{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:58:02Z","timestamp":1772773082621,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bcp.2018.03.020","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T20:42:15Z","timestamp":1521664935000},"page":"114-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Impaired Ca 2+ handling in resistance arteries from genetically obese Zucker rats: Role of the PI3K, ERK1\/2 and PKC signaling pathways"],"prefix":"10.1016","volume":"152","author":[{"given":"Ana","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Climent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albino","family":"Garc\u00eda-Sacrist\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bcp.2018.03.020_b0005","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/diabetes.52.5.1210","article-title":"NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older","volume":"52","author":"Alexander","year":"2003","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.bcp.2018.03.020_b0010","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.2337\/diabetes.54.8.2415","article-title":"Compromised arterial function in human type 2 diabetic patient","volume":"54","author":"Okon","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bcp.2018.03.020_b0015","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1152\/ajpheart.01308.2008","article-title":"Differential structural and functional changes in penile and coronary arteries from obese Zucker rats","volume":"297","author":"Villalba","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0020","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.bcp.2018.03.020_b0025","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1161\/01.RES.86.7.760","article-title":"Coupling of Ca(2+) to CREB activation and gene expression in intact cerebral arteries from mouse: roles of ryanodine receptors and voltage-dependent Ca(2+) channels","volume":"86","author":"Cartin","year":"2000","journal-title":"Circ. Res."},{"issue":"21","key":"10.1016\/j.bcp.2018.03.020_b0030","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1111\/febs.12414","article-title":"Vascular smooth muscle cell phenotype is defined by Ca2+-dependent transcription factors","volume":"280","author":"Kudryavtseva","year":"2013","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0035","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/j.1476-5381.1991.tb09850.x","article-title":"(+)-S-12967 and (\u2212)-S-12968: 1,4-dihydropyridine stereoisomers with calcium channel agonistic and antagonistic properties in rat resistance arteries","volume":"103","author":"Prieto","year":"1991","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2018.03.020_b0040","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1152\/jappl.2001.91.2.973","article-title":"Invited review: arteriolar smooth muscle mechanotransduction: Ca(2+) signaling pathways underlying myogenic reactivity","volume":"91","author":"Hill","year":"2001","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0045","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/01.RES.0000138582.36921.9e","article-title":"L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase\/myocardin\/SRF-dependent mechanism","volume":"95","author":"Wamhoff","year":"2004","journal-title":"Circ. Res."},{"issue":"13","key":"10.1016\/j.bcp.2018.03.020_b0050","doi-asserted-by":"crossref","first-page":"9596","DOI":"10.1074\/jbc.275.13.9596","article-title":"Requirement of ryanodine receptor subtypes 1 and 2 for Ca(2+)-induced Ca(2+) release in vascular myocytes","volume":"275","author":"Coussin","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2018.03.020_b0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/ajpcell.00267.2009","article-title":"Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells","volume":"298","author":"Navedo","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"7","key":"10.1016\/j.bcp.2018.03.020_b0060","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/j.1476-5381.2010.00955.x","article-title":"Phosphatidylinositol 3-kinase-\u03b4 up-regulates L-type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes","volume":"161","author":"Pinho","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2018.03.020_b0065","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00424-014-1604-1","article-title":"Effects of streptozotocin and unilateral nephrectomy on L-type Ca2+ channels and membrane capacitance in arteriolar smooth muscle cells","volume":"467","author":"Youm","year":"2015","journal-title":"Pflugers Arch."},{"issue":"6","key":"10.1016\/j.bcp.2018.03.020_b0070","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1152\/japplphysiol.01229.2003","article-title":"Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation","volume":"96","author":"Bowles","year":"2004","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0075","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1152\/japplphysiol.00235.2006","article-title":"Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine","volume":"101","author":"Witczak","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bcp.2018.03.020_b0080","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1167\/iovs.10-5377","article-title":"Diabetes-induced inhibition of voltage-dependent calcium channels in the retinal microvasculature: role of spermine","volume":"11","author":"Matsushita","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2018.03.020_b0085","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.RES.0000126405.38858.BC","article-title":"Leukemia inhibitory factor activates cardiac L-type Ca2+ channels via phosphorylation of serine 1829 in the rabbit Cav1.2 