem cells by flow cytometry and their biological characteristics","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0175","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1517\/14728222.12.4.491","article-title":"ABCA2 as a therapeutic target in cancer and nervous system disorders","volume":"12","author":"Mack","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0180","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/sj.leu.2404131","article-title":"Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38- cells","volume":"20","author":"de Grouw","year":"2006","journal-title":"Leukemia"},{"issue":"14 Pt 1","key":"10.1016\/j.bcp.2017.11.018_b0185","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1158\/1078-0432.CCR-05-2587","article-title":"ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia","volume":"12","author":"Steinbach","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0190","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1158\/1535-7163.MCT-06-0086","article-title":"Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia","volume":"5","author":"Efferth","year":"2006","journal-title":"Mol. Cancer Ther."},{"issue":"9","key":"10.1016\/j.bcp.2017.11.018_b0195","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/sj.onc.1210200","article-title":"Targeted therapy for cancer stem cells: the patched pathway and ABC transporters","volume":"26","author":"Lou","year":"2007","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0200","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1227\/01.NEU.0000255395.15657.06","article-title":"Clinical significance of ABCA2' a possible molecular marker for oligodendrogliomas","volume":"60","author":"Soichi","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bcp.2017.11.018_b0205","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.2147\/OTT.S140488","article-title":"The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia","volume":"10","author":"Aberuyi","year":"2017","journal-title":"Onco Targets Ther."},{"issue":"27","key":"10.1016\/j.bcp.2017.11.018_b0210","doi-asserted-by":"crossref","first-page":"19692","DOI":"10.1074\/jbc.M611056200","article-title":"ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain","volume":"282","author":"Sakai","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0215","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0022-2275(20)31566-2","article-title":"ABCA1 The gatekeeper for eliminating excess tissue cholesterol","volume":"42","author":"Oram","year":"2001","journal-title":"J. Lipid Res."},{"issue":"29","key":"10.1016\/j.bcp.2017.11.018_b0220","doi-asserted-by":"crossref","first-page":"27584","DOI":"10.1074\/jbc.M103264200","article-title":"Cellular localization and trafficking of the human ABCA1 transporter","volume":"276","author":"Neufeld","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.018_b0225","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1523\/JNEUROSCI.21-03-00849.2001","article-title":"Atp-binding cassette transporter ABC2\/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths","volume":"21","author":"Zhou","year":"2001","journal-title":"J. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2017.11.018_b0230","first-page":"89","article-title":"Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells","volume":"1683","author":"Davis","year":"2004","journal-title":"BBA"},{"issue":"8","key":"10.1016\/j.bcp.2017.11.018_b0235","doi-asserted-by":"crossref","first-page":"R298","DOI":"10.1016\/S0960-9822(00)00434-6","article-title":"Cholesterol homeostasis: ESCAPe from the ER","volume":"10","author":"Hampton","year":"2000","journal-title":"Curr. Biol."},{"issue":"33","key":"10.1016\/j.bcp.2017.11.018_b0240","doi-asserted-by":"crossref","first-page":"23797","DOI":"10.1016\/S0021-9258(18)35908-8","article-title":"Progesterone blocks cholesterol translocation from lysosomes","volume":"267","author":"Butler","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2017.11.018_b0245","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1074\/jbc.271.5.2627","article-title":"Progesterone inhibits cholesterol biosynthesis in cultured cells. Accumulation of cholesterol precursors","volume":"271","author":"Metherall","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.bcp.2017.11.018_b0250","doi-asserted-by":"crossref","first-page":"11796","DOI":"10.1016\/S0021-9258(18)80136-3","article-title":"The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one","volume":"264","author":"Liscum","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.018_b0255","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12177","article-title":"Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection","volume":"4","author":"Lu","year":"2015","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0260","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann-Pick disease type C","volume":"64","author":"Vanier","year":"2003","journal-title":"Clin. Genet."