{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:49:09Z","timestamp":1789915749648,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministerio de Econom\u00eda y Competitividad, Instituto de Salud Carlos III"},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Uni\u00f3n Europea","award":["PS0900968"],"award-info":[{"award-number":["PS0900968"]}]},{"name":"Uni\u00f3n Europea","award":["PI1400927"],"award-info":[{"award-number":["PI1400927"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bcp.2017.12.007","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T13:15:00Z","timestamp":1513170900000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1\/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain"],"prefix":"10.1016","volume":"148","author":[{"given":"Gabriela","family":"Riego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Le\u00e1nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2017.12.007_b0005","first-page":"3393","article-title":"Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats","volume":"61","author":"Austin","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bcp.2017.12.007_b0010","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1073\/pnas.96.14.7668","article-title":"Forebrain mechanisms of nociception and pain: analysis through imaging","volume":"96","author":"Casey","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2017.12.007_b0015","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jnr.22613","article-title":"Carbon monoxide: a gas that modulates nociception","volume":"89","author":"Fan","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bcp.2017.12.007_b0020","doi-asserted-by":"crossref","first-page":"e43693","DOI":"10.1371\/journal.pone.0043693","article-title":"Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice","volume":"7","author":"Hervera","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2017.12.007_b0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00213-013-3302-7","article-title":"Treatment with a carbon monoxide-releasing molecule inhibits chronic inflammatory pain in mice: nitric oxide contribution","volume":"231","author":"Negrete","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bcp.2017.12.007_b0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2013.01.072","article-title":"Importance of glial activation in neuropathic pain","volume":"716","author":"Mika","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.12.007_b0035","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.neubiorev.2008.12.005","article-title":"Contribution of the activation of satellite glia in sensory ganglia to pathological pain","volume":"33","author":"Takeda","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bcp.2017.12.007_b0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2009.09.030","article-title":"Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain","volume":"623","author":"Mika","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2017.12.007_b0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2013.05.023","article-title":"Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels","volume":"247","author":"Nishio","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2017.12.007_b0050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pain.2004.06.008","article-title":"Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain","volume":"111","author":"Kim","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.bcp.2017.12.007_b0055","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pneurobio.2012.09.003","article-title":"Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection","volume":"100","author":"Zhang","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bcp.2017.12.007_b0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3164\/jcbn.2008029","article-title":"Integrative survival response evoked by heme oxygenase-1 and heme metabolites","volume":"42","author":"Pae","year":"2008","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.bcp.2017.12.007_b0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresrev.2008.12.011","article-title":"R.W. 4th Gereau, M. Malcangio, G.R. Strichartz. MAP kinase and pain","volume":"60","author":"Ji","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bcp.2017.12.007_b0070","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0587-12.2012","article-title":"Abnormalities in hippocampal functioning with persistent pain","volume":"32","author":"Mutso","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2017.12.007_b0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.brainres.2011.01.002","article-title":"Role of different brain areas in peripheral nerve injury-induced neuropathic pain","volume":"1381","author":"Jaggi","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2017.12.007_b0080","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/brain\/awg102","article-title":"Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation","volume":"126","author":"Lorenz","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.bcp.2017.12.007_b0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bcp.2017.12.007_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bcp.2017.12.007_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bcp.2017.12.007_b0100","doi-asserted-by":"crossref","first-page":"e14321","DOI":"10.1371\/journal.pone.0014321","article-title":"The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice","volume":"5","author":"Hervera","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2017.12.007_b0105","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00213-013-3053-5","article-title":"Effects of treatment with a carbon monoxide-releasing molecule and a heme oxygenase 1 inducer in the antinociceptive effects of morphine in different models of acute and chronic pain in mice","volume":"228","author":"Hervera","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bcp.2017.12.007_b0110","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s00213-016-4271-4","article-title":"The role of carbon monoxide on the anti-nociceptive effects and expression of cannabinoid 2 receptors during painful diabetic neuropathy in mice","volume":"233","author":"Castany","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bcp.2017.12.007_b0115","doi-asserted-by":"crossref","first-page":"e0146427","DOI":"10.1371\/journal.pone.0146427","article-title":"The induction of heme oxygenase 1 decreases painful diabetic neuropathy and enhances the antinociceptive effects of morphine in diabetic mice","volume":"11","author":"Castany","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2017.12.007_b0120","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1096\/fj.06-6346fje","article-title":"Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin","volume":"20","author":"Shan","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2017.12.007_b0125","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1124\/jpet.114.215681","article-title":"Treatment with a heme oxygenase 1 inducer enhances the antinociceptive effects of \u00b5-opioid, \u03b4-opioid, and cannabinoid 2 receptors during inflammatory pain","volume":"351","author":"Carcol\u00e9","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2017.12.007_b0130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/156720211798120972","article-title":"Nrf2 and NF-\u03baB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes","volume":"8","author":"Negi","year":"2011","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.bcp.2017.12.007_b0135","doi-asserted-by":"crossref","first-page":"e0180998","DOI":"10.1371\/journal.pone.0180998","article-title":"The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice","volume":"12","author":"McDonnell","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2017.12.007_b0140","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1124\/mol.106.025478","article-title":"Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-d-aspartate-dependent mechanisms","volume":"70","author":"Daulhac","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2017.12.007_b0145","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1523\/JNEUROSCI.5290-05.2006","article-title":"A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance","volume":"26","author":"Zhuang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2017.12.007_b0150","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2008.03.017","article-title":"Activation of JNK pathway in persistent pain","volume":"437","author":"Gao","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bcp.2017.12.007_b0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fphar.2017.00048","article-title":"Blockade of P2X4 receptors inhibits neuropathic pain-related behavior by preventing MMP-9 activation and consequently, pronociceptive interleukin release in a rat model","volume":"8","author":"Jurga","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2017.12.007_b0160","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.2174\/0929867321666140915143040","article-title":"p38 MAPK: a potential target of chronic pain","volume":"21","author":"Lin","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bcp.2017.12.007_b0165","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.freeradbiomed.2004.09.015","article-title":"Heme oxygenase expression in human central nervous system disorders","volume":"37","author":"Schipper","year":"2004","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2017.12.007_b0170","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/bph.12729","article-title":"Carbon monoxide and the CNS: challenges and achievements","volume":"172","author":"Queiroga","year":"2015","journal-title":"Br. J. Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217307190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295217307190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T04:25:40Z","timestamp":1535171140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295217307190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":34,"alternative-id":["S0006295217307190"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2017.12.007","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1\/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2017.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}