subunit","volume":"94","author":"Takahashi","year":"2004","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bcp.2018.03.020_b0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/physrev.00016.2013","article-title":"L-type CaV1.2 calcium channels: from in vitro findings to in vivo function","volume":"94","author":"Hoffmann","year":"2014","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0095","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1161\/01.RES.0000138017.76125.8b","article-title":"Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate","volume":"95","author":"Le Blanc","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2018.03.020_b0100","doi-asserted-by":"crossref","first-page":"40347","DOI":"10.1074\/jbc.M508441200","article-title":"G{alpha}q inhibits cardiac L-type Ca2+ channels through phosphatidylinositol 3-kinase","volume":"280","author":"Lu","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0105","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.RES.0000030861.13850.F1","article-title":"Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats","volume":"91","author":"Northcot","year":"2002","journal-title":"Circ. Res."},{"issue":"463","key":"10.1016\/j.bcp.2018.03.020_b0110","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf9647","article-title":"Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes","volume":"10","author":"Nystoriak","year":"2017","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.bcp.2018.03.020_b0115","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1152\/ajpregu.00245.2005","article-title":"Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats","volume":"290","author":"Naik Xiang","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0120","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/ajpheart.00440.2011","article-title":"Changes in myofilament proteins, but not Ca2+ regulation are associated with a high-fat diet-induced improvement in contractile function in heart failure","volume":"301","author":"Cheng","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2018.03.020_b0125","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1152\/ajpheart.01204.2010","article-title":"Impaired Ca2+ handling in penile arteries from prediabetic Zucker rats: involvement of Rho kinase","volume":"300","author":"Villalba","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"15","key":"10.1016\/j.bcp.2018.03.020_b0130","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/CIRCULATIONAHA.105.563213","article-title":"Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms","volume":"113","author":"Kim","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2018.03.020_b0135","first-page":"412","article-title":"Endothelial dysfunction, obesity and insulin resistance","volume":"11","author":"Prieto","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2018.03.020_b0140","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1152\/ajpheart.01034.2006","article-title":"Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries","volume":"292","author":"Villalba","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2018.03.020_b0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2337\/db15-1547","article-title":"Reduction of hypothalamic endoplasmic reticulum stress activates browning of white fat and ameliorates obesity","volume":"66","author":"Contreras","year":"2017","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.bcp.2018.03.020_b0150","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1152\/ajprenal.00459.2006","article-title":"Voltage-gated Ca2+ entry and ryanodine receptor Ca2+-induced Ca2+ release in preglomerular arterioles","volume":"292","author":"Fellner","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"21","key":"10.1016\/j.bcp.2018.03.020_b0155","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1113\/jphysiol.2012.241315","article-title":"K. Size-dependent heterogeneity of contractile Ca2+ sensitization in rat arterial smooth muscle","volume":"590","author":"Kitazawa","year":"2012","journal-title":"J Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0160","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0008-6363(99)00106-6","article-title":"Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C","volume":"43","author":"Ungvari","year":"1999","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0165","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diabetes.55.03.06.db05-1284","article-title":"Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db\/db type 2 diabetic mice","volume":"55","author":"Pereira","year":"2006","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.bcp.2018.03.020_b0170","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00424-013-1387-9","article-title":"Up-regulation of ryanodine receptor expression increases the calcium-induced calcium release and spontaneous calcium signals in cerebral arteries from hindlimb unloaded rats","volume":"466","author":"Morel","year":"2014","journal-title":"Pflugers Arch."},{"issue":"1","key":"10.1016\/j.bcp.2018.03.020_b0175","doi-asserted-by":"crossref","first-page":"e53321","DOI":"10.1371\/journal.pone.0053321","article-title":"Abnormal Ca2+ spark\/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice","volume":"8","author":"Rueda","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2018.03.020_b0180","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1475-2840-9-8","article-title":"Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia","volume":"9","author":"Searls","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"issue":"8","key":"10.1016\/j.bcp.2018.03.020_b0185","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/CIRCRESAHA.110.221242","article-title":"Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat","volume":"107","author":"Tong","year":"2010","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.bcp.2018.03.020_b0190","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ceca.2014.08.006","article-title":"Endoplasmic reticulum stress in insulin resistance and diabetes","volume":"56","author":"Guerrero-Hern\u00e1ndez","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcp.2018.03.020_b0195","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/hh2001.097864","article-title":"Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca2 channels","volume":"89","author":"Macrez","year":"2001","journal-title":"Circ. Res."