{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:44:22Z","timestamp":1785451462286,"version":"3.56.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["SAF 2009-08460"],"award-info":[{"award-number":["SAF 2009-08460"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["IT-616-13"],"award-info":[{"award-number":["IT-616-13"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.bcp.2018.08.012","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T23:27:04Z","timestamp":1533857224000},"page":"258-265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Selective up-regulation of cannabinoid CB1 receptor coupling to Go-proteins in suicide victims with mood disorders"],"prefix":"10.1016","volume":"157","author":[{"given":"Susana","family":"Mato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuencisla","family":"Pilar-Cu\u00e9llar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa M.","family":"Valdiz\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gonz\u00e1lez-Maeso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Rodr\u00edguez-Puertas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Meana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Sall\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicto","family":"Crespo-Facorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Pazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.bcp.2018.08.012_b0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-8993(95)00523-S","article-title":"Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims","volume":"688","author":"Arango","year":"1995","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bcp.2018.08.012_b0010","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1471-4159.1999.0720282.x","article-title":"Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides","volume":"72","author":"Garcia-Sevilla","year":"1999","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.bcp.2018.08.012_b0015","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.mp.4001067","article-title":"Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors","volume":"7","author":"Gonzalez-Maeso","year":"2002","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bcp.2018.08.012_b0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.bcp.2018.08.012_b0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/35072566","article-title":"Research and treatment approaches to depression","volume":"2","author":"Wong","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.bcp.2018.08.012_b0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pharmthera.2012.12.002","article-title":"Endocannabinoid system and mood disorders: priming a target for new therapies","volume":"138","author":"Micale","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.012_b0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International Union of Pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2018.08.012_b0040","first-page":"27","article-title":"Cannabinoid receptors: G-protein-mediated signal transduction mechanisms","volume":"59","author":"Childers","year":"1993","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.bcp.2018.08.012_b0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The endocannabinoid system and the brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"issue":"5\u20136","key":"10.1016\/j.bcp.2018.08.012_b0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00008877-200509000-00006","article-title":"Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression?","volume":"16","author":"Hill","year":"2005","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bcp.2018.08.012_b0055","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroscience.2011.09.031","article-title":"CB1 receptor-deficient mice as a model for depression","volume":"204","author":"Valverde","year":"2012","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.bcp.2018.08.012_b0060","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.biopsych.2006.12.001","article-title":"Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress","volume":"62","author":"Bortolato","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.bcp.2018.08.012_b0065","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/j.1471-4159.2008.05567.x","article-title":"Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment","volume":"106","author":"Hill","year":"2008","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.bcp.2018.08.012_b0070","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1471-4159.2009.05898.x","article-title":"Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine","volume":"108","author":"Rodriguez-Gaztelumendi","year":"2009","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.012_b0075","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12640-017-9708-y","article-title":"Changes in the brain endocannabinoid system in rat models of depression","volume":"31","author":"Smaga","year":"2017","journal-title":"Neurotox. Res."},{"issue":"43","key":"10.1016\/j.bcp.2018.08.012_b0080","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.1523\/JNEUROSCI.1636-07.2007","article-title":"Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex","volume":"27","author":"Bambico","year":"2007","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.bcp.2018.08.012_b0085","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2005.10.006","article-title":"A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders","volume":"26","author":"Witkin","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.bcp.2018.08.012_b0090","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00702-008-0131-7","article-title":"Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents","volume":"115","author":"Hill","year":"2008","journal-title":"J. Neural Transm."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.012_b0095","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1124\/mol.109.060079","article-title":"Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms","volume":"77","author":"Mato","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2018.08.012_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2018.07.009","article-title":"The endocannabinoid system in mental disorders: evidence from human brain studies","author":"Ibarra-Lecue","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2018.08.012_b0105","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.euroneuro.2008.05.003","article-title":"Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression","volume":"18","author":"Domschke","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2018.08.012_b0110","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.phrs.2010.01.002","article-title":"Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression","volume":"61","author":"Monteleone","year":"2010","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.bcp.2018.08.012_b0115","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1177\/0269881112454229","article-title":"Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes","volume":"26","author":"Mitjans","year":"2012","journal-title":"J. Psychopharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.012_b0120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00213-013-2995-y","article-title":"Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment","volume":"227","author":"Mitjans","year":"2013","journal-title":"Psychopharmacology"},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2018.08.012_b0125","first-page":"161","article-title":"Cannabinoid receptors in postmortem human brain: a radiometric and transductional study in major depression","volume":"134","author":"Mato","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.012_b0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/sj.mp.4001376","article-title":"Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims","volume":"9","author":"Hungund","year":"2004","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.bcp.2018.08.012_b0135","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jpsychires.2012.03.021","article-title":"Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear","volume":"46","author":"Choi","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bcp.2018.08.012_b0140","series-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM III-R)","author":"American Psychiatric Association","year":"1987"},{"issue":"7","key":"10.1016\/j.bcp.2018.08.012_b0145","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1017\/S1461145709990940","article-title":"Agonist-dependent modulation of G-protein coupling and transduction of 5-HT1A receptors in rat dorsal raphe nucleus","volume":"13","author":"Valdiz\u00e1n","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2018.08.012_b0150","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1001\/archpsyc.57.9.850","article-title":"Brain serotonin2 receptors in major depression: a positron emission tomography study","volume":"57","author":"Yatham","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"issue":"9","key":"10.1016\/j.bcp.2018.08.012_b0155","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1017\/S1461145709000285","article-title":"Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls","volume":"12","author":"Shelton","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2018.08.012_b0160","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0893-133X(01)00310-4","article-title":"Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims","volume":"25","author":"Arango","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1016\/j.bcp.2018.08.012_b0165","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1038\/sj.npp.1300525","article-title":"Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression","volume":"29","author":"Si","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"9600","key":"10.1016\/j.bcp.2018.08.012_b0170","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(07)61721-8","article-title":"Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials","volume":"370","author":"Christensen","year":"2007","journal-title":"Lancet"},{"issue":"9740","key":"10.1016\/j.bcp.2018.08.012_b0175","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0140-6736(10)60935-X","article-title":"Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial","volume":"376","author":"Topol","year":"2010","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.bcp.2018.08.012_b0180","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/mp.2011.82","article-title":"Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers","volume":"17","author":"Hirvonen","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"11","key":"10.1016\/j.bcp.2018.08.012_b0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166005","article-title":"Marijuana use is associated with behavioral approach and depressive symptoms in adolescents and emerging adults","volume":"11","author":"Wright","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bcp.2018.08.012_b0190","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.addbeh.2005.05.052","article-title":"Decreased depression in marijuana users","volume":"31","author":"Denson","year":"2006","journal-title":"Addict. Behav."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.012_b0195","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bcp.2011.10.018","article-title":"The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: evidence from postmortem human brain","volume":"83","author":"Erdozain","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2018.08.012_b0200","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fphar.2016.00415","article-title":"Biased agonism of three different cannabinoid receptor agonists in mouse brain cortex","volume":"7","author":"Diez-Alarcia","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2018.08.012_b0205","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1073\/pnas.051632598","article-title":"Most central nervous system D2 dopamine receptors are coupled to their effectors by Go","volume":"98","author":"Jiang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"22","key":"10.1016\/j.bcp.2018.08.012_b0210","doi-asserted-by":"crossref","first-page":"13806","DOI":"10.1016\/S0021-9258(18)89817-9","article-title":"Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain","volume":"259","author":"Sternweis","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.012_b0215","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-5793(92)80770-H","article-title":"Heterogeneity of three electrophoretically distinct Go alpha-subunits in mammalian brain","volume":"307","author":"Spicher","year":"1992","journal-title":"FEBS Lett."},{"issue":"5042","key":"10.1016\/j.bcp.2018.08.012_b0220","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.1347957","article-title":"Gz-mediated hormonal inhibition of cyclic AMP accumulation","volume":"255","author":"Wong","year":"1992","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.bcp.2018.08.012_b0225","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0166-2236(94)90157-0","article-title":"Modulation of ion-channel function by G-protein-coupled receptors","volume":"17","author":"Hille","year":"1994","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.bcp.2018.08.012_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.270.1.1","article-title":"Mammalian membrane-bound adenylyl cyclases","volume":"270","author":"Taussig","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.bcp.2018.08.012_b0235","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1016\/S0021-9258(19)83894-2","article-title":"Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities","volume":"261","author":"Katada","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2018.08.012_b0240","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0006-8993(94)91552-0","article-title":"Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims","volume":"633","author":"Cowburn","year":"1994","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.012_b0245","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1046\/j.1471-4159.1999.0731121.x","article-title":"G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death","volume":"73","author":"Dowlatshahi","year":"1999","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.012_b0250","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/157015906776359586","article-title":"Heterotrimeric g proteins: insights into the neurobiology of mood disorders","volume":"4","author":"Gonzalez-Maeso","year":"2006","journal-title":"Curr. Neuropharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2018.08.012_b0255","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1038\/sj.npp.1301092","article-title":"Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis","volume":"31","author":"Hill","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.bcp.2018.08.012_b0260","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.neuropharm.2003.11.004","article-title":"Influence of age, postmortem delay and freezing storage period on cannabinoid receptor density and functionality in human brain","volume":"46","author":"Mato","year":"2004","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bcp.2018.08.012_b0265","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0893-133X(01)00342-6","article-title":"Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain","volume":"26","author":"Gonz\u00e1lez-Maeso","year":"2002","journal-title":"Neuropsychopharmacology"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218303320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218303320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:05:04Z","timestamp":1762095904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295218303320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":53,"alternative-id":["S0006295218303320"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2018.08.012","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective up-regulation of cannabinoid CB1 receptor coupling to Go-proteins in suicide victims with mood disorders","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2018.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}