{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:24:10Z","timestamp":1791473050757,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.bcp.2018.05.008","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T22:44:24Z","timestamp":1526510664000},"page":"213-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats"],"prefix":"10.1016","volume":"154","author":[{"given":"Yukiko","family":"Hattori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shioji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Fukumitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2018.05.008_b0005","series-title":"Handbook of Pesticide Toxicology, Vol. 3, Classes of Pesticides","first-page":"1217","article-title":"In 18.5 TCDD and other acnegenic materials","author":"Gasiewicz","year":"1991"},{"key":"10.1016\/j.bcp.2018.05.008_b0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/15287398909531288","article-title":"Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand","volume":"27","author":"Pirkle","year":"1989","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.bcp.2018.05.008_b0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pa.22.040182.002505","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity","volume":"22","author":"Poland","year":"1982","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2018.05.008_b0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.1996.0210","article-title":"Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity","volume":"140","author":"Fernandez-Salguero","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.taap.2013.06.024","article-title":"Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice","volume":"272","author":"Harrill","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.pa.35.040195.001515","article-title":"The aryl hydrocarbon receptor complex","volume":"35","author":"Hankinson","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2018.05.008_b0035","doi-asserted-by":"crossref","first-page":"16478","DOI":"10.1016\/S0021-9258(19)84730-0","article-title":"Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex","volume":"264","author":"Denison","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2018.05.008_b0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.pharmtox.39.1.103","article-title":"Induction of cytochrome P4501A1","volume":"39","author":"Whitlock","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2018.05.008_b0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/10408449309105013","article-title":"Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons","volume":"23","author":"Peterson","year":"1993","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.bcp.2018.05.008_b0050","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00499037","article-title":"Embryotoxic effects in mice treated wtih 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"272","author":"Nebert","year":"1972","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0055","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/taap.1995.1052","article-title":"Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status","volume":"131","author":"Gray","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0060","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/taap.1998.8433","article-title":"Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation","volume":"150","author":"Faqi","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0065","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0892-0362(00)00094-5","article-title":"Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats","volume":"22","author":"Amin","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bcp.2018.05.008_b0070","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(00)02792-6","article-title":"Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans","volume":"356","author":"Guo","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2018.05.008_b0075","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.reprotox.2012.07.005","article-title":"Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls","volume":"34","author":"Grandjean","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bcp.2018.05.008_b0080","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.chemosphere.2012.08.024","article-title":"Blood levels of PCDDs, PCDFs, and coplanar PCBs in Yusho mothers and their descendants: association with fetal Yusho disease","volume":"90","author":"Tsukimori","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.bcp.2018.05.008_b0085","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1289\/ehp.1306533","article-title":"Behavioral sexual dimorphism in school-age children and early developmental exposure to dioxins and PCBs: a follow-up study of the Duisburg Cohort","volume":"122","author":"Winneke","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bcp.2018.05.008_b0090","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/toxsci\/53.2.411","article-title":"Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects","volume":"53","author":"Hurst","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bcp.2018.05.008_b0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/taap.2001.9143","article-title":"Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring","volume":"173","author":"Chen","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0100","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1210\/en.2005-1125","article-title":"Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats","volume":"147","author":"Mutoh","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2018.05.008_b0105","doi-asserted-by":"crossref","first-page":"18440","DOI":"10.1074\/jbc.M111.335158","article-title":"Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin","volume":"287","author":"Takeda","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2018.05.008_b0110","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1124\/jpet.109.151282","article-title":"Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior","volume":"329","author":"Takeda","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2018.05.008_b0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1124\/mol.113.088575","article-title":"Maternal exposure to dioxin imprints sexual immaturity of the pups through fixing the status of the reduced expression of hypothalamic gonadotropin-releasing hormone","volume":"85","author":"Takeda","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0120","doi-asserted-by":"crossref","first-page":"10586","DOI":"10.1074\/jbc.M116.764332","article-title":"Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration","volume":"292","author":"Takeda","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2018.05.008_b0125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.taap.2014.09.001","article-title":"2,3,4,7,8-Pentachlorodibenzofuran