},{"issue":"35","key":"10.1016\/j.bcp.2018.03.020_b0200","doi-asserted-by":"crossref","first-page":"32545","DOI":"10.1074\/jbc.M102582200","article-title":"Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes","volume":"276","author":"Quignard","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2018.03.020_b0205","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nn1300","article-title":"PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane","volume":"7","author":"Viard","year":"2004","journal-title":"Nat. Neurosci."},{"issue":"394 (Pt 3)","key":"10.1016\/j.bcp.2018.03.020_b0210","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/BJ20051471","article-title":"Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle","volume":"15","author":"Wang","year":"2006","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0215","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/01.HYP.0000118518.20331.e8","article-title":"PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?","volume":"43","author":"Northcott","year":"2004","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0220","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.CIR.99.3.392","article-title":"Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance arteries","volume":"99","author":"Touyz","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2018.03.020_b0225","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/hy0202.103129","article-title":"Endothelin-1-induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways","volume":"39","author":"Cain","year":"2002","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0230","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/cvr\/cvq063","article-title":"Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes","volume":"87","author":"Smani","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.bcp.2018.03.020_b0235","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.febslet.2010.12.022","article-title":"kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance","volume":"585","author":"Turban","year":"2011","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.bcp.2018.03.020_b0240","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1152\/ajpheart.00818.2003","article-title":"Protein kinase betaII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation","volume":"286","author":"Bohlen","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2018.03.020_b0245","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2337\/db07-0792","article-title":"Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries","volume":"57","author":"Bakker","year":"2008","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bcp.2018.03.020_b0250","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1161\/ATVBAHA.110.210070","article-title":"Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway","volume":"30","author":"Payne","year":"2010","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2018.03.020_b0255","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.bbrc.2014.03.065","article-title":"Protein kinase C\u03b4 contributes to phenylephrine-mediated contraction in the aortae of high fat diet-induced obese mice","volume":"446","author":"Liu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"31","key":"10.1016\/j.bcp.2018.03.020_b0260","doi-asserted-by":"crossref","first-page":"11112","DOI":"10.1073\/pnas.0500360102","article-title":"Constitutively active L-type Ca2+ channels","volume":"102","author":"Navedo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.bcp.2018.03.020_b0265","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1152\/ajpheart.01261.2006","article-title":"Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery","volume":"292","author":"Cobine","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.bcp.2018.03.020_b0270","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1167\/iovs.12-9542","article-title":"Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels","volume":"53","author":"Potts","year":"2012","journal-title":"Invest. Ophthalmol Vis. Sci."},{"issue":"52","key":"10.1016\/j.bcp.2018.03.020_b0275","doi-asserted-by":"crossref","first-page":"43024","DOI":"10.1074\/jbc.M509147200","article-title":"PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2","volume":"280","author":"Maddali","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218301254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218301254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T22:52:29Z","timestamp":1534978349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295218301254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":55,"alternative-id":["S0006295218301254"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2018.03.020","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Ca2+ handling in resistance arteries from genetically obese Zucker rats: Role of the PI3K, ERK1\/2 and PKC signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2018.03.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}