{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:47:13Z","timestamp":1778672833820,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.bcp.2018.08.019","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T09:00:05Z","timestamp":1534496405000},"page":"339-358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Probing the molecular basis for affinity\/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors"],"prefix":"10.1016","volume":"158","author":[{"given":"Pella Cecilia","family":"S\u00f6derhielm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Balle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Bak-Nyhus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline M.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip K.","family":"Ahring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders A.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2018.08.019_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.apha.2017.03.003","article-title":"GABAA receptors and the diversity in their structure and pharmacology","volume":"79","author":"Chua","year":"2017","journal-title":"Adv. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/pr.108.00505","article-title":"International Union of Pharmacology. LXX. Subtypes of \u03b3-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function. Update","volume":"60","author":"Olsen","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2018.08.019_b0015","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev-pharmtox-011613-135947","article-title":"GABAA receptor subtypes: therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism","volume":"54","author":"Rudolph","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.bcp.2018.08.019_b0020","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.neuron.2015.03.042","article-title":"The GABAA receptor as a therapeutic target for neurodevelopmental disorders","volume":"86","author":"Braat","year":"2015","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bcp.2018.08.019_b0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/gbb.12321","article-title":"GABAA receptor subtype involvement in addictive behaviour","volume":"16","author":"Stephens","year":"2017","journal-title":"Genes. Brain. Behav."},{"issue":"4","key":"10.1016\/j.bcp.2018.08.019_b0030","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tips.2009.12.005","article-title":"Binding, activation and modulation of Cys-loop receptors","volume":"31","author":"Miller","year":"2010","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2018.08.019_b0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.apha.2014.10.002","article-title":"Allosteric modulation of GABAA receptors via multiple drug-binding sites","volume":"72","author":"Sieghart","year":"2015","journal-title":"Adv. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2018.08.019_b0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrd3502","article-title":"Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes","volume":"10","author":"Rudolph","year":"2011","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"4","key":"10.1016\/j.bcp.2018.08.019_b0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11940-016-0401-x","article-title":"The role of benzodiazepines in the treatment of epilepsy","volume":"18","author":"Ochoa","year":"2016","journal-title":"Curr. Treat. Options. Neurol."},{"key":"10.1016\/j.bcp.2018.08.019_b0050","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1038\/ncomms7803","article-title":"Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype","volume":"6","author":"Ralvenius","year":"2015","journal-title":"Nat. Commun."},{"issue":"7176","key":"10.1016\/j.bcp.2018.08.019_b0055","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature06493","article-title":"Reversal of pathological pain through specific spinal GABAA receptor subtypes","volume":"451","author":"Knabl","year":"2008","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bcp.2018.08.019_b0060","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2174\/156802611795371314","article-title":"GABAA receptor subtype-selective modulators. II. \u03b15-selective inverse agonists for cognition enhancement","volume":"11","author":"Atack","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2018.08.019_b0065","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2174\/156802611795371350","article-title":"GABAA receptor subtype-selective modulators. I. \u03b12\/\u03b13-selective agonists as non-sedating anxiolytics","volume":"11","author":"Atack","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2018.08.019_b0070","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","article-title":"Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor \u03b11 subtype","volume":"3","author":"McKernan","year":"2000","journal-title":"Nat. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2018.08.019_b0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-2999(02)01279-7","article-title":"Mechanism of \u03b1-subunit selectivity of benzodiazepine pharmacology at \u03b3-aminobutyric acid type A receptors","volume":"437","author":"Wingrove","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.019_b0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-2999(02)02191-X","article-title":"Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABAA receptor subtypes","volume":"451","author":"Sanna","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"19","key":"10.1016\/j.bcp.2018.08.019_b0085","doi-asserted-by":"crossref","first-page":"13370","DOI":"10.1074\/jbc.274.19.13370","article-title":"Structural elements of the \u03b3-aminobutyric acid type A receptor conferring subtype selectivity for benzodiazepine site ligands","volume":"274","author":"Renard","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2018.08.019_b0090","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0026-895X(25)13682-1","article-title":"Cloning