is far less potent than 2,3,7,8-tetrachlorodibenzo-p-dioxin in disrupting the pituitary-gonad axis of the rat fetus","volume":"281","author":"Taura","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0130","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2131\/jts.35.365","article-title":"Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis","volume":"35","author":"Matsumoto","year":"2010","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.bcp.2018.05.008_b0135","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s12020-014-0257-3","article-title":"Dioxin-induced fetal growth retardation: the role of a preceding attenuation in the circulating level of glucocorticoid","volume":"47","author":"Hattori","year":"2014","journal-title":"Endocrine"},{"key":"10.1016\/j.bcp.2018.05.008_b0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2131\/jts.42.13","article-title":"\u03b1-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis","volume":"42","author":"Takeda","year":"2017","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.bcp.2018.05.008_b0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/humupd\/dmv008","article-title":"Morphological and functional maturation of Leydig cells: from rodent models to primates","volume":"21","author":"Teerds","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.bcp.2018.05.008_b0150","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1530\/acta.0.0990466","article-title":"Control of testicular steroidogenesis in foetal rat: effect of decapitation on testosterone and plasma luteinizing hormone-like activity","volume":"99","author":"Habert","year":"1982","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.bcp.2018.05.008_b0155","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1095\/biolreprod58.1.116","article-title":"Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis","volume":"58","author":"El-Gehani","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bcp.2018.05.008_b0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/01485019108987654","article-title":"Developmental changes in in vitro testosterone production by dispersed Leydig cells during fetal life in rats","volume":"27","author":"Habert","year":"1991","journal-title":"Arch. Androl."},{"key":"10.1016\/j.bcp.2018.05.008_b0165","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.taap.2012.08.026","article-title":"Aryl-hydrocarbon receptor activity modulates prolactin expression in the pituitary","volume":"265","author":"Moran","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0170","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ar.1091570208","article-title":"Hormonal determinants of the development of masculine and feminine behavior in male and female rats","volume":"157","author":"Whalen","year":"1967","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bcp.2018.05.008_b0175","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1126\/science.6163211","article-title":"Sexual differentiation of the central nervous system","volume":"211","author":"MacLusky","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.bcp.2018.05.008_b0180","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/nn1325","article-title":"Sexual differentiation of the vertebrate nervous system","volume":"7","author":"Morris","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bcp.2018.05.008_b0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/physrev.00010.2007","article-title":"Estradiol and the developing brain","volume":"88","author":"McCarthy","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2018.05.008_b0190","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bcp.2006.01.017","article-title":"Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions","volume":"72","author":"Bock","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0195","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature21080","article-title":"Feedback control of AHR signalling regulates intestinal immunity","volume":"542","author":"Schiering","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2018.05.008_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2018.02.031","article-title":"Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells","author":"Schiering","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2018.05.008_b0205","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2131\/jts.33.405","article-title":"Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor","volume":"33","author":"Minami","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.bcp.2018.05.008_b0210","first-page":"1153","article-title":"Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice","volume":"14","author":"Biljes","year":"2015","journal-title":"EXCLI J."},{"key":"10.1016\/j.bcp.2018.05.008_b0215","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/carcin\/16.6.1403","article-title":"Expression of Ah receptor (TCDD receptor) during human monocytic differentiation","volume":"16","author":"Hayashi","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2018.05.008_b0220","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1210\/endo-116-4-1565","article-title":"Ontogeny of hypothalamic luteinizing hormone-releasing hormone (GnRH) and pituitary GnRH receptors in fetal and neonatal rats","volume":"116","author":"Aubert","year":"1985","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2018.05.008_b0225","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mce.2010.12.027","article-title":"Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression","volume":"333","author":"Cao","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bcp.2018.05.008_b0230","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1165\/rcmb.2012-0497OC","article-title":"Dioxin and estrogen signaling in lung adenocarcinoma cells with different aryl hydrocarbon receptor\/estrogen receptor \u03b1 phenotypes","volume":"49","author":"Kuo","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bcp.2018.05.008_b0235","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI112340","article-title":"Regulation of rat luteinizing hormone subunit messenger ribonucleic acids by gonadal steroid hormones","volume":"77","author":"Gharib","year":"1986","journal-title":"J. Clin. Invest."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629521830193X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629521830193X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T20:22:32Z","timestamp":1661286152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629521830193X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":47,"alternative-id":["S000629521830193X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2018.05.008","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2018.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}