},{"issue":"43","key":"10.1016\/j.bcp.2017.11.018_b0265","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1073\/pnas.0807450105","article-title":"Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex","volume":"105","author":"Urano","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"7","key":"10.1016\/j.bcp.2017.11.018_b0270","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1083\/jcb.200811005","article-title":"Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning","volume":"185","author":"Rocha","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2017.11.018_b0275","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/bse0570043","article-title":"Cholesterol trafficking and distribution","volume":"57","author":"Iaea","year":"2015","journal-title":"Essays Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.018_b0280","first-page":"235","article-title":"The Niemann-Pick C lesion and its relationship to the intracellular distribution and utilization of LDL cholesterol","volume":"1225","author":"Pentchev","year":"1994","journal-title":"BBA"},{"issue":"13","key":"10.1016\/j.bcp.2017.11.018_b0285","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/j.febslet.2010.04.047","article-title":"Defective cholesterol trafficking in Niemann-Pick C-deficient cells","volume":"584","author":"Peake","year":"2010","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0290","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/bbrc.1993.2228","article-title":"Niemann-Pick C disease: cystine and lipids accumulate in the murine model of this lysosomal cholesterol lipidosis","volume":"196","author":"Butler","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"25","key":"10.1016\/j.bcp.2017.11.018_b0295","doi-asserted-by":"crossref","first-page":"26167","DOI":"10.1074\/jbc.M311591200","article-title":"Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport","volume":"279","author":"te Vruchte","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0300","first-page":"303","article-title":"The low density lipoprotein receptor","volume":"988","author":"Schneider","year":"1989","journal-title":"BBA"},{"issue":"12","key":"10.1016\/j.bcp.2017.11.018_b0305","first-page":"1152","article-title":"The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells","volume":"1811","author":"Davis","year":"2011","journal-title":"BBA"},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0310","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/bj2710121","article-title":"Reversible effects of sphingomyelin degradation on cholesterol distribution and metabolism in fibroblasts and transformed neuroblastoma cells","volume":"271","author":"Porn","year":"1990","journal-title":"Biochem. J."},{"issue":"11","key":"10.1016\/j.bcp.2017.11.018_b0315","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.274.11.6979","article-title":"Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol","volume":"274","author":"Luker","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0320","first-page":"168","article-title":"The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism","volume":"1841","author":"Davis","year":"2014","journal-title":"BBA"},{"issue":"9","key":"10.1016\/j.bcp.2017.11.018_b0325","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-2275(20)37735-X","article-title":"Regulation of cholesterol biosynthesis and esterification by 25-hydroxycholesterol in a macrophage-like cell line: uncoupling by progesterone","volume":"25","author":"Miller","year":"1984","journal-title":"J. Lipid Res."},{"issue":"45","key":"10.1016\/j.bcp.2017.11.018_b0330","doi-asserted-by":"crossref","first-page":"47010","DOI":"10.1074\/jbc.M408690200","article-title":"Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum","volume":"279","author":"Du","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0335","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.febslet.2007.11.083","article-title":"Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors","volume":"582","author":"Fernandez-Alvarez","year":"2008","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0340","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1124\/mol.61.2.379","article-title":"Reciprocal regulation of beta(1)-adrenergic receptor gene transcription by Sp1 and early growth response gene 1: induction of EGR-1 inhibits the expression of the beta(1)-adrenergic receptor gene","volume":"61","author":"Bahouth","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"27","key":"10.1016\/j.bcp.2017.11.018_b0345","doi-asserted-by":"crossref","first-page":"25512","DOI":"10.1074\/jbc.M101354200","article-title":"The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase","volume":"276","author":"Fukada","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5551\/jat.13.1","article-title":"ABCA1 and biogenesis of HDL","volume":"13","author":"Yokoyama","year":"2006","journal-title":"J. Atheroscler. Thromb."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0355","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1091\/mbc.E08-07-0785","article-title":"Sterols are mainly in the cytoplasmic leaflet of the plasma membrane and the endocytic recycling compartment in CHO cells","volume":"20","author":"Mondal","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"26","key":"10.1016\/j.bcp.2017.11.018_b0360","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1016\/S0021-9258(19)47337-7","article-title":"Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level","volume":"266","author":"Xu","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"32","key":"10.1016\/j.bcp.2017.11.018_b0365","doi-asserted-by":"crossref","first-page":"11664","DOI":"10.1073\/pnas.0404766101","article-title":"How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids","volume":"101","author":"Lange","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"43","key":"10.1016\/j.bcp.2017.11.018_b0370","doi-asserted-by":"crossref","first-page":"36126","DOI":"10.1074\/jbc.M507149200","article-title":"Activation of membrane cholesterol by displacement from phospholipids","volume":"280","author":"Lange","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0375","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1016\/S0006-3495(02)75340-X","article-title":"Determination of membrane cholesterol partition coefficient using a lipid vesicle-cyclodextrin binary system: effect of phospholipid acyl chain unsaturation and headgroup composition","volume":"83","author":"Niu","year":"2002","journal-title":"Biophys. J."