{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:18:36Z","timestamp":1780517916143,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","award":["D106-35A13"],"award-info":[{"award-number":["D106-35A13"]}],"id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.bcp.2018.02.027","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T05:07:19Z","timestamp":1519362439000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH 3 cells and in olfactory sensory (Rolf B1.T) neurons"],"prefix":"10.1016","volume":"151","author":[{"given":"Edmund Cheung","family":"So","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Qun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny Hsu","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ching","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Nan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2018.02.027_b0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1744-8069-6-88","article-title":"ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain","volume":"6","author":"Li","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bcp.2018.02.027_b0010","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fnmol.2017.00282","article-title":"Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3","volume":"10","author":"Osmakov","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.bcp.2018.02.027_b0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10753-014-9972-4","article-title":"Inhibition of peripheral nociceptors by aminoglycosides produces analgesia in inflammatory pain models in the rat","volume":"38","author":"Mercado","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.bcp.2018.02.027_b0020","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neuroscience.2016.12.008","article-title":"ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury","volume":"343","author":"Mazzone","year":"2017","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2010.09.001","article-title":"A nonproton ligand sensor in the acid-sensing ion channel","volume":"68","author":"Yu","year":"2010","journal-title":"Neuron"},{"issue":"43","key":"10.1016\/j.bcp.2018.02.027_b0030","doi-asserted-by":"crossref","first-page":"36059","DOI":"10.1074\/jbc.M112.360487","article-title":"Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline","volume":"287","author":"Alijevic","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2018.02.027_b0035","doi-asserted-by":"crossref","first-page":"C699","DOI":"10.1152\/ajpcell.00188.2012","article-title":"Structure and activity of the acid-sensing ion channels","volume":"303","author":"Sherwood","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bcp.2018.02.027_b0040","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuropharm.2013.07.018","article-title":"2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type gamma-aminobutyric acid receptors","volume":"75","author":"Xiao","year":"2013","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.bcp.2018.02.027_b0045","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/head.12152","article-title":"pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators","volume":"53","author":"Yan","year":"2013","journal-title":"Headache"},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/chan.26978","article-title":"Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs","volume":"8","author":"Smith","year":"2014","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.bcp.2018.02.027_b0055","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuropharm.2017.08.004","article-title":"Pharmacological modulation of acid-sensing Ion channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ)","volume":"125","author":"Besson","year":"2017","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.bcp.2018.02.027_b0060","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1124\/jpet.115.222802","article-title":"Amiloride and GMQ Allosteric Modulation of the GABA-A rho1 Receptor: Influences of the Intersubunit Site","volume":"353","author":"Snell","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2018.02.027_b0065","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M117.814707","article-title":"The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of native FMRFamide peptide","author":"Yang","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2018.02.027_b0070","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1210\/er.2010-0005","article-title":"Ion channels and signaling in the pituitary gland","volume":"31","author":"Stojilkovic","year":"2010","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.bcp.2018.02.027_b0075","doi-asserted-by":"crossref","first-page":"e115310","DOI":"10.1371\/journal.pone.0115310","article-title":"Expression and activity of acid-sensing ion channels in the mouse anterior pituitary","volume":"9","author":"Du","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bcp.2018.02.027_b0080","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0026-895X(24)26494-4","article-title":"Stimulatory effects of delta-hexachlorocyclohexane on Ca2+-activated K+ currents in GH3 lactotrophs","volume":"57","author":"Wu","year":"2000","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2018.02.027_b0085","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/jop.2004.20.563","article-title":"The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells","volume":"20","author":"Sheu","year":"2004","journal-title":"J. Ocul. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bcp.2018.02.027_b0090","doi-asserted-by":"crossref","first-page":"C1397","DOI":"10.1152\/ajpcell.00311.2009","article-title":"A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts","volume":"297","author":"Henney","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"12","key":"10.1016\/j.bcp.2018.02.027_b0095","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1002\/jcp.25788","article-title":"Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels","volume":"232","author":"Wu","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.bcp.2018.02.027_b0100","doi-asserted-by":"crossref","first-page":"e78203","DOI":"10.1371\/journal.pone.0078203","article-title":"TRPV1 channels are functionally coupled with BK(mSlo1) channels in rat dorsal root ganglion (DRG) neurons","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0105","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neuron.2016.11.019","article-title":"BK channels are required for multisensory plasticity in the oculomotor system","volume":"93","author":"Nelson","year":"2017","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0027-5107(96)00003-6","article-title":"Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor","volume":"354","author":"Honda","year":"1996","journal-title":"Mutat. Res."},{"issue":"5","key":"10.1016\/j.bcp.2018.02.027_b0115","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/14712598.2017.1308481","article-title":"Spinal cord injuries: how could cell therapy help?","volume":"17","author":"Badner","year":"2017","journal-title":"Expert Opin. Biol. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2018.02.027_b0120","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1159\/000475436","article-title":"Synergistic inhibition of delayed rectifier K+ and voltage-gated Na+ currents by artemisinin in pituitary tumor (GH3) cells","volume":"41","author":"So","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2018.02.027_b0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1098-1136(199603)16:3<247::AID-GLIA7>3.0.CO;2-Z","article-title":"Spontaneous immortalisation of ensheathing cells from adult rat olfactory nerve","volume":"16","author":"Sonigra","year":"1996","journal-title":"Glia"},{"issue":"32","key":"10.1016\/j.bcp.2018.02.027_b0130","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1021\/jf302320f","article-title":"In vitro neuropeptide Y mRNA expressing model for screening essences that may affect appetite using Rolf B1.T cells","volume":"60","author":"Chen","year":"2012","journal-title":"J. Agric. Food Chem."},{"issue":"21","key":"10.1016\/j.bcp.2018.02.027_b0135","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1111\/bph.13276","article-title":"Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na+ and Ca2+-activated K+ currents in GH3 pituitary tumour cells","volume":"172","author":"Lo","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2018.02.027_b0140","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0026-895X(24)26494-4","article-title":"Stimulatory effects of delta-hexachlorocyclohexane on Ca(2+)-activated K(+) currents in GH(3) lactotrophs","volume":"57","author":"Wu","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2018.02.027_b0145","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2180-7-5","article-title":"Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells","volume":"7","author":"Khoufache","year":"2007","journal-title":"BMC Microbiol."},{"issue":"12","key":"10.1016\/j.bcp.2018.02.027_b0150","doi-asserted-by":"crossref","first-page":"e3401","DOI":"10.1371\/journal.pntd.0003401","article-title":"Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside","volume":"8","author":"Kulke","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/mol.106.022970","article-title":"Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae","volume":"70","author":"Maertens","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2018.02.027_b0160","first-page":"161","article-title":"Functional coupling of voltage-dependent L-type Ca2+ current to Ca2+-activated K+ current in pituitary GH3 cells","volume":"44","author":"Wu","year":"2001","journal-title":"Chin. J. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2004.03.078","article-title":"Chlorotoxin-mediated disinhibition of noradrenergic locus coeruleus neurons using a conditional transgenic approach","volume":"1016","author":"Salbaum","year":"2004","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.bcp.2018.02.027_b0170","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1177\/154405910508400513","article-title":"Properties of BKCa channels in oral keratinocytes","volume":"84","author":"Shieh","year":"2005","journal-title":"J. Dent. Res."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2018.02.027_b0175","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jns.2015.08.1526","article-title":"Age-related changes of inactivating BK channels in rat dorsal root ganglion neurons","volume":"358","author":"Yu","year":"2015","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2018.02.027_b0180","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0022-3565(24)35276-0","article-title":"Characterization of tetrandrine-induced inhibition of large-conductance calcium-activated potassium channels in a human endothelial cell line (HUV-EC-C)","volume":"292","author":"Wu","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218300844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218300844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:04:15Z","timestamp":1751414655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295218300844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":36,"alternative-id":["S0006295218300844"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2018.02.027","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2018.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}