of cDNA sequences encoding human \u03b12 and \u03b13 \u03b3-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant \u03b11-, \u03b12-, \u03b13-, and \u03b15-containing human \u03b3-aminobutyric acidA receptors","volume":"43","author":"Hadingham","year":"1993","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2018.08.019_b0095","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1111\/j.1471-4159.1990.tb01237.x","article-title":"\u03b3-aminobutyric acidA receptor \u03b15-subunit creates novel type II benzodiazepine receptor pharmacology","volume":"54","author":"Pritchett","year":"1990","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bcp.2018.08.019_b0100","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/jpet.105.096701","article-title":"Indiplon is a high-affinity positive allosteric modulator with selectivity for \u03b11 subunit-containing GABAA receptors","volume":"317","author":"Petroski","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0105","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bcp.2014.12.010","article-title":"GABAA \u03b15 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085","volume":"93","author":"de Lucas","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2018.08.019_b0110","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1073\/pnas.88.4.1421","article-title":"\u03b3-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site","volume":"88","author":"Pritchett","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2018.08.019_b0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0014-2999(98)00456-7","article-title":"Amino acid residue 200 on the \u03b11 subunit of GABAA receptors affects the interaction with selected benzodiazepine binding site ligands","volume":"354","author":"Schaerer","year":"1998","journal-title":"Eur. J. Pharmacol."},{"issue":"13","key":"10.1016\/j.bcp.2018.08.019_b0120","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1074\/jbc.M109.079319","article-title":"Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors","volume":"285","author":"Jensen","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2018.08.019_b0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(89)90359-4","article-title":"Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension","volume":"77","author":"Horton","year":"1989","journal-title":"Gene"},{"issue":"48","key":"10.1016\/j.bcp.2018.08.019_b0130","doi-asserted-by":"crossref","first-page":"46020","DOI":"10.1074\/jbc.M207663200","article-title":"Forced subunit assembly in \u03b11\u03b22\u03b32 GABAA receptors. Insight into the absolute arrangement","volume":"277","author":"Baumann","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"39","key":"10.1016\/j.bcp.2018.08.019_b0135","doi-asserted-by":"crossref","first-page":"36275","DOI":"10.1074\/jbc.M105240200","article-title":"Subunit arrangement of \u03b3-aminobutyric acid type A receptors","volume":"276","author":"Baumann","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6649","key":"10.1016\/j.bcp.2018.08.019_b0140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/38738","article-title":"Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors","volume":"389","author":"Mihic","year":"1997","journal-title":"Nature"},{"issue":"49","key":"10.1016\/j.bcp.2018.08.019_b0145","doi-asserted-by":"crossref","first-page":"16256","DOI":"10.1523\/JNEUROSCI.1495-14.2014","article-title":"Probing \u03b14\u03b2\u03b4 GABAA receptor heterogeneity: differential regional effects of a functionally selective \u03b14\u03b21\u03b4\/\u03b14\u03b23\u03b4 receptor agonist on tonic and phasic inhibition in rat brain","volume":"34","author":"Hoestgaard-Jensen","year":"2014","journal-title":"J. Neurosci."},{"issue":"6454","key":"10.1016\/j.bcp.2018.08.019_b0150","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/366479a0","article-title":"Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities","volume":"366","author":"Eisele","year":"1993","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bcp.2018.08.019_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088456","article-title":"Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for \u03b12- versus \u03b11-GABAA-receptor complexes","volume":"9","author":"Jensen","year":"2014","journal-title":"PLoS One"},{"issue":"7514","key":"10.1016\/j.bcp.2018.08.019_b0160","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature13293","article-title":"Crystal structure of a human GABAA receptor","volume":"512","author":"Miller","year":"2014","journal-title":"Nature."},{"issue":"7712","key":"10.1016\/j.bcp.2018.08.019_b0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41586-018-0255-3","article-title":"Structure of a human synaptic GABAA receptor","volume":"559","author":"Zhu","year":"2018","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/j.bcp.2018.08.019_b0170","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"the universal protein knowledgebase","volume":"45","author":"The-UniProt-Consortium, UniProt","year":"2017","journal-title":"Nucl. Acids Res."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.019_b0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/prot.10613","article-title":"A hierarchical approach to all-atom protein loop prediction","volume":"55","author":"Jacobson","year":"2004","journal-title":"Proteins"},{"issue":"11","key":"10.1016\/j.bcp.2018.08.019_b0180","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1110\/ps.062416606","article-title":"Statistical potential for assessment and prediction of protein structures","volume":"15","author":"Shen","year":"2006","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.019_b0185","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm050540c","article-title":"Novel procedure for modeling ligand\/receptor induced fit effects","volume":"49","author":"Sherman","year":"2006","journal-title":"J. Med. Chem."