},{"key":"10.1016\/j.bcp.2017.11.018_b0380","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cca.2013.11.026","article-title":"NPC1, intracellular cholesterol trafficking and atherosclerosis","volume":"429","author":"Yu","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bcp.2017.11.018_b0385","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ceb.2015.04.002","article-title":"Novel mechanisms of intracellular cholesterol transport: oxysterol-binding proteins and membrane contact sites","volume":"35","author":"Du","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"Pt 15","key":"10.1016\/j.bcp.2017.11.018_b0390","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1242\/jcs.129270","article-title":"Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L","volume":"126","author":"van der Kant","year":"2013","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0395","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1021\/mp200129p","article-title":"Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels","volume":"8","author":"Shawahna","year":"2011","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0400","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/abbs\/gms095","article-title":"Endosomal cholesterol trafficking: protein factors at a glance","volume":"45","author":"Du","year":"2013","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"issue":"6246","key":"10.1016\/j.bcp.2017.11.018_b0405","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1126\/science.aab1346","article-title":"Intracellular transport. Phosphatidylserine transport by ORP\/Osh proteins is driven by phosphatidylinositol 4-phosphate","volume":"349","author":"Moser von Filseck","year":"2015","journal-title":"Science"},{"issue":"6246","key":"10.1016\/j.bcp.2017.11.018_b0410","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.aab1370","article-title":"Intracellular transport. PI4P\/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts","volume":"349","author":"Chung","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0415","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/tra.12015","article-title":"The AAA ATPase VPS4\/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III","volume":"14","author":"Du","year":"2013","journal-title":"Traffic"},{"issue":"5","key":"10.1016\/j.bcp.2017.11.018_b0420","first-page":"799","article-title":"Sphingolipids and lysosomal pathologies","volume":"1841","author":"Schulze","year":"2014","journal-title":"BBA"},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0425","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1042\/BST20130083","article-title":"Metabolic and cellular bases of sphingolipidoses","volume":"41","author":"Sandhoff","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bcp.2017.11.018_b0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: from synthesis to breakdown","volume":"688","author":"Gault","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"issue":"41","key":"10.1016\/j.bcp.2017.11.018_b0435","doi-asserted-by":"crossref","first-page":"12629","DOI":"10.1021\/bi060610x","article-title":"Ceramide drives cholesterol out of the ordered lipid bilayer phase into the crystal phase in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine\/cholesterol\/ceramide ternary mixtures","volume":"45","author":"Ali","year":"2006","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0440","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cmet.2010.05.016","article-title":"Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes","volume":"12","author":"Wang","year":"2010","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0445","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbamem.2005.08.002","article-title":"Displacement of sterols from sterol\/sphingomyelin domains in fluid bilayer membranes by competing molecules","volume":"1715","author":"Alanko","year":"2005","journal-title":"BBA"},{"issue":"4","key":"10.1016\/j.bcp.2017.11.018_b0450","first-page":"674","article-title":"Principles of lysosomal membrane degradation: cellular topology and biochemistry of lysosomal lipid degradation","volume":"1793","author":"Schulze","year":"2009","journal-title":"BBA"},{"key":"10.1016\/j.bcp.2017.11.018_b0455","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.cellbio.21.122303.120013","article-title":"Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids","volume":"21","author":"Kolter","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.bcp.2017.11.018_b0460","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nm.1876","article-title":"Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium","volume":"14","author":"Lloyd-Evans","year":"2008","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.bcp.2017.11.018_b0465","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1194\/jlr.M054528","article-title":"Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2","volume":"55","author":"Oninla","year":"2014","journal-title":"J. Lipid Res."},{"issue":"46","key":"10.1016\/j.bcp.2017.11.018_b0470","doi-asserted-by":"crossref","first-page":"30271","DOI":"10.1074\/jbc.273.46.30271","article-title":"Lysosomal degradation on vesicular membrane surfaces. Enhanced glucosylceramide degradation by lysosomal anionic lipids and activators","volume":"273","author":"Wilkening","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2017.11.018_b0475","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ncomms1735","article-title":"Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release","volume":"3","author":"Shen","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2017.11.018_b0480","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10616","article-title":"Intracellular sphingosine releases calcium from lysosomes","volume":"4","author":"Hoglinger","year":"2015","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.bcp.2017.11.018_b0485","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nbd.2004.09.011","article-title":"ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease","volume":"18","author":"Mace","year":"2005","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.bcp.2017.11.018_b0490","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/ajmg.b.30345","article-title":"Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease","volume":"141B","author":"Wollmer","year":"2006","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"9","key":"10.1016\/j.bcp.2017.11.018_b0495","doi-asserted-by":"crossref","first-page":"e73129","DOI":"10.1371\/journal.pone.0073129","article-title":"Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bcp.2017.11.018_b0500","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2174\/156720510793499002","article-title":"The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Abeta fragment generation","volume":"7","author":"Davis","year":"2010","journal-title":"Curr. Alzheimer Res."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0505","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1074\/jbc.M111.288258","article-title":"Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization","volume":"287","author":"Michaki","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2017.11.018_b0510","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2174\/156720501209151019105834","article-title":"The ATP-binding cassette transporter-2 (ABCA2) overexpression modulates sphingosine levels and transcription of the amyloid precursor protein (APP) gene","volume":"12","author":"Davis","year":"2015","journal-title":"Curr. Alzheimer Res."},{"issue":"6801","key":"10.1016\/j.bcp.2017.11.018_b0515","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"issue":"7068","key":"10.1016\/j.bcp.2017.11.018_b0520","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature04399","article-title":"Role of cholesterol and lipid organization in disease","volume":"438","author":"Maxfield","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2017.11.018_b0525","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosissup.2015.02.003","article-title":"PCSK9 antibodies: a new class of lipid-lowering drugs","volume":"18","author":"Gouni-Berthold","year":"2015","journal-title":"Atheroscler. Suppl."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0530","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cmet.2008.05.001","article-title":"Ezetimibe blocks internalization of the NPC1L1\/cholesterol complex","volume":"7","author":"Chang","year":"2008","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.bcp.2017.11.018_b0535","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.cmet.2008.04.001","article-title":"The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1","volume":"7","author":"Ge","year":"2008","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.bcp.2017.11.018_b0540","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00041433-199610000-00012","article-title":"Macrophages and atherosclerotic plaque stability","volume":"7","author":"Libby","year":"1996","journal-title":"Curr. Opin. Lipidol."},{"issue":"7","key":"10.1016\/j.bcp.2017.11.018_b0545","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1050-1738(97)00086-8","article-title":"Free cholesterol-induced cytotoxicity a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions","volume":"7","author":"Tabas","year":"1997","journal-title":"Trends Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.bcp.2017.11.018_b0550","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.ATV.18.3.423","article-title":"Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death","volume":"18","author":"Kellner-Weibel","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"31","key":"10.1016\/j.bcp.2017.11.018_b0555","doi-asserted-by":"crossref","first-page":"23807","DOI":"10.1074\/jbc.M002087200","article-title":"Free cholesterol loading of macrophages induces apoptosis involving the fas pathway","volume":"275","author":"Yao","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2017.11.018_b0560","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ncb1035","article-title":"The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages","volume":"5","author":"Feng","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.bcp.2017.11.018_b0565","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1074\/jbc.270.11.5772","article-title":"Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol","volume":"270","author":"Warner","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2017.11.018_b0570","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.atherosclerosis.2012.05.039","article-title":"Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice","volume":"223","author":"Calpe-Berdiel","year":"2012","journal-title":"Atherosclerosis"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217306998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217306998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T09:21:17Z","timestamp":1751102477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295217306998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":114,"alternative-id":["S0006295217306998"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2017.11.018","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2017.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}