},{"issue":"20","key":"10.1016\/j.bcp.2018.08.019_b0190","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1073\/pnas.0400220101","article-title":"Positioning of the \u03b1-subunit isoforms confers a functional signature to \u03b3-aminobutyric acid type A receptors","volume":"101","author":"Minier","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0195","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0021-9258(18)45961-3","article-title":"A single histidine in GABAA receptors is essential for benzodiazepine agonist binding","volume":"267","author":"Wieland","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.bcp.2018.08.019_b0200","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1021\/jm00052a019","article-title":"Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor","volume":"37","author":"Wieland","year":"1994","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2018.08.019_b0205","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00001756-199302000-00018","article-title":"Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue","volume":"4","author":"Kleingoor","year":"1993","journal-title":"Neuroreport"},{"issue":"4","key":"10.1016\/j.bcp.2018.08.019_b0210","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00726-012-1456-y","article-title":"Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review","volume":"44","author":"Karim","year":"2013","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.bcp.2018.08.019_b0215","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/bph.12340","article-title":"The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors","volume":"170","author":"Hoestgaard-Jensen","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"46","key":"10.1016\/j.bcp.2018.08.019_b0220","doi-asserted-by":"crossref","first-page":"10682","DOI":"10.1523\/JNEUROSCI.1166-05.2005","article-title":"Evidence for a significant role of \u03b13-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines","volume":"25","author":"Dias","year":"2005","journal-title":"J. Neurosci."},{"issue":"36","key":"10.1016\/j.bcp.2018.08.019_b0225","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1073\/pnas.0801854105","article-title":"A conserved salt bridge critical for GABAA receptor function and loop C dynamics","volume":"105","author":"Venkatachalan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"22","key":"10.1016\/j.bcp.2018.08.019_b0230","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1021\/jm800889m","article-title":"Structural requirements for eszopiclone and zolpidem binding to the \u03b3-aminobutyric acid type-A (GABAA) receptor are different","volume":"51","author":"Hanson","year":"2008","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2018.08.019_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052323","article-title":"A unified model of the GABAA receptor comprising agonist and benzodiazepine binding sites","volume":"8","author":"Bergmann","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0240","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1124\/jpet.108.138859","article-title":"NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy","volume":"327","author":"Mirza","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0245","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0014-5793(98)00803-5","article-title":"Pharmacology of recombinant \u03b3-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated \u03b1-subunits","volume":"431","author":"Benson","year":"1998","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0250","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.pharmthera.2005.04.014","article-title":"Treating insomnia: current and investigational pharmacological approaches","volume":"112","author":"Ebert","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2018.08.019_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2007.10.016","article-title":"GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon","volume":"580","author":"Wegner","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2018.08.019_b0260","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0896-6273(94)90330-1","article-title":"A novel allosteric modulatory site on the GABAA receptor \u03b2 subunit","volume":"12","author":"Wafford","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2018.08.019_b0265","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.1073\/pnas.94.20.11031","article-title":"The interaction of the general anesthetic etomidate with the \u03b3-aminobutyric acid type A receptor is influenced by a single amino acid","volume":"94","author":"Belelli","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2018.08.019_b0270","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1124\/mol.115.099291","article-title":"A multifaceted GABAA receptor modulator: functional properties and molecular mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)","volume":"88","author":"Hammer","year":"2015","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2018.08.019_b0275","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/0269881109354927","article-title":"MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans","volume":"25","author":"Atack","year":"2011","journal-title":"J. Psychopharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218303435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295218303435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:04:02Z","timestamp":1757768642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295218303435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":55,"alternative-id":["S0006295218303435"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2018.08.019","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probing the molecular basis for affinity\/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2018.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}